Abstract:
Background and Purpose:Cancer-related fatigue (CRF) is widely recognized as one of the most common symptoms and side effects of cancer and/or its treatment. However, neuropathological mechanisms contributing to CRF are largely unknown, and the lack of knowledge makes CRF difficult to treat. Recent research has shown dissociation between changes in the brain and muscle signals during voluntary motor performance in cancer survivors with CRF, and this dissociation may be caused by an interruption in functional coupling (FC) of the two signals. The goal of this study was to assess the FC between EEG (cortical signal) and EMG (muscular signal) in individuals with CRF and compare the FC with that of healthy controls during a motor task that led to progressive muscle fatigue. Method:Eight cancer survivors with CRF and nine healthy participants sustained an isometric elbow flexion contraction (at 30% maximal level) until self-perceived exhaustion. The entire duration of the EEG and EMG recordings was divided into the first-half (less-fatigue stage) and second-half (more-fatigue stage) artifact-free epochs without overlapping. The EEG-EMG coupling (measured by coherence of the two signals) in each group and stage was computed. Coherence values at different frequencies were statistically analyzed using a repeated-measure general linear model. Results:The results demonstrated that compared to healthy controls, CRF participants sustained the contraction for a significantly shorter time and exhibited robust and significantly lower EEG-EMG coherence at the alpha (8~14 Hz) and beta (15~35 Hz) frequency bands. Both the CRF and healthy control groups exhibited significantly decreased EEG-EMG coherence from the less-fatigue to more-fatigue stages at the alpha and beta frequency bands, indicating fatigue-induced weakening of functional corticomuscular coupling. Conclusion:Impaired functional coupling between the brain and muscle signals could be a consequence of cancer and/or its treatment, and it may be one of the contributing factors to the abnormal feeling of fatigue that caused the early failure of sustaining a prolonged motor task.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Jiang C,Yang Q,Chen T,Siemionow V,Ranganathan VK,Yan AF,Yue GHdoi
10.1155/2019/2490750subject
Has Abstractpub_date
2019-06-26 00:00:00pages
2490750eissn
2090-5904issn
1687-5443journal_volume
2019pub_type
杂志文章abstract::Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment. RT is effective for tumor eradication, and survival rates are high. However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive "late" effects that may take years...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/698528
更新日期:2013-01-01 00:00:00
abstract::Although many studies have investigated the functions of histidine triad nucleotide-binding protein 1 (HINT1), its roles in neurobiological processes remain to be fully elucidated. As a member of the histidine triad (HIT) enzyme superfamily, HINT1 is distributed in almost every organ and has both enzymatic and nonenzy...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/5181925
更新日期:2017-01-01 00:00:00
abstract::Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective function...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8583420
更新日期:2016-01-01 00:00:00
abstract::Neurophysiological and neuroimaging data suggest that the brains of not only children but also adults are reorganized based on sensory inputs and behaviors. Plastic changes in the brain are generally beneficial; however, maladaptive cortical reorganization in the auditory cortex may lead to hearing disorders such as t...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2018/2546250
更新日期:2018-05-20 00:00:00
abstract::The present study investigates whether a combined cognitive and physical training may induce changes in the cortical activity as measured via electroencephalogram (EEG) and whether this change may index a deceleration of pathological processes of brain aging. Seventy seniors meeting the clinical criteria of mild cogni...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/172192
更新日期:2015-01-01 00:00:00
abstract::Temporal mechanisms for processing auditory musical rhythms are well established, in which a perceived beat is beneficial for timing purposes. It is yet unknown whether such beat-based timing would also underlie visual perception of temporally structured, ecological stimuli connected to music: dance. In this study, we...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/1678390
更新日期:2016-01-01 00:00:00
abstract::Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscill...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/1478684
更新日期:2016-01-01 00:00:00
abstract::Elevated brain activation, or hyperexcitability, induces cognitive impairment and confers an increased risk of Alzheimer's disease (AD). Blocking the overexcitation of the neural network may be a promising new strategy to prevent, halt, and even reverse this condition. Physical exercise has been shown to be an effecti...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/9132720
更新日期:2020-03-18 00:00:00
abstract::Background. Clinically, electroacupuncture (EA) is the most common therapy for aging-related cognitive impairment (CI). However, the underlying pathomechanism remains unidentified. The aims of this study were to observe the effect of EA on cognitive function and explore the potential mechanism by which EA acts on the ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8853720
更新日期:2020-11-04 00:00:00
abstract:Background:Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. Th...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/9460364
更新日期:2020-09-22 00:00:00
abstract::Ionizing radiation is omnipresent. We are continuously exposed to natural (e.g., radon and cosmic) and man-made radiation sources, including those from industry but especially from the medical sector. The increasing use of medical radiation modalities, in particular those employing low-dose radiation such as CT scans,...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/1243527
更新日期:2016-01-01 00:00:00
abstract::Histamine H4 receptor has been confirmed to play a role in evoking peripheral pruritus. However, the ionic and intracellular signaling mechanism of activation of H4 receptor on the dorsal root ganglion (DRG) neurons is still unknown. By using cell culture and calcium imaging, we studied the underlying mechanism of act...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/1682972
更新日期:2016-01-01 00:00:00
abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/4135708
更新日期:2018-10-10 00:00:00
abstract::The objective of this study was to assess the evolution of diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI) over the first month of life in asphyxiated newborns treated with hypothermia and to compare it with that of healthy newborns. Asphyxiated newborns treated with hypothermia were enrolled prosp...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/653727
更新日期:2015-01-01 00:00:00
abstract:Background:Parkinson's disease (PD) patients experience cognitive impairment which has been related to reduced quality of life and functional disability. These symptoms usually progress until dementia occurs. Some studies have been published assessing the efficacy of cognitive treatments on improving cognition, functio...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2018/2651918
更新日期:2018-05-06 00:00:00
abstract::The recent developments of a particular approach to analyzing motor synergies based on the principle of motor abundance has allowed a quantitative assessment of multi-effector coordination in motor tasks involving anticipatory adjustments to self-triggered postural perturbations and in voluntary postural sway. This ap...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2005.119
更新日期:2005-01-01 00:00:00
abstract::The plasticity of brain function, especially reorganization after stroke or sensory loss, has been investigated extensively. Based upon its special characteristics, the olfactory system allows the investigation of functional networks in patients with smell loss, as it holds the unique ability to be activated by the se...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/140419
更新日期:2014-01-01 00:00:00
abstract::To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/5625768
更新日期:2020-07-01 00:00:00
abstract::The aim of the present study was to assess the role of action observation treatment (AOT) in the rehabilitation of upper limb motor functions in children with cerebral palsy. We carried out a two-group, parallel randomized controlled trial. Eighteen children (aged 5-11 yr) entered the study: 11 were treated children, ...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/4843985
更新日期:2018-07-04 00:00:00
abstract::Neuropathic pain increases the risk of cardiovascular diseases including hypertension with the characteristic of sympathetic overactivity. The enhanced tonically active glutamatergic input to the rostral ventrolateral medulla (RVLM) contributes to sympathetic overactivity and blood pressure (BP) in cardiovascular dise...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/4174010
更新日期:2017-01-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS) can enhance the effect of conventional therapies in post-stroke neurorehabilitation. The ability to predict an individual's potential for tDCS-induced recovery may permit rehabilitation providers to make rational decisions about who will be a good candidate for tDCS thera...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8859394
更新日期:2020-11-25 00:00:00
abstract::A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and exp...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2011/649325
更新日期:2011-01-01 00:00:00
abstract::Objective. To explore cortical reorganization of patients recovered from Bell's palsy (BP) by task-state functional magnetic resonance imaging (fMRI) during finger and orofacial movements and provide more evidence for acupuncture clinical treatment of BP. Methods. We collected 17 BP patients with complete clinical rec...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8231726
更新日期:2016-01-01 00:00:00
abstract::We do not all grow older in the same way. Some individuals have a cognitive decline earlier and faster than others who are older in years but cerebrally younger. This is particularly easy to verify in people who have maintained regular physical activity and healthy and cognitively stimulating lifestyle and even in the...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/7219461
更新日期:2017-01-01 00:00:00
abstract::Adult hippocampal neurogenesis is a process involving the continuous generation of newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested that hippocampal neurogenesis contributes to some forms of hippocampus-dependent learning and memory; however, the detailed mechanism concerning how th...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2015/717958
更新日期:2015-01-01 00:00:00
abstract::Transcranial Direct Current Stimulation (tDCS) is an emerging tool to improve upper limb motor functions after stroke acquired in adulthood; however, there is a paucity of reports on its efficacy for upper limb motor rehabilitation in congenital or early-acquired stroke. In this pilot study we have explored, for the f...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/2184398
更新日期:2019-01-15 00:00:00
abstract::The entorhinal cortex (EC) is a nodal and independent mnemonic element of the medial temporal lobe memory circuit as it forms a bidirectional interface between the neocortex and hippocampus. Within the EC, intra- and inter-lamellar associational connections occur via horizontal and columnar projections, respectively. ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/814815
更新日期:2008-01-01 00:00:00
abstract::Prenatal stress (PS) has long-term sequelae for the morphological and functional status of the central nervous system of the progeny. A PS-induced proinflammatory status of the organism may result in an impairment of both hippocampal synaptic plasticity and hippocampus-dependent memory formation in adults. We addresse...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/3152129
更新日期:2019-01-21 00:00:00
abstract::Childhood emotional trauma contributes significantly to certain psychopathologies, such as post-traumatic stress disorder. In experimental animals, however, whether or not early-life stress results in behavioral abnormalities in adult animals still remains controversial. Here, we investigated both short-term and long-...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/163908
更新日期:2014-01-01 00:00:00
abstract::Following central motor lesions, two forms of adaptation can be observed which lead to improved mobility: (1) the development of spastic muscle tone, and (2) the activation of spinal locomotor centers induced by specific treadmill training. Tension development during spastic gait is different from that during normal g...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2001.83
更新日期:2001-01-01 00:00:00