Abstract:
:Histamine H4 receptor has been confirmed to play a role in evoking peripheral pruritus. However, the ionic and intracellular signaling mechanism of activation of H4 receptor on the dorsal root ganglion (DRG) neurons is still unknown. By using cell culture and calcium imaging, we studied the underlying mechanism of activation of H4 receptor on the DRG neuron. Immepip dihydrobromide (immepip)-a histamine H4 receptor special agonist under cutaneous injection-obviously induced itch behavior of mice. Immepip-induced scratching behavior could be blocked by TRPV1 antagonist AMG9810 and PLC pathway inhibitor U73122. Application of immepip (8.3-50 μM) could also induce a dose-dependent increase in intracellular Ca(2+) ([Ca(2+)]i) of DRG neurons. We found that 77.8% of the immepip-sensitized DRG neurons respond to the TRPV1 selective agonist capsaicin. U73122 could inhibit immepip-induced Ca(2+) responses. In addition, immepip-induced [Ca(2+)]i increase could be blocked by ruthenium red, capsazepine, and AMG9810; however it could not be blocked by TRPA1 antagonist HC-030031. These results indicate that TRPV1 but not TRPA1 is the important ion channel to induce the DRG neurons' responses in the downstream signaling pathway of histamine H4 receptor and suggest that TRPV1 may be involved in the mechanism of histamine-induced itch response by H4 receptor activation.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Jian T,Yang N,Yang Y,Zhu C,Yuan X,Yu G,Wang C,Wang Z,Shi H,Tang M,He Q,Lan L,Wu G,Tang Zdoi
10.1155/2016/1682972subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1682972eissn
2090-5904issn
1687-5443journal_volume
2016pub_type
杂志文章abstract::High-frequency synchronization has been found in many real neural systems and is confirmed by excitatory/inhibitory (E/I) network models. However, the functional role played by it remains elusive. In this paper, it is found that high-frequency synchronization in E/I neuronal networks could improve the firing rate cont...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8823111
更新日期:2020-11-09 00:00:00
abstract::Evidence suggests that inflammation and neurogenesis play an important role in major depressive disorder (MDD). Mahuang-Fuzi-Xixin decoction (MFX), as the traditional Chinese prescription, has been widely applied for asthma, migraine, and MDD in clinics. However, the effects of MFX on the potential mechanism in MDD ar...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/1571392
更新日期:2019-11-11 00:00:00
abstract:Background:Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. Th...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/9460364
更新日期:2020-09-22 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of axons projecting in...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/9828725
更新日期:2018-08-06 00:00:00
abstract:UNLABELLED:Objective. Magnetic seizure therapy (MST) is a novel, experimental therapeutic intervention, which combines therapeutic aspects of electroconvulsive therapy (ECT) and transcranial magnetic stimulation, in order to achieve the efficacy of the former with the safety of the latter. MST might prove to be a valua...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2015/521398
更新日期:2015-01-01 00:00:00
abstract:Background:Phosphene generation is an objective physical measure of potential transcranial alternating current stimulation (tACS) biological side effects. Interpretations from phosphene analysis can serve as a first step in understanding underlying mechanisms of tACS in healthy human subjects and assist validation of c...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/8525706
更新日期:2018-12-06 00:00:00
abstract::Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons. It has also been shown to acutely induce epileptic seizure behavior in freely moving rats. However, whether CTZ indu...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/310146
更新日期:2014-01-01 00:00:00
abstract::The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is necessary for proper hair cell (HC) mechanotransduction and hearing. Cell junctions are indispensable for the establishment of compositionally distinct fluid compartments in the inner ear. Ototoxic drug cisplatin can damage SV ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8851525
更新日期:2020-09-22 00:00:00
abstract::With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute phase upon stroke onset, which not only is a difficult way to am...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2020/1969482
更新日期:2020-01-27 00:00:00
abstract::Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learn...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/9353929
更新日期:2016-01-01 00:00:00
abstract::Emotionally arousing events are typically better remembered than mundane ones, in part because emotionally relevant aspects of our environment are prioritized in attention. Such biased attentional tuning is itself the result of associative processes through which we learn affective and motivational relevance of cues. ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/6817349
更新日期:2017-01-01 00:00:00
abstract::The motor function is controlled by the motor system that comprises a series of cortical and subcortical areas interacting via anatomical connections. The motor function will be disturbed when the stroke lesion impairs either any of these areas or their connections. More and more evidence indicates that the reorganiza...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/924192
更新日期:2013-01-01 00:00:00
abstract::Neuropathies are characterized by a complex response of the central nervous system to injuries. Glial cells are recruited to maintain neuronal homeostasis but dysregulated activation leads to pain signaling amplification and reduces the glial neuroprotective power. Recently, we highlighted the property of α7 nicotinic...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/396908
更新日期:2015-01-01 00:00:00
abstract::Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic ne...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2011/921680
更新日期:2011-01-01 00:00:00
