Noncanonical Roles of hα-syn (A53T) in the Pathogenesis of Parkinson's Disease: Synaptic Pathology and Neuronal Aging.

abstract：:We analyzed operant discrimination in detelencephalated pigeons and neuroanatomical substrates after long-term detelencephalation. In Experiment I, experimental pigeons with massive telencephalic ablation and control pigeons were conditioned to key peck for food. Successive discrimination was made under alternating re...

journal_title：Neural plasticity

authors： Cerutti SM,Diaz-Cintra S,Cintra L,Ferrari EA

更新日期：2003-01-01 00:00:00

abstract：:Accumulating evidence implicates a role for brain structures outside the ascending auditory pathway in tinnitus, the phantom perception of sound. In addition to other factors such as age-dependent hearing loss, high-level sound exposure is a prominent cause of tinnitus. Here, we examined how noise exposure altered the...

journal_title：Neural plasticity

authors： Zhang L,Wu C,Martel DT,West M,Sutton MA,Shore SE

更新日期：2021-01-14 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the elderly; important risk factors are old age and inheritance of the apolipoprotein E4 (APOE4) allele. Changes in amyloid precursor protein (APP) binding, trafficking, and sorting may be important AD causative factors. Secretase-mediated APP cleavage pr...

journal_title：Neural plasticity

authors： Zollo A,Allen Z,Rasmussen HF,Iannuzzi F,Shi Y,Larsen A,Maier TJ,Matrone C

更新日期：2017-01-01 00:00:00

abstract：:Adult hippocampal neurogenesis is a process involving the continuous generation of newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested that hippocampal neurogenesis contributes to some forms of hippocampus-dependent learning and memory; however, the detailed mechanism concerning how th...

journal_title：Neural plasticity

authors： Yau SY,Li A,So KF

更新日期：2015-01-01 00:00:00

abstract：:Despite the fact that astrocytes are the most abundant glial cells, critical for brain function, few studies have dealt with their possible role in neurodegenerative diseases like Parkinson's disease (PD). This article explores relevant evidence on the involvement of astrocytes in experimental PD neurodegeneration fro...

journal_title：Neural plasticity

authors： Udovin L,Quarracino C,Herrera MI,Capani F,Otero-Losada M,Perez-Lloret S

更新日期：2020-02-07 00:00:00

abstract：:Several research studies point to the fact that sensory and cognitive reductions like cataracts, deafness, macular degeneration, or even lack of activity after job retirement, precede the onset of Alzheimer's disease. To simulate Alzheimer's disease earlier stages, which manifest in sensory cortices, we used a computa...

journal_title：Neural plasticity

authors： Aguiar-Furucho MA,Peláez FJR

更新日期：2020-10-14 00:00:00

abstract：:Traumatic brain injury (TBI) is a worldwide endemic that results in unacceptably high morbidity and mortality. Secondary injury processes following primary injury are composed of intricate interactions between assorted molecules that ultimately dictate the degree of longer-term neurological deficits. One comparatively...

journal_title：Neural plasticity

authors： Budinich CS,Chen H,Lowe D,Rosenberger JG,Bernstock JD,McCabe JT

更新日期：2012-01-01 00:00:00

abstract：:The role of the right hemisphere (RH) in recovery from aphasia is incompletely understood. The present study quantified RH grey matter (GM) volume in individuals with chronic stroke-induced aphasia and cognitively healthy people using voxel-based morphometry. We compared group differences in GM volume in the entire RH...

journal_title：Neural plasticity

authors： Lukic S,Barbieri E,Wang X,Caplan D,Kiran S,Rapp B,Parrish TB,Thompson CK

更新日期：2017-01-01 00:00:00

abstract：Objective:To compare the effects of training of jaw and finger movements with and without visual feedback on precision and accuracy. Method:Twenty healthy participants (10 men and 10 women; mean age 24.6 ± 0.8 years) performed two tasks: a jaw open-close movement and a finger lifting task with and without visual feedb...

