Abstract:
:Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons. It has also been shown to acutely induce epileptic seizure behavior in freely moving rats. However, whether CTZ induced seizure rats could develop to have recurrent seizure still remains unknown. In the current study, we demonstrated that 46% of the CTZ induced seizure rats developed to have recurrent seizure behavior as well as epileptic EEG with a starting latency between 2 weeks and several months. In those chronic seizure rats 6 months after the seizure induction by the CTZ, our immunohistochemistry results showed that both GAD and GAT-1 were significantly decreased across CA1, CA3, and dentate gyrus area of the hippocampus studied. In addition, both BDNF and its receptor TrkB were also decreased in hippocampus of the chronic CTZ seizure rats. Our results indicate that CTZ induced seizure is capable of developing to have recurrent seizure, and the decreased GABA synthesis and transport as well as the impaired BDNF-TrkB signaling pathway may contribute to the development of the recurrent seizure. Thus, CTZ seizure rats may provide a novel animal model for epilepsy study and anticonvulsant drug testing in the future.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Kong S,Cheng Z,Liu J,Wang Ydoi
10.1155/2014/310146subject
Has Abstractpub_date
2014-01-01 00:00:00pages
310146eissn
2090-5904issn
1687-5443journal_volume
2014pub_type
杂志文章abstract::Although many studies have investigated the functions of histidine triad nucleotide-binding protein 1 (HINT1), its roles in neurobiological processes remain to be fully elucidated. As a member of the histidine triad (HIT) enzyme superfamily, HINT1 is distributed in almost every organ and has both enzymatic and nonenzy...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/5181925
更新日期:2017-01-01 00:00:00
abstract::Embryonic neuroepithelia and adult subventricular zone (SVZ) stem and progenitor cells express nestin. We characterized a transgenic line that expresses enhanced green fluorescent protein (eGFP) specified to neural tissue by the second intronic enhancer of the nestin promoter that had several novel features. During em...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2010/894374
更新日期:2010-01-01 00:00:00
abstract::Proper functioning of the visual system depends on maturation of both excitatory and inhibitory synapses within the visual cortex. Considering that perisomatic inhibition is one of the key factors that control the critical period in visual cortex, it is pertinent to understand its regulation by visual experience. To d...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/415135
更新日期:2009-01-01 00:00:00
abstract::Postural problems play a central role in the motor dysfunction of children with cerebral palsy (CP). Therefore, they spend more time in sitting than in standing to perform vital tasks of daily life. The focus of this article is to describe the pathophysiology of postural control in sitting and outline some implication...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2005.221
更新日期:2005-01-01 00:00:00
abstract::One of the most significant effects of neural plasticity manifests in the case of sensory deprivation when cortical areas that were originally specialized for the functions of the deprived sense take over the processing of another modality. Vision and audition represent two important senses needed to navigate through ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/9603469
更新日期:2019-12-02 00:00:00
abstract::The role of attentional mechanisms in peripheral vision loss remains an outstanding question. Our study was aimed at determining the effect of genetically determined peripheral retinal dystrophy caused by Retinitis Pigmentosa (RP) on visual cortical function and tested the recruitment of attentional mechanisms using f...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/8136354
更新日期:2019-06-25 00:00:00
abstract::Inhibitors of HMG-CoA reductase (statins), widely used to lower cholesterol in coronary heart and vascular disease, are effective drugs in reducing the risk of stroke and improving its outcome in the long term. After ischemic stroke, cardiac autonomic dysfunction and psychological problems are common complications rel...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/585783
更新日期:2015-01-01 00:00:00
abstract::Following central motor lesions, two forms of adaptation can be observed which lead to improved mobility: (1) the development of spastic muscle tone, and (2) the activation of spinal locomotor centers induced by specific treadmill training. Tension development during spastic gait is different from that during normal g...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2001.83
更新日期:2001-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/6724631.]. ...
