Heterogeneous Acupuncture Effects of Taixi (KI3) on Functional Connectivity in Healthy Youth and Elder: A Functional MRI Study Using Regional Homogeneity and Large-Scale Functional Connectivity Analysis.

Abstract:

:Heterogeneous neurological responses of acupuncture between different groups have been proposed by previous studies but rarely studied. The study described here was designed to explore the divergence of acupuncture at Taixi (KI3) on spontaneous activity of brain regions and functional connectivity (FC) between healthy youth and elder with functional magnetic resonance imaging (fMRI). 20 healthy young volunteers and 20 healthy elders underwent 10-minute-resting-state fMRI before acupuncture, and then acupuncture at Taixi (KI3) for 3 minutes; after withdrawing the needles, volunteers underwent a second fMRI scan for 10 minutes. Regional homogeneity (ReHo) and large-scale FC analysis using Power 264 atlas were utilized to analyze the changes of brain spontaneous activity. Compared with the resting state, the decreased ReHo after acupuncture at KI3 in both groups were concentrated in the left postcentral, right paracentral lobule, and right SMA. Moreover, the subjects in the HY group showed declined ReHo in brain regions involving the right lingual and precentral. However, those subjects in the HE group presented decreased ReHo in the right postcentral and precentral, left supramarginal gyrus and SMA, and both cingulum middle after needling in KI3. Compared with the resting state, the HY group in the postneedling state showed lower mean intranetwork FC in sensory/somatomotor and subcortical network. And the internetwork FC between sensory/somatomotor and dorsal attention had significantly decreased after acupuncture. Furthermore, the internetwork FC between subcortical and dorsal attention and between subcortical and cerebellar showed the most obvious elevations after needling in the HY group. In the elder group, both FCs of internetwork and intranetwork primarily involving sensory/somatomotor, cingulo-opercular, and dorsal attention were declined after acupuncture. These results indicated that acupuncture at KI3 had heterogeneous acupuncture effects in different age groups. Our study led to converging evidence supporting the acupuncture effect segregation of different condition subjects and supporting evidence for prevention and treatment with acupuncture in the future.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

He L,Chen G,Zheng R,Hu Y,Chen X,Ruan J

doi

10.1155/2020/8884318

subject

Has Abstract

pub_date

2020-12-08 00:00:00

pages

8884318

eissn

2090-5904

issn

1687-5443

journal_volume

2020

pub_type

杂志文章
  • Quantification of Upper Limb Motor Recovery and EEG Power Changes after Robot-Assisted Bilateral Arm Training in Chronic Stroke Patients: A Prospective Pilot Study.

    abstract:Background:Bilateral arm training (BAT) has shown promise in expediting progress toward upper limb recovery in chronic stroke patients, but its neural correlates are poorly understood. Objective:To evaluate changes in upper limb function and EEG power after a robot-assisted BAT in chronic stroke patients. Methods:In ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/8105480

    authors: Gandolfi M,Formaggio E,Geroin C,Storti SF,Boscolo Galazzo I,Bortolami M,Saltuari L,Picelli A,Waldner A,Manganotti P,Smania N

    更新日期:2018-03-26 00:00:00

  • The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention.

    abstract::Traumatic brain injury (TBI) is a serious medical and social problem worldwide. Because of the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still lacking. The microglial cells are resident tissue macrophages located in the brain and have two major polarization states, M1 phenotype and M2 ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5405104

    authors: Xu H,Wang Z,Li J,Wu H,Peng Y,Fan L,Chen J,Gu C,Yan F,Wang L,Chen G

    更新日期:2017-01-01 00:00:00

  • Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke.

    abstract::Perinatal stroke is a leading cause of congenital hemiparesis and neurocognitive deficits in children. Dysfunctions in the large-scale resting-state functional networks may underlie cognitive and behavioral disability in these children. We studied resting-state functional connectivity in patients with perinatal stroke...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/2306406

    authors: Ilves N,Ilves P,Laugesaar R,Juurmaa J,Männamaa M,Lõo S,Loorits D,Tomberg T,Kolk A,Talvik I,Talvik T