journal_title：Neural plasticity

authors： Chen Y,Wu S,Tang Z,Zhang J,Wang L,Yu L,Wang K,Svensson P

更新日期：2019-11-18 00:00:00

abstract：:Success in locomotor rehabilitation programs can be improved with the use of brain-computer interfaces (BCIs). Although a wealth of research has demonstrated that locomotion is largely controlled by spinal mechanisms, the brain is of utmost importance in monitoring locomotor patterns and therefore contains information...

journal_title：Neural plasticity

authors： Cheron G,Duvinage M,De Saedeleer C,Castermans T,Bengoetxea A,Petieau M,Seetharaman K,Hoellinger T,Dan B,Dutoit T,Sylos Labini F,Lacquaniti F,Ivanenko Y

更新日期：2012-01-01 00:00:00

abstract：:Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons. It has also been shown to acutely induce epileptic seizure behavior in freely moving rats. However, whether CTZ indu...

journal_title：Neural plasticity

authors： Kong S,Cheng Z,Liu J,Wang Y

更新日期：2014-01-01 00:00:00

abstract：Background:Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. Th...

journal_title：Neural plasticity

authors： Chen J,Hu B,Qin P,Gao W,Liu C,Zi D,Ding X,Yu Y,Cui G,Lu L

更新日期：2020-09-22 00:00:00

abstract：:Prenatal stress (PS) has long-term sequelae for the morphological and functional status of the central nervous system of the progeny. A PS-induced proinflammatory status of the organism may result in an impairment of both hippocampal synaptic plasticity and hippocampus-dependent memory formation in adults. We addresse...

journal_title：Neural plasticity

authors： Grigoryan G,Lonnemann N,Korte M

更新日期：2019-01-21 00:00:00

abstract：:The entorhinal cortex (EC) is a nodal and independent mnemonic element of the medial temporal lobe memory circuit as it forms a bidirectional interface between the neocortex and hippocampus. Within the EC, intra- and inter-lamellar associational connections occur via horizontal and columnar projections, respectively. ...

journal_title：Neural plasticity

authors： Ma L,Alonso A,Dickson CT

更新日期：2008-01-01 00:00:00

abstract：:One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during develo...

journal_title：Neural plasticity

authors： Baroncelli L,Braschi C,Spolidoro M,Begenisic T,Maffei L,Sale A

更新日期：2011-01-01 00:00:00

abstract：:Focal hand dystonia (FHd) is a recalcitrant, disabling movement disorder, characterized by involuntary co-contractions of agonists and antagonists, that can develop in patients who overuse or misuse their hands. The aim of this study was to document clinical neuromusculoskeletal performance and somatosensory responses...

journal_title：Neural plasticity

authors： Byl NN,Nagarajan SS,Merzenich MM,Roberts T,McKenzie A

更新日期：2002-01-01 00:00:00

abstract：:Aging is a complex process strongly determined by genetics. Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs). CNVs represent a significant source of genetic variation in the human genome and have been implicated in several diso...

journal_title：Neural plasticity

authors： Villela D,Suemoto CK,Leite R,Pasqualucci CA,Grinberg LT,Pearson P,Rosenberg C

更新日期：2018-06-28 00:00:00

abstract：:Adverse early life experiences can negatively affect behaviors later in life. Maternal separation (MS) has been extensively investigated in animal models in the adult phase of MS. The study aimed to explore the mechanism by which MS negatively affects C57BL/6N mice, especially the effects caused by MS in the early pha...

journal_title：Neural plasticity

authors： Bian Y,Yang L,Wang Z,Wang Q,Zeng L,Xu G

更新日期：2015-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a serious medical and social problem worldwide. Because of the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still lacking. The microglial cells are resident tissue macrophages located in the brain and have two major polarization states, M1 phenotype and M2 ...

journal_title：Neural plasticity

authors： Xu H,Wang Z,Li J,Wu H,Peng Y,Fan L,Chen J,Gu C,Yan F,Wang L,Chen G

更新日期：2017-01-01 00:00:00

abstract：:Although quantitative analysis of the sleep electroencephalogram (EEG) has uncovered important aspects of brain activity during sleep in adolescents and adults, similar findings from preschool-age children remain scarce. This study utilized our time-frequency method to examine sleep oscillations as characteristic feat...

