Contralateral Metabolic Activation Related to Plastic Changes in the Spinal Cord after Peripheral Nerve Injury in Rats.

Abstract:

:We have previously reported the crossed-withdrawal reflex in which the rats with nerve injury developed behavioral pain responses of the injured paw to stimuli applied to the contralateral uninjured paw. This reflex indicates that contralateral plastic changes may occur in the spinal cord after unilateral nerve injury. The present study was performed to elucidate the mechanisms and morphological correlates underlying the crossed-withdrawal reflex by using quantitative (14)C-2-deoxyglucose (2-DG) autoradiography which can examine metabolic activities and spatial patterns simultaneously. Under pentobarbital anesthesia, rats were subjected to unilateral nerve injury. Mechanical allodynia was tested for two weeks after nerve injury. After nerve injury, neuropathic pain behaviors developed progressively. The crossed-withdrawal reflex was observed at two weeks postoperatively. Contralateral enhancement of 2-DG uptake in the ventral horn of the spinal cord to electrical stimulation of the uninjured paw was observed. These results suggest that the facilitation of information processing from the uninjured side to the injured side may contribute to the crossed-withdrawal reflex by plastic changes in the spinal cord of nerve-injured rats.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Won R,Lee BH

doi

10.1155/2015/438319

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

438319

eissn

2090-5904

issn

1687-5443

journal_volume

2015

pub_type

杂志文章
  • Evolution of Apparent Diffusion Coefficient and Fractional Anisotropy in the Cerebrum of Asphyxiated Newborns Treated with Hypothermia over the First Month of Life.

    abstract::The objective of this study was to assess the evolution of diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI) over the first month of life in asphyxiated newborns treated with hypothermia and to compare it with that of healthy newborns. Asphyxiated newborns treated with hypothermia were enrolled prosp...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/653727

    authors: Kwan S,Boudes E,Benseler A,Gilbert G,Saint-Martin C,Shevell M,Wintermark P

    更新日期:2015-01-01 00:00:00

  • Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats.

    abstract::Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of axons projecting in...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/9828725

    authors: Hodgetts SI,Yoon JH,Fogliani A,Akinpelu EA,Baron-Heeris D,Houwers IGJ,Wheeler LPG,Majda BT,Santhakumar S,Lovett SJ,Duce E,Pollett MA,Wiseman TM,Fehily B,Harvey AR

    更新日期:2018-08-06 00:00:00

  • Altered Brain Activity and Functional Connectivity in Unilateral Sudden Sensorineural Hearing Loss.

    abstract:Background:Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. Th...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/9460364

    authors: Chen J,Hu B,Qin P,Gao W,Liu C,Zi D,Ding X,Yu Y,Cui G,Lu L

    更新日期:2020-09-22 00:00:00

  • Methods to Compare Predicted and Observed Phosphene Experience in tACS Subjects.

    abstract:Background:Phosphene generation is an objective physical measure of potential transcranial alternating current stimulation (tACS) biological side effects. Interpretations from phosphene analysis can serve as a first step in understanding underlying mechanisms of tACS in healthy human subjects and assist validation of c...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/8525706

    authors: Indahlastari A,Kasinadhuni AK,Saar C,Castellano K,Mousa B,Chauhan M,Mareci TH,Sadleir RJ

    更新日期:2018-12-06 00:00:00

  • Neural Plastic Effects of Cognitive Training on Aging Brain.

    abstract::Increasing research has evidenced that our brain retains a capacity to change in response to experience until late adulthood. This implies that cognitive training can possibly ameliorate age-associated cognitive decline by inducing training-specific neural plastic changes at both neural and behavioral levels. This lon...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/535618

    authors: Leung NT,Tam HM,Chu LW,Kwok TC,Chan F,Lam LC,Woo J,Lee TM

    更新日期:2015-01-01 00:00:00

  • Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking.

    abstract::Evidence from neuropathological, genetic, animal model, and biochemical studies has indicated that the accumulation of amyloid-beta (Aβ) is associated with, and probably induces, profound neuronal changes in brain regions critical for memory and cognition in the development of Alzheimer's disease (AD). There is consid...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/3204519

    authors: Guntupalli S,Widagdo J,Anggono V

    更新日期:2016-01-01 00:00:00

  • The role of NMDA receptor subtypes in short-term plasticity in the rat entorhinal cortex.

    abstract::We have previously shown that spontaneous release of glutamate in the entorhinal cortex (EC) is tonically facilitated via activation of presynaptic NMDA receptors (NMDAr) containing the NR2B subunit. Here we show that the same receptors mediate short-term plasticity manifested by frequency-dependent facilitation of ev...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2008/872456

    authors: Chamberlain SE,Yang J,Jones RS

    更新日期:2008-01-01 00:00:00

  • Correlation of clinical neuromusculoskeletal and central somatosensory performance: variability in controls and patients with severe and mild focal hand dystonia.