journal_title:Neural plasticity
pub_type: 杂志文章,已发布勘误
doi:10.1155/2017/3634598
更新日期:2017-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of dementia in the elderly; important risk factors are old age and inheritance of the apolipoprotein E4 (APOE4) allele. Changes in amyloid precursor protein (APP) binding, trafficking, and sorting may be important AD causative factors. Secretase-mediated APP cleavage pr...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/1892612
更新日期:2017-01-01 00:00:00
abstract::Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke. However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in diabetes. We aim to investigate the effect and the potential mechanism of NLRP3 inflammasome in diabetic mice with cerebral ischemia-reperfusion i...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/9163521
更新日期:2018-04-24 00:00:00
abstract::Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic ne...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2011/921680
更新日期:2011-01-01 00:00:00
abstract::There is a general consensus that sleep is strictly linked to memory, learning, and, in general, to the mechanisms of neural plasticity, and that this link may directly affect recovery processes. In fact, a coherent pattern of empirical findings points to beneficial effect of sleep on learning and plastic processes, a...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/103949
更新日期:2013-01-01 00:00:00
abstract::Functional and morphological studies in children affected by Attention Deficit Hyperactivity Disorder (ADHD) suggest a prefrontal cortex (PFc) dysfunction. This cortical region is regulated by subcortical systems including noradrenergic (NEergic), dopaminergic (DAergic), cholinergic, serotonergic, and histaminergic pa...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2004.133
更新日期:2004-01-01 00:00:00
abstract::Traumatic brain injury (TBI) is a worldwide endemic that results in unacceptably high morbidity and mortality. Secondary injury processes following primary injury are composed of intricate interactions between assorted molecules that ultimately dictate the degree of longer-term neurological deficits. One comparatively...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2012/378307
更新日期:2012-01-01 00:00:00
abstract::Cerebral palsy (CP) has long been investigated to be associated with a range of motor and cognitive dysfunction. As the two most common CP subtypes, spastic cerebral palsy (SCP) and dyskinetic cerebral palsy (DCP) may share common and distinct elements in their pathophysiology. However, the common and distinct dysfunc...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/7058953
更新日期:2018-08-15 00:00:00
abstract::The endocannabinoids N-arachidonoylethanolamide (or anandamide, AEA) and 2-arachidonoylglycerol (2-AG) belong to the larger groups of N-acylethanolamines (NAEs) and monoacylglycerol (MAG) lipid classes, respectively. They are biologically active lipid molecules that activate G-protein-coupled cannabinoid receptors fou...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/2426398
更新日期:2016-01-01 00:00:00
abstract::Dizziness and vertigo frequently occur after cochlear implantation (CI) surgery, particularly during the early stages. It could recover over time but some of the patients suffered from delayed or sustained vestibular symptoms after CI. This study used rat animal models to investigate the effect of unilateral cochleost...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/7287180
更新日期:2016-01-01 00:00:00
abstract::Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression (LTD) at the medial perforant path-granule cell synapse in early postnat...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2012/237913
更新日期:2012-01-01 00:00:00
abstract::Studies have shown that, depending on its severity and context, stress can affect neural plasticity. Most related studies focused on synaptic plasticity and long-term potentiation (LTP) of principle cells. However, evidence suggests that following high-frequency stimulation, which induces LTP in principal cells, modif...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/194097
更新日期:2008-01-01 00:00:00
abstract::Stimulating regeneration in the brain has the potential to rescue neuronal networks and counteract progressive pathological changes in Alzheimer's disease (AD). This study investigated whether drugs with different mechanisms of action could enhance neurogenesis and improve cognition in mice receiving human neural stem...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/370432
更新日期:2015-01-01 00:00:00
abstract::To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/5625768
更新日期:2020-07-01 00:00:00
abstract::Chronic stress can impair hippocampal neurogenesis, increase neuronal apoptosis, and cause depressive-like behaviors. Our previous studies found that Radix Scutellariae (RS) can rescue the stress-induced neuronal injury, but the mechanism is not clear. Here, we continued to investigate the underlying antidepressant me...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8886715
更新日期:2020-11-13 00:00:00
abstract::Traumatic brain injury (TBI) is a serious medical and social problem worldwide. Because of the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still lacking. The microglial cells are resident tissue macrophages located in the brain and have two major polarization states, M1 phenotype and M2 ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/5405104
更新日期:2017-01-01 00:00:00
abstract::Little is known about prenatal and perinatal brain injury resulting in subsequent clumsy behavior in children. One candidate motor system is the pyramidal tract. The tract traverses the entire central nervous system and, through direct and indirect connections to the brainstem and spinal cord sensory and motor nuclei,...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.2003.77
更新日期:2003-01-01 00:00:00
abstract::The habituation/cross-habituation test (HaXha) is a spontaneous odor discrimination task that has been used for many decades to evaluate olfactory function in animals. Animals are presented repeatedly with the same odorant after which a new odorant is introduced. The time the animal explores the odor object is measure...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/9131284
更新日期:2016-01-01 00:00:00
abstract::The most dramatic progress in the restoration of hearing takes place in the first months after cochlear implantation. To map the brain activity underlying this process, we used positron emission tomography at three time points: within 14 days, three months, and six months after switch-on. Fifteen recently implanted ad...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2013/318521
更新日期:2013-01-01 00:00:00
abstract::Studies on visually deprived individuals provide one of the most striking demonstrations that the brain is highly plastic and is able to rewire as a function of the sensory input it receives from the environment. In the current paper, we focus on spatial abilities that are typically related to the dorsal visual pathwa...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2012/687659
更新日期:2012-01-01 00:00:00
abstract::Evidence suggests that inflammation and neurogenesis play an important role in major depressive disorder (MDD). Mahuang-Fuzi-Xixin decoction (MFX), as the traditional Chinese prescription, has been widely applied for asthma, migraine, and MDD in clinics. However, the effects of MFX on the potential mechanism in MDD ar...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/1571392
更新日期:2019-11-11 00:00:00
abstract::The song of zebra finch is stable in life after it was learned successfully. Vocal plasticity is thought to be a motor exploration that can support continuous learning and optimization of performance. The activity of RA, an important pre-motor nucleus in songbird's brain, influences the song directly. This variability...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2012/931780
更新日期:2012-01-01 00:00:00