Abstract:
:Memory is our ability to store and remember past experiences; it is the result of changes in neuronal circuits of specific brain areas as the hippocampus. During memory formation, neurons integrate their functions and increase the strength of their connections, so that synaptic plasticity is improved and consolidated. All these processes recruit several proteins at the synapses, whose expression is highly regulated by DNA methylation and histone tails posttranslational modifications. Steroids are known to influence memory process, and, among them, neurosteroids are implicated in neurodegenerative disease related to memory loss and cognitive impairment. The epigenetic control of neurosteroids involvement in memory formation and maintenance could represent the basis for neuroregenerative therapies.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Colciago A,Magnaghi Vdoi
10.1155/2016/5985021subject
Has Abstractpub_date
2016-01-01 00:00:00pages
5985021eissn
2090-5904issn
1687-5443journal_volume
2016pub_type
杂志文章,评审abstract::Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2007/91236
更新日期:2007-01-01 00:00:00
abstract::Increasing research has evidenced that our brain retains a capacity to change in response to experience until late adulthood. This implies that cognitive training can possibly ameliorate age-associated cognitive decline by inducing training-specific neural plastic changes at both neural and behavioral levels. This lon...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/535618
更新日期:2015-01-01 00:00:00
abstract::Autosomal dominant nonsyndromic hearing loss (ADNSHL) is extremely heterogeneous. So far the genetic etiological contribution of the gene POU4F3 associated with ADNSHL has been rarely reported. In our previous study, a c.603_604delGG mutation in the hair cell specific gene POU4F3 has been identified as the pathogenic ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/9890827
更新日期:2016-01-01 00:00:00
abstract::One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during develo...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2011/286073
更新日期:2011-01-01 00:00:00
abstract::We have previously reported the crossed-withdrawal reflex in which the rats with nerve injury developed behavioral pain responses of the injured paw to stimuli applied to the contralateral uninjured paw. This reflex indicates that contralateral plastic changes may occur in the spinal cord after unilateral nerve injury...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/438319
更新日期:2015-01-01 00:00:00
abstract::Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early o...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2015/434127
更新日期:2015-01-01 00:00:00
abstract::Functional and morphological studies in children affected by Attention Deficit Hyperactivity Disorder (ADHD) suggest a prefrontal cortex (PFc) dysfunction. This cortical region is regulated by subcortical systems including noradrenergic (NEergic), dopaminergic (DAergic), cholinergic, serotonergic, and histaminergic pa...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2004.133
更新日期:2004-01-01 00:00:00
abstract::The role of the right hemisphere (RH) in recovery from aphasia is incompletely understood. The present study quantified RH grey matter (GM) volume in individuals with chronic stroke-induced aphasia and cognitively healthy people using voxel-based morphometry. We compared group differences in GM volume in the entire RH...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/5601509
更新日期:2017-01-01 00:00:00
abstract::The GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex. GWS is characterized by focal epileptic electroencephalographic discharges and associated contralateral myoclonus. In neocortical slices obtained from GWS rat...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2000.9
更新日期:2000-01-01 00:00:00
abstract::Little is known about prenatal and perinatal brain injury resulting in subsequent clumsy behavior in children. One candidate motor system is the pyramidal tract. The tract traverses the entire central nervous system and, through direct and indirect connections to the brainstem and spinal cord sensory and motor nuclei,...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.2003.77
更新日期:2003-01-01 00:00:00
abstract:Background:Parkinson's disease (PD) patients experience cognitive impairment which has been related to reduced quality of life and functional disability. These symptoms usually progress until dementia occurs. Some studies have been published assessing the efficacy of cognitive treatments on improving cognition, functio...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2018/2651918
更新日期:2018-05-06 00:00:00
abstract::Elevated brain activation, or hyperexcitability, induces cognitive impairment and confers an increased risk of Alzheimer's disease (AD). Blocking the overexcitation of the neural network may be a promising new strategy to prevent, halt, and even reverse this condition. Physical exercise has been shown to be an effecti...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/9132720
更新日期:2020-03-18 00:00:00
abstract::Ample evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood. Through multiple approaches, we demonstrate that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HPA axis and in brain...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8866187
更新日期:2020-08-28 00:00:00
abstract::The present study investigates whether a combined cognitive and physical training may induce changes in the cortical activity as measured via electroencephalogram (EEG) and whether this change may index a deceleration of pathological processes of brain aging. Seventy seniors meeting the clinical criteria of mild cogni...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/172192
更新日期:2015-01-01 00:00:00
abstract::Recently, transcranial alternating current stimulation (tACS) has emerged as a tool to enhance human cognitive processes. Here, we provide a brief summary of the rationale behind tACS-induced effects on task-relevant brain oscillations and associated cognitive functions and review previous studies in young subjects th...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/4274127
