Complete and partial lesions of the pyramidal tract in the rat affect qualitative measures of skilled movements: impairment in fixations as a model for clumsy behavior.

Abstract:

:Little is known about prenatal and perinatal brain injury resulting in subsequent clumsy behavior in children. One candidate motor system is the pyramidal tract. The tract traverses the entire central nervous system and, through direct and indirect connections to the brainstem and spinal cord sensory and motor nuclei, is involved in the learning and execution of skilled movements. Here, rats, either naive or pretrained on a number of motor tasks, were assessed for acute and chronic impairments following complete or incomplete pyramidal tract lesions. Postsurgery rats with complete lesions were impaired on the qualitative measures of limb aiming, supination, and posture. Impaired movements require fixations, complementary movements in different body segments. The impairment in fixations was manifest acutely and underwent no improvement with subsequent training/testing. The finding that complete and partial pyramidal tract lesions produce chronic impairment in fixations provides insight for understanding clumsy behavior in humans and its potential remediation via specific training in making fixations.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Whishaw IQ,Piecharka DM,Drever FR

doi

10.1155/NP.2003.77

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

77-92

issue

1-2

eissn

2090-5904

issn

1687-5443

journal_volume

10

pub_type

杂志文章
  • Plasticity of the dorsal "spatial" stream in visually deprived individuals.

    abstract::Studies on visually deprived individuals provide one of the most striking demonstrations that the brain is highly plastic and is able to rewire as a function of the sensory input it receives from the environment. In the current paper, we focus on spatial abilities that are typically related to the dorsal visual pathwa...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2012/687659

    authors: Dormal G,Lepore F,Collignon O

    更新日期:2012-01-01 00:00:00

  • Dopaminergic Modulation of Striatal Inhibitory Transmission and Long-Term Plasticity.

    abstract::Dopamine (DA) modulates glutamatergic synaptic transmission and its plasticity in the striatum; however it is not well known how DA modulates long-term plasticity of striatal GABAergic inhibitory synapses. This work focused on the analysis of both dopaminergic modulation of inhibitory synapses and the synaptic plastic...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/789502

    authors: Nieto Mendoza E,Hernández Echeagaray E

    更新日期:2015-01-01 00:00:00

  • Effects of Motor Training on Accuracy and Precision of Jaw and Finger Movements.

    abstract:Objective:To compare the effects of training of jaw and finger movements with and without visual feedback on precision and accuracy. Method:Twenty healthy participants (10 men and 10 women; mean age 24.6 ± 0.8 years) performed two tasks: a jaw open-close movement and a finger lifting task with and without visual feedb...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/9593464

    authors: Chen Y,Wu S,Tang Z,Zhang J,Wang L,Yu L,Wang K,Svensson P

    更新日期:2019-11-18 00:00:00

  • Right Hemisphere Grey Matter Volume and Language Functions in Stroke Aphasia.

    abstract::The role of the right hemisphere (RH) in recovery from aphasia is incompletely understood. The present study quantified RH grey matter (GM) volume in individuals with chronic stroke-induced aphasia and cognitively healthy people using voxel-based morphometry. We compared group differences in GM volume in the entire RH...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/5601509

    authors: Lukic S,Barbieri E,Wang X,Caplan D,Kiran S,Rapp B,Parrish TB,Thompson CK

    更新日期:2017-01-01 00:00:00

  • Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure.

    abstract::Neuropathic pain increases the risk of cardiovascular diseases including hypertension with the characteristic of sympathetic overactivity. The enhanced tonically active glutamatergic input to the rostral ventrolateral medulla (RVLM) contributes to sympathetic overactivity and blood pressure (BP) in cardiovascular dise...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/4174010

    authors: Wang W,Zou Z,Tan X,Zhang RW,Ren CZ,Yao XY,Li CB,Wang WZ,Shi XY

    更新日期:2017-01-01 00:00:00

  • α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity.

