Abstract:
:We have previously reported the crossed-withdrawal reflex in which the rats with nerve injury developed behavioral pain responses of the injured paw to stimuli applied to the contralateral uninjured paw. This reflex indicates that contralateral plastic changes may occur in the spinal cord after unilateral nerve injury. The present study was performed to elucidate the mechanisms and morphological correlates underlying the crossed-withdrawal reflex by using quantitative (14)C-2-deoxyglucose (2-DG) autoradiography which can examine metabolic activities and spatial patterns simultaneously. Under pentobarbital anesthesia, rats were subjected to unilateral nerve injury. Mechanical allodynia was tested for two weeks after nerve injury. After nerve injury, neuropathic pain behaviors developed progressively. The crossed-withdrawal reflex was observed at two weeks postoperatively. Contralateral enhancement of 2-DG uptake in the ventral horn of the spinal cord to electrical stimulation of the uninjured paw was observed. These results suggest that the facilitation of information processing from the uninjured side to the injured side may contribute to the crossed-withdrawal reflex by plastic changes in the spinal cord of nerve-injured rats.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Won R,Lee BHdoi
10.1155/2015/438319subject
Has Abstractpub_date
2015-01-01 00:00:00pages
438319eissn
2090-5904issn
1687-5443journal_volume
2015pub_type
杂志文章abstract::Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons. It has also been shown to acutely induce epileptic seizure behavior in freely moving rats. However, whether CTZ indu...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/310146
更新日期:2014-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
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journal_title:Neural plasticity
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journal_title:Neural plasticity
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pub_type: 杂志文章,评审
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Neural plasticity
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2012/378307
更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-01-15 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/1682972
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/108969
更新日期:2008-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/7219461
更新日期:2017-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/8105480
更新日期:2018-03-26 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2015/521398
更新日期:2015-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2020/8858415
更新日期:2020-08-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/6790743
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2011/649325
更新日期:2011-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2010/894374
更新日期:2010-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2000.9
更新日期:2000-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/1478684
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/172192
更新日期:2015-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/9460364
更新日期:2020-09-22 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/3026749
更新日期:2017-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8764238
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/6208414
更新日期:2019-08-28 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/9364091
更新日期:2016-01-01 00:00:00