Abstract:
:Ionizing radiation is omnipresent. We are continuously exposed to natural (e.g., radon and cosmic) and man-made radiation sources, including those from industry but especially from the medical sector. The increasing use of medical radiation modalities, in particular those employing low-dose radiation such as CT scans, raises concerns regarding the effects of cumulative exposure doses and the inappropriate utilization of these imaging techniques. One of the major goals in the radioprotection field is to better understand the potential health risk posed to the unborn child after radiation exposure to the pregnant mother, of which the first convincing evidence came from epidemiological studies on in utero exposed atomic bomb survivors. In the following years, animal models have proven to be an essential tool to further characterize brain developmental defects and consequent functional deficits. However, the identification of a possible dose threshold is far from complete and a sound link between early defects and persistent anomalies has not yet been established. This review provides an overview of the current knowledge on brain developmental and persistent defects resulting from in utero radiation exposure and addresses the many questions that still remain to be answered.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Verreet T,Verslegers M,Quintens R,Baatout S,Benotmane MAdoi
10.1155/2016/1243527subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1243527eissn
2090-5904issn
1687-5443journal_volume
2016pub_type
杂志文章,评审abstract::Prenatal stress (PS) has long-term sequelae for the morphological and functional status of the central nervous system of the progeny. A PS-induced proinflammatory status of the organism may result in an impairment of both hippocampal synaptic plasticity and hippocampus-dependent memory formation in adults. We addresse...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/3152129
更新日期:2019-01-21 00:00:00
abstract::Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2007/91236
更新日期:2007-01-01 00:00:00
abstract::The song of zebra finch is stable in life after it was learned successfully. Vocal plasticity is thought to be a motor exploration that can support continuous learning and optimization of performance. The activity of RA, an important pre-motor nucleus in songbird's brain, influences the song directly. This variability...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2012/931780
更新日期:2012-01-01 00:00:00
abstract::Several research studies point to the fact that sensory and cognitive reductions like cataracts, deafness, macular degeneration, or even lack of activity after job retirement, precede the onset of Alzheimer's disease. To simulate Alzheimer's disease earlier stages, which manifest in sensory cortices, we used a computa...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8895369
更新日期:2020-10-14 00:00:00
abstract:Objective:To compare the effects of training of jaw and finger movements with and without visual feedback on precision and accuracy. Method:Twenty healthy participants (10 men and 10 women; mean age 24.6 ± 0.8 years) performed two tasks: a jaw open-close movement and a finger lifting task with and without visual feedb...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/9593464
更新日期:2019-11-18 00:00:00
abstract::The most dramatic progress in the restoration of hearing takes place in the first months after cochlear implantation. To map the brain activity underlying this process, we used positron emission tomography at three time points: within 14 days, three months, and six months after switch-on. Fifteen recently implanted ad...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2013/318521
更新日期:2013-01-01 00:00:00
abstract:Background and Purpose:Cancer-related fatigue (CRF) is widely recognized as one of the most common symptoms and side effects of cancer and/or its treatment. However, neuropathological mechanisms contributing to CRF are largely unknown, and the lack of knowledge makes CRF difficult to treat. Recent research has shown di...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/2490750
更新日期:2019-06-26 00:00:00
abstract::One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during develo...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2011/286073
更新日期:2011-01-01 00:00:00
abstract:Objective:To determine whether and how longitudinal acupuncture modulates the impaired default mode network (DMN) in chronic migraine (CM) patients without aura. Methods:Resting-state functional magnetic resonance imaging (fMRI) data from 14 CM patients treated with longitudinal pre- and postacupuncture treatment (PPA...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/5047463
更新日期:2019-03-18 00:00:00
abstract::Motoneurons develop extensive dendritic trees for receiving excitatory and inhibitory synaptic inputs to perform a variety of complex motor tasks. At birth, the somatodendritic domains of mouse hypoglossal and lumbar motoneurons have dense filopodia and spines. Consistent with Vaughn's synaptotropic hypothesis, we pro...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/3423267
更新日期:2016-01-01 00:00:00
abstract::Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have rev...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2014/321209
更新日期:2014-01-01 00:00:00
abstract::Accumulating evidence implicates a role for brain structures outside the ascending auditory pathway in tinnitus, the phantom perception of sound. In addition to other factors such as age-dependent hearing loss, high-level sound exposure is a prominent cause of tinnitus. Here, we examined how noise exposure altered the...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2021/8833087
更新日期:2021-01-14 00:00:00
