Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APP/PS1 Mice.

Abstract:

:Elevated brain activation, or hyperexcitability, induces cognitive impairment and confers an increased risk of Alzheimer's disease (AD). Blocking the overexcitation of the neural network may be a promising new strategy to prevent, halt, and even reverse this condition. Physical exercise has been shown to be an effective cognitive enhancer that reduces the risk of AD in elderly individuals, but the underlying mechanisms are far from being fully understood. We explored whether long-term treadmill exercise attenuates amyloid precursor protein (APP)/presenilin-1 (PS1) mutation-induced aberrant network activity and thus improves cognition by altering the numbers and/or distribution of voltage-gated sodium channels (Nav) in transgenic mice. APP/PS1 mice aged 2, 3.5, 5, 6.5, 8, and 9 months underwent treadmill exercise with different durations or at different stages of AD. The alterations in memory, electroencephalogram (EEG) recordings, and expression levels and distributions of Nav functional members (Nav1.1α, Nav1.2, Nav1.6, and Navβ2) were evaluated. The results revealed that treadmill exercise with 12- and 24-week durations 1) induced significant improvement in novel object recognition (NOR) memory and Morris water maze (MWM) spatial memory; 2) partially reduced abnormal spike activity; and 3) redressed the disturbed cellular distribution of Nav1.1α, aberrant Navβ2 cleavage augmentation, and Nav1.6 upregulation. Additionally, APP/PS1 mice in the 24-week exercise group showed better performance in the NOR task and a large decrease in Nav1.6 expression, which was close to the wild-type level. This study suggests that exercise improves cognition and neural activity by altering the numbers and distribution of hippocampal Nav in APP/PS1 mice. Long-term treadmill exercise, for about 24 weeks, starting in the preclinical stage, is a promising therapeutic strategy for preventing AD and halting its progress.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Tan YX,Liu GC,Chen HL,Lu MN,Chen B,Hu T,Zhang L,Mao R,Li S,Mei R,Wang XY,Xiyang YB

doi

10.1155/2020/9132720

subject

Has Abstract

pub_date

2020-03-18 00:00:00

pages

9132720

eissn

2090-5904

issn

1687-5443

journal_volume

2020

pub_type

杂志文章
  • The GABA-withdrawal syndrome: a model of local status epilepticus.

    abstract::The GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex. GWS is characterized by focal epileptic electroencephalographic discharges and associated contralateral myoclonus. In neocortical slices obtained from GWS rat...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2000.9

    authors: Silva-Barrat C,Champagnat J,Menini C

    更新日期:2000-01-01 00:00:00

  • Magnetic Seizure Therapy for Unipolar and Bipolar Depression: A Systematic Review.

    abstract:UNLABELLED:Objective. Magnetic seizure therapy (MST) is a novel, experimental therapeutic intervention, which combines therapeutic aspects of electroconvulsive therapy (ECT) and transcranial magnetic stimulation, in order to achieve the efficacy of the former with the safety of the latter. MST might prove to be a valua...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2015/521398

    authors: Cretaz E,Brunoni AR,Lafer B

    更新日期:2015-01-01 00:00:00

  • Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus.

    abstract::Accumulating evidence implicates a role for brain structures outside the ascending auditory pathway in tinnitus, the phantom perception of sound. In addition to other factors such as age-dependent hearing loss, high-level sound exposure is a prominent cause of tinnitus. Here, we examined how noise exposure altered the...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2021/8833087

    authors: Zhang L,Wu C,Martel DT,West M,Sutton MA,Shore SE

    更新日期:2021-01-14 00:00:00

  • Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex.

    abstract::Associative fear learning, in which stimulation of whiskers is paired with mild electric shock to the tail, modifies the barrel cortex, the functional representation of sensory receptors involved in the conditioning, by inducing formation of new inhibitory synapses on single-synapse spines of the cognate barrel hollow...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/9828517

    authors: Jasinska M,Siucinska E,Jasek E,Litwin JA,Pyza E,Kossut M

    更新日期:2016-01-01 00:00:00

  • Neurosteroids Involvement in the Epigenetic Control of Memory Formation and Storage.

    abstract::Memory is our ability to store and remember past experiences; it is the result of changes in neuronal circuits of specific brain areas as the hippocampus. During memory formation, neurons integrate their functions and increase the strength of their connections, so that synaptic plasticity is improved and consolidated....

