Effects of Temporary Functional Deafferentation in Chronic Stroke Patients: Who Profits More?

Abstract:

:Temporary functional deafferentation (TFD) by an anesthetic cream on the stroke-affected forearm was shown to improve sensorimotor abilities of stroke patients. The present study investigated different predictors for sensorimotor improvements during TFD and indicated outcome differences between patients grouped in subcortical lesions only and lesions with any cortical involvement. Thirty-four chronic stroke patients were temporarily deafferented on the more affected forearm by an anesthetic cream. Somatosensory performance was assessed using von Frey Hair and grating orientation task; motor performance was assessed by a shape-sorter-drum task. Seven potential predictors were entered into three linear multiple regression models. Furthermore, effects of TFD on outcome variables for the two groups (cortical versus subcortical lesion) were compared. Sex and sensory deficit were significant predictors for changes in motor function while age accounted for changes in grating orienting task. Males, patients with a stronger sensory deficit, and older patients profited more. None of the potential predictors made significant contributions to changes in threshold for touch. Furthermore, there were no differences in sensorimotor improvement between lesion site groups. The effects of TFD together with the low predictability of the investigated parameters suggest that characteristics of patients alone are not suitable to exclude some patients from TFD.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Sens E,Franz M,Preul C,Meissner W,Witte OW,Miltner WHR,Weiss T

doi

10.1155/2018/7392024

subject

Has Abstract

pub_date

2018-07-29 00:00:00

pages

7392024

eissn

2090-5904

issn

1687-5443

journal_volume

2018

pub_type

杂志文章
  • The Gαo Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons.

    abstract::Mastoparan-7 (Mas-7), an analogue of the peptide mastoparan, which is derived from wasp venom, is a direct activator of Pertussis toxin- (PTX-) sensitive G proteins. Mas-7 produces several biological effects in different cell types; however, little is known about how Mas-7 influences mature hippocampal neurons. We exa...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/4258171

    authors: Ramírez VT,Ramos-Fernández E,Inestrosa NC

    更新日期:2016-01-01 00:00:00

  • Postural dysfunction in children with cerebral palsy: some implications for therapeutic guidance.

    abstract::Postural problems play a central role in the motor dysfunction of children with cerebral palsy (CP). Therefore, they spend more time in sitting than in standing to perform vital tasks of daily life. The focus of this article is to describe the pathophysiology of postural control in sitting and outline some implication...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2005.221

    authors: Carlberg EB,Hadders-Algra M

    更新日期:2005-01-01 00:00:00

  • AMPA receptor trafficking in homeostatic synaptic plasticity: functional molecules and signaling cascades.

    abstract::Homeostatic synaptic plasticity is a negative-feedback response employed to compensate for functional disturbances in the nervous system. Typically, synaptic activity is strengthened when neuronal firing is chronically suppressed or weakened when neuronal activity is chronically elevated. At both the whole cell and en...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2012/825364

    authors: Wang G,Gilbert J,Man HY

    更新日期:2012-01-01 00:00:00

  • Brain connectivity plasticity in the motor network after ischemic stroke.

    abstract::The motor function is controlled by the motor system that comprises a series of cortical and subcortical areas interacting via anatomical connections. The motor function will be disturbed when the stroke lesion impairs either any of these areas or their connections. More and more evidence indicates that the reorganiza...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2013/924192

    authors: Jiang L,Xu H,Yu C

    更新日期:2013-01-01 00:00:00

  • Boosting the Motor Outcome of the Untrained Hand by Action Observation: Mirror Visual Feedback, Video Therapy, or Both Combined-What Is More Effective?

    abstract::Action observation (AO) allows access to a network that processes visuomotor and sensorimotor inputs and is believed to be involved in observational learning of motor skills. We conducted three consecutive experiments to examine the boosting effect of AO on the motor outcome of the untrained hand by either mirror visu...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/8369262

    authors: Bähr F,Ritter A,Seidel G,Puta C,Gabriel HHW,Hamzei F

    更新日期:2018-04-10 00:00:00

  • Functional topography of human corpus callosum: an FMRI mapping study.

    abstract::The concept of a topographical map of the corpus callosum (CC) has emerged from human lesion studies and from electrophysiological and anatomical tracing investigations in other mammals. Over the last few years a rising number of researchers have been reporting functional magnetic resonance imaging (fMRI) activation i...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2013/251308

    authors: Fabri M,Polonara G

    更新日期:2013-01-01 00:00:00

  • Autism: a "critical period" disorder?

    abstract::Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic ne...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2011/921680

    authors: LeBlanc JJ,Fagiolini M

    更新日期:2011-01-01 00:00:00

  • Neurosteroids Involvement in the Epigenetic Control of Memory Formation and Storage.

    abstract::Memory is our ability to store and remember past experiences; it is the result of changes in neuronal circuits of specific brain areas as the hippocampus. During memory formation, neurons integrate their functions and increase the strength of their connections, so that synaptic plasticity is improved and consolidated....