更新日期:2016-01-01 00:00:00
abstract::The plasticity of brain function, especially reorganization after stroke or sensory loss, has been investigated extensively. Based upon its special characteristics, the olfactory system allows the investigation of functional networks in patients with smell loss, as it holds the unique ability to be activated by the se...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/140419
更新日期:2014-01-01 00:00:00
abstract::Postural problems play a central role in the motor dysfunction of children with cerebral palsy (CP). Therefore, they spend more time in sitting than in standing to perform vital tasks of daily life. The focus of this article is to describe the pathophysiology of postural control in sitting and outline some implication...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2005.221
更新日期:2005-01-01 00:00:00
abstract::The motor and nonmotor symptoms of PD involve several brain regions. However, whether α-syn pathology originating from the SNc can directly lead to the pathological changes in distant cerebral regions and induce PD-related symptoms remains unclear. Here, AAV9-synapsin-mCherry-human SNCA (A53T) was injected into the un...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/6283754
更新日期:2020-03-21 00:00:00
abstract::Neurogenesis in the hippocampus is influenced by several factors including external stimuli. In addition to their involvement in learning and memory processes, newborn neurons of the dentate gyrus (DG) buffer against the effects of stress. Although the response of these cells to environmental stimuli has been shown, t...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/4960869
更新日期:2018-05-22 00:00:00
abstract::Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures. GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system. Accumulating evidence de...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2020/8858415
更新日期:2020-08-01 00:00:00
abstract::Cholinergic mechanism is involved in motor behavior. In songbirds, the robust nucleus of the arcopallium (RA) is a song premotor nucleus in the pallium and receives cholinergic inputs from the basal forebrain. The activity of projection neurons in RA determines song motor behavior. Although many evidences suggest that...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/7246827
更新日期:2016-01-01 00:00:00
abstract::Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learn...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/9353929
更新日期:2016-01-01 00:00:00
abstract::Alzheimer's disease (AD) is one of the most serious public health concerns facing the world. Its characteristic feature is neuroinflammation due to microglial activation. Electroacupuncture is one of the therapies employed to improve the condition of patients with AD, although its mechanism of action is still to be de...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8867547
更新日期:2020-09-04 00:00:00
abstract::Neurophysiological and neuroimaging data suggest that the brains of not only children but also adults are reorganized based on sensory inputs and behaviors. Plastic changes in the brain are generally beneficial; however, maladaptive cortical reorganization in the auditory cortex may lead to hearing disorders such as t...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2018/2546250
更新日期:2018-05-20 00:00:00
abstract::Childhood emotional trauma contributes significantly to certain psychopathologies, such as post-traumatic stress disorder. In experimental animals, however, whether or not early-life stress results in behavioral abnormalities in adult animals still remains controversial. Here, we investigated both short-term and long-...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/163908
更新日期:2014-01-01 00:00:00
abstract::Freezing of gait (FoG) is among the most disabling symptoms of Parkinson's disease (PD) patients. Recent studies showed that action observation training (AOT) with repetitive practice of the observed actions represents a strategy to induce longer-lasting effects compared with standard physiotherapy. We investigated wh...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/4897276
更新日期:2018-05-27 00:00:00
abstract:Background:Phosphene generation is an objective physical measure of potential transcranial alternating current stimulation (tACS) biological side effects. Interpretations from phosphene analysis can serve as a first step in understanding underlying mechanisms of tACS in healthy human subjects and assist validation of c...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/8525706
更新日期:2018-12-06 00:00:00
abstract::The habituation/cross-habituation test (HaXha) is a spontaneous odor discrimination task that has been used for many decades to evaluate olfactory function in animals. Animals are presented repeatedly with the same odorant after which a new odorant is introduced. The time the animal explores the odor object is measure...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/9131284
更新日期:2016-01-01 00:00:00
abstract::Focal hand dystonia (FHd) is a recalcitrant, disabling movement disorder, characterized by involuntary co-contractions of agonists and antagonists, that can develop in patients who overuse or misuse their hands. The aim of this study was to document clinical neuromusculoskeletal performance and somatosensory responses...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.2002.177
更新日期:2002-01-01 00:00:00
abstract::Temporal mechanisms for processing auditory musical rhythms are well established, in which a perceived beat is beneficial for timing purposes. It is yet unknown whether such beat-based timing would also underlie visual perception of temporally structured, ecological stimuli connected to music: dance. In this study, we...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/1678390
更新日期:2016-01-01 00:00:00