New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity.

Abstract:

:Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain the whole picture of depressive disorders. In this review, we discussed new treatment directions of depression, including modulation of glutamatergic system and noninvasive brain stimulation. Dysfunction of glutamatergic neurotransmission plays an important role in the pathophysiology of depression. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has rapid and lasting antidepressive effects in previous studies. In addition to ketamine, other glutamatergic modulators, such as sarcosine, also show potential antidepressant effect in animal models or clinical trials. Noninvasive brain stimulation is another new treatment strategy beyond pharmacotherapy. Growing evidence has demonstrated that superficial brain stimulations, such as transcranial magnetic stimulation, transcranial direct current stimulation, cranial electrotherapy stimulation, and magnetic seizure therapy, can improve depressive symptoms. The antidepressive effect of these brain stimulations may be through modulating neuroplasticity. In conclusion, drugs that modulate neurotransmission via NMDA receptor and noninvasive brain stimulation may provide new directions of treatment for depression. Furthermore, exploring the underlying mechanisms will help in developing novel therapies for depression in the future.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Huang YJ,Lane HY,Lin CH

doi

10.1155/2017/4605971

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

4605971

eissn

2090-5904

issn

1687-5443

journal_volume

2017

pub_type

杂志文章,评审
  • Mutation in the Hair Cell Specific Gene POU4F3 Is a Common Cause for Autosomal Dominant Nonsyndromic Hearing Loss in Chinese Hans.

    abstract::Autosomal dominant nonsyndromic hearing loss (ADNSHL) is extremely heterogeneous. So far the genetic etiological contribution of the gene POU4F3 associated with ADNSHL has been rarely reported. In our previous study, a c.603_604delGG mutation in the hair cell specific gene POU4F3 has been identified as the pathogenic ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/9890827

    authors: He L,Pang X,Chen P,Wu H,Yang T

    更新日期:2016-01-01 00:00:00

  • Acupuncture Reversible Effects on Altered Default Mode Network of Chronic Migraine Accompanied with Clinical Symptom Relief.

    abstract:Objective:To determine whether and how longitudinal acupuncture modulates the impaired default mode network (DMN) in chronic migraine (CM) patients without aura. Methods:Resting-state functional magnetic resonance imaging (fMRI) data from 14 CM patients treated with longitudinal pre- and postacupuncture treatment (PPA...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/5047463

    authors: Zou Y,Tang W,Li X,Xu M,Li J

    更新日期:2019-03-18 00:00:00

  • Noncanonical Roles of hα-syn (A53T) in the Pathogenesis of Parkinson's Disease: Synaptic Pathology and Neuronal Aging.

    abstract::The motor and nonmotor symptoms of PD involve several brain regions. However, whether α-syn pathology originating from the SNc can directly lead to the pathological changes in distant cerebral regions and induce PD-related symptoms remains unclear. Here, AAV9-synapsin-mCherry-human SNCA (A53T) was injected into the un...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/6283754

    authors: Wang QJ,Chen AD,Chen HC,Wang DX,Cai YT,Yin J,Jing YH,Gao LP

    更新日期:2020-03-21 00:00:00

  • Functional Connectivity Alterations in Children with Spastic and Dyskinetic Cerebral Palsy.

    abstract::Cerebral palsy (CP) has long been investigated to be associated with a range of motor and cognitive dysfunction. As the two most common CP subtypes, spastic cerebral palsy (SCP) and dyskinetic cerebral palsy (DCP) may share common and distinct elements in their pathophysiology. However, the common and distinct dysfunc...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/7058953

    authors: Qin Y,Li Y,Sun B,He H,Peng R,Zhang T,Li J,Luo C,Sun C,Yao D

    更新日期:2018-08-15 00:00:00

  • Plasticity of horizontal connections at a functional border in adult rat somatosensory cortex.

