Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG.

Abstract:

:Recently several lines of evidence demonstrated that methylcobalamin (MeCbl) might have potential analgesic effect in experimental and clinical studies. However, it was reported that MeCbl had no effect on treating lumbar spinal stenosis induced pain. Thus, the effects of short-term and long-term administration of MeCbl were examined in the chronic compression of dorsal root ganglion (CCD) model. We found that mechanical allodynia was significantly inhibited by a continuous application of high dose and a single treatment of a super high dose of MeCbl. Little is known about mechanisms underlying the analgesia of MeCbl. We examined the effect of MeCbl on the spontaneous activity (SA), the excitability, and hyperpolarization-activated nonselective cation ion current in compressed medium-sized dorsal root ganglion (DRG) neurons using extracellular single fiber recording in vivo and whole-cell patch clamp in vitro. We found that MeCbl significantly inhibited the SA of A-type sensory neurons in a dose-dependent manner and inhibited the excitability of medium-sized DRG neurons. In addition, MeCbl also decreased I h current density in injured medium-sized DRG neurons. Our results proved that MeCbl might exert an analgesic effect through the inhibition I h current and then might inhibit the hyperexcitability of primary sensory neurons under neuropathic pain state.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Zhang M,Han W,Zheng J,Meng F,Jiao X,Hu S,Xu H

doi

10.1155/2015/197392

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

197392

eissn

2090-5904

issn

1687-5443

journal_volume

2015

pub_type

杂志文章
  • Translational approach to behavioral learning: lessons from cerebellar plasticity.

    abstract::The role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learning capacity of the...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2013/853654

    authors: Cheron G,Dan B,Márquez-Ruiz J

    更新日期:2013-01-01 00:00:00

  • Neurogenesis, exercise, and cognitive late effects of pediatric radiotherapy.

    abstract::Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment. RT is effective for tumor eradication, and survival rates are high. However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive "late" effects that may take years...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2013/698528

    authors: Rodgers SP,Trevino M,Zawaski JA,Gaber MW,Leasure JL

    更新日期:2013-01-01 00:00:00

  • Spatial Integration of Somatosensory Inputs during Sensory-Motor Plasticity Phenomena Is Normal in Focal Hand Dystonia.

    abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/4135708

    authors: Terranova C,Rizzo V,Morgante F,Maggio R,Calamuneri A,Chillemi G,Girlanda P,Quartarone A

    更新日期:2018-10-10 00:00:00

  • Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic α7 Nicotinic Receptor Drugs.

    abstract::Stimulating regeneration in the brain has the potential to rescue neuronal networks and counteract progressive pathological changes in Alzheimer's disease (AD). This study investigated whether drugs with different mechanisms of action could enhance neurogenesis and improve cognition in mice receiving human neural stem...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/370432

    authors: Lilja AM,Malmsten L,Röjdner J,Voytenko L,Verkhratsky A,Ögren SO,Nordberg A,Marutle A

    更新日期:2015-01-01 00:00:00

  • Visual deprivation decreases somatic GAD65 puncta number on layer 2/3 pyramidal neurons in mouse visual cortex.

    abstract::Proper functioning of the visual system depends on maturation of both excitatory and inhibitory synapses within the visual cortex. Considering that perisomatic inhibition is one of the key factors that control the critical period in visual cortex, it is pertinent to understand its regulation by visual experience. To d...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2009/415135

    authors: Kreczko A,Goel A,Song L,Lee HK

    更新日期:2009-01-01 00:00:00

  • New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity.

    abstract::Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/4605971

    authors: Huang YJ,Lane HY,Lin CH

    更新日期:2017-01-01 00:00:00

  • Neural Plastic Effects of Cognitive Training on Aging Brain.