    abstract::Focal hand dystonia (FHd) is a recalcitrant, disabling movement disorder, characterized by involuntary co-contractions of agonists and antagonists, that can develop in patients who overuse or misuse their hands. The aim of this study was to document clinical neuromusculoskeletal performance and somatosensory responses...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/NP.2002.177

    authors: Byl NN,Nagarajan SS,Merzenich MM,Roberts T,McKenzie A

    更新日期:2002-01-01 00:00:00

  • Long-Term Impairment of Sound Processing in the Auditory Midbrain by Daily Short-Term Exposure to Moderate Noise.

    abstract::Most citizen people are exposed daily to environmental noise at moderate levels with a short duration. The aim of the present study was to determine the effects of daily short-term exposure to moderate noise on sound level processing in the auditory midbrain. Sound processing properties of auditory midbrain neurons we...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/3026749

    authors: Cheng L,Wang SH,Peng K,Liao XM

    更新日期:2017-01-01 00:00:00

  • Translational approach to behavioral learning: lessons from cerebellar plasticity.

    abstract::The role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learning capacity of the...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2013/853654

    authors: Cheron G,Dan B,Márquez-Ruiz J

    更新日期:2013-01-01 00:00:00

  • Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain.

    abstract::Magnetic resonance imaging (MRI) of the human brain has provided converging evidence that visual deprivation induces regional changes in white matter (WM) microstructure. It remains unclear how these changes modify network connections between brain regions. Here we used diffusion-weighted MRI to relate differences in ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/6029241

    authors: Reislev NL,Dyrby TB,Siebner HR,Kupers R,Ptito M

    更新日期:2016-01-01 00:00:00

  • AMPA receptor trafficking in homeostatic synaptic plasticity: functional molecules and signaling cascades.

    abstract::Homeostatic synaptic plasticity is a negative-feedback response employed to compensate for functional disturbances in the nervous system. Typically, synaptic activity is strengthened when neuronal firing is chronically suppressed or weakened when neuronal activity is chronically elevated. At both the whole cell and en...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2012/825364

    authors: Wang G,Gilbert J,Man HY

    更新日期:2012-01-01 00:00:00

  • The Cross-Modal Effects of Sensory Deprivation on Spatial and Temporal Processes in Vision and Audition: A Systematic Review on Behavioral and Neuroimaging Research since 2000.

    abstract::One of the most significant effects of neural plasticity manifests in the case of sensory deprivation when cortical areas that were originally specialized for the functions of the deprived sense take over the processing of another modality. Vision and audition represent two important senses needed to navigate through ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/9603469

    authors: Bell L,Wagels L,Neuschaefer-Rube C,Fels J,Gur RE,Konrad K

    更新日期:2019-12-02 00:00:00

  • Differential induction of long-term potentiation in the horizontal versus columnar superficial connections to layer II cells of the entorhinal cortex.

    abstract::The entorhinal cortex (EC) is a nodal and independent mnemonic element of the medial temporal lobe memory circuit as it forms a bidirectional interface between the neocortex and hippocampus. Within the EC, intra- and inter-lamellar associational connections occur via horizontal and columnar projections, respectively. ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2008/814815

    authors: Ma L,Alonso A,Dickson CT

    更新日期:2008-01-01 00:00:00

  • An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice.

    abstract::Inbred mouse models are widely used to study age-related hearing loss (AHL). Many genes associated with AHL have been mapped in a variety of strains. However, little is known about gene variants that have the converse function-protective genes that confer strong resistance to hearing loss. Previously, we reported that...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8889264

    authors: Zheng QY,Kui L,Xu F,Zheng T,Li B,McCarty M,Sun Z,Zhang A,Liu L,Starlard-Davenport A,Stepanyan R,Hu BH,Lu L

    更新日期:2020-06-08 00:00:00

  • Increased signal complexity improves the breadth of generalization in auditory perceptual learning.

    abstract::Perceptual learning can be specific to a trained stimulus or optimally generalized to novel stimuli with the breadth of generalization being imperative for how we structure perceptual training programs. Adapting an established auditory interval discrimination paradigm to utilise complex signals, we trained human adult...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2013/879047

    authors: Brown DJ,Proulx MJ

    更新日期:2013-01-01 00:00:00

  • Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus.

    abstract::Accumulating evidence implicates a role for brain structures outside the ascending auditory pathway in tinnitus, the phantom perception of sound. In addition to other factors such as age-dependent hearing loss, high-level sound exposure is a prominent cause of tinnitus. Here, we examined how noise exposure altered the...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2021/8833087

    authors: Zhang L,Wu C,Martel DT,West M,Sutton MA,Shore SE

    更新日期:2021-01-14 00:00:00

  • α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity.

    abstract::Neuropathies are characterized by a complex response of the central nervous system to injuries. Glial cells are recruited to maintain neuronal homeostasis but dysregulated activation leads to pain signaling amplification and reduces the glial neuroprotective power. Recently, we highlighted the property of α7 nicotinic...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/396908

    authors: Di Cesare Mannelli L,Tenci B,Zanardelli M,Failli P,Ghelardini C

    更新日期:2015-01-01 00:00:00

  • Involvement of norepinephrine in the control of activity and attentive processes in animal models of attention deficit hyperactivity disorder.