    abstract::Horizontal connections in superficial cortical layers integrate information across sensory maps by connecting related functional columns. It has been hypothesized that these connections mediate cortical reorganization via synaptic plasticity. However, it is not known if the horizontal connections from discontinuous co...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2009/294192

    authors: Marik SA,Hickmott PW

    更新日期:2009-01-01 00:00:00

  • Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex.

    abstract::Associative fear learning, in which stimulation of whiskers is paired with mild electric shock to the tail, modifies the barrel cortex, the functional representation of sensory receptors involved in the conditioning, by inducing formation of new inhibitory synapses on single-synapse spines of the cognate barrel hollow...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/9828517

    authors: Jasinska M,Siucinska E,Jasek E,Litwin JA,Pyza E,Kossut M

    更新日期:2016-01-01 00:00:00

  • α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity.

    abstract::Neuropathies are characterized by a complex response of the central nervous system to injuries. Glial cells are recruited to maintain neuronal homeostasis but dysregulated activation leads to pain signaling amplification and reduces the glial neuroprotective power. Recently, we highlighted the property of α7 nicotinic...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/396908

    authors: Di Cesare Mannelli L,Tenci B,Zanardelli M,Failli P,Ghelardini C

    更新日期:2015-01-01 00:00:00

  • Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease.

    abstract::Motoneurons develop extensive dendritic trees for receiving excitatory and inhibitory synaptic inputs to perform a variety of complex motor tasks. At birth, the somatodendritic domains of mouse hypoglossal and lumbar motoneurons have dense filopodia and spines. Consistent with Vaughn's synaptotropic hypothesis, we pro...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/3423267

    authors: Kanjhan R,Noakes PG,Bellingham MC

    更新日期:2016-01-01 00:00:00

  • Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG.

    abstract::Recently several lines of evidence demonstrated that methylcobalamin (MeCbl) might have potential analgesic effect in experimental and clinical studies. However, it was reported that MeCbl had no effect on treating lumbar spinal stenosis induced pain. Thus, the effects of short-term and long-term administration of MeC...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/197392

    authors: Zhang M,Han W,Zheng J,Meng F,Jiao X,Hu S,Xu H

    更新日期:2015-01-01 00:00:00

  • Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores.

    abstract:Background:One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in resting-state functional MRI have been investigated to a limited extent. Fluctuations...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/2357107

    authors: Goodin P,Lamp G,Vidyasagar R,Connelly A,Rose S,Campbell BCV,Tse T,Ma H,Howells D,Hankey GJ,Davis S,Donnan G,Carey LM

    更新日期:2019-07-28 00:00:00

  • Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke.

    abstract::Perinatal stroke is a leading cause of congenital hemiparesis and neurocognitive deficits in children. Dysfunctions in the large-scale resting-state functional networks may underlie cognitive and behavioral disability in these children. We studied resting-state functional connectivity in patients with perinatal stroke...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/2306406

    authors: Ilves N,Ilves P,Laugesaar R,Juurmaa J,Männamaa M,Lõo S,Loorits D,Tomberg T,Kolk A,Talvik I,Talvik T

    更新日期:2016-01-01 00:00:00

  • Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging.

    abstract::The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8882207

    authors: Couto TA,Xu S,da Silva PA,Wu C,Neergaard K,Wang MY,Zhang J,Xiang Y,Yuan Z

    更新日期:2020-10-06 00:00:00

  • Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism.

    abstract::The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plastici...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/6595740

    authors: Hoxha E,Lippiello P,Scelfo B,Tempia F,Ghirardi M,Miniaci MC

    更新日期:2017-01-01 00:00:00

  • Effects of Temporary Functional Deafferentation in Chronic Stroke Patients: Who Profits More?

