Alzheimer's Disease as a Result of Stimulus Reduction in a GABA-A-Deficient Brain: A Neurocomputational Model.

abstract：:Mastoparan-7 (Mas-7), an analogue of the peptide mastoparan, which is derived from wasp venom, is a direct activator of Pertussis toxin- (PTX-) sensitive G proteins. Mas-7 produces several biological effects in different cell types; however, little is known about how Mas-7 influences mature hippocampal neurons. We exa...

journal_title：Neural plasticity

authors： Ramírez VT,Ramos-Fernández E,Inestrosa NC

更新日期：2016-01-01 00:00:00

abstract：:Emotionally arousing events are typically better remembered than mundane ones, in part because emotionally relevant aspects of our environment are prioritized in attention. Such biased attentional tuning is itself the result of associative processes through which we learn affective and motivational relevance of cues. ...

journal_title：Neural plasticity

authors： Ehlers MR,Todd RM

更新日期：2017-01-01 00:00:00

abstract：:Recently, transcranial alternating current stimulation (tACS) has emerged as a tool to enhance human cognitive processes. Here, we provide a brief summary of the rationale behind tACS-induced effects on task-relevant brain oscillations and associated cognitive functions and review previous studies in young subjects th...

journal_title：Neural plasticity

authors： Antonenko D,Faxel M,Grittner U,Lavidor M,Flöel A

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to investigate the effect of subdiaphragmatic vagotomy on insulin sensitivity, secretion, and degradation in metabolic programmed mice, induced by a low-protein diet early in life, followed by exposure to a high-fat diet in adulthood. Weaned 30-day-old C57Bl/6 mice were submitted to a low-pro...

journal_title：Neural plasticity

authors： Lubaczeuski C,Gonçalves LM,Vettorazzi JF,Kurauti MA,Santos-Silva JC,Bonfleur ML,Boschero AC,Costa-Júnior JM,Carneiro EM

更新日期：2017-01-01 00:00:00

abstract：:Previous studies have demonstrated that amnestic mild cognitive impairment (aMCI) has disrupted properties of large-scale cortical networks based on cortical thickness and gray matter volume. However, it is largely unknown whether the topological properties of cortical networks based on geometric measures (i.e., sulca...

journal_title：Neural plasticity

authors： Li Q,Li X,Wang X,Li Y,Li K,Yu Y,Yin C,Li S,Han Y

更新日期：2016-01-01 00:00:00

abstract：:The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during...

journal_title：Neural plasticity

authors： Couto TA,Xu S,da Silva PA,Wu C,Neergaard K,Wang MY,Zhang J,Xiang Y,Yuan Z

更新日期：2020-10-06 00:00:00

abstract：:Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurodegenerative disorders such as Parkinson's disease (PD). In sporadic PD, the most common age-related neurodegenerative movement disorder, nigrostriatal dopaminergic deficits are responsible for the onset of motor symptoms...

journal_title：Neural plasticity

authors： Longhena F,Faustini G,Missale C,Pizzi M,Spano P,Bellucci A

更新日期：2017-01-01 00:00:00

abstract：:We have previously shown that spontaneous release of glutamate in the entorhinal cortex (EC) is tonically facilitated via activation of presynaptic NMDA receptors (NMDAr) containing the NR2B subunit. Here we show that the same receptors mediate short-term plasticity manifested by frequency-dependent facilitation of ev...

journal_title：Neural plasticity

authors： Chamberlain SE,Yang J,Jones RS

更新日期：2008-01-01 00:00:00

abstract：:The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plastici...

journal_title：Neural plasticity

authors： Hoxha E,Lippiello P,Scelfo B,Tempia F,Ghirardi M,Miniaci MC

更新日期：2017-01-01 00:00:00

abstract：:The plasticity of brain function, especially reorganization after stroke or sensory loss, has been investigated extensively. Based upon its special characteristics, the olfactory system allows the investigation of functional networks in patients with smell loss, as it holds the unique ability to be activated by the se...