abstract::Perceptual learning can be specific to a trained stimulus or optimally generalized to novel stimuli with the breadth of generalization being imperative for how we structure perceptual training programs. Adapting an established auditory interval discrimination paradigm to utilise complex signals, we trained human adult...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2013/879047
更新日期:2013-01-01 00:00:00
abstract::Little is known about prenatal and perinatal brain injury resulting in subsequent clumsy behavior in children. One candidate motor system is the pyramidal tract. The tract traverses the entire central nervous system and, through direct and indirect connections to the brainstem and spinal cord sensory and motor nuclei,...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.2003.77
更新日期:2003-01-01 00:00:00
abstract::Neurophysiological and neuroimaging data suggest that the brains of not only children but also adults are reorganized based on sensory inputs and behaviors. Plastic changes in the brain are generally beneficial; however, maladaptive cortical reorganization in the auditory cortex may lead to hearing disorders such as t...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2018/2546250
更新日期:2018-05-20 00:00:00
abstract::Stimulating regeneration in the brain has the potential to rescue neuronal networks and counteract progressive pathological changes in Alzheimer's disease (AD). This study investigated whether drugs with different mechanisms of action could enhance neurogenesis and improve cognition in mice receiving human neural stem...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/370432
更新日期:2015-01-01 00:00:00
abstract:Background and Purpose:Cancer-related fatigue (CRF) is widely recognized as one of the most common symptoms and side effects of cancer and/or its treatment. However, neuropathological mechanisms contributing to CRF are largely unknown, and the lack of knowledge makes CRF difficult to treat. Recent research has shown di...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/2490750
更新日期:2019-06-26 00:00:00
abstract::We do not all grow older in the same way. Some individuals have a cognitive decline earlier and faster than others who are older in years but cerebrally younger. This is particularly easy to verify in people who have maintained regular physical activity and healthy and cognitively stimulating lifestyle and even in the...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/7219461
更新日期:2017-01-01 00:00:00
abstract::Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2007/91236
更新日期:2007-01-01 00:00:00
abstract::One of the most significant effects of neural plasticity manifests in the case of sensory deprivation when cortical areas that were originally specialized for the functions of the deprived sense take over the processing of another modality. Vision and audition represent two important senses needed to navigate through ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/9603469
更新日期:2019-12-02 00:00:00
abstract::Postural problems play a central role in the motor dysfunction of children with cerebral palsy (CP). Therefore, they spend more time in sitting than in standing to perform vital tasks of daily life. The focus of this article is to describe the pathophysiology of postural control in sitting and outline some implication...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2005.221
更新日期:2005-01-01 00:00:00
abstract::The habituation/cross-habituation test (HaXha) is a spontaneous odor discrimination task that has been used for many decades to evaluate olfactory function in animals. Animals are presented repeatedly with the same odorant after which a new odorant is introduced. The time the animal explores the odor object is measure...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/9131284
更新日期:2016-01-01 00:00:00
abstract::Temporary functional deafferentation (TFD) by an anesthetic cream on the stroke-affected forearm was shown to improve sensorimotor abilities of stroke patients. The present study investigated different predictors for sensorimotor improvements during TFD and indicated outcome differences between patients grouped in sub...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/7392024
更新日期:2018-07-29 00:00:00
abstract::Inbred mouse models are widely used to study age-related hearing loss (AHL). Many genes associated with AHL have been mapped in a variety of strains. However, little is known about gene variants that have the converse function-protective genes that confer strong resistance to hearing loss. Previously, we reported that...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8889264
更新日期:2020-06-08 00:00:00
abstract::With action video games (AVGs) becoming increasingly popular worldwide, the cognitive benefits of AVG experience have attracted continuous research attention over the past two decades. Research has repeatedly shown that AVG experience can causally enhance cognitive ability and is related to neural plasticity in gray m...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/7543686
更新日期:2017-01-01 00:00:00
abstract::Childhood emotional trauma contributes significantly to certain psychopathologies, such as post-traumatic stress disorder. In experimental animals, however, whether or not early-life stress results in behavioral abnormalities in adult animals still remains controversial. Here, we investigated both short-term and long-...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/163908
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/6724631.]. ...
journal_title:Neural plasticity
pub_type: 杂志文章,已发布勘误
doi:10.1155/2017/3634598
更新日期:2017-01-01 00:00:00
abstract::Chronic stress can impair hippocampal neurogenesis, increase neuronal apoptosis, and cause depressive-like behaviors. Our previous studies found that Radix Scutellariae (RS) can rescue the stress-induced neuronal injury, but the mechanism is not clear. Here, we continued to investigate the underlying antidepressant me...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8886715
更新日期:2020-11-13 00:00:00