Neurosteroids Involvement in the Epigenetic Control of Memory Formation and Storage.

Abstract:

:Memory is our ability to store and remember past experiences; it is the result of changes in neuronal circuits of specific brain areas as the hippocampus. During memory formation, neurons integrate their functions and increase the strength of their connections, so that synaptic plasticity is improved and consolidated. All these processes recruit several proteins at the synapses, whose expression is highly regulated by DNA methylation and histone tails posttranslational modifications. Steroids are known to influence memory process, and, among them, neurosteroids are implicated in neurodegenerative disease related to memory loss and cognitive impairment. The epigenetic control of neurosteroids involvement in memory formation and maintenance could represent the basis for neuroregenerative therapies.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Colciago A,Magnaghi V

doi

10.1155/2016/5985021

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

5985021

eissn

2090-5904

issn

1687-5443

journal_volume

2016

pub_type

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