    更新日期:2016-01-01 00:00:00

  • Dopaminergic Modulation of Striatal Inhibitory Transmission and Long-Term Plasticity.

    abstract::Dopamine (DA) modulates glutamatergic synaptic transmission and its plasticity in the striatum; however it is not well known how DA modulates long-term plasticity of striatal GABAergic inhibitory synapses. This work focused on the analysis of both dopaminergic modulation of inhibitory synapses and the synaptic plastic...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/789502

    authors: Nieto Mendoza E,Hernández Echeagaray E

    更新日期:2015-01-01 00:00:00

  • Contralateral Metabolic Activation Related to Plastic Changes in the Spinal Cord after Peripheral Nerve Injury in Rats.

    abstract::We have previously reported the crossed-withdrawal reflex in which the rats with nerve injury developed behavioral pain responses of the injured paw to stimuli applied to the contralateral uninjured paw. This reflex indicates that contralateral plastic changes may occur in the spinal cord after unilateral nerve injury...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/438319

    authors: Won R,Lee BH

    更新日期:2015-01-01 00:00:00

  • Genetics and function of neocortical GABAergic interneurons in neurodevelopmental disorders.

    abstract::A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and exp...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2011/649325

    authors: Rossignol E

    更新日期:2011-01-01 00:00:00

  • Genetic dissection of learning and memory in mice.

    abstract::In this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies and whole genome sear...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/np.2004.217

    authors: Mineur YS,Crusio WE,Sluyter F

    更新日期:2004-01-01 00:00:00

  • Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele.

    abstract::Alzheimer's disease (AD) is the most common form of dementia in the elderly; important risk factors are old age and inheritance of the apolipoprotein E4 (APOE4) allele. Changes in amyloid precursor protein (APP) binding, trafficking, and sorting may be important AD causative factors. Secretase-mediated APP cleavage pr...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/1892612

    authors: Zollo A,Allen Z,Rasmussen HF,Iannuzzi F,Shi Y,Larsen A,Maier TJ,Matrone C

    更新日期:2017-01-01 00:00:00

  • Evolution of Apparent Diffusion Coefficient and Fractional Anisotropy in the Cerebrum of Asphyxiated Newborns Treated with Hypothermia over the First Month of Life.

    abstract::The objective of this study was to assess the evolution of diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI) over the first month of life in asphyxiated newborns treated with hypothermia and to compare it with that of healthy newborns. Asphyxiated newborns treated with hypothermia were enrolled prosp...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/653727

    authors: Kwan S,Boudes E,Benseler A,Gilbert G,Saint-Martin C,Shevell M,Wintermark P

    更新日期:2015-01-01 00:00:00

  • Effect of Group-Based Rehabilitation Combining Action Observation with Physiotherapy on Freezing of Gait in Parkinson's Disease.

    abstract::Freezing of gait (FoG) is among the most disabling symptoms of Parkinson's disease (PD) patients. Recent studies showed that action observation training (AOT) with repetitive practice of the observed actions represents a strategy to induce longer-lasting effects compared with standard physiotherapy. We investigated wh...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/4897276

    authors: Pelosin E,Barella R,Bet C,Magioncalda E,Putzolu M,Di Biasio F,Cerulli C,Casaleggio M,Abbruzzese G,Avanzino L

    更新日期:2018-05-27 00:00:00

  • Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions.

    abstract::The formation of fear memories is a powerful and highly evolutionary conserved mechanism that serves the behavioral adaptation to environmental threats. Accordingly, classical fear conditioning paradigms have been employed to investigate fundamental molecular processes of memory formation. Evidence suggests that a cir...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/3750307

    authors: Albrecht A,Stork O

    更新日期:2017-01-01 00:00:00

  • Long-Term Impairment of Sound Processing in the Auditory Midbrain by Daily Short-Term Exposure to Moderate Noise.

