Sitting Less and Moving More: Improved Glycaemic Control for Type 2 Diabetes Prevention and Management.

Abstract:

:Epidemiological evidence indicates that excessive time spent in sedentary behaviours (too much sitting) is associated with an increased risk of type 2 diabetes (T2D). Here, we highlight findings of experimental studies corroborating and extending the epidemiological evidence and showing the potential benefits for T2D of reducing and breaking up sitting time across the whole day. We also discuss future research opportunities and consider emerging implications for T2D prevention and management. This new evidence is stimulating an expansion of diabetes-related physical activity guidelines-suggesting that in addition to moderate-vigorous physical activity, reducing and regularly interrupting prolonged sitting time is likely to have important and varied benefits across the spectrum of diabetes risk.

journal_name

Curr Diab Rep

journal_title

Current diabetes reports

authors

Dempsey PC,Owen N,Yates TE,Kingwell BA,Dunstan DW

doi

10.1007/s11892-016-0797-4

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

114

issue

11

eissn

1534-4827

issn

1539-0829

pii

10.1007/s11892-016-0797-4

journal_volume

16

pub_type

杂志文章,评审
  • Assessing Psychological Insulin Resistance in Type 2 Diabetes: a Critical Comparison of Measures.

    abstract:PURPOSE OF REVIEW:This study aims to examine the operationalisation of 'psychological insulin resistance' (PIR) among people with type 2 diabetes and to identify and critique relevant measures. RECENT FINDINGS:PIR has been operationalised as (1) the assessment of attitudes or beliefs about insulin therapy and (2) hypo...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-017-0873-4

    authors: Holmes-Truscott E,Pouwer F,Speight J

    更新日期:2017-07-01 00:00:00

  • Cardiovascular fitness and type 2 diabetes.

    abstract::Exercise has long been recognized as a cornerstone in diabetes care. Even so, modern science is just beginning to understand the physiologic impact cardiovascular fitness has on long-term diabetes management, and the prevention or delay, of type 2 diabetes. Recent advances in research are defining the metabolic pathwa...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-002-0109-z

    authors: Mullooly C

    更新日期:2002-10-01 00:00:00

  • Gut Immunity and Type 1 Diabetes: a Mélange of Microbes, Diet, and Host Interactions?

    abstract::Type 1 diabetes (T1D) is a complex autoimmune disease, and first stages of the disease typically develop early in life. Genetic as well as environmental factors are thought to contribute to the risk of developing autoimmunity against pancreatic beta cells. Several environmental factors, such as breastfeeding or early ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0753-3

    authors: Endesfelder D,Engel M,Zu Castell W

    更新日期:2016-07-01 00:00:00

  • Emerging Insights and Interventions for Diabetic Retinopathy.

    abstract:PURPOSE OF REVIEW:To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss. RECENT FINDINGS:Advances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies e...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1218-2

    authors: Honasoge A,Nudleman E,Smith M,Rajagopal R

    更新日期:2019-09-10 00:00:00

  • Practical, practice, and policy relevant trials.

    abstract::There is a well-documented gap between research and practice in diabetes and many other chronic illnesses. This gap is due, in part, to limitations of the research database. Different types of clinical trials have recently been called for that address issues central to clinicians, administrative decision makers, and p...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-004-0065-x

    authors: Glasgow RE

    更新日期:2004-04-01 00:00:00

  • Metabolomic Biomarkers in the Progression to Type 1 Diabetes.

    abstract::Metabolomics is the snapshot of all detectable metabolites and lipids in biological materials and has potential in reflecting genetic and environmental factors contributing to the development of complex diseases, such as type 1 diabetes. The progression to seroconversion to development of type 1 diabetes has been stud...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0820-9

    authors: Overgaard AJ,Kaur S,Pociot F

    更新日期:2016-12-01 00:00:00

  • Genetics of diabetes complications.

