Statins Promote Long-Term Recovery after Ischemic Stroke by Reconnecting Noradrenergic Neuronal Circuitry.

abstract：:Motoneurons develop extensive dendritic trees for receiving excitatory and inhibitory synaptic inputs to perform a variety of complex motor tasks. At birth, the somatodendritic domains of mouse hypoglossal and lumbar motoneurons have dense filopodia and spines. Consistent with Vaughn's synaptotropic hypothesis, we pro...

journal_title：Neural plasticity

authors： Kanjhan R,Noakes PG,Bellingham MC

更新日期：2016-01-01 00:00:00

abstract：:We analyzed operant discrimination in detelencephalated pigeons and neuroanatomical substrates after long-term detelencephalation. In Experiment I, experimental pigeons with massive telencephalic ablation and control pigeons were conditioned to key peck for food. Successive discrimination was made under alternating re...

journal_title：Neural plasticity

authors： Cerutti SM,Diaz-Cintra S,Cintra L,Ferrari EA

更新日期：2003-01-01 00:00:00

abstract：:Studies have shown that, depending on its severity and context, stress can affect neural plasticity. Most related studies focused on synaptic plasticity and long-term potentiation (LTP) of principle cells. However, evidence suggests that following high-frequency stimulation, which induces LTP in principal cells, modif...

journal_title：Neural plasticity

authors： Yarom O,Maroun M,Richter-Levin G

更新日期：2008-01-01 00:00:00

abstract：:One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during develo...

journal_title：Neural plasticity

authors： Baroncelli L,Braschi C,Spolidoro M,Begenisic T,Maffei L,Sale A

更新日期：2011-01-01 00:00:00

abstract：:Cerebral palsy (CP) has long been investigated to be associated with a range of motor and cognitive dysfunction. As the two most common CP subtypes, spastic cerebral palsy (SCP) and dyskinetic cerebral palsy (DCP) may share common and distinct elements in their pathophysiology. However, the common and distinct dysfunc...

journal_title：Neural plasticity

authors： Qin Y,Li Y,Sun B,He H,Peng R,Zhang T,Li J,Luo C,Sun C,Yao D

更新日期：2018-08-15 00:00:00

abstract：:Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures. GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system. Accumulating evidence de...

journal_title：Neural plasticity

authors： Hou X,Rong C,Wang F,Liu X,Sun Y,Zhang HT

更新日期：2020-08-01 00:00:00

abstract：:Background. Clinically, electroacupuncture (EA) is the most common therapy for aging-related cognitive impairment (CI). However, the underlying pathomechanism remains unidentified. The aims of this study were to observe the effect of EA on cognitive function and explore the potential mechanism by which EA acts on the ...

journal_title：Neural plasticity

authors： Hou Z,Qiu R,Wei Q,Liu Y,Wang M,Mei T,Zhang Y,Song L,Shao X,Shang H,Chen J,Sun Z

更新日期：2020-11-04 00:00:00

abstract：:Chronic stress can impair hippocampal neurogenesis, increase neuronal apoptosis, and cause depressive-like behaviors. Our previous studies found that Radix Scutellariae (RS) can rescue the stress-induced neuronal injury, but the mechanism is not clear. Here, we continued to investigate the underlying antidepressant me...

journal_title：Neural plasticity

authors： Zhao F,Zhang C,Xiao D,Zhang W,Zhou L,Gu S,Qu R

更新日期：2020-11-13 00:00:00

abstract：:We do not all grow older in the same way. Some individuals have a cognitive decline earlier and faster than others who are older in years but cerebrally younger. This is particularly easy to verify in people who have maintained regular physical activity and healthy and cognitively stimulating lifestyle and even in the...

journal_title：Neural plasticity

authors： Mandolesi L,Gelfo F,Serra L,Montuori S,Polverino A,Curcio G,Sorrentino G

更新日期：2017-01-01 00:00:00

abstract：:Elevated brain activation, or hyperexcitability, induces cognitive impairment and confers an increased risk of Alzheimer's disease (AD). Blocking the overexcitation of the neural network may be a promising new strategy to prevent, halt, and even reverse this condition. Physical exercise has been shown to be an effecti...