journal_title：Neural plasticity

authors： Olbrich E,Rusterholz T,LeBourgeois MK,Achermann P

更新日期：2017-01-01 00:00:00

abstract：:Recently, transcranial alternating current stimulation (tACS) has emerged as a tool to enhance human cognitive processes. Here, we provide a brief summary of the rationale behind tACS-induced effects on task-relevant brain oscillations and associated cognitive functions and review previous studies in young subjects th...

journal_title：Neural plasticity

authors： Antonenko D,Faxel M,Grittner U,Lavidor M,Flöel A

更新日期：2016-01-01 00:00:00

abstract：:Tinnitus is the phantom perception of sound in the absence of an acoustic stimulus. To date, the purported neural correlates of tinnitus from animal models have not been adequately characterized with translational technology in the human brain. The aim of the present study was to measure changes in oxy-hemoglobin conc...

journal_title：Neural plasticity

authors： Issa M,Bisconti S,Kovelman I,Kileny P,Basura GJ

更新日期：2016-01-01 00:00:00

abstract：:Dizziness and vertigo frequently occur after cochlear implantation (CI) surgery, particularly during the early stages. It could recover over time but some of the patients suffered from delayed or sustained vestibular symptoms after CI. This study used rat animal models to investigate the effect of unilateral cochleost...

journal_title：Neural plasticity

authors： Suh MW,Hyun J,Lyu AR,Kim DW,Park SJ,Choi JW,Hur GM,Park YH

更新日期：2016-01-01 00:00:00

abstract：:High-frequency synchronization has been found in many real neural systems and is confirmed by excitatory/inhibitory (E/I) network models. However, the functional role played by it remains elusive. In this paper, it is found that high-frequency synchronization in E/I neuronal networks could improve the firing rate cont...

journal_title：Neural plasticity

authors： Han F,Wang Z,Fan H,Zhang Y

更新日期：2020-11-09 00:00:00

abstract：:Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early o...

journal_title：Neural plasticity

authors： Leite RT,Nogueira Sde O,do Nascimento JP,de Lima LS,da Nóbrega TB,Virgínio Mda S,Moreno LM,Sampaio BH,de Matos E Souza FG

更新日期：2015-01-01 00:00:00

abstract：:Patients suffering from chronic disorders of consciousness (DOC) are characterized by profound unawareness and an impairment of large-scale cortical and subcortical connectivity. In this study, we applied an electrophysiological approach aimed at identifying the residual audiomotor connectivity patterns that are thoug...

journal_title：Neural plasticity

authors： Naro A,Leo A,Cannavò A,Buda A,Bruno R,Salviera C,Bramanti P,Calabrò RS

更新日期：2015-01-01 00:00:00

abstract：:Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable att...

journal_title：Neural plasticity

authors： Cairns EA,Baldridge WH,Kelly ME

更新日期：2016-01-01 00:00:00

abstract：:To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and ...

journal_title：Neural plasticity

authors： Wang H,Bing D,Li J,Xie L,Xiong F,Lan L,Wang D,Guan J,Wang Q

更新日期：2020-07-01 00:00:00

abstract：:Previous studies have demonstrated that amnestic mild cognitive impairment (aMCI) has disrupted properties of large-scale cortical networks based on cortical thickness and gray matter volume. However, it is largely unknown whether the topological properties of cortical networks based on geometric measures (i.e., sulca...

journal_title：Neural plasticity

authors： Li Q,Li X,Wang X,Li Y,Li K,Yu Y,Yin C,Li S,Han Y

更新日期：2016-01-01 00:00:00

abstract：Objective:To determine whether and how longitudinal acupuncture modulates the impaired default mode network (DMN) in chronic migraine (CM) patients without aura. Methods:Resting-state functional magnetic resonance imaging (fMRI) data from 14 CM patients treated with longitudinal pre- and postacupuncture treatment (PPA...

journal_title：Neural plasticity

authors： Zou Y,Tang W,Li X,Xu M,Li J

更新日期：2019-03-18 00:00:00