Abstract:
:Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment. RT is effective for tumor eradication, and survival rates are high. However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive "late" effects that may take years to fully manifest. These late effects likely derive from a long-term decrement in cell proliferation, combined with a neural environment that is hostile to plasticity, both of which are induced by RT. Long-term suppression of cell proliferation deprives the brain of the raw materials needed for optimum cognitive performance (such as new neurons in the hippocampus and new glia in frontal cortex), while chronic inflammation and dearth of trophic substances (such as growth hormone) limit neuroplastic potential in existing circuitry. Potential treatments for cognitive late effects should address both of these conditions. Exercise represents one such potential treatment, since it has the capacity to enhance cell proliferation, as well as to promote a neural milieu permissive for plasticity. Here, we review the evidence that cognitive late effects can be traced to RT-induced suppression of cell proliferation and hostile environmental conditions, as well as emerging evidence that exercise may be effective as an independent or adjuvant therapy.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Rodgers SP,Trevino M,Zawaski JA,Gaber MW,Leasure JLdoi
10.1155/2013/698528subject
Has Abstractpub_date
2013-01-01 00:00:00pages
698528eissn
2090-5904issn
1687-5443journal_volume
2013pub_type
杂志文章,评审abstract::Autosomal dominant nonsyndromic hearing loss (ADNSHL) is extremely heterogeneous. So far the genetic etiological contribution of the gene POU4F3 associated with ADNSHL has been rarely reported. In our previous study, a c.603_604delGG mutation in the hair cell specific gene POU4F3 has been identified as the pathogenic ...
journal_title:Neural plasticity
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
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journal_title:Neural plasticity
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doi:10.1155/2012/375148
更新日期:2012-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/3423267
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abstract::Alzheimer's disease (AD) is the most common form of dementia in elderly people. It is an irreversible and progressive brain disease. In this paper, we utilized diffusion-weighted imaging (DWI) to detect abnormal topological organization of white matter (WM) structural networks. We compared the differences between WM c...
journal_title:Neural plasticity
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journal_title:Neural plasticity
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更新日期:2013-01-01 00:00:00
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journal_title:Neural plasticity
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doi:10.1155/2020/8895369
更新日期:2020-10-14 00:00:00
abstract::Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable att...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/391349
更新日期:2015-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/585783
更新日期:2015-01-01 00:00:00
abstract::Using functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimicked in vivo conditi...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/108969
更新日期:2008-01-01 00:00:00
abstract::Proper functioning of the visual system depends on maturation of both excitatory and inhibitory synapses within the visual cortex. Considering that perisomatic inhibition is one of the key factors that control the critical period in visual cortex, it is pertinent to understand its regulation by visual experience. To d...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/415135
更新日期:2009-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2012/687659
更新日期:2012-01-01 00:00:00
abstract::Tinnitus is the phantom perception of sound in the absence of an acoustic stimulus. To date, the purported neural correlates of tinnitus from animal models have not been adequately characterized with translational technology in the human brain. The aim of the present study was to measure changes in oxy-hemoglobin conc...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/7453149
更新日期:2016-01-01 00:00:00
abstract::Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early o...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2015/434127
更新日期:2015-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/194097
更新日期:2008-01-01 00:00:00
abstract::Several studies have associated reduced expression of synaptosomal-associated protein of 25 kDa (SNAP-25) with schizophrenia, yet little is known about its role in the illness. In this paper, a forebrain glutamatergic neuron-specific SNAP-25 knockout mouse model was constructed and studied to explore the possible path...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/4526417
更新日期:2017-01-01 00:00:00
abstract::High-frequency synchronization has been found in many real neural systems and is confirmed by excitatory/inhibitory (E/I) network models. However, the functional role played by it remains elusive. In this paper, it is found that high-frequency synchronization in E/I neuronal networks could improve the firing rate cont...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8823111
更新日期:2020-11-09 00:00:00
abstract::Dementia affects millions of elderly worldwide causing remarkable costs to society, but effective treatment is still lacking. Acupuncture is one of the complementary therapies that has been applied to cognitive deficits such as Alzheimer's disease (AD) and vascular cognitive impairment (VCI), while the underlying mech...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2021/8868447
更新日期:2021-01-12 00:00:00
abstract::Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective function...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8583420
更新日期:2016-01-01 00:00:00
abstract::The GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex. GWS is characterized by focal epileptic electroencephalographic discharges and associated contralateral myoclonus. In neocortical slices obtained from GWS rat...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2000.9
更新日期:2000-01-01 00:00:00
abstract:Background and Purpose:Cancer-related fatigue (CRF) is widely recognized as one of the most common symptoms and side effects of cancer and/or its treatment. However, neuropathological mechanisms contributing to CRF are largely unknown, and the lack of knowledge makes CRF difficult to treat. Recent research has shown di...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/2490750
更新日期:2019-06-26 00:00:00
abstract::Chronic stress can impair hippocampal neurogenesis, increase neuronal apoptosis, and cause depressive-like behaviors. Our previous studies found that Radix Scutellariae (RS) can rescue the stress-induced neuronal injury, but the mechanism is not clear. Here, we continued to investigate the underlying antidepressant me...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8886715
更新日期:2020-11-13 00:00:00
abstract::Most citizen people are exposed daily to environmental noise at moderate levels with a short duration. The aim of the present study was to determine the effects of daily short-term exposure to moderate noise on sound level processing in the auditory midbrain. Sound processing properties of auditory midbrain neurons we...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/3026749
更新日期:2017-01-01 00:00:00
abstract::We have previously reported the crossed-withdrawal reflex in which the rats with nerve injury developed behavioral pain responses of the injured paw to stimuli applied to the contralateral uninjured paw. This reflex indicates that contralateral plastic changes may occur in the spinal cord after unilateral nerve injury...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/438319
更新日期:2015-01-01 00:00:00
abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/4135708
更新日期:2018-10-10 00:00:00
abstract::The formation of fear memories is a powerful and highly evolutionary conserved mechanism that serves the behavioral adaptation to environmental threats. Accordingly, classical fear conditioning paradigms have been employed to investigate fundamental molecular processes of memory formation. Evidence suggests that a cir...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/3750307
更新日期:2017-01-01 00:00:00
abstract::Traumatic brain injury (TBI) is a serious medical and social problem worldwide. Because of the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still lacking. The microglial cells are resident tissue macrophages located in the brain and have two major polarization states, M1 phenotype and M2 ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/5405104
更新日期:2017-01-01 00:00:00
abstract::The most dramatic progress in the restoration of hearing takes place in the first months after cochlear implantation. To map the brain activity underlying this process, we used positron emission tomography at three time points: within 14 days, three months, and six months after switch-on. Fifteen recently implanted ad...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2013/318521
更新日期:2013-01-01 00:00:00