journal_title：Neural plasticity

authors： Tan YX,Liu GC,Chen HL,Lu MN,Chen B,Hu T,Zhang L,Mao R,Li S,Mei R,Wang XY,Xiyang YB

更新日期：2020-03-18 00:00:00

abstract：:Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke. However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in diabetes. We aim to investigate the effect and the potential mechanism of NLRP3 inflammasome in diabetic mice with cerebral ischemia-reperfusion i...

journal_title：Neural plasticity

authors： Hong P,Li FX,Gu RN,Fang YY,Lai LY,Wang YW,Tao T,Xu SY,You ZJ,Zhang HF

更新日期：2018-04-24 00:00:00

abstract：:The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during...

journal_title：Neural plasticity

authors： Couto TA,Xu S,da Silva PA,Wu C,Neergaard K,Wang MY,Zhang J,Xiang Y,Yuan Z

更新日期：2020-10-06 00:00:00

abstract：:Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain...

journal_title：Neural plasticity

authors： Huang YJ,Lane HY,Lin CH

更新日期：2017-01-01 00:00:00

abstract：:Temporary functional deafferentation (TFD) by an anesthetic cream on the stroke-affected forearm was shown to improve sensorimotor abilities of stroke patients. The present study investigated different predictors for sensorimotor improvements during TFD and indicated outcome differences between patients grouped in sub...

journal_title：Neural plasticity

authors： Sens E,Franz M,Preul C,Meissner W,Witte OW,Miltner WHR,Weiss T

更新日期：2018-07-29 00:00:00

abstract：:Postural problems play a central role in the motor dysfunction of children with cerebral palsy (CP). Therefore, they spend more time in sitting than in standing to perform vital tasks of daily life. The focus of this article is to describe the pathophysiology of postural control in sitting and outline some implication...

journal_title：Neural plasticity

authors： Carlberg EB,Hadders-Algra M

更新日期：2005-01-01 00:00:00

abstract：:Although many studies have investigated the functions of histidine triad nucleotide-binding protein 1 (HINT1), its roles in neurobiological processes remain to be fully elucidated. As a member of the histidine triad (HIT) enzyme superfamily, HINT1 is distributed in almost every organ and has both enzymatic and nonenzy...

journal_title：Neural plasticity

authors： Liu P,Liu Z,Wang J,Ma X,Dang Y

更新日期：2017-01-01 00:00:00

abstract：:Two principal component analyses of anxiety were undertaken investigating two strains of mice (ABP/Le and C57BL/6ByJ) in two different experiments, both classical tests for assessing anxiety in rodents. The elevated plus-maze and staircase were used for the first experiment, and a free exploratory paradigm and light-d...

journal_title：Neural plasticity

authors： Clément Y,Joubert C,Kopp C,Lepicard EM,Venault P,Misslin R,Cadot M,Chapouthier G

更新日期：2007-01-01 00:00:00

abstract：:Neurogenesis in the hippocampus is influenced by several factors including external stimuli. In addition to their involvement in learning and memory processes, newborn neurons of the dentate gyrus (DG) buffer against the effects of stress. Although the response of these cells to environmental stimuli has been shown, t...

journal_title：Neural plasticity

authors： Ramírez-Rodríguez GB,Ocaña-Fernández MDÁ,Ortiz-López L

更新日期：2018-05-22 00:00:00

abstract：:Action observation (AO) allows access to a network that processes visuomotor and sensorimotor inputs and is believed to be involved in observational learning of motor skills. We conducted three consecutive experiments to examine the boosting effect of AO on the motor outcome of the untrained hand by either mirror visu...

journal_title：Neural plasticity

authors： Bähr F,Ritter A,Seidel G,Puta C,Gabriel HHW,Hamzei F

更新日期：2018-04-10 00:00:00

abstract：Background:Previous reviews have generally reported cognitive//behavioral improvements after cognitively oriented treatments (COTs) in persons with MCI. However, comparatively little is known about the neural mechanisms associated with such cognitive improvement. Objective:The primary aim of the current review was to ...

journal_title：Neural plasticity

authors： Miotto EC,Batista AX,Simon SS,Hampstead BM

更新日期：2018-12-02 00:00:00

abstract：Background:Despite intensive rehabilitation efforts, most stroke survivors have persistent functional disability of the paretic arm and hand. These motor impairments may be due in part to maladaptive changes in structural and functional connections between brain regions. The following early stage clinical trial study p...

