Autism: a "critical period" disorder?

Abstract:

:Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic neurodevelopmental disorder diagnosed by abnormal socialization, impaired communication, and repetitive behaviors or restricted interests. The underlying cause is still largely unknown and there is no fully effective treatment or cure. We propose that alteration of the expression and/or timing of critical period circuit refinement in primary sensory brain areas may significantly contribute to autistic phenotypes, including cognitive and behavioral impairments. Dissection of the cellular and molecular mechanisms governing well-established critical periods represents a powerful tool to identify new potential therapeutic targets to restore normal plasticity and function in affected neuronal circuits.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

LeBlanc JJ,Fagiolini M

doi

10.1155/2011/921680

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

921680

eissn

2090-5904

issn

1687-5443

journal_volume

2011

pub_type

杂志文章,评审
  • Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions.

    abstract::The formation of fear memories is a powerful and highly evolutionary conserved mechanism that serves the behavioral adaptation to environmental threats. Accordingly, classical fear conditioning paradigms have been employed to investigate fundamental molecular processes of memory formation. Evidence suggests that a cir...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/3750307

    authors: Albrecht A,Stork O

    更新日期:2017-01-01 00:00:00

  • Long-Term Impairment of Sound Processing in the Auditory Midbrain by Daily Short-Term Exposure to Moderate Noise.

    abstract::Most citizen people are exposed daily to environmental noise at moderate levels with a short duration. The aim of the present study was to determine the effects of daily short-term exposure to moderate noise on sound level processing in the auditory midbrain. Sound processing properties of auditory midbrain neurons we...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/3026749

    authors: Cheng L,Wang SH,Peng K,Liao XM

    更新日期:2017-01-01 00:00:00

  • Transcranial Direct Current Stimulation (tDCS) in Unilateral Cerebral Palsy: A Pilot Study of Motor Effect.

    abstract::Transcranial Direct Current Stimulation (tDCS) is an emerging tool to improve upper limb motor functions after stroke acquired in adulthood; however, there is a paucity of reports on its efficacy for upper limb motor rehabilitation in congenital or early-acquired stroke. In this pilot study we have explored, for the f...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2019/2184398

    authors: Inguaggiato E,Bolognini N,Fiori S,Cioni G

    更新日期:2019-01-15 00:00:00

  • Effect of Group-Based Rehabilitation Combining Action Observation with Physiotherapy on Freezing of Gait in Parkinson's Disease.

    abstract::Freezing of gait (FoG) is among the most disabling symptoms of Parkinson's disease (PD) patients. Recent studies showed that action observation training (AOT) with repetitive practice of the observed actions represents a strategy to induce longer-lasting effects compared with standard physiotherapy. We investigated wh...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/4897276

    authors: Pelosin E,Barella R,Bet C,Magioncalda E,Putzolu M,Di Biasio F,Cerulli C,Casaleggio M,Abbruzzese G,Avanzino L

    更新日期:2018-05-27 00:00:00

  • HINT1 in Neuropsychiatric Diseases: A Potential Neuroplastic Mediator.

    abstract::Although many studies have investigated the functions of histidine triad nucleotide-binding protein 1 (HINT1), its roles in neurobiological processes remain to be fully elucidated. As a member of the histidine triad (HIT) enzyme superfamily, HINT1 is distributed in almost every organ and has both enzymatic and nonenzy...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5181925

    authors: Liu P,Liu Z,Wang J,Ma X,Dang Y

    更新日期:2017-01-01 00:00:00

  • The Gαo Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons.

    abstract::Mastoparan-7 (Mas-7), an analogue of the peptide mastoparan, which is derived from wasp venom, is a direct activator of Pertussis toxin- (PTX-) sensitive G proteins. Mas-7 produces several biological effects in different cell types; however, little is known about how Mas-7 influences mature hippocampal neurons. We exa...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/4258171

    authors: Ramírez VT,Ramos-Fernández E,Inestrosa NC

    更新日期:2016-01-01 00:00:00

  • Different Degree Centrality Changes in the Brain after Acupuncture on Contralateral or Ipsilateral Acupoint in Patients with Chronic Shoulder Pain: A Resting-State fMRI Study.

