Caveolin-1 in the Pathogenesis of Diabetic Nephropathy: Potential Therapeutic Target?

abstract：:There is a well-documented gap between research and practice in diabetes and many other chronic illnesses. This gap is due, in part, to limitations of the research database. Different types of clinical trials have recently been called for that address issues central to clinicians, administrative decision makers, and p...

journal_title：Current diabetes reports

authors： Glasgow RE

更新日期：2004-04-01 00:00:00

abstract：PURPOSE OF THE REVIEW:In this study, we will analyse how diabetes induces the reactivation of organs' developmental programmes and growth, discuss how thyroid hormone (TH) signalling orchestrates these processes, and suggest novel strategies for exploiting TH-mediated reparative and regenerative properties. RECENT FIN...

journal_title：Current diabetes reports

authors： Mantzouratou P,Lavecchia AM,Novelli R,Xinaris C

更新日期：2020-09-28 00:00:00

abstract：:The occurrence and progression of nephropathy associated with early onset type 2 diabetes (T2D) is a consequence of the ongoing epidemic of childhood obesity. Minimal evidence regarding treatment effectiveness of renovascular comorbidities in youth with early onset T2D is available, due to the relatively recent emerge...

journal_title：Current diabetes reports

authors： Solis-Herrera C,Triplitt CL,Lynch JL

更新日期：2014-02-01 00:00:00

abstract：:Autonomic dysfunction is a frequent and relevant complication of diabetes mellitus, as it is associated with increased morbidity and mortality. In addition, it is today considered as predictive of the most severe diabetic complications, like nephropathy and retinopathy. The classical methods of screening are the cardi...

journal_title：Current diabetes reports

authors： Bernardi L,Bianchi L

更新日期：2016-11-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a vision-threatening complication of diabetes. Timely diagnosis and intervention are essential for treatment that reduces the risk of vision loss. A good color retinal (fundus) photograph can be used as a surrogate for face-to-face evaluation of DR. The use of computers to assist or fully ...

journal_title：Current diabetes reports

authors： Li B,Li HK

更新日期：2013-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Type 2 diabetes is common, burdensome, and preventable. Landmark trials such as the Diabetes Prevention Program (DPP) demonstrated that resource-intensive lifestyle support interventions resulting in modest weight loss via healthy diet changes and physical activity can lower the rate of diabetes devel...

journal_title：Current diabetes reports

authors： Ackermann RT,O'Brien MJ

更新日期：2020-02-20 00:00:00

abstract：:Painful neuropathies are frequently encountered in clinical practice as an early or late complication of several systemic disorders. Among them, diabetes is one of the most important due to its epidemiology and the relevance for regulatory agencies in the assessment of efficacy of new analgesics. However, the presenta...

journal_title：Current diabetes reports

authors： Lauria G,Ziegler D,Malik R,Merkies IS,Waxman SG,Faber CG,PROPANE Study group.

更新日期：2014-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreas transplantation enables complete patient independence from exogenous insulin administration and increases both patient survival and quality of life. Despite this, there has been a decline in pancreas transplantation for the past 20 years, influenced by changing donor demographics with more hi...

journal_title：Current diabetes reports

authors： Hamaoui K,Papalois V

更新日期：2019-07-10 00:00:00

abstract：PURPOSE OF REVIEW:Validated thermodynamic energy balance models that predict weight change are ever more in use today. Delivery of model predictions using web-based applets and/or smart phones has transformed these models into viable clinical tools. Here, we provide the general framework for thermodynamic energy balanc...

journal_title：Current diabetes reports

authors： Thomas DM,Scioletti M,Heymsfield SB

更新日期：2019-08-31 00:00:00

abstract：:Although type 1 diabetes remains the most common type of diabetes in the pediatric population, there has been a dramatic rise in type 2 diabetes in youth. Clinical distinctions between these two major types have become blurred. As genetic and biochemical measures become more affordable and available, practical applica...