    abstract::Neuropathies are characterized by a complex response of the central nervous system to injuries. Glial cells are recruited to maintain neuronal homeostasis but dysregulated activation leads to pain signaling amplification and reduces the glial neuroprotective power. Recently, we highlighted the property of α7 nicotinic...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/396908

    authors: Di Cesare Mannelli L,Tenci B,Zanardelli M,Failli P,Ghelardini C

    更新日期:2015-01-01 00:00:00

  • Stimulus- and Neural-Referred Visual Receptive Field Properties following Hemispherectomy: A Case Study Revisited.

    abstract::Damage to the visual system can result in (a partial) loss of vision, in response to which the visual system may functionally reorganize. Yet the timing, extent, and conditions under which this occurs are not well understood. Hence, studies in individuals with diverse congenital and acquired conditions and using vario...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/6067871

    authors: Halbertsma HN,Haak KV,Cornelissen FW

    更新日期:2019-09-03 00:00:00

  • Genetics and function of neocortical GABAergic interneurons in neurodevelopmental disorders.

    abstract::A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and exp...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2011/649325

    authors: Rossignol E

    更新日期:2011-01-01 00:00:00

  • Statins Promote Long-Term Recovery after Ischemic Stroke by Reconnecting Noradrenergic Neuronal Circuitry.

    abstract::Inhibitors of HMG-CoA reductase (statins), widely used to lower cholesterol in coronary heart and vascular disease, are effective drugs in reducing the risk of stroke and improving its outcome in the long term. After ischemic stroke, cardiac autonomic dysfunction and psychological problems are common complications rel...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/585783

    authors: Cho KJ,Cheon SY,Kim GW

    更新日期:2015-01-01 00:00:00

  • Recovery of olfactory function induces neuroplasticity effects in patients with smell loss.

    abstract::The plasticity of brain function, especially reorganization after stroke or sensory loss, has been investigated extensively. Based upon its special characteristics, the olfactory system allows the investigation of functional networks in patients with smell loss, as it holds the unique ability to be activated by the se...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2014/140419

    authors: Kollndorfer K,Kowalczyk K,Hoche E,Mueller CA,Pollak M,Trattnig S,Schöpf V

    更新日期:2014-01-01 00:00:00

  • Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain.

    abstract::Aging is a complex process strongly determined by genetics. Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs). CNVs represent a significant source of genetic variation in the human genome and have been implicated in several diso...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/2406170

    authors: Villela D,Suemoto CK,Leite R,Pasqualucci CA,Grinberg LT,Pearson P,Rosenberg C

    更新日期:2018-06-28 00:00:00

  • Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice.

    abstract::Adverse early life experiences can negatively affect behaviors later in life. Maternal separation (MS) has been extensively investigated in animal models in the adult phase of MS. The study aimed to explore the mechanism by which MS negatively affects C57BL/6N mice, especially the effects caused by MS in the early pha...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/627837

    authors: Bian Y,Yang L,Wang Z,Wang Q,Zeng L,Xu G

    更新日期:2015-01-01 00:00:00

  • Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification.

    abstract::The endocannabinoids N-arachidonoylethanolamide (or anandamide, AEA) and 2-arachidonoylglycerol (2-AG) belong to the larger groups of N-acylethanolamines (NAEs) and monoacylglycerol (MAG) lipid classes, respectively. They are biologically active lipid molecules that activate G-protein-coupled cannabinoid receptors fou...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/2426398

    authors: Keereetaweep J,Chapman KD

    更新日期:2016-01-01 00:00:00

  • Apolipoprotein E antibodies affect the retention of passive avoidance memory in the chick.

    abstract::Isoforms of apolipoprotein E (ApoE) have been implicated as risk factors in Alzheimer's disease. We have, therefore, examined the possible role of ApoE in memory formation, using a one-trial passive avoidance task in day-old chicks. Birds were trained on the task and then at various times pre or post-training were inj...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/NP.1998.29

    authors: Lancashire C,Mileusnic R,Rose SP

    更新日期:1998-07-01 00:00:00

  • Targeted Neuromodulation of Abnormal Interhemispheric Connectivity to Promote Neural Plasticity and Recovery of Arm Function after Stroke: A Randomized Crossover Clinical Trial Study Protocol.