    abstract::Chronic shoulder pain (CSP) is the third most common musculoskeletal problem. For maximum treatment effectiveness, most acupuncturists usually choose acupoint in the nonpainful side, to alleviate pain or improve shoulder function. This method is named opposite needling, which means acupuncture points on the right side...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/5701042

    authors: Yan CQ,Huo JW,Wang X,Zhou P,Zhang YN,Li JL,Kim M,Shao JK,Hu SQ,Wang LQ,Liu CZ

    更新日期:2020-04-25 00:00:00

  • Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging.

    abstract::The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8882207

    authors: Couto TA,Xu S,da Silva PA,Wu C,Neergaard K,Wang MY,Zhang J,Xiang Y,Yuan Z

    更新日期:2020-10-06 00:00:00

  • Brain plasticity and disease: a matter of inhibition.

    abstract::One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during develo...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2011/286073

    authors: Baroncelli L,Braschi C,Spolidoro M,Begenisic T,Maffei L,Sale A

    更新日期:2011-01-01 00:00:00

  • In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders.

    abstract::Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer's disease, and epilepsy point to the involve...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9847696

    authors: Pantazopoulos H,Berretta S

    更新日期:2016-01-01 00:00:00

  • Quantification of Upper Limb Motor Recovery and EEG Power Changes after Robot-Assisted Bilateral Arm Training in Chronic Stroke Patients: A Prospective Pilot Study.

    abstract:Background:Bilateral arm training (BAT) has shown promise in expediting progress toward upper limb recovery in chronic stroke patients, but its neural correlates are poorly understood. Objective:To evaluate changes in upper limb function and EEG power after a robot-assisted BAT in chronic stroke patients. Methods:In ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/8105480

    authors: Gandolfi M,Formaggio E,Geroin C,Storti SF,Boscolo Galazzo I,Bortolami M,Saltuari L,Picelli A,Waldner A,Manganotti P,Smania N

    更新日期:2018-03-26 00:00:00

  • Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus.

    abstract::Accumulating evidence implicates a role for brain structures outside the ascending auditory pathway in tinnitus, the phantom perception of sound. In addition to other factors such as age-dependent hearing loss, high-level sound exposure is a prominent cause of tinnitus. Here, we examined how noise exposure altered the...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2021/8833087

    authors: Zhang L,Wu C,Martel DT,West M,Sutton MA,Shore SE

    更新日期:2021-01-14 00:00:00

  • Genetic dissection of learning and memory in mice.

    abstract::In this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies and whole genome sear...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/np.2004.217

    authors: Mineur YS,Crusio WE,Sluyter F

    更新日期:2004-01-01 00:00:00

  • Different Brain Connectivity between Responders and Nonresponders to Dual-Mode Noninvasive Brain Stimulation over Bilateral Primary Motor Cortices in Stroke Patients.

    abstract::Noninvasive brain stimulation (NBS), such as repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS), has been used in stroke patients with motor impairment. NBS can help recovery from brain damage by modulating cortical excitability. However, the efficacy of NBS varies am...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/3826495

    authors: Lee J,Lee A,Kim H,Shin M,Yun SM,Jung Y,Chang WH,Kim YH

    更新日期:2019-04-07 00:00:00

  • Brain-Specific SNAP-25 Deletion Leads to Elevated Extracellular Glutamate Level and Schizophrenia-Like Behavior in Mice.

