Radix Scutellariae Ameliorates Stress-Induced Depressive-Like Behaviors via Protecting Neurons through the TGFβ3-Smad2/3-Nedd9 Signaling Pathway.

Abstract:

:Chronic stress can impair hippocampal neurogenesis, increase neuronal apoptosis, and cause depressive-like behaviors. Our previous studies found that Radix Scutellariae (RS) can rescue the stress-induced neuronal injury, but the mechanism is not clear. Here, we continued to investigate the underlying antidepressant mechanisms of the RS extract. A 7-week chronic unpredictable mild stress (CUMS) procedure was used to establish a murine depression model. 0.75 g/kg or 1.5 g/kg RS was administered daily to the mice during the last 4 weeks. Depressive-like behaviors were evaluated by the sucrose preference test (SPT), forced swimming test (FST), open field test (OFT), and tail suspension test (TST). The neuroprotective effect of RS was evaluated with the expression of hippocampal neuron-related markers and apoptosis-associated proteins by Nissl staining, immunohistochemistry, and western blot. Transforming growth factor-β3 (TGFβ3) pathway-related proteins were detected by western blot. Results showed that RS could ameliorate depressive-like behaviors, increase the expression of the antiapoptotic protein B-cell lymphoma 2 (BCL-2), reduce the expression of the proapoptotic protein BCL-2-associated X (BAX), and increase the number of doublecortin- (DCX-), microtubule-associated protein 2- (MAP2-), and neuronal nucleus- (NeuN-) positive cells in the hippocampus. Moreover, RS could reverse the CUMS-induced decrease of TGFβ3 protein, promote the phosphorylation of SMAD2/3, and increase the expression of downstream NEDD9 protein. These results suggest that RS could exert antidepressant effects via protecting neurons. And the molecular mechanism might be related to the regulation of the TGFβ3-SMAD2/3-NEDD9 pathway.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Zhao F,Zhang C,Xiao D,Zhang W,Zhou L,Gu S,Qu R

doi

10.1155/2020/8886715

subject

Has Abstract

pub_date

2020-11-13 00:00:00

pages

8886715

eissn

2090-5904

issn

1687-5443

journal_volume

2020

pub_type

杂志文章
  • Plasticity of horizontal connections at a functional border in adult rat somatosensory cortex.

    abstract::Horizontal connections in superficial cortical layers integrate information across sensory maps by connecting related functional columns. It has been hypothesized that these connections mediate cortical reorganization via synaptic plasticity. However, it is not known if the horizontal connections from discontinuous co...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2009/294192

    authors: Marik SA,Hickmott PW

    更新日期:2009-01-01 00:00:00

  • The GABA-withdrawal syndrome: a model of local status epilepticus.

    abstract::The GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex. GWS is characterized by focal epileptic electroencephalographic discharges and associated contralateral myoclonus. In neocortical slices obtained from GWS rat...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2000.9

    authors: Silva-Barrat C,Champagnat J,Menini C

    更新日期:2000-01-01 00:00:00

  • Astrocyte-secreted matricellular proteins in CNS remodelling during development and disease.

    abstract::Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have rev...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2014/321209

    authors: Jones EV,Bouvier DS

    更新日期:2014-01-01 00:00:00

  • Neurogenesis, exercise, and cognitive late effects of pediatric radiotherapy.

    abstract::Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment. RT is effective for tumor eradication, and survival rates are high. However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive "late" effects that may take years...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2013/698528

    authors: Rodgers SP,Trevino M,Zawaski JA,Gaber MW,Leasure JL

    更新日期:2013-01-01 00:00:00

  • Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome.

    abstract::Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learn...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9353929

    authors: Yang T,Zhao H,Lu C,Li X,Xie Y,Fu H,Xu H

    更新日期:2016-01-01 00:00:00

  • Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking.

    abstract::Evidence from neuropathological, genetic, animal model, and biochemical studies has indicated that the accumulation of amyloid-beta (Aβ) is associated with, and probably induces, profound neuronal changes in brain regions critical for memory and cognition in the development of Alzheimer's disease (AD). There is consid...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/3204519

    authors: Guntupalli S,Widagdo J,Anggono V

    更新日期:2016-01-01 00:00:00

  • Effects of Transcranial Alternating Current Stimulation on Cognitive Functions in Healthy Young and Older Adults.