    abstract:Background:Despite intensive rehabilitation efforts, most stroke survivors have persistent functional disability of the paretic arm and hand. These motor impairments may be due in part to maladaptive changes in structural and functional connections between brain regions. The following early stage clinical trial study p...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/9875326

    authors: Borich MR,Wolf SL,Tan AQ,Palmer JA

    更新日期:2018-03-12 00:00:00

  • Cortical Reorganization in Patients Recovered from Bell's Palsy: An Orofacial and Finger Movements Task-State fMRI Study.

    abstract::Objective. To explore cortical reorganization of patients recovered from Bell's palsy (BP) by task-state functional magnetic resonance imaging (fMRI) during finger and orofacial movements and provide more evidence for acupuncture clinical treatment of BP. Methods. We collected 17 BP patients with complete clinical rec...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/8231726

    authors: Lee J,Yang J,Li C,Yuan A,Wu H,Wang A,Xue Q,Wang T,Wang L,Gao T

    更新日期:2016-01-01 00:00:00

  • HINT1 in Neuropsychiatric Diseases: A Potential Neuroplastic Mediator.

    abstract::Although many studies have investigated the functions of histidine triad nucleotide-binding protein 1 (HINT1), its roles in neurobiological processes remain to be fully elucidated. As a member of the histidine triad (HIT) enzyme superfamily, HINT1 is distributed in almost every organ and has both enzymatic and nonenzy...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5181925

    authors: Liu P,Liu Z,Wang J,Ma X,Dang Y

    更新日期:2017-01-01 00:00:00

  • Sustained Activity of Metabotropic Glutamate Receptor: Homer, Arrestin, and Beyond.

    abstract::When activated, metabotropic glutamate receptors (mGlus) exert long-lasting changes within the glutamatergic synapses. One mechanism is a tonic effect of downstream signal transduction pathways via sustained activation of mGlu itself. Like many other G protein-coupled receptors (GPCRs), mGlu can exist in a constitutiv...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5125624

    authors: Chung G,Kim SJ

    更新日期:2017-01-01 00:00:00

  • Transcranial Direct Current Stimulation (tDCS) in Unilateral Cerebral Palsy: A Pilot Study of Motor Effect.

    abstract::Transcranial Direct Current Stimulation (tDCS) is an emerging tool to improve upper limb motor functions after stroke acquired in adulthood; however, there is a paucity of reports on its efficacy for upper limb motor rehabilitation in congenital or early-acquired stroke. In this pilot study we have explored, for the f...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2019/2184398

    authors: Inguaggiato E,Bolognini N,Fiori S,Cioni G

    更新日期:2019-01-15 00:00:00

  • Quantification of Upper Limb Motor Recovery and EEG Power Changes after Robot-Assisted Bilateral Arm Training in Chronic Stroke Patients: A Prospective Pilot Study.

    abstract:Background:Bilateral arm training (BAT) has shown promise in expediting progress toward upper limb recovery in chronic stroke patients, but its neural correlates are poorly understood. Objective:To evaluate changes in upper limb function and EEG power after a robot-assisted BAT in chronic stroke patients. Methods:In ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/8105480

    authors: Gandolfi M,Formaggio E,Geroin C,Storti SF,Boscolo Galazzo I,Bortolami M,Saltuari L,Picelli A,Waldner A,Manganotti P,Smania N

    更新日期:2018-03-26 00:00:00

  • Spinal cord lesion: effects of and perspectives for treatment.

    abstract::Following central motor lesions, two forms of adaptation can be observed which lead to improved mobility: (1) the development of spastic muscle tone, and (2) the activation of spinal locomotor centers induced by specific treadmill training. Tension development during spastic gait is different from that during normal g...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2001.83

    authors: Dietz V

    更新日期:2001-01-01 00:00:00

  • High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population.