journal_title：Neural plasticity

authors： Kollndorfer K,Kowalczyk K,Hoche E,Mueller CA,Pollak M,Trattnig S,Schöpf V

更新日期：2014-01-01 00:00:00

abstract：:Autosomal dominant nonsyndromic hearing loss (ADNSHL) is extremely heterogeneous. So far the genetic etiological contribution of the gene POU4F3 associated with ADNSHL has been rarely reported. In our previous study, a c.603_604delGG mutation in the hair cell specific gene POU4F3 has been identified as the pathogenic ...

journal_title：Neural plasticity

authors： He L,Pang X,Chen P,Wu H,Yang T

更新日期：2016-01-01 00:00:00

abstract：:Measurement of sleep microarchitecture and neural oscillations is an increasingly popular technique for quantifying EEG sleep activity. Many studies have examined sleep spindle oscillations in sleep-disordered adults; however reviews of this literature are scarce. As such, our overarching aim was to critically review ...

journal_title：Neural plasticity

authors： Weiner OM,Dang-Vu TT

更新日期：2016-01-01 00:00:00

abstract：:Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated ...

journal_title：Neural plasticity

authors： Raber J

更新日期：2007-01-01 00:00:00

abstract：:A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and exp...

journal_title：Neural plasticity

authors： Rossignol E

更新日期：2011-01-01 00:00:00

abstract：:Aging is a complex process strongly determined by genetics. Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs). CNVs represent a significant source of genetic variation in the human genome and have been implicated in several diso...

journal_title：Neural plasticity

authors： Villela D,Suemoto CK,Leite R,Pasqualucci CA,Grinberg LT,Pearson P,Rosenberg C

更新日期：2018-06-28 00:00:00

abstract：:Elevated brain activation, or hyperexcitability, induces cognitive impairment and confers an increased risk of Alzheimer's disease (AD). Blocking the overexcitation of the neural network may be a promising new strategy to prevent, halt, and even reverse this condition. Physical exercise has been shown to be an effecti...

journal_title：Neural plasticity

authors： Tan YX,Liu GC,Chen HL,Lu MN,Chen B,Hu T,Zhang L,Mao R,Li S,Mei R,Wang XY,Xiyang YB

更新日期：2020-03-18 00:00:00

abstract：:Increasing research has evidenced that our brain retains a capacity to change in response to experience until late adulthood. This implies that cognitive training can possibly ameliorate age-associated cognitive decline by inducing training-specific neural plastic changes at both neural and behavioral levels. This lon...

journal_title：Neural plasticity

authors： Leung NT,Tam HM,Chu LW,Kwok TC,Chan F,Lam LC,Woo J,Lee TM

更新日期：2015-01-01 00:00:00

abstract：:Chronic stress can impair hippocampal neurogenesis, increase neuronal apoptosis, and cause depressive-like behaviors. Our previous studies found that Radix Scutellariae (RS) can rescue the stress-induced neuronal injury, but the mechanism is not clear. Here, we continued to investigate the underlying antidepressant me...

journal_title：Neural plasticity

authors： Zhao F,Zhang C,Xiao D,Zhang W,Zhou L,Gu S,Qu R

更新日期：2020-11-13 00:00:00

abstract：:Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate thedevelopment and maintenance of dendritic spines is limited. We recently reported that cyclin-dependent kinase 5 (Cdk5) is required f...

journal_title：Neural plasticity

authors： Jin X,Sasamoto K,Nagai J,Yamazaki Y,Saito K,Goshima Y,Inoue T,Ohshima T

更新日期：2016-01-01 00:00:00

abstract：:Ionizing radiation is omnipresent. We are continuously exposed to natural (e.g., radon and cosmic) and man-made radiation sources, including those from industry but especially from the medical sector. The increasing use of medical radiation modalities, in particular those employing low-dose radiation such as CT scans,...

