Abstract:
:Recently several lines of evidence demonstrated that methylcobalamin (MeCbl) might have potential analgesic effect in experimental and clinical studies. However, it was reported that MeCbl had no effect on treating lumbar spinal stenosis induced pain. Thus, the effects of short-term and long-term administration of MeCbl were examined in the chronic compression of dorsal root ganglion (CCD) model. We found that mechanical allodynia was significantly inhibited by a continuous application of high dose and a single treatment of a super high dose of MeCbl. Little is known about mechanisms underlying the analgesia of MeCbl. We examined the effect of MeCbl on the spontaneous activity (SA), the excitability, and hyperpolarization-activated nonselective cation ion current in compressed medium-sized dorsal root ganglion (DRG) neurons using extracellular single fiber recording in vivo and whole-cell patch clamp in vitro. We found that MeCbl significantly inhibited the SA of A-type sensory neurons in a dose-dependent manner and inhibited the excitability of medium-sized DRG neurons. In addition, MeCbl also decreased I h current density in injured medium-sized DRG neurons. Our results proved that MeCbl might exert an analgesic effect through the inhibition I h current and then might inhibit the hyperexcitability of primary sensory neurons under neuropathic pain state.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Zhang M,Han W,Zheng J,Meng F,Jiao X,Hu S,Xu Hdoi
10.1155/2015/197392subject
Has Abstractpub_date
2015-01-01 00:00:00pages
197392eissn
2090-5904issn
1687-5443journal_volume
2015pub_type
杂志文章abstract::The role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learning capacity of the...
journal_title:Neural plasticity
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更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/9890827
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
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doi:10.1155/2018/8369262
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journal_title:Neural plasticity
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更新日期:2018-04-05 00:00:00
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journal_title:Neural plasticity
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更新日期:2020-06-08 00:00:00
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更新日期:2016-01-01 00:00:00
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doi:10.1155/2018/8105480
更新日期:2018-03-26 00:00:00
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更新日期:2017-01-01 00:00:00
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更新日期:2018-07-29 00:00:00
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