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5985021

    authors: Colciago A,Magnaghi V

    更新日期:2016-01-01 00:00:00

  • Evolution of Apparent Diffusion Coefficient and Fractional Anisotropy in the Cerebrum of Asphyxiated Newborns Treated with Hypothermia over the First Month of Life.

    abstract::The objective of this study was to assess the evolution of diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI) over the first month of life in asphyxiated newborns treated with hypothermia and to compare it with that of healthy newborns. Asphyxiated newborns treated with hypothermia were enrolled prosp...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/653727

    authors: Kwan S,Boudes E,Benseler A,Gilbert G,Saint-Martin C,Shevell M,Wintermark P

    更新日期:2015-01-01 00:00:00

  • Genesis and Maintenance of Attentional Biases: The Role of the Locus Coeruleus-Noradrenaline System.

    abstract::Emotionally arousing events are typically better remembered than mundane ones, in part because emotionally relevant aspects of our environment are prioritized in attention. Such biased attentional tuning is itself the result of associative processes through which we learn affective and motivational relevance of cues. ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/6817349

    authors: Ehlers MR,Todd RM

    更新日期:2017-01-01 00:00:00

  • Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis.

    abstract::The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is necessary for proper hair cell (HC) mechanotransduction and hearing. Cell junctions are indispensable for the establishment of compositionally distinct fluid compartments in the inner ear. Ototoxic drug cisplatin can damage SV ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8851525

    authors: Zhang N,Cai J,Xu L,Wang H,Liu W

    更新日期:2020-09-22 00:00:00

  • Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG.

    abstract::Recently several lines of evidence demonstrated that methylcobalamin (MeCbl) might have potential analgesic effect in experimental and clinical studies. However, it was reported that MeCbl had no effect on treating lumbar spinal stenosis induced pain. Thus, the effects of short-term and long-term administration of MeC...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/197392

    authors: Zhang M,Han W,Zheng J,Meng F,Jiao X,Hu S,Xu H

    更新日期:2015-01-01 00:00:00

  • Mahuang-Fuzi-Xixin Decoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis.

    abstract::Evidence suggests that inflammation and neurogenesis play an important role in major depressive disorder (MDD). Mahuang-Fuzi-Xixin decoction (MFX), as the traditional Chinese prescription, has been widely applied for asthma, migraine, and MDD in clinics. However, the effects of MFX on the potential mechanism in MDD ar...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/1571392

    authors: Jing W,Song S,Sun H,Chen Y,Zhao Q,Zhang Y,Dai G,Ju W

    更新日期:2019-11-11 00:00:00

  • The Habituation/Cross-Habituation Test Revisited: Guidance from Sniffing and Video Tracking.

    abstract::The habituation/cross-habituation test (HaXha) is a spontaneous odor discrimination task that has been used for many decades to evaluate olfactory function in animals. Animals are presented repeatedly with the same odorant after which a new odorant is introduced. The time the animal explores the odor object is measure...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/9131284

    authors: Coronas-Samano G,Ivanova AV,Verhagen JV

    更新日期:2016-01-01 00:00:00

  • Spindle Oscillations in Sleep Disorders: A Systematic Review.

    abstract::Measurement of sleep microarchitecture and neural oscillations is an increasingly popular technique for quantifying EEG sleep activity. Many studies have examined sleep spindle oscillations in sleep-disordered adults; however reviews of this literature are scarce. As such, our overarching aim was to critically review ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/7328725

    authors: Weiner OM,Dang-Vu TT

    更新日期:2016-01-01 00:00:00

  • Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation Exposure.

    abstract::Ionizing radiation is omnipresent. We are continuously exposed to natural (e.g., radon and cosmic) and man-made radiation sources, including those from industry but especially from the medical sector. The increasing use of medical radiation modalities, in particular those employing low-dose radiation such as CT scans,...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/1243527

    authors: Verreet T,Verslegers M,Quintens R,Baatout S,Benotmane MA

    更新日期:2016-01-01 00:00:00

  • Spinal cord lesion: effects of and perspectives for treatment.

    abstract::Following central motor lesions, two forms of adaptation can be observed which lead to improved mobility: (1) the development of spastic muscle tone, and (2) the activation of spinal locomotor centers induced by specific treadmill training. Tension development during spastic gait is different from that during normal g...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2001.83

    authors: Dietz V

    更新日期:2001-01-01 00:00:00

  • Baseline Motor Impairment Predicts Transcranial Direct Current Stimulation Combined with Physical Therapy-Induced Improvement in Individuals with Chronic Stroke.

    abstract::Transcranial direct current stimulation (tDCS) can enhance the effect of conventional therapies in post-stroke neurorehabilitation. The ability to predict an individual's potential for tDCS-induced recovery may permit rehabilitation providers to make rational decisions about who will be a good candidate for tDCS thera...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8859394

    authors: Baltar A,Piscitelli D,Marques D,Shirahige L,Monte-Silva K

    更新日期:2020-11-25 00:00:00

  • Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging.

    abstract::The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8882207

    authors: Couto TA,Xu S,da Silva PA,Wu C,Neergaard K,Wang MY,Zhang J,Xiang Y,Yuan Z