journal_title：Neural plasticity

authors： Borich MR,Wolf SL,Tan AQ,Palmer JA

更新日期：2018-03-12 00:00:00

abstract：:Histamine H4 receptor has been confirmed to play a role in evoking peripheral pruritus. However, the ionic and intracellular signaling mechanism of activation of H4 receptor on the dorsal root ganglion (DRG) neurons is still unknown. By using cell culture and calcium imaging, we studied the underlying mechanism of act...

journal_title：Neural plasticity

authors： Jian T,Yang N,Yang Y,Zhu C,Yuan X,Yu G,Wang C,Wang Z,Shi H,Tang M,He Q,Lan L,Wu G,Tang Z

更新日期：2016-01-01 00:00:00

abstract：:Cholinergic mechanism is involved in motor behavior. In songbirds, the robust nucleus of the arcopallium (RA) is a song premotor nucleus in the pallium and receives cholinergic inputs from the basal forebrain. The activity of projection neurons in RA determines song motor behavior. Although many evidences suggest that...

journal_title：Neural plasticity

authors： Meng W,Wang SH,Li DF

更新日期：2016-01-01 00:00:00

abstract：:Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression (LTD) at the medial perforant path-granule cell synapse in early postnat...

journal_title：Neural plasticity

authors： Guli X,Tokay T,Rohde M,Bender RA,Köhling R,Kirschstein T

更新日期：2012-01-01 00:00:00

abstract：:There is a general consensus that sleep is strictly linked to memory, learning, and, in general, to the mechanisms of neural plasticity, and that this link may directly affect recovery processes. In fact, a coherent pattern of empirical findings points to beneficial effect of sleep on learning and plastic processes, a...

journal_title：Neural plasticity

authors： Gorgoni M,D'Atri A,Lauri G,Rossini PM,Ferlazzo F,De Gennaro L

更新日期：2013-01-01 00:00:00

abstract：:The entorhinal cortex (EC) is a nodal and independent mnemonic element of the medial temporal lobe memory circuit as it forms a bidirectional interface between the neocortex and hippocampus. Within the EC, intra- and inter-lamellar associational connections occur via horizontal and columnar projections, respectively. ...

journal_title：Neural plasticity

authors： Ma L,Alonso A,Dickson CT

更新日期：2008-01-01 00:00:00

abstract：:The motor function is controlled by the motor system that comprises a series of cortical and subcortical areas interacting via anatomical connections. The motor function will be disturbed when the stroke lesion impairs either any of these areas or their connections. More and more evidence indicates that the reorganiza...

journal_title：Neural plasticity

authors： Jiang L,Xu H,Yu C

更新日期：2013-01-01 00:00:00

abstract：:Dopamine (DA) modulates glutamatergic synaptic transmission and its plasticity in the striatum; however it is not well known how DA modulates long-term plasticity of striatal GABAergic inhibitory synapses. This work focused on the analysis of both dopaminergic modulation of inhibitory synapses and the synaptic plastic...

journal_title：Neural plasticity

authors： Nieto Mendoza E,Hernández Echeagaray E

更新日期：2015-01-01 00:00:00

abstract：:Focal hand dystonia (FHd) is a recalcitrant, disabling movement disorder, characterized by involuntary co-contractions of agonists and antagonists, that can develop in patients who overuse or misuse their hands. The aim of this study was to document clinical neuromusculoskeletal performance and somatosensory responses...

journal_title：Neural plasticity

authors： Byl NN,Nagarajan SS,Merzenich MM,Roberts T,McKenzie A

更新日期：2002-01-01 00:00:00

abstract：Objective:To determine whether and how longitudinal acupuncture modulates the impaired default mode network (DMN) in chronic migraine (CM) patients without aura. Methods:Resting-state functional magnetic resonance imaging (fMRI) data from 14 CM patients treated with longitudinal pre- and postacupuncture treatment (PPA...

journal_title：Neural plasticity

authors： Zou Y,Tang W,Li X,Xu M,Li J

更新日期：2019-03-18 00:00:00