    abstract::Most citizen people are exposed daily to environmental noise at moderate levels with a short duration. The aim of the present study was to determine the effects of daily short-term exposure to moderate noise on sound level processing in the auditory midbrain. Sound processing properties of auditory midbrain neurons we...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/3026749

    authors: Cheng L,Wang SH,Peng K,Liao XM

    更新日期:2017-01-01 00:00:00

  • Manipulation of Auditory Inputs as Rehabilitation Therapy for Maladaptive Auditory Cortical Reorganization.

    abstract::Neurophysiological and neuroimaging data suggest that the brains of not only children but also adults are reorganized based on sensory inputs and behaviors. Plastic changes in the brain are generally beneficial; however, maladaptive cortical reorganization in the auditory cortex may lead to hearing disorders such as t...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2018/2546250

    authors: Okamoto H

    更新日期:2018-05-20 00:00:00

  • ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses.

    abstract::Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression (LTD) at the medial perforant path-granule cell synapse in early postnat...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2012/237913

    authors: Guli X,Tokay T,Rohde M,Bender RA,Köhling R,Kirschstein T

    更新日期:2012-01-01 00:00:00

  • Spinal cord lesion: effects of and perspectives for treatment.

    abstract::Following central motor lesions, two forms of adaptation can be observed which lead to improved mobility: (1) the development of spastic muscle tone, and (2) the activation of spinal locomotor centers induced by specific treadmill training. Tension development during spastic gait is different from that during normal g...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2001.83

    authors: Dietz V

    更新日期:2001-01-01 00:00:00

  • Functional Connectivity Alterations in Children with Spastic and Dyskinetic Cerebral Palsy.

    abstract::Cerebral palsy (CP) has long been investigated to be associated with a range of motor and cognitive dysfunction. As the two most common CP subtypes, spastic cerebral palsy (SCP) and dyskinetic cerebral palsy (DCP) may share common and distinct elements in their pathophysiology. However, the common and distinct dysfunc...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/7058953

    authors: Qin Y,Li Y,Sun B,He H,Peng R,Zhang T,Li J,Luo C,Sun C,Yao D

    更新日期:2018-08-15 00:00:00

  • Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities.

    abstract::With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute phase upon stroke onset, which not only is a difficult way to am...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/1969482

    authors: Liu W,Wang X,O'Connor M,Wang G,Han F

    更新日期:2020-01-27 00:00:00

  • Effects of Temporary Functional Deafferentation in Chronic Stroke Patients: Who Profits More?

    abstract::Temporary functional deafferentation (TFD) by an anesthetic cream on the stroke-affected forearm was shown to improve sensorimotor abilities of stroke patients. The present study investigated different predictors for sensorimotor improvements during TFD and indicated outcome differences between patients grouped in sub...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/7392024

    authors: Sens E,Franz M,Preul C,Meissner W,Witte OW,Miltner WHR,Weiss T

    更新日期:2018-07-29 00:00:00

  • In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders.

    abstract::Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer's disease, and epilepsy point to the involve...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9847696

    authors: Pantazopoulos H,Berretta S

    更新日期:2016-01-01 00:00:00

  • Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG.

    abstract::Recently several lines of evidence demonstrated that methylcobalamin (MeCbl) might have potential analgesic effect in experimental and clinical studies. However, it was reported that MeCbl had no effect on treating lumbar spinal stenosis induced pain. Thus, the effects of short-term and long-term administration of MeC...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/197392

    authors: Zhang M,Han W,Zheng J,Meng F,Jiao X,Hu S,Xu H

    更新日期:2015-01-01 00:00:00

  • Brain plasticity and disease: a matter of inhibition.

    abstract::One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during develo...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2011/286073

    authors: Baroncelli L,Braschi C,Spolidoro M,Begenisic T,Maffei L,Sale A

    更新日期:2011-01-01 00:00:00

  • GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway.

    abstract::Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures. GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system. Accumulating evidence de...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/8858415

    authors: Hou X,Rong C,Wang F,Liu X,Sun Y,Zhang HT

    更新日期:2020-08-01 00:00:00

  • Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats.