    更新日期:2020-10-06 00:00:00

  • Human Auditory and Adjacent Nonauditory Cerebral Cortices Are Hypermetabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS).

    abstract::Tinnitus is the phantom perception of sound in the absence of an acoustic stimulus. To date, the purported neural correlates of tinnitus from animal models have not been adequately characterized with translational technology in the human brain. The aim of the present study was to measure changes in oxy-hemoglobin conc...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/7453149

    authors: Issa M,Bisconti S,Kovelman I,Kileny P,Basura GJ

    更新日期:2016-01-01 00:00:00

  • Mirror Visual Feedback to Improve Bradykinesia in Parkinson's Disease.

    abstract::Mirror visual feedback (MVF) therapy has been applied to improve upper limb function in stroke. When combined with motor training, MVF improves the performance of the trained and untrained hand by enhancing the excitability of both primary motor cortices (M1s). Bradykinesia is a typical feature of Parkinson's disease ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/8764238

    authors: Bonassi G,Pelosin E,Ogliastro C,Cerulli C,Abbruzzese G,Avanzino L

    更新日期:2016-01-01 00:00:00

  • Nestin reporter transgene labels multiple central nervous system precursor cells.

    abstract::Embryonic neuroepithelia and adult subventricular zone (SVZ) stem and progenitor cells express nestin. We characterized a transgenic line that expresses enhanced green fluorescent protein (eGFP) specified to neural tissue by the second intronic enhancer of the nestin promoter that had several novel features. During em...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2010/894374

    authors: Walker AS,Goings GE,Kim Y,Miller RJ,Chenn A,Szele FG

    更新日期:2010-01-01 00:00:00

  • Functional Corticomuscular Signal Coupling Is Weakened during Voluntary Motor Action in Cancer-Related Fatigue.

    abstract:Background and Purpose:Cancer-related fatigue (CRF) is widely recognized as one of the most common symptoms and side effects of cancer and/or its treatment. However, neuropathological mechanisms contributing to CRF are largely unknown, and the lack of knowledge makes CRF difficult to treat. Recent research has shown di...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/2490750

    authors: Jiang C,Yang Q,Chen T,Siemionow V,Ranganathan VK,Yan AF,Yue GH

    更新日期:2019-06-26 00:00:00

  • GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway.

    abstract::Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures. GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system. Accumulating evidence de...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/8858415

    authors: Hou X,Rong C,Wang F,Liu X,Sun Y,Zhang HT

    更新日期:2020-08-01 00:00:00

  • Spatial Integration of Somatosensory Inputs during Sensory-Motor Plasticity Phenomena Is Normal in Focal Hand Dystonia.

    abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/4135708

    authors: Terranova C,Rizzo V,Morgante F,Maggio R,Calamuneri A,Chillemi G,Girlanda P,Quartarone A

    更新日期:2018-10-10 00:00:00

  • The GABA-withdrawal syndrome: a model of local status epilepticus.

    abstract::The GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex. GWS is characterized by focal epileptic electroencephalographic discharges and associated contralateral myoclonus. In neocortical slices obtained from GWS rat...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2000.9

    authors: Silva-Barrat C,Champagnat J,Menini C

    更新日期:2000-01-01 00:00:00

  • Enhanced Visual Attentional Modulation in Patients with Inherited Peripheral Retinal Degeneration in the Absence of Cortical Degeneration.

    abstract::The role of attentional mechanisms in peripheral vision loss remains an outstanding question. Our study was aimed at determining the effect of genetically determined peripheral retinal dystrophy caused by Retinitis Pigmentosa (RP) on visual cortical function and tested the recruitment of attentional mechanisms using f...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/8136354

    authors: Ferreira S,Pereira AC,Quendera B,Reis A,Silva ED,Castelo-Branco M

    更新日期:2019-06-25 00:00:00

  • Brain-Specific SNAP-25 Deletion Leads to Elevated Extracellular Glutamate Level and Schizophrenia-Like Behavior in Mice.

    abstract::Several studies have associated reduced expression of synaptosomal-associated protein of 25 kDa (SNAP-25) with schizophrenia, yet little is known about its role in the illness. In this paper, a forebrain glutamatergic neuron-specific SNAP-25 knockout mouse model was constructed and studied to explore the possible path...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/4526417

    authors: Yang H,Zhang M,Shi J,Zhou Y,Wan Z,Wang Y,Wan Y,Li J,Wang Z,Fei J

    更新日期:2017-01-01 00:00:00

  • New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity.

    abstract::Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/4605971

    authors: Huang YJ,Lane HY,Lin CH

    更新日期:2017-01-01 00:00:00

  • Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores.

    abstract:Background:One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in resting-state functional MRI have been investigated to a limited extent. Fluctuations...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/2357107

    authors: Goodin P,Lamp G,Vidyasagar R,Connelly A,Rose S,Campbell BCV,Tse T,Ma H,Howells D,Hankey GJ,Davis S,Donnan G,Carey LM

    更新日期:2019-07-28 00:00:00