    abstract::Functional and morphological studies in children affected by Attention Deficit Hyperactivity Disorder (ADHD) suggest a prefrontal cortex (PFc) dysfunction. This cortical region is regulated by subcortical systems including noradrenergic (NEergic), dopaminergic (DAergic), cholinergic, serotonergic, and histaminergic pa...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2004.133

    authors: Viggiano D,Ruocco LA,Arcieri S,Sadile AG

    更新日期:2004-01-01 00:00:00

  • Cortical Reorganization in Patients Recovered from Bell's Palsy: An Orofacial and Finger Movements Task-State fMRI Study.

    abstract::Objective. To explore cortical reorganization of patients recovered from Bell's palsy (BP) by task-state functional magnetic resonance imaging (fMRI) during finger and orofacial movements and provide more evidence for acupuncture clinical treatment of BP. Methods. We collected 17 BP patients with complete clinical rec...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/8231726

    authors: Lee J,Yang J,Li C,Yuan A,Wu H,Wang A,Xue Q,Wang T,Wang L,Gao T

    更新日期:2016-01-01 00:00:00

  • GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway.

    abstract::Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures. GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system. Accumulating evidence de...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/8858415

    authors: Hou X,Rong C,Wang F,Liu X,Sun Y,Zhang HT

    更新日期:2020-08-01 00:00:00

  • Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson's Disease Animal Models from a Molecular Signaling Perspective.

    abstract::Despite the fact that astrocytes are the most abundant glial cells, critical for brain function, few studies have dealt with their possible role in neurodegenerative diseases like Parkinson's disease (PD). This article explores relevant evidence on the involvement of astrocytes in experimental PD neurodegeneration fro...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/1859431

    authors: Udovin L,Quarracino C,Herrera MI,Capani F,Otero-Losada M,Perez-Lloret S

    更新日期:2020-02-07 00:00:00

  • Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism.

    abstract::The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plastici...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/6595740

    authors: Hoxha E,Lippiello P,Scelfo B,Tempia F,Ghirardi M,Miniaci MC

    更新日期:2017-01-01 00:00:00

  • Neurosteroids Involvement in the Epigenetic Control of Memory Formation and Storage.

    abstract::Memory is our ability to store and remember past experiences; it is the result of changes in neuronal circuits of specific brain areas as the hippocampus. During memory formation, neurons integrate their functions and increase the strength of their connections, so that synaptic plasticity is improved and consolidated....

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5985021

    authors: Colciago A,Magnaghi V

    更新日期:2016-01-01 00:00:00

  • Three MYO15A Mutations Identified in One Chinese Family with Autosomal Recessive Nonsyndromic Hearing Loss.

    abstract::Hearing impairment is one of the most common sensory disease, of which more than 50% is attributed to a genetic etiology. The goal of this research is to explore the genetic cause of a Chinese deafness pedigree who was excluded of GJB2, SLC26A4, or MtDNA12SrRNA variants. Three variants, c.3971C>A (p.A1324D), c.4011ins...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/5898025

    authors: Zhang F,Xu L,Xiao Y,Li J,Bai X,Wang H

    更新日期:2018-04-05 00:00:00

  • Spatial Integration of Somatosensory Inputs during Sensory-Motor Plasticity Phenomena Is Normal in Focal Hand Dystonia.

    abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/4135708

    authors: Terranova C,Rizzo V,Morgante F,Maggio R,Calamuneri A,Chillemi G,Girlanda P,Quartarone A

    更新日期:2018-10-10 00:00:00

  • Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks.

    abstract::Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscill...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/1478684

    authors: Vanvinckenroye A,Vandewalle G,Phillips C,Chellappa SL

    更新日期:2016-01-01 00:00:00

  • Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer's Disease Animal Model.

    abstract::Alzheimer's disease (AD) is one of the most serious public health concerns facing the world. Its characteristic feature is neuroinflammation due to microglial activation. Electroacupuncture is one of the therapies employed to improve the condition of patients with AD, although its mechanism of action is still to be de...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8867547

    authors: Li Y,Jiang J,Tang Q,Tian H,Wang S,Wang Z,Liu H,Yang J,Ren J

    更新日期:2020-09-04 00:00:00

  • Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure.

    abstract::Neuropathic pain increases the risk of cardiovascular diseases including hypertension with the characteristic of sympathetic overactivity. The enhanced tonically active glutamatergic input to the rostral ventrolateral medulla (RVLM) contributes to sympathetic overactivity and blood pressure (BP) in cardiovascular dise...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/4174010

    authors: Wang W,Zou Z,Tan X,Zhang RW,Ren CZ,Yao XY,Li CB,Wang WZ,Shi XY

    更新日期:2017-01-01 00:00:00

  • Stimulus- and Neural-Referred Visual Receptive Field Properties following Hemispherectomy: A Case Study Revisited.

    abstract::Damage to the visual system can result in (a partial) loss of vision, in response to which the visual system may functionally reorganize. Yet the timing, extent, and conditions under which this occurs are not well understood. Hence, studies in individuals with diverse congenital and acquired conditions and using vario...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/6067871

    authors: Halbertsma HN,Haak KV,Cornelissen FW

    更新日期:2019-09-03 00:00:00