    abstract::Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of axons projecting in...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/9828725

    authors: Hodgetts SI,Yoon JH,Fogliani A,Akinpelu EA,Baron-Heeris D,Houwers IGJ,Wheeler LPG,Majda BT,Santhakumar S,Lovett SJ,Duce E,Pollett MA,Wiseman TM,Fehily B,Harvey AR

    更新日期:2018-08-06 00:00:00

  • HINT1 in Neuropsychiatric Diseases: A Potential Neuroplastic Mediator.

    abstract::Although many studies have investigated the functions of histidine triad nucleotide-binding protein 1 (HINT1), its roles in neurobiological processes remain to be fully elucidated. As a member of the histidine triad (HIT) enzyme superfamily, HINT1 is distributed in almost every organ and has both enzymatic and nonenzy...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5181925

    authors: Liu P,Liu Z,Wang J,Ma X,Dang Y

    更新日期:2017-01-01 00:00:00

  • Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson's Disease Animal Models from a Molecular Signaling Perspective.

    abstract::Despite the fact that astrocytes are the most abundant glial cells, critical for brain function, few studies have dealt with their possible role in neurodegenerative diseases like Parkinson's disease (PD). This article explores relevant evidence on the involvement of astrocytes in experimental PD neurodegeneration fro...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/1859431

    authors: Udovin L,Quarracino C,Herrera MI,Capani F,Otero-Losada M,Perez-Lloret S

    更新日期:2020-02-07 00:00:00

  • Afferent connections to the rostrolateral part of the periaqueductal gray: a critical region influencing the motivation drive to hunt and forage.

    abstract::Previous studies have shown that a particular site in the periaqueductal gray (PAG), the rostrolateral PAG, influences the motivation drive to forage or hunt. To have a deeper understanding on the putative paths involved in the decision-making process between foraging, hunting, and other behavioral responses, in the p...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2009/612698

    authors: Mota-Ortiz SR,Sukikara MH,Felicio LF,Canteras NS

    更新日期:2009-01-01 00:00:00

  • Different Degree Centrality Changes in the Brain after Acupuncture on Contralateral or Ipsilateral Acupoint in Patients with Chronic Shoulder Pain: A Resting-State fMRI Study.

    abstract::Chronic shoulder pain (CSP) is the third most common musculoskeletal problem. For maximum treatment effectiveness, most acupuncturists usually choose acupoint in the nonpainful side, to alleviate pain or improve shoulder function. This method is named opposite needling, which means acupuncture points on the right side...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/5701042

    authors: Yan CQ,Huo JW,Wang X,Zhou P,Zhang YN,Li JL,Kim M,Shao JK,Hu SQ,Wang LQ,Liu CZ

    更新日期:2020-04-25 00:00:00

  • Action Video Game Experience Related to Altered Large-Scale White Matter Networks.

    abstract::With action video games (AVGs) becoming increasingly popular worldwide, the cognitive benefits of AVG experience have attracted continuous research attention over the past two decades. Research has repeatedly shown that AVG experience can causally enhance cognitive ability and is related to neural plasticity in gray m...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/7543686

    authors: Gong D,Ma W,Gong J,He H,Dong L,Zhang D,Li J,Luo C,Yao D

    更新日期:2017-01-01 00:00:00

  • Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome.

    abstract::Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learn...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9353929

    authors: Yang T,Zhao H,Lu C,Li X,Xie Y,Fu H,Xu H

    更新日期:2016-01-01 00:00:00

  • Human Auditory and Adjacent Nonauditory Cerebral Cortices Are Hypermetabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS).

    abstract::Tinnitus is the phantom perception of sound in the absence of an acoustic stimulus. To date, the purported neural correlates of tinnitus from animal models have not been adequately characterized with translational technology in the human brain. The aim of the present study was to measure changes in oxy-hemoglobin conc...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/7453149

    authors: Issa M,Bisconti S,Kovelman I,Kileny P,Basura GJ

    更新日期:2016-01-01 00:00:00