    abstract::Recently, transcranial alternating current stimulation (tACS) has emerged as a tool to enhance human cognitive processes. Here, we provide a brief summary of the rationale behind tACS-induced effects on task-relevant brain oscillations and associated cognitive functions and review previous studies in young subjects th...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/4274127

    authors: Antonenko D,Faxel M,Grittner U,Lavidor M,Flöel A

    更新日期:2016-01-01 00:00:00

  • Cortical Reorganization in Patients Recovered from Bell's Palsy: An Orofacial and Finger Movements Task-State fMRI Study.

    abstract::Objective. To explore cortical reorganization of patients recovered from Bell's palsy (BP) by task-state functional magnetic resonance imaging (fMRI) during finger and orofacial movements and provide more evidence for acupuncture clinical treatment of BP. Methods. We collected 17 BP patients with complete clinical rec...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/8231726

    authors: Lee J,Yang J,Li C,Yuan A,Wu H,Wang A,Xue Q,Wang T,Wang L,Gao T

    更新日期:2016-01-01 00:00:00

  • Topological Properties of Large-Scale Cortical Networks Based on Multiple Morphological Features in Amnestic Mild Cognitive Impairment.

    abstract::Previous studies have demonstrated that amnestic mild cognitive impairment (aMCI) has disrupted properties of large-scale cortical networks based on cortical thickness and gray matter volume. However, it is largely unknown whether the topological properties of cortical networks based on geometric measures (i.e., sulca...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/3462309

    authors: Li Q,Li X,Wang X,Li Y,Li K,Yu Y,Yin C,Li S,Han Y

    更新日期:2016-01-01 00:00:00

  • From spinal central pattern generators to cortical network: integrated BCI for walking rehabilitation.

    abstract::Success in locomotor rehabilitation programs can be improved with the use of brain-computer interfaces (BCIs). Although a wealth of research has demonstrated that locomotion is largely controlled by spinal mechanisms, the brain is of utmost importance in monitoring locomotor patterns and therefore contains information...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2012/375148

    authors: Cheron G,Duvinage M,De Saedeleer C,Castermans T,Bengoetxea A,Petieau M,Seetharaman K,Hoellinger T,Dan B,Dutoit T,Sylos Labini F,Lacquaniti F,Ivanenko Y

    更新日期:2012-01-01 00:00:00

  • Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice.

    abstract::Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke. However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in diabetes. We aim to investigate the effect and the potential mechanism of NLRP3 inflammasome in diabetic mice with cerebral ischemia-reperfusion i...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/9163521

    authors: Hong P,Li FX,Gu RN,Fang YY,Lai LY,Wang YW,Tao T,Xu SY,You ZJ,Zhang HF

    更新日期:2018-04-24 00:00:00

  • Human Auditory and Adjacent Nonauditory Cerebral Cortices Are Hypermetabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS).

    abstract::Tinnitus is the phantom perception of sound in the absence of an acoustic stimulus. To date, the purported neural correlates of tinnitus from animal models have not been adequately characterized with translational technology in the human brain. The aim of the present study was to measure changes in oxy-hemoglobin conc...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/7453149

    authors: Issa M,Bisconti S,Kovelman I,Kileny P,Basura GJ

    更新日期:2016-01-01 00:00:00

  • Quantification of Upper Limb Motor Recovery and EEG Power Changes after Robot-Assisted Bilateral Arm Training in Chronic Stroke Patients: A Prospective Pilot Study.

    abstract:Background:Bilateral arm training (BAT) has shown promise in expediting progress toward upper limb recovery in chronic stroke patients, but its neural correlates are poorly understood. Objective:To evaluate changes in upper limb function and EEG power after a robot-assisted BAT in chronic stroke patients. Methods:In ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/8105480

    authors: Gandolfi M,Formaggio E,Geroin C,Storti SF,Boscolo Galazzo I,Bortolami M,Saltuari L,Picelli A,Waldner A,Manganotti P,Smania N