    abstract::Increasing research has evidenced that our brain retains a capacity to change in response to experience until late adulthood. This implies that cognitive training can possibly ameliorate age-associated cognitive decline by inducing training-specific neural plastic changes at both neural and behavioral levels. This lon...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/535618

    authors: Leung NT,Tam HM,Chu LW,Kwok TC,Chan F,Lam LC,Woo J,Lee TM

    更新日期:2015-01-01 00:00:00

  • Operant discriminative learning and evidence of subtelencephalic plastic changes after long-term detelencephalation in pigeons.

    abstract::We analyzed operant discrimination in detelencephalated pigeons and neuroanatomical substrates after long-term detelencephalation. In Experiment I, experimental pigeons with massive telencephalic ablation and control pigeons were conditioned to key peck for food. Successive discrimination was made under alternating re...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/NP.2003.247

    authors: Cerutti SM,Diaz-Cintra S,Cintra L,Ferrari EA

    更新日期:2003-01-01 00:00:00

  • Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity.

    abstract::The development of new strategies to renew and repair neuronal networks using neural plasticity induced by stem cell graft could enable new therapies to cure diseases that were considered lethal until now. In adequate microenvironment a neuronal progenitor must receive molecular signal of a specific cellular context t...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/1568145

    authors: Ramírez-Barrantes R,Cordova C,Poblete H,Muñoz P,Marchant I,Wianny F,Olivero P

    更新日期:2016-01-01 00:00:00

  • Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain.

    abstract::Aging is a complex process strongly determined by genetics. Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs). CNVs represent a significant source of genetic variation in the human genome and have been implicated in several diso...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/2406170

    authors: Villela D,Suemoto CK,Leite R,Pasqualucci CA,Grinberg LT,Pearson P,Rosenberg C

    更新日期:2018-06-28 00:00:00

  • Astrocyte-secreted matricellular proteins in CNS remodelling during development and disease.

    abstract::Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have rev...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2014/321209

    authors: Jones EV,Bouvier DS

    更新日期:2014-01-01 00:00:00

  • Mutation in the Hair Cell Specific Gene POU4F3 Is a Common Cause for Autosomal Dominant Nonsyndromic Hearing Loss in Chinese Hans.

    abstract::Autosomal dominant nonsyndromic hearing loss (ADNSHL) is extremely heterogeneous. So far the genetic etiological contribution of the gene POU4F3 associated with ADNSHL has been rarely reported. In our previous study, a c.603_604delGG mutation in the hair cell specific gene POU4F3 has been identified as the pathogenic ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/9890827

    authors: He L,Pang X,Chen P,Wu H,Yang T

    更新日期:2016-01-01 00:00:00

  • Boosting the Motor Outcome of the Untrained Hand by Action Observation: Mirror Visual Feedback, Video Therapy, or Both Combined-What Is More Effective?

    abstract::Action observation (AO) allows access to a network that processes visuomotor and sensorimotor inputs and is believed to be involved in observational learning of motor skills. We conducted three consecutive experiments to examine the boosting effect of AO on the motor outcome of the untrained hand by either mirror visu...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/8369262

    authors: Bähr F,Ritter A,Seidel G,Puta C,Gabriel HHW,Hamzei F

    更新日期:2018-04-10 00:00:00

  • Three MYO15A Mutations Identified in One Chinese Family with Autosomal Recessive Nonsyndromic Hearing Loss.

    abstract::Hearing impairment is one of the most common sensory disease, of which more than 50% is attributed to a genetic etiology. The goal of this research is to explore the genetic cause of a Chinese deafness pedigree who was excluded of GJB2, SLC26A4, or MtDNA12SrRNA variants. Three variants, c.3971C>A (p.A1324D), c.4011ins...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/5898025

    authors: Zhang F,Xu L,Xiao Y,Li J,Bai X,Wang H

    更新日期:2018-04-05 00:00:00

  • An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice.

