Abstract:
:Emotionally arousing events are typically better remembered than mundane ones, in part because emotionally relevant aspects of our environment are prioritized in attention. Such biased attentional tuning is itself the result of associative processes through which we learn affective and motivational relevance of cues. We propose that the locus coeruleus-noradrenaline (LC-NA) system plays an important role in the genesis of attentional biases through associative learning processes as well as their maintenance. We further propose that individual differences in and disruptions of the LC-NA system underlie the development of maladaptive biases linked to psychopathology. We provide support for the proposed role of the LC-NA system by first reviewing work on attentional biases in development and its link to psychopathology in relation to alterations and individual differences in NA availability. We focus on pharmacological manipulations to demonstrate the effect of a disrupted system as well as the ADRA2b polymorphism as a tool to investigate naturally occurring differences in NA availability. We next review associative learning processes that-modulated by the LC-NA system-result in such implicit attentional biases. Further, we demonstrate how NA may influence aversive and appetitive conditioning linked to anxiety disorders as well as addiction and depression.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Ehlers MR,Todd RMdoi
10.1155/2017/6817349subject
Has Abstractpub_date
2017-01-01 00:00:00pages
6817349eissn
2090-5904issn
1687-5443journal_volume
2017pub_type
杂志文章,评审abstract::The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is necessary for proper hair cell (HC) mechanotransduction and hearing. Cell junctions are indispensable for the establishment of compositionally distinct fluid compartments in the inner ear. Ototoxic drug cisplatin can damage SV ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8851525
更新日期:2020-09-22 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
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abstract::The concept of a topographical map of the corpus callosum (CC) has emerged from human lesion studies and from electrophysiological and anatomical tracing investigations in other mammals. Over the last few years a rising number of researchers have been reporting functional magnetic resonance imaging (fMRI) activation i...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2013/251308
更新日期:2013-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/698528
更新日期:2013-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/108969
更新日期:2008-01-01 00:00:00
abstract::We have previously shown that spontaneous release of glutamate in the entorhinal cortex (EC) is tonically facilitated via activation of presynaptic NMDA receptors (NMDAr) containing the NR2B subunit. Here we show that the same receptors mediate short-term plasticity manifested by frequency-dependent facilitation of ev...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/872456
更新日期:2008-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/6067871
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/2426398
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/9652978
更新日期:2017-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/9890827
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/924192
更新日期:2013-01-01 00:00:00
abstract::Previous studies have shown that a particular site in the periaqueductal gray (PAG), the rostrolateral PAG, influences the motivation drive to forage or hunt. To have a deeper understanding on the putative paths involved in the decision-making process between foraging, hunting, and other behavioral responses, in the p...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/612698
更新日期:2009-01-01 00:00:00
abstract::Inhibitors of HMG-CoA reductase (statins), widely used to lower cholesterol in coronary heart and vascular disease, are effective drugs in reducing the risk of stroke and improving its outcome in the long term. After ischemic stroke, cardiac autonomic dysfunction and psychological problems are common complications rel...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/585783
更新日期:2015-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/7328725
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/3826495
更新日期:2019-04-07 00:00:00
abstract::The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plastici...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/6595740
更新日期:2017-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/7453149
更新日期:2016-01-01 00:00:00
abstract::Chronic shoulder pain (CSP) is the third most common musculoskeletal problem. For maximum treatment effectiveness, most acupuncturists usually choose acupoint in the nonpainful side, to alleviate pain or improve shoulder function. This method is named opposite needling, which means acupuncture points on the right side...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/5701042
更新日期:2020-04-25 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/415135
更新日期:2009-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of dementia in the elderly; important risk factors are old age and inheritance of the apolipoprotein E4 (APOE4) allele. Changes in amyloid precursor protein (APP) binding, trafficking, and sorting may be important AD causative factors. Secretase-mediated APP cleavage pr...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/1892612
更新日期:2017-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/6160959
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/163908
更新日期:2014-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/np.2004.217
更新日期:2004-01-01 00:00:00
abstract::To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/5625768
更新日期:2020-07-01 00:00:00
abstract::Several research studies point to the fact that sensory and cognitive reductions like cataracts, deafness, macular degeneration, or even lack of activity after job retirement, precede the onset of Alzheimer's disease. To simulate Alzheimer's disease earlier stages, which manifest in sensory cortices, we used a computa...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8895369
更新日期:2020-10-14 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2020/1859431
更新日期:2020-02-07 00:00:00
abstract::In this study, we attempted to test whether tyrosine hydroxylase (TH), the first rate-limiting enzyme of catecholamine synthesis, is confined to the perikarya of activated magnocellular vasopressinergic (VPergic) neurons or is also present in their distal axons in the pituitary posterior lobe (PL). In addition, we eva...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.2000.179
更新日期:2000-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/6029241
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
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