    更新日期:2018-03-26 00:00:00

  • Genesis and Maintenance of Attentional Biases: The Role of the Locus Coeruleus-Noradrenaline System.

    abstract::Emotionally arousing events are typically better remembered than mundane ones, in part because emotionally relevant aspects of our environment are prioritized in attention. Such biased attentional tuning is itself the result of associative processes through which we learn affective and motivational relevance of cues. ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/6817349

    authors: Ehlers MR,Todd RM

    更新日期:2017-01-01 00:00:00

  • Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic α7 Nicotinic Receptor Drugs.

    abstract::Stimulating regeneration in the brain has the potential to rescue neuronal networks and counteract progressive pathological changes in Alzheimer's disease (AD). This study investigated whether drugs with different mechanisms of action could enhance neurogenesis and improve cognition in mice receiving human neural stem...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/370432

    authors: Lilja AM,Malmsten L,Röjdner J,Voytenko L,Verkhratsky A,Ögren SO,Nordberg A,Marutle A

    更新日期:2015-01-01 00:00:00

  • The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy.

    abstract::Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurodegenerative disorders such as Parkinson's disease (PD). In sporadic PD, the most common age-related neurodegenerative movement disorder, nigrostriatal dopaminergic deficits are responsible for the onset of motor symptoms...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5012129

    authors: Longhena F,Faustini G,Missale C,Pizzi M,Spano P,Bellucci A

    更新日期:2017-01-01 00:00:00

  • Recovery of olfactory function induces neuroplasticity effects in patients with smell loss.

    abstract::The plasticity of brain function, especially reorganization after stroke or sensory loss, has been investigated extensively. Based upon its special characteristics, the olfactory system allows the investigation of functional networks in patients with smell loss, as it holds the unique ability to be activated by the se...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2014/140419

    authors: Kollndorfer K,Kowalczyk K,Hoche E,Mueller CA,Pollak M,Trattnig S,Schöpf V

    更新日期:2014-01-01 00:00:00

  • TRPV1 and PLC Participate in Histamine H4 Receptor-Induced Itch.

    abstract::Histamine H4 receptor has been confirmed to play a role in evoking peripheral pruritus. However, the ionic and intracellular signaling mechanism of activation of H4 receptor on the dorsal root ganglion (DRG) neurons is still unknown. By using cell culture and calcium imaging, we studied the underlying mechanism of act...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/1682972

    authors: Jian T,Yang N,Yang Y,Zhu C,Yuan X,Yu G,Wang C,Wang Z,Shi H,Tang M,He Q,Lan L,Wu G,Tang Z

    更新日期:2016-01-01 00:00:00

  • Spindle Oscillations in Sleep Disorders: A Systematic Review.

    abstract::Measurement of sleep microarchitecture and neural oscillations is an increasingly popular technique for quantifying EEG sleep activity. Many studies have examined sleep spindle oscillations in sleep-disordered adults; however reviews of this literature are scarce. As such, our overarching aim was to critically review ...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/7328725

    authors: Weiner OM,Dang-Vu TT

    更新日期:2016-01-01 00:00:00

  • Genetics and function of neocortical GABAergic interneurons in neurodevelopmental disorders.

    abstract::A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and exp...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2011/649325

    authors: Rossignol E

    更新日期:2011-01-01 00:00:00

  • Sustained Activity of Metabotropic Glutamate Receptor: Homer, Arrestin, and Beyond.

    abstract::When activated, metabotropic glutamate receptors (mGlus) exert long-lasting changes within the glutamatergic synapses. One mechanism is a tonic effect of downstream signal transduction pathways via sustained activation of mGlu itself. Like many other G protein-coupled receptors (GPCRs), mGlu can exist in a constitutiv...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5125624

    authors: Chung G,Kim SJ

    更新日期:2017-01-01 00:00:00

  • Visual Timing of Structured Dance Movements Resembles Auditory Rhythm Perception.