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5985021

    authors: Colciago A,Magnaghi V

    更新日期:2016-01-01 00:00:00

  • Memory effects of benzodiazepines: memory stages and types versus binding-site subtypes.

    abstract::Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent gen...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2005.289

    authors: Savić MM,Obradović DI,Ugresić ND,Bokonjić DR

    更新日期:2005-01-01 00:00:00

  • Carbachol-Induced Reduction in the Activity of Adult Male Zebra Finch RA Projection Neurons.

    abstract::Cholinergic mechanism is involved in motor behavior. In songbirds, the robust nucleus of the arcopallium (RA) is a song premotor nucleus in the pallium and receives cholinergic inputs from the basal forebrain. The activity of projection neurons in RA determines song motor behavior. Although many evidences suggest that...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/7246827

    authors: Meng W,Wang SH,Li DF

    更新日期:2016-01-01 00:00:00

  • GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway.

    abstract::Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures. GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system. Accumulating evidence de...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/8858415

    authors: Hou X,Rong C,Wang F,Liu X,Sun Y,Zhang HT

    更新日期:2020-08-01 00:00:00

  • Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain.

    abstract::Magnetic resonance imaging (MRI) of the human brain has provided converging evidence that visual deprivation induces regional changes in white matter (WM) microstructure. It remains unclear how these changes modify network connections between brain regions. Here we used diffusion-weighted MRI to relate differences in ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/6029241

    authors: Reislev NL,Dyrby TB,Siebner HR,Kupers R,Ptito M

    更新日期:2016-01-01 00:00:00

  • Neuroplastic effects of combined computerized physical and cognitive training in elderly individuals at risk for dementia: an eLORETA controlled study on resting states.

    abstract::The present study investigates whether a combined cognitive and physical training may induce changes in the cortical activity as measured via electroencephalogram (EEG) and whether this change may index a deceleration of pathological processes of brain aging. Seventy seniors meeting the clinical criteria of mild cogni...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/172192

    authors: Styliadis C,Kartsidis P,Paraskevopoulos E,Ioannides AA,Bamidis PD

    更新日期:2015-01-01 00:00:00

  • The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy.

    abstract::Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurodegenerative disorders such as Parkinson's disease (PD). In sporadic PD, the most common age-related neurodegenerative movement disorder, nigrostriatal dopaminergic deficits are responsible for the onset of motor symptoms...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5012129

    authors: Longhena F,Faustini G,Missale C,Pizzi M,Spano P,Bellucci A

    更新日期:2017-01-01 00:00:00

  • Spatial Integration of Somatosensory Inputs during Sensory-Motor Plasticity Phenomena Is Normal in Focal Hand Dystonia.

    abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/4135708

    authors: Terranova C,Rizzo V,Morgante F,Maggio R,Calamuneri A,Chillemi G,Girlanda P,Quartarone A

    更新日期:2018-10-10 00:00:00

  • Boosting the Motor Outcome of the Untrained Hand by Action Observation: Mirror Visual Feedback, Video Therapy, or Both Combined-What Is More Effective?

    abstract::Action observation (AO) allows access to a network that processes visuomotor and sensorimotor inputs and is believed to be involved in observational learning of motor skills. We conducted three consecutive experiments to examine the boosting effect of AO on the motor outcome of the untrained hand by either mirror visu...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/8369262

    authors: Bähr F,Ritter A,Seidel G,Puta C,Gabriel HHW,Hamzei F

    更新日期:2018-04-10 00:00:00

  • Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke.