    abstract::A large body of evidence indicates that the risk for developing chronic diabetic complications is under the control of genetic factors. Previous studies using a candidate gene approach have uncovered a number of genetic loci that may shape this risk, such as the VEGF gene for retinopathy, the ELMO1 gene for nephropath...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-010-0147-x

    authors: Doria A

    更新日期:2010-12-01 00:00:00

  • Thyroid Hormone Signalling Alteration in Diabetic Nephropathy and Cardiomyopathy: a "Switch" to the Foetal Gene Programme.

    abstract:PURPOSE OF THE REVIEW:In this study, we will analyse how diabetes induces the reactivation of organs' developmental programmes and growth, discuss how thyroid hormone (TH) signalling orchestrates these processes, and suggest novel strategies for exploiting TH-mediated reparative and regenerative properties. RECENT FIN...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01344-6

    authors: Mantzouratou P,Lavecchia AM,Novelli R,Xinaris C

    更新日期:2020-09-28 00:00:00

  • What Makes Sodium-Glucose Co-Transporter-2 Inhibitors Stand out in Heart Failure?

    abstract:PURPOSE OF REVIEW:We highlight the unique properties of the sodium-glucose cotransporter-2 (SGLT-2 inhibitors) which may lend favorably to their efficient integration in the background of other heart failure (HF) therapies. We also discuss the unique aspects of SGLT-2 inhibitor dosing, lack of titration needs, effects ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01347-3

    authors: Khan MS,Vaduganathan M

    更新日期:2020-10-11 00:00:00

  • Breast-feeding and diabetes: long-term impact on mothers and their infants.

    abstract::In the general population, breast-feeding is associated with a reduced risk of the offspring being overweight later in life by 22% to 24% across the age spectrum, from preschool children to adults. There is a dose-response gradient with increasing duration of breast-feeding, and lowest risk with prolonged, exclusive b...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-008-0050-x

    authors: Gunderson EP

    更新日期:2008-08-01 00:00:00

  • Self- and Social-Regulation in Type 1 Diabetes Management During Late Adolescence and Emerging Adulthood.

    abstract:PURPOSE OF REVIEW:This paper aims to examine how self-regulation (i.e., cognition, emotion) and social-regulation (i.e., parents, friends, romantic partners) are interrelated risk and protective factors for type 1 diabetes management during late adolescence and emerging adulthood. RECENT FINDINGS:Problems in cognitive...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-018-0995-3

    authors: Wiebe DJ,Berg CA,Mello D,Kelly CS

    更新日期:2018-03-21 00:00:00

  • Self-Care Disparities Among Adults with Type 2 Diabetes in the USA.

    abstract::Suboptimal glycemic control is more common among non-Hispanic Blacks (NHBs) and Hispanics than non-Hispanic Whites (NHWs). Disparities in the performance of self-care behaviors may contribute to this. To synthesize knowledge on current self-care disparities, we reviewed studies from January 2011-March 2016 that includ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0796-5

    authors: Mayberry LS,Bergner EM,Chakkalakal RJ,Elasy TA,Osborn CY

    更新日期:2016-11-01 00:00:00

  • The Continuing Evolution of Precision Health in Type 2 Diabetes: Achievements and Challenges.

    abstract:PURPOSE OF REVIEW:The purpose of this review was to summarize recent advances in the genomics of type 2 diabetes (T2D) and to highlight current initiatives to advance precision health. RECENT FINDINGS:Generation of multi-omic data to measure each of the "biologic layers," developments in describing genomic function an...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1137-2

    authors: Lin Y,Wessel J

    更新日期:2019-02-26 00:00:00

  • FTO and obesity: mechanisms of association.

    abstract::The Fat mass and obesity associated (FTO) gene is a newly identified genetic factor for obesity. However, the exact molecular mechanisms responsible for the effect of FTO on obesity remain largely unknown. Recent studies from genome-wide associated studies reveal that genetic variants in the FTO gene are associated no...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-014-0486-0

    authors: Zhao X,Yang Y,Sun BF,Zhao YL,Yang YG

    更新日期:2014-01-01 00:00:00

  • Psychosocial issues in youth with type 2 diabetes mellitus.