    abstract::Temporal mechanisms for processing auditory musical rhythms are well established, in which a perceived beat is beneficial for timing purposes. It is yet unknown whether such beat-based timing would also underlie visual perception of temporally structured, ecological stimuli connected to music: dance. In this study, we...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/1678390

    authors: Su YH,Salazar-López E

    更新日期:2016-01-01 00:00:00

  • Altered Brain Activity and Functional Connectivity in Unilateral Sudden Sensorineural Hearing Loss.

    abstract:Background:Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. Th...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/9460364

    authors: Chen J,Hu B,Qin P,Gao W,Liu C,Zi D,Ding X,Yu Y,Cui G,Lu L

    更新日期:2020-09-22 00:00:00

  • The Habituation/Cross-Habituation Test Revisited: Guidance from Sniffing and Video Tracking.

    abstract::The habituation/cross-habituation test (HaXha) is a spontaneous odor discrimination task that has been used for many decades to evaluate olfactory function in animals. Animals are presented repeatedly with the same odorant after which a new odorant is introduced. The time the animal explores the odor object is measure...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/9131284

    authors: Coronas-Samano G,Ivanova AV,Verhagen JV

    更新日期:2016-01-01 00:00:00

  • The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts.

    abstract::Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early o...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2015/434127

    authors: Leite RT,Nogueira Sde O,do Nascimento JP,de Lima LS,da Nóbrega TB,Virgínio Mda S,Moreno LM,Sampaio BH,de Matos E Souza FG

    更新日期:2015-01-01 00:00:00

  • Different Visual Weighting due to Fast or Slow Vestibular Deafferentation: Before and after Schwannoma Surgery.

    abstract:Background:Feedback postural control depends upon information from somatosensation, vision, and the vestibular system that are weighted depending on their relative importance within the central nervous system. Following loss of any sensory component, the weighting changes, e.g., when suffering a vestibular loss, the mo...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/4826238

    authors: Tjernström F,Fransson PA,Kahlon B,Karlberg M,Lindberg S,Siesjö P,Magnusson M

    更新日期:2019-02-18 00:00:00

  • Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus.

    abstract::Accumulating evidence implicates a role for brain structures outside the ascending auditory pathway in tinnitus, the phantom perception of sound. In addition to other factors such as age-dependent hearing loss, high-level sound exposure is a prominent cause of tinnitus. Here, we examined how noise exposure altered the...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2021/8833087

    authors: Zhang L,Wu C,Martel DT,West M,Sutton MA,Shore SE

    更新日期:2021-01-14 00:00:00

  • Carbachol-Induced Reduction in the Activity of Adult Male Zebra Finch RA Projection Neurons.

    abstract::Cholinergic mechanism is involved in motor behavior. In songbirds, the robust nucleus of the arcopallium (RA) is a song premotor nucleus in the pallium and receives cholinergic inputs from the basal forebrain. The activity of projection neurons in RA determines song motor behavior. Although many evidences suggest that...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/7246827

    authors: Meng W,Wang SH,Li DF

    更新日期:2016-01-01 00:00:00

  • Magnetic Seizure Therapy for Unipolar and Bipolar Depression: A Systematic Review.

    abstract:UNLABELLED:Objective. Magnetic seizure therapy (MST) is a novel, experimental therapeutic intervention, which combines therapeutic aspects of electroconvulsive therapy (ECT) and transcranial magnetic stimulation, in order to achieve the efficacy of the former with the safety of the latter. MST might prove to be a valua...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2015/521398

    authors: Cretaz E,Brunoni AR,Lafer B

    更新日期:2015-01-01 00:00:00

  • Mirror Visual Feedback to Improve Bradykinesia in Parkinson's Disease.

    abstract::Mirror visual feedback (MVF) therapy has been applied to improve upper limb function in stroke. When combined with motor training, MVF improves the performance of the trained and untrained hand by enhancing the excitability of both primary motor cortices (M1s). Bradykinesia is a typical feature of Parkinson's disease ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/8764238

    authors: Bonassi G,Pelosin E,Ogliastro C,Cerulli C,Abbruzzese G,Avanzino L

    更新日期:2016-01-01 00:00:00