    abstract::To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/5625768

    authors: Wang H,Bing D,Li J,Xie L,Xiong F,Lan L,Wang D,Guan J,Wang Q

    更新日期:2020-07-01 00:00:00

  • Different Brain Connectivity between Responders and Nonresponders to Dual-Mode Noninvasive Brain Stimulation over Bilateral Primary Motor Cortices in Stroke Patients.

    abstract::Noninvasive brain stimulation (NBS), such as repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS), has been used in stroke patients with motor impairment. NBS can help recovery from brain damage by modulating cortical excitability. However, the efficacy of NBS varies am...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/3826495

    authors: Lee J,Lee A,Kim H,Shin M,Yun SM,Jung Y,Chang WH,Kim YH

    更新日期:2019-04-07 00:00:00

  • New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity.

    abstract::Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/4605971

    authors: Huang YJ,Lane HY,Lin CH

    更新日期:2017-01-01 00:00:00

  • Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores.

    abstract:Background:One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in resting-state functional MRI have been investigated to a limited extent. Fluctuations...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/2357107

    authors: Goodin P,Lamp G,Vidyasagar R,Connelly A,Rose S,Campbell BCV,Tse T,Ma H,Howells D,Hankey GJ,Davis S,Donnan G,Carey LM

    更新日期:2019-07-28 00:00:00

  • Genesis and Maintenance of Attentional Biases: The Role of the Locus Coeruleus-Noradrenaline System.

    abstract::Emotionally arousing events are typically better remembered than mundane ones, in part because emotionally relevant aspects of our environment are prioritized in attention. Such biased attentional tuning is itself the result of associative processes through which we learn affective and motivational relevance of cues. ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/6817349

    authors: Ehlers MR,Todd RM

    更新日期:2017-01-01 00:00:00

  • Topological Properties of Large-Scale Cortical Networks Based on Multiple Morphological Features in Amnestic Mild Cognitive Impairment.

    abstract::Previous studies have demonstrated that amnestic mild cognitive impairment (aMCI) has disrupted properties of large-scale cortical networks based on cortical thickness and gray matter volume. However, it is largely unknown whether the topological properties of cortical networks based on geometric measures (i.e., sulca...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/3462309

    authors: Li Q,Li X,Wang X,Li Y,Li K,Yu Y,Yin C,Li S,Han Y

    更新日期:2016-01-01 00:00:00

  • Radix Scutellariae Ameliorates Stress-Induced Depressive-Like Behaviors via Protecting Neurons through the TGFβ3-Smad2/3-Nedd9 Signaling Pathway.

    abstract::Chronic stress can impair hippocampal neurogenesis, increase neuronal apoptosis, and cause depressive-like behaviors. Our previous studies found that Radix Scutellariae (RS) can rescue the stress-induced neuronal injury, but the mechanism is not clear. Here, we continued to investigate the underlying antidepressant me...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8886715

    authors: Zhao F,Zhang C,Xiao D,Zhang W,Zhou L,Gu S,Qu R

    更新日期:2020-11-13 00:00:00

  • Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice.

    abstract::Neurogenesis in the hippocampus is influenced by several factors including external stimuli. In addition to their involvement in learning and memory processes, newborn neurons of the dentate gyrus (DG) buffer against the effects of stress. Although the response of these cells to environmental stimuli has been shown, t...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/4960869

    authors: Ramírez-Rodríguez GB,Ocaña-Fernández MDÁ,Ortiz-López L

    更新日期:2018-05-22 00:00:00

  • Brain plasticity and disease: a matter of inhibition.

    abstract::One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during develo...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2011/286073

    authors: Baroncelli L,Braschi C,Spolidoro M,Begenisic T,Maffei L,Sale A

    更新日期:2011-01-01 00:00:00