journal_title：Current diabetes reports

authors： Pihoker C

更新日期：2006-04-01 00:00:00

abstract：:Suspicion that fructose-containing caloric sweeteners (FCCS) may play a causal role in the development of metabolic diseases has elicited intense basic and clinical research over the past 10 years. Prospective cohort studies converge to indicate that FCCS, and more specifically sugar-sweetened beverages (SSBs), consum...

journal_title：Current diabetes reports

authors： Tappy L,Lê KA

更新日期：2015-08-01 00:00:00

abstract：:As the incidence of diabetes mellitus continues to rise, parallel increases in the rates of diabetic atherosclerotic vascular disease are projected to impart major health and socioeconomic challenges for authorities worldwide. Diabetes results in a proatherogenic phenotype, manifesting in an accelerated, diffuse, poly...

journal_title：Current diabetes reports

authors： Puri R,Kataoka Y,Uno K,Nicholls SJ

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The micro/macrovascular complications of diabetes cause considerable morbidity and premature mortality. The SGLT2 inhibitors are the first diabetes medications with significant benefits on microvascular disease (nephropathy) and macrovascular cardiovascular disease. In this review, we evaluate one of ...

journal_title：Current diabetes reports

authors： Ekanayake P,Hupfeld C,Mudaliar S

更新日期：2020-11-23 00:00:00

abstract：PURPOSE OF REVIEW:Great strides have recently been made in elucidating the role of genetic sequence variation in diabetes pathogenesis. Increasingly, studies are focusing on other factors that may contribute to the pathogenesis of diabetes, such as epigenetics, a term "traditionally" encompassing changes to the DNA tha...

journal_title：Current diabetes reports

authors： Zhang H,Pollin TI

更新日期：2018-10-02 00:00:00

abstract：:Pharmacologic doses of glucocorticoids and chronic renal failure are challenging comorbidities and complications for safe and effective dosing of insulin for the management of hospitalized patients with diabetes. Glucocorticoids are used widely in hospitalized patients and will commonly provoke new-onset hyperglycemia...

journal_title：Current diabetes reports

authors： Baldwin D,Apel J

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity is closely linked with the pathogenesis of type 2 diabetes (T2DM) and cardiovascular disease (CVD), and whilst smoking cessation is associated with weight gain, there are concerns that this weight gain may offset the benefit of CVD risk reduction especially in those with considerable post-cess...

journal_title：Current diabetes reports

authors： Kos K

更新日期：2020-12-08 00:00:00

abstract：:Diabetic polyneuropathy (DPN) is the most common complication that emerges early in patients who have diabetes. Curative treatment for overt or symptomatic DPN has not been established, requiring much effort to explore new modalities. Thus, the use of various kinds of stem cells as a potential therapeutic option for D...

journal_title：Current diabetes reports

authors： Mizukami H,Yagihashi S

更新日期：2016-09-01 00:00:00

abstract：:Little published research exists on psychosocial issues in adolescents with type 2 diabetes mellitus (T2DM), because until two decades ago, diabetes diagnosed in children and adolescents was almost exclusively type 1 diabetes mellitus or insulin-dependent diabetes. In the past two decades, rates of T2DM have increased...

journal_title：Current diabetes reports

authors： Anderson BJ,McKay SV

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies have shown that disasters may exacerbate the comorbidities in vulnerable populations such as those with a pre-existing chronic medical condition like diabetes. This article highlights recent studies that look at the impact of disasters on people with diabetes and also shows recent resources fo...

journal_title：Current diabetes reports

authors： Allweiss P

更新日期：2019-11-20 00:00:00

abstract：:National guidelines indicate patients with elevated low- density lipoprotein cholesterol should consume less than 7% of calories from saturated fat and less than 200 mg of cholesterol. Trans fatty acids should also be limited. Incorporation of functional foods, such as stanol-containing margarine, soy products, and so...

