Abstract:
:Transcranial Direct Current Stimulation (tDCS) is an emerging tool to improve upper limb motor functions after stroke acquired in adulthood; however, there is a paucity of reports on its efficacy for upper limb motor rehabilitation in congenital or early-acquired stroke. In this pilot study we have explored, for the first time, the immediate effects, and their short-term persistence, of a single application of anodal tDCS on chronic upper limb motor disorders in children and young individuals with Unilateral Cerebral Palsy (UCP). To this aim, in a crossover sham-controlled study, eight subjects aged 10-28 years with UCP underwent two sessions of active and sham tDCS. Anodal tDCS (1.5 mA, 20 min) was delivered over the primary motor cortex (M1) of the ipsilesional hemisphere. Results showed, only following the active stimulation, an immediate improvement in unimanual gross motor dexterity of hemiplegic, but not of nonhemiplegic, hand in Box and Block test (BBT). Such improvement remained stable for at least 90 minutes. Performance of both hands in Hand Grip Strength test was not modified by anodal tDCS. Improvement in BBT was unrelated to participants' age or lesion size, as revealed by MRI data analysis. No serious adverse effects occurred after tDCS; some mild and transient side effects (e.g., headache, tingling, and itchiness) were reported in a limited number of cases. This study provides an innovative contribution to scientific literature on the efficacy and safety of anodal tDCS in UCP. This trial is registered with NCT03137940.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Inguaggiato E,Bolognini N,Fiori S,Cioni Gdoi
10.1155/2019/2184398subject
Has Abstractpub_date
2019-01-15 00:00:00pages
2184398eissn
2090-5904issn
1687-5443journal_volume
2019pub_type
杂志文章,随机对照试验abstract::Mirror visual feedback (MVF) therapy has been applied to improve upper limb function in stroke. When combined with motor training, MVF improves the performance of the trained and untrained hand by enhancing the excitability of both primary motor cortices (M1s). Bradykinesia is a typical feature of Parkinson's disease ...
journal_title:Neural plasticity
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Neural plasticity
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
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doi:10.1155/2016/9890827
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Neural plasticity
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
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journal_title:Neural plasticity
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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