abstract::We analyzed operant discrimination in detelencephalated pigeons and neuroanatomical substrates after long-term detelencephalation. In Experiment I, experimental pigeons with massive telencephalic ablation and control pigeons were conditioned to key peck for food. Successive discrimination was made under alternating re...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.2003.247
更新日期:2003-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of dementia in elderly people. It is an irreversible and progressive brain disease. In this paper, we utilized diffusion-weighted imaging (DWI) to detect abnormal topological organization of white matter (WM) structural networks. We compared the differences between WM c...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/2947136
更新日期:2016-01-01 00:00:00
abstract::Functional and morphological studies in children affected by Attention Deficit Hyperactivity Disorder (ADHD) suggest a prefrontal cortex (PFc) dysfunction. This cortical region is regulated by subcortical systems including noradrenergic (NEergic), dopaminergic (DAergic), cholinergic, serotonergic, and histaminergic pa...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2004.133
更新日期:2004-01-01 00:00:00
abstract::Horizontal connections in superficial cortical layers integrate information across sensory maps by connecting related functional columns. It has been hypothesized that these connections mediate cortical reorganization via synaptic plasticity. However, it is not known if the horizontal connections from discontinuous co...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/294192
更新日期:2009-01-01 00:00:00
abstract::The GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex. GWS is characterized by focal epileptic electroencephalographic discharges and associated contralateral myoclonus. In neocortical slices obtained from GWS rat...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2000.9
更新日期:2000-01-01 00:00:00
abstract::Freezing of gait (FoG) is among the most disabling symptoms of Parkinson's disease (PD) patients. Recent studies showed that action observation training (AOT) with repetitive practice of the observed actions represents a strategy to induce longer-lasting effects compared with standard physiotherapy. We investigated wh...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/4897276
更新日期:2018-05-27 00:00:00
abstract::Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscill...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/1478684
更新日期:2016-01-01 00:00:00
abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/4135708
更新日期:2018-10-10 00:00:00
abstract::There is a general consensus that sleep is strictly linked to memory, learning, and, in general, to the mechanisms of neural plasticity, and that this link may directly affect recovery processes. In fact, a coherent pattern of empirical findings points to beneficial effect of sleep on learning and plastic processes, a...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/103949
更新日期:2013-01-01 00:00:00
abstract::Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurodegenerative disorders such as Parkinson's disease (PD). In sporadic PD, the most common age-related neurodegenerative movement disorder, nigrostriatal dopaminergic deficits are responsible for the onset of motor symptoms...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/5012129
更新日期:2017-01-01 00:00:00
abstract::Isoforms of apolipoprotein E (ApoE) have been implicated as risk factors in Alzheimer's disease. We have, therefore, examined the possible role of ApoE in memory formation, using a one-trial passive avoidance task in day-old chicks. Birds were trained on the task and then at various times pre or post-training were inj...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.1998.29
更新日期:1998-07-01 00:00:00
abstract::The role of the right hemisphere (RH) in recovery from aphasia is incompletely understood. The present study quantified RH grey matter (GM) volume in individuals with chronic stroke-induced aphasia and cognitively healthy people using voxel-based morphometry. We compared group differences in GM volume in the entire RH...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/5601509
更新日期:2017-01-01 00:00:00
abstract::Associative fear learning, in which stimulation of whiskers is paired with mild electric shock to the tail, modifies the barrel cortex, the functional representation of sensory receptors involved in the conditioning, by inducing formation of new inhibitory synapses on single-synapse spines of the cognate barrel hollow...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/9828517
更新日期:2016-01-01 00:00:00
abstract::The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8882207
更新日期:2020-10-06 00:00:00
abstract::In this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies and whole genome sear...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/np.2004.217
更新日期:2004-01-01 00:00:00
abstract::Dichoptic movie viewing has been shown to significantly improve visual acuity in amblyopia in children. Moreover, short-term occlusion of the amblyopic eye can transiently increase its contribution to binocular fusion in adults. In this study, we first asked whether dichoptic movie viewing could improve the visual fun...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/6208414
更新日期:2019-08-28 00:00:00
abstract::Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective function...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8583420
更新日期:2016-01-01 00:00:00
abstract::Using functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimicked in vivo conditi...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/108969
更新日期:2008-01-01 00:00:00