Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities.

Abstract:

:With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute phase upon stroke onset, which not only is a difficult way to ameliorate stroke symptoms but also presents a challenge for the patients to receive effective treatment in time. The brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult brain, which possesses a remarkable capability to repair brain damage. Recent promising preclinical outcomes have made BDNF a popular late-stage target in the development of novel stroke treatments. In this review, we aim to summarize the latest progress in the understanding of the cellular/molecular mechanisms underlying stroke pathogenesis, current strategies and difficulties in drug development, the mechanism of BDNF action in poststroke neurorehabilitation and neuroplasticity, and recent updates in novel therapeutic methods.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Liu W,Wang X,O'Connor M,Wang G,Han F

doi

10.1155/2020/1969482

subject

Has Abstract

pub_date

2020-01-27 00:00:00

pages

1969482

eissn

2090-5904

issn

1687-5443

journal_volume

2020

pub_type

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