    abstract::Inbred mouse models are widely used to study age-related hearing loss (AHL). Many genes associated with AHL have been mapped in a variety of strains. However, little is known about gene variants that have the converse function-protective genes that confer strong resistance to hearing loss. Previously, we reported that...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8889264

    authors: Zheng QY,Kui L,Xu F,Zheng T,Li B,McCarty M,Sun Z,Zhang A,Liu L,Starlard-Davenport A,Stepanyan R,Hu BH,Lu L

    更新日期:2020-06-08 00:00:00

  • Visual Timing of Structured Dance Movements Resembles Auditory Rhythm Perception.

    abstract::Temporal mechanisms for processing auditory musical rhythms are well established, in which a perceived beat is beneficial for timing purposes. It is yet unknown whether such beat-based timing would also underlie visual perception of temporally structured, ecological stimuli connected to music: dance. In this study, we...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/1678390

    authors: Su YH,Salazar-López E

    更新日期:2016-01-01 00:00:00

  • Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus.

    abstract::Accumulating evidence implicates a role for brain structures outside the ascending auditory pathway in tinnitus, the phantom perception of sound. In addition to other factors such as age-dependent hearing loss, high-level sound exposure is a prominent cause of tinnitus. Here, we examined how noise exposure altered the...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2021/8833087

    authors: Zhang L,Wu C,Martel DT,West M,Sutton MA,Shore SE

    更新日期:2021-01-14 00:00:00

  • Quantification of Upper Limb Motor Recovery and EEG Power Changes after Robot-Assisted Bilateral Arm Training in Chronic Stroke Patients: A Prospective Pilot Study.

    abstract:Background:Bilateral arm training (BAT) has shown promise in expediting progress toward upper limb recovery in chronic stroke patients, but its neural correlates are poorly understood. Objective:To evaluate changes in upper limb function and EEG power after a robot-assisted BAT in chronic stroke patients. Methods:In ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/8105480

    authors: Gandolfi M,Formaggio E,Geroin C,Storti SF,Boscolo Galazzo I,Bortolami M,Saltuari L,Picelli A,Waldner A,Manganotti P,Smania N

    更新日期:2018-03-26 00:00:00

  • Contribution of Short-Time Occlusion of the Amblyopic Eye to a Passive Dichoptic Video Treatment for Amblyopia beyond the Critical Period.

    abstract::Dichoptic movie viewing has been shown to significantly improve visual acuity in amblyopia in children. Moreover, short-term occlusion of the amblyopic eye can transiently increase its contribution to binocular fusion in adults. In this study, we first asked whether dichoptic movie viewing could improve the visual fun...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/6208414

    authors: Sauvan L,Stolowy N,Denis D,Matonti F,Chavane F,Hess RF,Reynaud A

    更新日期:2019-08-28 00:00:00

  • Postural synergies and their development.

    abstract::The recent developments of a particular approach to analyzing motor synergies based on the principle of motor abundance has allowed a quantitative assessment of multi-effector coordination in motor tasks involving anticipatory adjustments to self-triggered postural perturbations and in voluntary postural sway. This ap...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2005.119

    authors: Latash ML,Krishnamoorthy V,Scholz JP,Zatsiorsky VM

    更新日期:2005-01-01 00:00:00

  • The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy.

    abstract::Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurodegenerative disorders such as Parkinson's disease (PD). In sporadic PD, the most common age-related neurodegenerative movement disorder, nigrostriatal dopaminergic deficits are responsible for the onset of motor symptoms...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5012129

    authors: Longhena F,Faustini G,Missale C,Pizzi M,Spano P,Bellucci A

    更新日期:2017-01-01 00:00:00

  • Neurorehabilitation in Parkinson's Disease: A Critical Review of Cognitive Rehabilitation Effects on Cognition and Brain.