    abstract::Perinatal stroke is a leading cause of congenital hemiparesis and neurocognitive deficits in children. Dysfunctions in the large-scale resting-state functional networks may underlie cognitive and behavioral disability in these children. We studied resting-state functional connectivity in patients with perinatal stroke...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/2306406

    authors: Ilves N,Ilves P,Laugesaar R,Juurmaa J,Männamaa M,Lõo S,Loorits D,Tomberg T,Kolk A,Talvik I,Talvik T

    更新日期:2016-01-01 00:00:00

  • Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice.

    abstract::Adverse early life experiences can negatively affect behaviors later in life. Maternal separation (MS) has been extensively investigated in animal models in the adult phase of MS. The study aimed to explore the mechanism by which MS negatively affects C57BL/6N mice, especially the effects caused by MS in the early pha...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/627837

    authors: Bian Y,Yang L,Wang Z,Wang Q,Zeng L,Xu G

    更新日期:2015-01-01 00:00:00

  • The Habituation/Cross-Habituation Test Revisited: Guidance from Sniffing and Video Tracking.

    abstract::The habituation/cross-habituation test (HaXha) is a spontaneous odor discrimination task that has been used for many decades to evaluate olfactory function in animals. Animals are presented repeatedly with the same odorant after which a new odorant is introduced. The time the animal explores the odor object is measure...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/9131284

    authors: Coronas-Samano G,Ivanova AV,Verhagen JV

    更新日期:2016-01-01 00:00:00

  • Different Degree Centrality Changes in the Brain after Acupuncture on Contralateral or Ipsilateral Acupoint in Patients with Chronic Shoulder Pain: A Resting-State fMRI Study.

    abstract::Chronic shoulder pain (CSP) is the third most common musculoskeletal problem. For maximum treatment effectiveness, most acupuncturists usually choose acupoint in the nonpainful side, to alleviate pain or improve shoulder function. This method is named opposite needling, which means acupuncture points on the right side...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/5701042

    authors: Yan CQ,Huo JW,Wang X,Zhou P,Zhang YN,Li JL,Kim M,Shao JK,Hu SQ,Wang LQ,Liu CZ

    更新日期:2020-04-25 00:00:00

  • The Endocannabinoid System as a Therapeutic Target in Glaucoma.

    abstract::Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable att...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9364091

    authors: Cairns EA,Baldridge WH,Kelly ME

    更新日期:2016-01-01 00:00:00

  • Spindle Oscillations in Sleep Disorders: A Systematic Review.

    abstract::Measurement of sleep microarchitecture and neural oscillations is an increasingly popular technique for quantifying EEG sleep activity. Many studies have examined sleep spindle oscillations in sleep-disordered adults; however reviews of this literature are scarce. As such, our overarching aim was to critically review ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/7328725

    authors: Weiner OM,Dang-Vu TT

    更新日期:2016-01-01 00:00:00

  • Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions.

    abstract::The formation of fear memories is a powerful and highly evolutionary conserved mechanism that serves the behavioral adaptation to environmental threats. Accordingly, classical fear conditioning paradigms have been employed to investigate fundamental molecular processes of memory formation. Evidence suggests that a cir...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/3750307

    authors: Albrecht A,Stork O

    更新日期:2017-01-01 00:00:00

  • Nestin reporter transgene labels multiple central nervous system precursor cells.

    abstract::Embryonic neuroepithelia and adult subventricular zone (SVZ) stem and progenitor cells express nestin. We characterized a transgenic line that expresses enhanced green fluorescent protein (eGFP) specified to neural tissue by the second intronic enhancer of the nestin promoter that had several novel features. During em...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2010/894374

    authors: Walker AS,Goings GE,Kim Y,Miller RJ,Chenn A,Szele FG

    更新日期:2010-01-01 00:00:00

  • From spinal central pattern generators to cortical network: integrated BCI for walking rehabilitation.