    abstract::Temporary functional deafferentation (TFD) by an anesthetic cream on the stroke-affected forearm was shown to improve sensorimotor abilities of stroke patients. The present study investigated different predictors for sensorimotor improvements during TFD and indicated outcome differences between patients grouped in sub...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/7392024

    authors: Sens E,Franz M,Preul C,Meissner W,Witte OW,Miltner WHR,Weiss T

    更新日期:2018-07-29 00:00:00

  • Manipulation of Auditory Inputs as Rehabilitation Therapy for Maladaptive Auditory Cortical Reorganization.

    abstract::Neurophysiological and neuroimaging data suggest that the brains of not only children but also adults are reorganized based on sensory inputs and behaviors. Plastic changes in the brain are generally beneficial; however, maladaptive cortical reorganization in the auditory cortex may lead to hearing disorders such as t...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2018/2546250

    authors: Okamoto H

    更新日期:2018-05-20 00:00:00

  • Plasticity of the dorsal "spatial" stream in visually deprived individuals.

    abstract::Studies on visually deprived individuals provide one of the most striking demonstrations that the brain is highly plastic and is able to rewire as a function of the sensory input it receives from the environment. In the current paper, we focus on spatial abilities that are typically related to the dorsal visual pathwa...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2012/687659

    authors: Dormal G,Lepore F,Collignon O

    更新日期:2012-01-01 00:00:00

  • Increased signal complexity improves the breadth of generalization in auditory perceptual learning.

    abstract::Perceptual learning can be specific to a trained stimulus or optimally generalized to novel stimuli with the breadth of generalization being imperative for how we structure perceptual training programs. Adapting an established auditory interval discrimination paradigm to utilise complex signals, we trained human adult...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2013/879047

    authors: Brown DJ,Proulx MJ

    更新日期:2013-01-01 00:00:00

  • The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts.

    abstract::Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early o...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2015/434127

    authors: Leite RT,Nogueira Sde O,do Nascimento JP,de Lima LS,da Nóbrega TB,Virgínio Mda S,Moreno LM,Sampaio BH,de Matos E Souza FG

    更新日期:2015-01-01 00:00:00

  • Spindle Oscillations in Sleep Disorders: A Systematic Review.

    abstract::Measurement of sleep microarchitecture and neural oscillations is an increasingly popular technique for quantifying EEG sleep activity. Many studies have examined sleep spindle oscillations in sleep-disordered adults; however reviews of this literature are scarce. As such, our overarching aim was to critically review ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/7328725

    authors: Weiner OM,Dang-Vu TT

    更新日期:2016-01-01 00:00:00

  • Memory effects of benzodiazepines: memory stages and types versus binding-site subtypes.

    abstract::Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent gen...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2005.289

    authors: Savić MM,Obradović DI,Ugresić ND,Bokonjić DR

    更新日期:2005-01-01 00:00:00

  • Action Observation Treatment Improves Upper Limb Motor Functions in Children with Cerebral Palsy: A Combined Clinical and Brain Imaging Study.

    abstract::The aim of the present study was to assess the role of action observation treatment (AOT) in the rehabilitation of upper limb motor functions in children with cerebral palsy. We carried out a two-group, parallel randomized controlled trial. Eighteen children (aged 5-11 yr) entered the study: 11 were treated children, ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/4843985

    authors: Buccino G,Molinaro A,Ambrosi C,Arisi D,Mascaro L,Pinardi C,Rossi A,Gasparotti R,Fazzi E,Galli J

    更新日期:2018-07-04 00:00:00

  • Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence.

    abstract::The aim of this study was to investigate the effect of subdiaphragmatic vagotomy on insulin sensitivity, secretion, and degradation in metabolic programmed mice, induced by a low-protein diet early in life, followed by exposure to a high-fat diet in adulthood. Weaned 30-day-old C57Bl/6 mice were submitted to a low-pro...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/9652978

    authors: Lubaczeuski C,Gonçalves LM,Vettorazzi JF,Kurauti MA,Santos-Silva JC,Bonfleur ML,Boschero AC,Costa-Júnior JM,Carneiro EM

    更新日期:2017-01-01 00:00:00

  • The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer's Disease or Vascular Diseases through Regulating Neuroplasticity.

