The Endocannabinoid System as a Therapeutic Target in Glaucoma.

Abstract:

:Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable attention as a potential target for the treatment of glaucoma, largely due to the observed IOP lowering effects seen after administration of exogenous cannabinoids. However, recent evidence has suggested that modulation of the ECS may also be neuroprotective. This paper will review the use of cannabinoids in glaucoma, presenting pertinent information regarding the pathophysiology of glaucoma and how alterations in cannabinoid signalling may contribute to glaucoma pathology. Additionally, the mechanisms and potential for the use of cannabinoids and other novel agents that target the endocannabinoid system in the treatment of glaucoma will be discussed.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Cairns EA,Baldridge WH,Kelly ME

doi

10.1155/2016/9364091

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

9364091

eissn

2090-5904

issn

1687-5443

journal_volume

2016

pub_type

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