    abstract::Success in locomotor rehabilitation programs can be improved with the use of brain-computer interfaces (BCIs). Although a wealth of research has demonstrated that locomotion is largely controlled by spinal mechanisms, the brain is of utmost importance in monitoring locomotor patterns and therefore contains information...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2012/375148

    authors: Cheron G,Duvinage M,De Saedeleer C,Castermans T,Bengoetxea A,Petieau M,Seetharaman K,Hoellinger T,Dan B,Dutoit T,Sylos Labini F,Lacquaniti F,Ivanenko Y

    更新日期:2012-01-01 00:00:00

  • Mutation in the Hair Cell Specific Gene POU4F3 Is a Common Cause for Autosomal Dominant Nonsyndromic Hearing Loss in Chinese Hans.

    abstract::Autosomal dominant nonsyndromic hearing loss (ADNSHL) is extremely heterogeneous. So far the genetic etiological contribution of the gene POU4F3 associated with ADNSHL has been rarely reported. In our previous study, a c.603_604delGG mutation in the hair cell specific gene POU4F3 has been identified as the pathogenic ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/9890827

    authors: He L,Pang X,Chen P,Wu H,Yang T

    更新日期:2016-01-01 00:00:00

  • Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism.

    abstract::The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plastici...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/6595740

    authors: Hoxha E,Lippiello P,Scelfo B,Tempia F,Ghirardi M,Miniaci MC

    更新日期:2017-01-01 00:00:00

  • AMPA receptor trafficking in homeostatic synaptic plasticity: functional molecules and signaling cascades.

    abstract::Homeostatic synaptic plasticity is a negative-feedback response employed to compensate for functional disturbances in the nervous system. Typically, synaptic activity is strengthened when neuronal firing is chronically suppressed or weakened when neuronal activity is chronically elevated. At both the whole cell and en...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2012/825364

    authors: Wang G,Gilbert J,Man HY

    更新日期:2012-01-01 00:00:00

  • Genetics and function of neocortical GABAergic interneurons in neurodevelopmental disorders.

    abstract::A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and exp...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2011/649325

    authors: Rossignol E

    更新日期:2011-01-01 00:00:00

  • Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus.

    abstract::Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate thedevelopment and maintenance of dendritic spines is limited. We recently reported that cyclin-dependent kinase 5 (Cdk5) is required f...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/6790743

    authors: Jin X,Sasamoto K,Nagai J,Yamazaki Y,Saito K,Goshima Y,Inoue T,Ohshima T

    更新日期:2016-01-01 00:00:00

  • Heterogeneous Acupuncture Effects of Taixi (KI3) on Functional Connectivity in Healthy Youth and Elder: A Functional MRI Study Using Regional Homogeneity and Large-Scale Functional Connectivity Analysis.

    abstract::Heterogeneous neurological responses of acupuncture between different groups have been proposed by previous studies but rarely studied. The study described here was designed to explore the divergence of acupuncture at Taixi (KI3) on spontaneous activity of brain regions and functional connectivity (FC) between healthy...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8884318

    authors: He L,Chen G,Zheng R,Hu Y,Chen X,Ruan J

    更新日期:2020-12-08 00:00:00

  • ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses.

    abstract::Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression (LTD) at the medial perforant path-granule cell synapse in early postnat...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2012/237913

    authors: Guli X,Tokay T,Rohde M,Bender RA,Köhling R,Kirschstein T

    更新日期:2012-01-01 00:00:00

  • Contralateral Metabolic Activation Related to Plastic Changes in the Spinal Cord after Peripheral Nerve Injury in Rats.

    abstract::We have previously reported the crossed-withdrawal reflex in which the rats with nerve injury developed behavioral pain responses of the injured paw to stimuli applied to the contralateral uninjured paw. This reflex indicates that contralateral plastic changes may occur in the spinal cord after unilateral nerve injury...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/438319

    authors: Won R,Lee BH

    更新日期:2015-01-01 00:00:00