    abstract::Little published research exists on psychosocial issues in adolescents with type 2 diabetes mellitus (T2DM), because until two decades ago, diabetes diagnosed in children and adolescents was almost exclusively type 1 diabetes mellitus or insulin-dependent diabetes. In the past two decades, rates of T2DM have increased...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-009-0025-6

    authors: Anderson BJ,McKay SV

    更新日期:2009-04-01 00:00:00

  • Contrast-induced nephropathy: update with special emphasis on patients with diabetes.

    abstract::Contrast-induced nephropathy (CIN) continues to be a significant complication of the increasing use of iodinated contrast media. There have been few new insights into pathogenesis; despite multiple strategies aimed at prophylaxis, very few have proven efficacious. This article reviews our current knowledge regarding C...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-007-0077-4

    authors: Solomon R

    更新日期:2007-12-01 00:00:00

  • The place of GLP-1-based therapy in diabetes management: differences between DPP-4 inhibitors and GLP-1 receptor agonists.

    abstract::Type 2 diabetes is a progressive disease characterized by the need for additional antidiabetic agents overtime to maintain a stable level of glycemic control. The discovery of the glucagon like peptide 1, 1 of the 2 major incretins, was pivotal to the development of novel therapies, which can be used in individuals wi...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-013-0377-9

    authors: Eckerle Mize DL,Salehi M

    更新日期:2013-06-01 00:00:00

  • A review of adolescent adherence in type 1 diabetes and the untapped potential of diabetes providers to improve outcomes.

    abstract::Only 21 % of adolescents with type 1 diabetes (T1D) meet glycemic goals set forth by the American Diabetes Association. Adherence to therapy is a particular concern in this population, and the association between poor adherence and worsening glycemic control indicates that there is a critical need to improve adherence...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-015-0621-6

    authors: Datye KA,Moore DJ,Russell WE,Jaser SS

    更新日期:2015-08-01 00:00:00

  • Novel targets against retinal angiogenesis in diabetic retinopathy.

    abstract::Proliferative diabetic retinopathy (PDR), characterized by pathologic retinal angiogenesis, is a major cause of blindness in the USA and globally. Treatments targeting vascular endothelial growth factor (VEGF) have emerged as a beneficial part of the therapeutic armamentarium for this condition, highlighting the utili...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-012-0289-0

    authors: Wang S,Park JK,Duh EJ

    更新日期:2012-08-01 00:00:00

  • Inflammation and diabetic nephropathy.

    abstract::Diabetic nephropathy has become the main cause of renal failure, but unfortunately the intimate mechanisms leading to the development and progression of renal injury are not yet fully known. Activated innate immunity and inflammation are relevant factors in the pathogenesis of diabetes. Moreover, different inflammator...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-006-0080-1

    authors: Mora C,Navarro JF

    更新日期:2006-12-01 00:00:00

  • Sodium-Glucose Cotransporter Type 2 (SGLT-2) Inhibitors and Ketogenesis: the Good and the Bad.

    abstract:PURPOSE OF REVIEW:The micro/macrovascular complications of diabetes cause considerable morbidity and premature mortality. The SGLT2 inhibitors are the first diabetes medications with significant benefits on microvascular disease (nephropathy) and macrovascular cardiovascular disease. In this review, we evaluate one of ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01359-z

    authors: Ekanayake P,Hupfeld C,Mudaliar S

    更新日期:2020-11-23 00:00:00

  • What type of diabetes do young people have?

    abstract::Although type 1 diabetes remains the most common type of diabetes in the pediatric population, there has been a dramatic rise in type 2 diabetes in youth. Clinical distinctions between these two major types have become blurred. As genetic and biochemical measures become more affordable and available, practical applica...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-006-0020-0

    authors: Pihoker C

    更新日期:2006-04-01 00:00:00

  • Nutrition therapy for dyslipidemia.