    abstract:Background:Parkinson's disease (PD) patients experience cognitive impairment which has been related to reduced quality of life and functional disability. These symptoms usually progress until dementia occurs. Some studies have been published assessing the efficacy of cognitive treatments on improving cognition, functio...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2018/2651918

    authors: Díez-Cirarda M,Ibarretxe-Bilbao N,Peña J,Ojeda N

    更新日期:2018-05-06 00:00:00

  • Targeted Neuromodulation of Abnormal Interhemispheric Connectivity to Promote Neural Plasticity and Recovery of Arm Function after Stroke: A Randomized Crossover Clinical Trial Study Protocol.

    abstract:Background:Despite intensive rehabilitation efforts, most stroke survivors have persistent functional disability of the paretic arm and hand. These motor impairments may be due in part to maladaptive changes in structural and functional connections between brain regions. The following early stage clinical trial study p...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/9875326

    authors: Borich MR,Wolf SL,Tan AQ,Palmer JA

    更新日期:2018-03-12 00:00:00

  • Corrigendum to "Short-Term Monocular Deprivation Enhances Physiological Pupillary Oscillations".

    abstract::[This corrects the article DOI: 10.1155/2017/6724631.]. ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,已发布勘误

    doi:10.1155/2017/3634598

    authors: Binda P,Lunghi C

    更新日期:2017-01-01 00:00:00

  • Effects of Temporary Functional Deafferentation in Chronic Stroke Patients: Who Profits More?

    abstract::Temporary functional deafferentation (TFD) by an anesthetic cream on the stroke-affected forearm was shown to improve sensorimotor abilities of stroke patients. The present study investigated different predictors for sensorimotor improvements during TFD and indicated outcome differences between patients grouped in sub...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/7392024

    authors: Sens E,Franz M,Preul C,Meissner W,Witte OW,Miltner WHR,Weiss T

    更新日期:2018-07-29 00:00:00

  • Cortical plasticity after cochlear implantation.

    abstract::The most dramatic progress in the restoration of hearing takes place in the first months after cochlear implantation. To map the brain activity underlying this process, we used positron emission tomography at three time points: within 14 days, three months, and six months after switch-on. Fifteen recently implanted ad...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2013/318521

    authors: Petersen B,Gjedde A,Wallentin M,Vuust P

    更新日期:2013-01-01 00:00:00

  • From spinal central pattern generators to cortical network: integrated BCI for walking rehabilitation.

    abstract::Success in locomotor rehabilitation programs can be improved with the use of brain-computer interfaces (BCIs). Although a wealth of research has demonstrated that locomotion is largely controlled by spinal mechanisms, the brain is of utmost importance in monitoring locomotor patterns and therefore contains information...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2012/375148

    authors: Cheron G,Duvinage M,De Saedeleer C,Castermans T,Bengoetxea A,Petieau M,Seetharaman K,Hoellinger T,Dan B,Dutoit T,Sylos Labini F,Lacquaniti F,Ivanenko Y

    更新日期:2012-01-01 00:00:00

  • Nestin reporter transgene labels multiple central nervous system precursor cells.

    abstract::Embryonic neuroepithelia and adult subventricular zone (SVZ) stem and progenitor cells express nestin. We characterized a transgenic line that expresses enhanced green fluorescent protein (eGFP) specified to neural tissue by the second intronic enhancer of the nestin promoter that had several novel features. During em...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2010/894374

    authors: Walker AS,Goings GE,Kim Y,Miller RJ,Chenn A,Szele FG

    更新日期:2010-01-01 00:00:00

  • Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism.

    abstract::The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plastici...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/6595740

    authors: Hoxha E,Lippiello P,Scelfo B,Tempia F,Ghirardi M,Miniaci MC

    更新日期:2017-01-01 00:00:00

  • The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts.

    abstract::Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early o...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2015/434127

    authors: Leite RT,Nogueira Sde O,do Nascimento JP,de Lima LS,da Nóbrega TB,Virgínio Mda S,Moreno LM,Sampaio BH,de Matos E Souza FG

    更新日期:2015-01-01 00:00:00