Abstract:
:Traumatic brain injury (TBI) is a serious medical and social problem worldwide. Because of the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still lacking. The microglial cells are resident tissue macrophages located in the brain and have two major polarization states, M1 phenotype and M2 phenotype, when activated. The M1 phenotype is related to the release of proinflammatory cytokines and secondary brain injury, while the M2 phenotype has been proved to be responsible for the release of anti-inflammation cytokines and for central nervous system (CNS) repair. In animal models, pharmacological strategies inhibiting the M1 phenotype and promoting the M2 phenotype of microglial cells could alleviate cerebral damage and improve neurological function recovery after TBI. In this review, we aimed to summarize the current knowledge about the pathological significance of microglial M1/M2 polarization in the pathophysiology of TBI. In addition, we reviewed several drugs that have provided neuroprotective effects against brain injury following TBI by altering the polarization states of the microglia. We emphasized that future investigation of the regulation mechanisms of microglial M1/M2 polarization in TBI is anticipated, which could contribute to the development of new targets of pharmacological intervention in TBI.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Xu H,Wang Z,Li J,Wu H,Peng Y,Fan L,Chen J,Gu C,Yan F,Wang L,Chen Gdoi
10.1155/2017/5405104subject
Has Abstractpub_date
2017-01-01 00:00:00pages
5405104eissn
2090-5904issn
1687-5443journal_volume
2017pub_type
杂志文章,评审abstract::Histamine H4 receptor has been confirmed to play a role in evoking peripheral pruritus. However, the ionic and intracellular signaling mechanism of activation of H4 receptor on the dorsal root ganglion (DRG) neurons is still unknown. By using cell culture and calcium imaging, we studied the underlying mechanism of act...
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-04-25 00:00:00
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pub_type: 杂志文章
doi:10.1155/2018/9163521
更新日期:2018-04-24 00:00:00
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pub_type: 杂志文章
doi:10.1155/2020/8851525
更新日期:2020-09-22 00:00:00
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journal_title:Neural plasticity
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pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/4526417
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pub_type: 杂志文章
doi:10.1155/2018/8105480
更新日期:2018-03-26 00:00:00
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journal_title:Neural plasticity
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