    abstract::National guidelines indicate patients with elevated low- density lipoprotein cholesterol should consume less than 7% of calories from saturated fat and less than 200 mg of cholesterol. Trans fatty acids should also be limited. Incorporation of functional foods, such as stanol-containing margarine, soy products, and so...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-003-0084-z

    authors: Carson JA

    更新日期:2003-10-01 00:00:00

  • Family-Based Interventions Targeting Improvements in Health and Family Outcomes of Children and Adolescents with Type 1 Diabetes: a Systematic Review.

    abstract:PURPOSE OF REVIEW:A systematic review was conducted of family-based interventions to improve glycemic control, adherence, and psychosocial outcomes in children and adolescents with type 1 diabetes (T1D). Electronic databases were searched for randomized controlled trials (RCTs) published since the seminal Diabetes Cont...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-018-0981-9

    authors: Feldman MA,Anderson LM,Shapiro JB,Jedraszko AM,Evans M,Weil LEG,Garza KP,Weissberg-Benchell J

    更新日期:2018-02-19 00:00:00

  • Mobile Phone and Smartphone Technologies for Diabetes Care and Self-Management.

    abstract::Mobile and smartphone (mHealth) technologies have the potential to improve diabetes care and self-management, but little is known about their effectiveness and how patients, providers, and payers currently interact with them. We conducted a systematic review and found only 20 peer-reviewed articles, published since 20...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-015-0680-8

    authors: Garabedian LF,Ross-Degnan D,Wharam JF

    更新日期:2015-12-01 00:00:00

  • CNS Regulation of Glucose Homeostasis: Role of the Leptin-Melanocortin System.

    abstract:PURPOSE OF REVIEW:In this brief review, we highlight studies that have contributed to our current understanding of glucose homeostasis by the central nervous system (CNS) leptin-melanocortin system, particularly proopiomelanocortin neurons and melanocortin-4 receptors (MC4R). RECENT FINDINGS:Leptin deficiency is assoc...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01311-1

    authors: da Silva AA,do Carmo JM,Hall JE

    更新日期:2020-05-26 00:00:00

  • Fear of Hypoglycemia in Children and Adolescents and Their Parents with Type 1 Diabetes.

    abstract::Hypoglycemia is a frequent occurrence in children and adolescents with type 1 diabetes. A variety of efforts have been made to standardize the definition of hypoglycemia and to define one of its most significant psychosocial consequences-fear of hypoglycemia (FOH). In addition to documenting the experience of FOH in c...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0762-2

    authors: Driscoll KA,Raymond J,Naranjo D,Patton SR

    更新日期:2016-08-01 00:00:00

  • Insulin sensitivity and premenstrual syndrome.

    abstract::Maintaining normal blood glucose levels is a constant challenge for women with diabetes. Anecdotal reports reveal that many women question if menstrual cycle phases may affect their blood glucose levels. However, results from studies investigating the effect of the menstrual cycle on insulin sensitivity in diabetic wo...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-004-0079-4

    authors: Trout KK,Teff KL

    更新日期:2004-08-01 00:00:00

  • Therapeutic Strategies for Modulating the Extracellular Matrix to Improve Pancreatic Islet Function and Survival After Transplantation.

    abstract:PURPOSES OF REVIEW:Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to transplantation as treatment for type 1 diabetes, the ECM is disrupted impacting functional graft survival. Recently, strategies for restoring ECM have shown to improve t...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-018-1014-4

    authors: Smink AM,de Vos P

    更新日期:2018-05-19 00:00:00

  • Hyperglycemia and Diabetes Mellitus Following Organ Transplantation.

    abstract::Hyperglycemia is common following organ transplantation, regardless of the pre-transplant diabetes status. Transient post-transplant hyperglycemia and/or new-onset diabetes after transplantation (NODAT) are common and are associated with increased morbidity and mortality. NODAT and type 2 diabetes share similar charac...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-015-0707-1

    authors: Galindo RJ,Wallia A

    更新日期:2016-02-01 00:00:00