    abstract::Several studies have associated reduced expression of synaptosomal-associated protein of 25 kDa (SNAP-25) with schizophrenia, yet little is known about its role in the illness. In this paper, a forebrain glutamatergic neuron-specific SNAP-25 knockout mouse model was constructed and studied to explore the possible path...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/4526417

    authors: Yang H,Zhang M,Shi J,Zhou Y,Wan Z,Wang Y,Wan Y,Li J,Wang Z,Fei J

    更新日期:2017-01-01 00:00:00

  • Action Observation Treatment Improves Upper Limb Motor Functions in Children with Cerebral Palsy: A Combined Clinical and Brain Imaging Study.

    abstract::The aim of the present study was to assess the role of action observation treatment (AOT) in the rehabilitation of upper limb motor functions in children with cerebral palsy. We carried out a two-group, parallel randomized controlled trial. Eighteen children (aged 5-11 yr) entered the study: 11 were treated children, ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/4843985

    authors: Buccino G,Molinaro A,Ambrosi C,Arisi D,Mascaro L,Pinardi C,Rossi A,Gasparotti R,Fazzi E,Galli J

    更新日期:2018-07-04 00:00:00

  • The effects of early-life predator stress on anxiety- and depression-like behaviors of adult rats.

    abstract::Childhood emotional trauma contributes significantly to certain psychopathologies, such as post-traumatic stress disorder. In experimental animals, however, whether or not early-life stress results in behavioral abnormalities in adult animals still remains controversial. Here, we investigated both short-term and long-...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2014/163908

    authors: Chen LJ,Shen BQ,Liu DD,Li ST

    更新日期:2014-01-01 00:00:00

  • Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity.

    abstract::The development of new strategies to renew and repair neuronal networks using neural plasticity induced by stem cell graft could enable new therapies to cure diseases that were considered lethal until now. In adequate microenvironment a neuronal progenitor must receive molecular signal of a specific cellular context t...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/1568145

    authors: Ramírez-Barrantes R,Cordova C,Poblete H,Muñoz P,Marchant I,Wianny F,Olivero P

    更新日期:2016-01-01 00:00:00

  • Operant discriminative learning and evidence of subtelencephalic plastic changes after long-term detelencephalation in pigeons.

    abstract::We analyzed operant discrimination in detelencephalated pigeons and neuroanatomical substrates after long-term detelencephalation. In Experiment I, experimental pigeons with massive telencephalic ablation and control pigeons were conditioned to key peck for food. Successive discrimination was made under alternating re...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/NP.2003.247

    authors: Cerutti SM,Diaz-Cintra S,Cintra L,Ferrari EA

    更新日期:2003-01-01 00:00:00

  • Effects of Temporary Functional Deafferentation in Chronic Stroke Patients: Who Profits More?

    abstract::Temporary functional deafferentation (TFD) by an anesthetic cream on the stroke-affected forearm was shown to improve sensorimotor abilities of stroke patients. The present study investigated different predictors for sensorimotor improvements during TFD and indicated outcome differences between patients grouped in sub...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/7392024

    authors: Sens E,Franz M,Preul C,Meissner W,Witte OW,Miltner WHR,Weiss T

    更新日期:2018-07-29 00:00:00

  • Dopaminergic Modulation of Striatal Inhibitory Transmission and Long-Term Plasticity.

    abstract::Dopamine (DA) modulates glutamatergic synaptic transmission and its plasticity in the striatum; however it is not well known how DA modulates long-term plasticity of striatal GABAergic inhibitory synapses. This work focused on the analysis of both dopaminergic modulation of inhibitory synapses and the synaptic plastic...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/789502

    authors: Nieto Mendoza E,Hernández Echeagaray E

    更新日期:2015-01-01 00:00:00

  • Functional Corticomuscular Signal Coupling Is Weakened during Voluntary Motor Action in Cancer-Related Fatigue.