journal_title：Current diabetes reports

authors： Carson JA

更新日期：2003-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the treatment of type 2 diabetes from a cardiologist's view. RECENT FINDINGS:A new era in the treatment of type 2 diabetes began for the cardiologist in 2015 with the publication of the EMPA-REG outcome trial finding a significant reduction in CV death with empagliflozin (oral sodium-gluc...

journal_title：Current diabetes reports

authors： Chilton RJ,Gallegos KM,Silva-Cardoso J,Oliveros R,Pham S

更新日期：2018-11-08 00:00:00

abstract：:Bariatric surgery has emerged as the most durably effective treatment of type 2 diabetes (DM). However, the mechanisms governing improvement in glucose homeostasis have yet to be fully elucidated. In this review we discuss the various types of surgical interventions and the multitude of factors that potentially mediat...

journal_title：Current diabetes reports

authors： Nguyen KT,Korner J

更新日期：2014-01-01 00:00:00

abstract：:Low- and middle-income countries (LMICs) face a rapid change in the nutrition transition toward increases in noncommunicable diseases. Underlying this transition are shifts in the agricultural system and the subsequent growth of the modern retail and food service sectors across all regions and countries, a change in t...

journal_title：Current diabetes reports

authors： Popkin BM

更新日期：2015-09-01 00:00:00

abstract：:In this review article, we first present a brief overview of the vascular and neural components of diabetic retinopathy. Next, the multifocal electroretinogram (mfERG) technique, which can map neuroretinal function noninvasively, is described. Findings in diabetic retinal disease using the mfERG are reviewed. We then ...

journal_title：Current diabetes reports

authors： Bearse MA Jr,Ozawa GY

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Review innovations in health care financing promoting health system investments in addressing medical and social determinants of health (SDH) for patients with diabetes. RECENT FINDINGS:Particular payment models implemented in the public and private sectors increasingly offer flexibility in health ca...

journal_title：Current diabetes reports

authors： Saulsberry L,Peek M

更新日期：2019-11-20 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review was to summarize recent advances in the genomics of type 2 diabetes (T2D) and to highlight current initiatives to advance precision health. RECENT FINDINGS:Generation of multi-omic data to measure each of the "biologic layers," developments in describing genomic function an...

journal_title：Current diabetes reports

authors： Lin Y,Wessel J

更新日期：2019-02-26 00:00:00

abstract：:The common form of hereditary hemochromatosis is an autosomal recessive disorder most prevalent in Caucasians that results in excessive iron storage. The clinical manifestations of hemochromatosis are protean. HFE genotype, which determines the degree of iron overload and duration of disease have profound effects on d...

journal_title：Current diabetes reports

authors： Creighton Mitchell T,McClain DA

更新日期：2014-01-01 00:00:00

abstract：:Neonatal hypoglycemia is an important consequence for the infant of the mother with diabetes. We have reviewed 24 published papers of various protocols for control of glucose in pregnant diabetic women during labor and delivery including our own published work. A relationship of maternal glucose during labor and neona...

journal_title：Current diabetes reports

authors： Ryan EA,Al-Agha R

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The Diabetes Prevention Program (DPP) is an evidence-based lifestyle change program for prediabetes that is associated with a 58% reduction in 3-year diabetes incidence, and it has been supported by the American Medical Association and the Centers for Disease Control and Prevention. However, 9 in 10 p...

journal_title：Current diabetes reports

authors： Jasik CB,Joy E,Brunisholz KD,Kirley K

更新日期：2018-08-08 00:00:00

abstract：:Type 1 and type 2 diabetes both accelerate cardiovascular disease, yet the triggers are likely different for the two types of diabetes. Results from large-scale clinical trials suggest that intense blood glucose control can reduce cardiovascular events many years later in patients with type 1 diabetes. In type 2 diabe...

journal_title：Current diabetes reports

authors： Averill MM,Bornfeldt KE

更新日期：2009-02-01 00:00:00