Right Hemisphere Grey Matter Volume and Language Functions in Stroke Aphasia.

Abstract:

:The role of the right hemisphere (RH) in recovery from aphasia is incompletely understood. The present study quantified RH grey matter (GM) volume in individuals with chronic stroke-induced aphasia and cognitively healthy people using voxel-based morphometry. We compared group differences in GM volume in the entire RH and in RH regions-of-interest. Given that lesion site is a critical source of heterogeneity associated with poststroke language ability, we used voxel-based lesion symptom mapping (VLSM) to examine the relation between lesion site and language performance in the aphasic participants. Finally, using results derived from the VLSM as a covariate, we evaluated the relation between GM volume in the RH and language ability across domains, including comprehension and production processes both at the word and sentence levels and across spoken and written modalities. Between-subject comparisons showed that GM volume in the RH SMA was reduced in the aphasic group compared to the healthy controls. We also found that, for the aphasic group, increased RH volume in the MTG and the SMA was associated with better language comprehension and production scores, respectively. These data suggest that the RH may support functions previously performed by LH regions and have important implications for understanding poststroke reorganization.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Lukic S,Barbieri E,Wang X,Caplan D,Kiran S,Rapp B,Parrish TB,Thompson CK

doi

10.1155/2017/5601509

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

5601509

eissn

2090-5904

issn

1687-5443

journal_volume

2017

pub_type

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