    abstract::Dementia affects millions of elderly worldwide causing remarkable costs to society, but effective treatment is still lacking. Acupuncture is one of the complementary therapies that has been applied to cognitive deficits such as Alzheimer's disease (AD) and vascular cognitive impairment (VCI), while the underlying mech...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2021/8868447

    authors: Ji S,Duan J,Hou X,Zhou L,Qin W,Niu H,Luo S,Zhang Y,Chan P,Jin X

    更新日期:2021-01-12 00:00:00

  • Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer's Disease: A Diffusion MRI Study with DTI and HARDI Models.

    abstract::Alzheimer's disease (AD) is the most common form of dementia in elderly people. It is an irreversible and progressive brain disease. In this paper, we utilized diffusion-weighted imaging (DWI) to detect abnormal topological organization of white matter (WM) structural networks. We compared the differences between WM c...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/2947136

    authors: Wang T,Shi F,Jin Y,Yap PT,Wee CY,Zhang J,Yang C,Li X,Xiao S,Shen D

    更新日期:2016-01-01 00:00:00

  • Immune Challenge Alters Reactivity of Hippocampal Noradrenergic System in Prenatally Stressed Aged Mice.

    abstract::Prenatal stress (PS) has long-term sequelae for the morphological and functional status of the central nervous system of the progeny. A PS-induced proinflammatory status of the organism may result in an impairment of both hippocampal synaptic plasticity and hippocampus-dependent memory formation in adults. We addresse...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/3152129

    authors: Grigoryan G,Lonnemann N,Korte M

    更新日期:2019-01-21 00:00:00

  • Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APP/PS1 Mice.

    abstract::Elevated brain activation, or hyperexcitability, induces cognitive impairment and confers an increased risk of Alzheimer's disease (AD). Blocking the overexcitation of the neural network may be a promising new strategy to prevent, halt, and even reverse this condition. Physical exercise has been shown to be an effecti...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/9132720

    authors: Tan YX,Liu GC,Chen HL,Lu MN,Chen B,Hu T,Zhang L,Mao R,Li S,Mei R,Wang XY,Xiyang YB

    更新日期:2020-03-18 00:00:00

  • Different Brain Connectivity between Responders and Nonresponders to Dual-Mode Noninvasive Brain Stimulation over Bilateral Primary Motor Cortices in Stroke Patients.

    abstract::Noninvasive brain stimulation (NBS), such as repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS), has been used in stroke patients with motor impairment. NBS can help recovery from brain damage by modulating cortical excitability. However, the efficacy of NBS varies am...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/3826495

    authors: Lee J,Lee A,Kim H,Shin M,Yun SM,Jung Y,Chang WH,Kim YH

    更新日期:2019-04-07 00:00:00

  • Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer's Disease Animal Model.

    abstract::Alzheimer's disease (AD) is one of the most serious public health concerns facing the world. Its characteristic feature is neuroinflammation due to microglial activation. Electroacupuncture is one of the therapies employed to improve the condition of patients with AD, although its mechanism of action is still to be de...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8867547

    authors: Li Y,Jiang J,Tang Q,Tian H,Wang S,Wang Z,Liu H,Yang J,Ren J

    更新日期:2020-09-04 00:00:00

  • Autism: a "critical period" disorder?

    abstract::Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic ne...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2011/921680

    authors: LeBlanc JJ,Fagiolini M

    更新日期:2011-01-01 00:00:00

  • The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention.

    abstract::Traumatic brain injury (TBI) is a serious medical and social problem worldwide. Because of the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still lacking. The microglial cells are resident tissue macrophages located in the brain and have two major polarization states, M1 phenotype and M2 ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5405104

    authors: Xu H,Wang Z,Li J,Wu H,Peng Y,Fan L,Chen J,Gu C,Yan F,Wang L,Chen G

    更新日期:2017-01-01 00:00:00