journal_title：Neural plasticity

authors： Verreet T,Verslegers M,Quintens R,Baatout S,Benotmane MA

更新日期：2016-01-01 00:00:00

abstract：:Heterogeneous neurological responses of acupuncture between different groups have been proposed by previous studies but rarely studied. The study described here was designed to explore the divergence of acupuncture at Taixi (KI3) on spontaneous activity of brain regions and functional connectivity (FC) between healthy...

journal_title：Neural plasticity

authors： He L,Chen G,Zheng R,Hu Y,Chen X,Ruan J

更新日期：2020-12-08 00:00:00

abstract：:Adverse early life experiences can negatively affect behaviors later in life. Maternal separation (MS) has been extensively investigated in animal models in the adult phase of MS. The study aimed to explore the mechanism by which MS negatively affects C57BL/6N mice, especially the effects caused by MS in the early pha...

journal_title：Neural plasticity

authors： Bian Y,Yang L,Wang Z,Wang Q,Zeng L,Xu G

更新日期：2015-01-01 00:00:00

abstract：:Dishabituation is a return of a habituated response if context or contingency changes. In the mammalian olfactory system, metabotropic glutamate receptor mediated synaptic depression of cortical afferents underlies short-term habituation to odors. It was hypothesized that a known antagonistic interaction between these...

journal_title：Neural plasticity

authors： Smith JJ,Shionoya K,Sullivan RM,Wilson DA

更新日期：2009-01-01 00:00:00

abstract：:Dichoptic movie viewing has been shown to significantly improve visual acuity in amblyopia in children. Moreover, short-term occlusion of the amblyopic eye can transiently increase its contribution to binocular fusion in adults. In this study, we first asked whether dichoptic movie viewing could improve the visual fun...

journal_title：Neural plasticity

authors： Sauvan L,Stolowy N,Denis D,Matonti F,Chavane F,Hess RF,Reynaud A

更新日期：2019-08-28 00:00:00

abstract：:Damage to the visual system can result in (a partial) loss of vision, in response to which the visual system may functionally reorganize. Yet the timing, extent, and conditions under which this occurs are not well understood. Hence, studies in individuals with diverse congenital and acquired conditions and using vario...

journal_title：Neural plasticity

authors： Halbertsma HN,Haak KV,Cornelissen FW

更新日期：2019-09-03 00:00:00

abstract：:Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer's disease, and epilepsy point to the involve...

journal_title：Neural plasticity

authors： Pantazopoulos H,Berretta S

更新日期：2016-01-01 00:00:00

abstract：:The song of zebra finch is stable in life after it was learned successfully. Vocal plasticity is thought to be a motor exploration that can support continuous learning and optimization of performance. The activity of RA, an important pre-motor nucleus in songbird's brain, influences the song directly. This variability...

journal_title：Neural plasticity

authors： Liao SQ,Hou GQ,Pan X,Liao CS,Li DF

更新日期：2012-01-01 00:00:00

abstract：Background:Parkinson's disease (PD) patients experience cognitive impairment which has been related to reduced quality of life and functional disability. These symptoms usually progress until dementia occurs. Some studies have been published assessing the efficacy of cognitive treatments on improving cognition, functio...

journal_title：Neural plasticity

authors： Díez-Cirarda M,Ibarretxe-Bilbao N,Peña J,Ojeda N

更新日期：2018-05-06 00:00:00

abstract：:Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable att...

journal_title：Neural plasticity

authors： Cairns EA,Baldridge WH,Kelly ME

更新日期：2016-01-01 00:00:00

abstract：:The development of new strategies to renew and repair neuronal networks using neural plasticity induced by stem cell graft could enable new therapies to cure diseases that were considered lethal until now. In adequate microenvironment a neuronal progenitor must receive molecular signal of a specific cellular context t...

journal_title：Neural plasticity

authors： Ramírez-Barrantes R,Cordova C,Poblete H,Muñoz P,Marchant I,Wianny F,Olivero P

更新日期：2016-01-01 00:00:00