    abstract:Background and Purpose:Cancer-related fatigue (CRF) is widely recognized as one of the most common symptoms and side effects of cancer and/or its treatment. However, neuropathological mechanisms contributing to CRF are largely unknown, and the lack of knowledge makes CRF difficult to treat. Recent research has shown di...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/2490750

    authors: Jiang C,Yang Q,Chen T,Siemionow V,Ranganathan VK,Yan AF,Yue GH

    更新日期:2019-06-26 00:00:00

  • High-Frequency Synchronization Improves Firing Rate Contrast and Information Transmission Efficiency in E/I Neuronal Networks.

    abstract::High-frequency synchronization has been found in many real neural systems and is confirmed by excitatory/inhibitory (E/I) network models. However, the functional role played by it remains elusive. In this paper, it is found that high-frequency synchronization in E/I neuronal networks could improve the firing rate cont...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8823111

    authors: Han F,Wang Z,Fan H,Zhang Y

    更新日期:2020-11-09 00:00:00

  • Mutation in the Hair Cell Specific Gene POU4F3 Is a Common Cause for Autosomal Dominant Nonsyndromic Hearing Loss in Chinese Hans.

    abstract::Autosomal dominant nonsyndromic hearing loss (ADNSHL) is extremely heterogeneous. So far the genetic etiological contribution of the gene POU4F3 associated with ADNSHL has been rarely reported. In our previous study, a c.603_604delGG mutation in the hair cell specific gene POU4F3 has been identified as the pathogenic ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/9890827

    authors: He L,Pang X,Chen P,Wu H,Yang T

    更新日期:2016-01-01 00:00:00

  • Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy.

    abstract::Dizziness and vertigo frequently occur after cochlear implantation (CI) surgery, particularly during the early stages. It could recover over time but some of the patients suffered from delayed or sustained vestibular symptoms after CI. This study used rat animal models to investigate the effect of unilateral cochleost...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/7287180

    authors: Suh MW,Hyun J,Lyu AR,Kim DW,Park SJ,Choi JW,Hur GM,Park YH

    更新日期:2016-01-01 00:00:00

  • The Endocannabinoid System as a Therapeutic Target in Glaucoma.

    abstract::Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable att...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9364091

    authors: Cairns EA,Baldridge WH,Kelly ME

    更新日期:2016-01-01 00:00:00

  • Action Video Game Experience Related to Altered Large-Scale White Matter Networks.

    abstract::With action video games (AVGs) becoming increasingly popular worldwide, the cognitive benefits of AVG experience have attracted continuous research attention over the past two decades. Research has repeatedly shown that AVG experience can causally enhance cognitive ability and is related to neural plasticity in gray m...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/7543686

    authors: Gong D,Ma W,Gong J,He H,Dong L,Zhang D,Li J,Luo C,Yao D

    更新日期:2017-01-01 00:00:00

  • Corrigendum to "Short-Term Monocular Deprivation Enhances Physiological Pupillary Oscillations".

    abstract::[This corrects the article DOI: 10.1155/2017/6724631.]. ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,已发布勘误

    doi:10.1155/2017/3634598

    authors: Binda P,Lunghi C

    更新日期:2017-01-01 00:00:00

  • The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts.

    abstract::Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early o...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2015/434127

    authors: Leite RT,Nogueira Sde O,do Nascimento JP,de Lima LS,da Nóbrega TB,Virgínio Mda S,Moreno LM,Sampaio BH,de Matos E Souza FG

    更新日期:2015-01-01 00:00:00

  • Radix Scutellariae Ameliorates Stress-Induced Depressive-Like Behaviors via Protecting Neurons through the TGFβ3-Smad2/3-Nedd9 Signaling Pathway.

    abstract::Chronic stress can impair hippocampal neurogenesis, increase neuronal apoptosis, and cause depressive-like behaviors. Our previous studies found that Radix Scutellariae (RS) can rescue the stress-induced neuronal injury, but the mechanism is not clear. Here, we continued to investigate the underlying antidepressant me...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8886715

    authors: Zhao F,Zhang C,Xiao D,Zhang W,Zhou L,Gu S,Qu R

    更新日期:2020-11-13 00:00:00