Abstract:
:Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke. However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in diabetes. We aim to investigate the effect and the potential mechanism of NLRP3 inflammasome in diabetic mice with cerebral ischemia-reperfusion injury. A type 2 diabetic mouse model was induced by a high-fat diet and streptozotocin (STZ). Diabetic mice received MCC950 (the specific molecule NLRP3 inhibitor) or vehicle 60 minutes before the middle cerebral artery occlusion (MCAO) and reperfusion. MCC950 reduced the neurological deficit score of 24 h after cerebral ischemia reperfusion and improved the 28-day survival rate of cerebral ischemia-reperfusion injury in diabetic mice. Furthermore, we found that the mRNA transcription levels of NLRP3, IL-1β, and caspase-1 in the core ischemic area were remarkably amplified in diabetic mice with cerebral ischemia-reperfusion injury, whereas this phenomenon was obviously attenuated by MCC950 pretreatment. In conclusion, the NLRP3 inflammasome was involved in the complex diseases of diabetic stroke. MCC950, the NLRP3 specific inhibitor, ameliorated diabetic mice with cerebral ischemia-reperfusion injury and improved the 28-day survival rate during the recovery stage of ischemic stroke.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Hong P,Li FX,Gu RN,Fang YY,Lai LY,Wang YW,Tao T,Xu SY,You ZJ,Zhang HFdoi
10.1155/2018/9163521subject
Has Abstractpub_date
2018-04-24 00:00:00pages
9163521eissn
2090-5904issn
1687-5443journal_volume
2018pub_type
杂志文章abstract:Objective:To determine whether and how longitudinal acupuncture modulates the impaired default mode network (DMN) in chronic migraine (CM) patients without aura. Methods:Resting-state functional magnetic resonance imaging (fMRI) data from 14 CM patients treated with longitudinal pre- and postacupuncture treatment (PPA...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/5047463
更新日期:2019-03-18 00:00:00
abstract::Temporal mechanisms for processing auditory musical rhythms are well established, in which a perceived beat is beneficial for timing purposes. It is yet unknown whether such beat-based timing would also underlie visual perception of temporally structured, ecological stimuli connected to music: dance. In this study, we...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/1678390
更新日期:2016-01-01 00:00:00
abstract::The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8882207
更新日期:2020-10-06 00:00:00
abstract::Adult hippocampal neurogenesis is a process involving the continuous generation of newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested that hippocampal neurogenesis contributes to some forms of hippocampus-dependent learning and memory; however, the detailed mechanism concerning how th...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2015/717958
更新日期:2015-01-01 00:00:00
abstract::Heterogeneous neurological responses of acupuncture between different groups have been proposed by previous studies but rarely studied. The study described here was designed to explore the divergence of acupuncture at Taixi (KI3) on spontaneous activity of brain regions and functional connectivity (FC) between healthy...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8884318
更新日期:2020-12-08 00:00:00
abstract::Traumatic brain injury (TBI) is a worldwide endemic that results in unacceptably high morbidity and mortality. Secondary injury processes following primary injury are composed of intricate interactions between assorted molecules that ultimately dictate the degree of longer-term neurological deficits. One comparatively...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2012/378307
更新日期:2012-01-01 00:00:00
abstract::Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early o...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2015/434127
更新日期:2015-01-01 00:00:00
abstract::Neurophysiological and neuroimaging data suggest that the brains of not only children but also adults are reorganized based on sensory inputs and behaviors. Plastic changes in the brain are generally beneficial; however, maladaptive cortical reorganization in the auditory cortex may lead to hearing disorders such as t...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2018/2546250
更新日期:2018-05-20 00:00:00
abstract::The role of the right hemisphere (RH) in recovery from aphasia is incompletely understood. The present study quantified RH grey matter (GM) volume in individuals with chronic stroke-induced aphasia and cognitively healthy people using voxel-based morphometry. We compared group differences in GM volume in the entire RH...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/5601509
更新日期:2017-01-01 00:00:00
abstract::Recently several lines of evidence demonstrated that methylcobalamin (MeCbl) might have potential analgesic effect in experimental and clinical studies. However, it was reported that MeCbl had no effect on treating lumbar spinal stenosis induced pain. Thus, the effects of short-term and long-term administration of MeC...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/197392
更新日期:2015-01-01 00:00:00
abstract::Evidence from neuropathological, genetic, animal model, and biochemical studies has indicated that the accumulation of amyloid-beta (Aβ) is associated with, and probably induces, profound neuronal changes in brain regions critical for memory and cognition in the development of Alzheimer's disease (AD). There is consid...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/3204519
更新日期:2016-01-01 00:00:00
abstract::Dopamine (DA) modulates glutamatergic synaptic transmission and its plasticity in the striatum; however it is not well known how DA modulates long-term plasticity of striatal GABAergic inhibitory synapses. This work focused on the analysis of both dopaminergic modulation of inhibitory synapses and the synaptic plastic...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/789502
更新日期:2015-01-01 00:00:00
abstract::Using functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimicked in vivo conditi...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/108969
更新日期:2008-01-01 00:00:00
abstract::The most dramatic progress in the restoration of hearing takes place in the first months after cochlear implantation. To map the brain activity underlying this process, we used positron emission tomography at three time points: within 14 days, three months, and six months after switch-on. Fifteen recently implanted ad...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2013/318521
更新日期:2013-01-01 00:00:00
abstract::Functional and morphological studies in children affected by Attention Deficit Hyperactivity Disorder (ADHD) suggest a prefrontal cortex (PFc) dysfunction. This cortical region is regulated by subcortical systems including noradrenergic (NEergic), dopaminergic (DAergic), cholinergic, serotonergic, and histaminergic pa...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2004.133
更新日期:2004-01-01 00:00:00
abstract::There is a general consensus that sleep is strictly linked to memory, learning, and, in general, to the mechanisms of neural plasticity, and that this link may directly affect recovery processes. In fact, a coherent pattern of empirical findings points to beneficial effect of sleep on learning and plastic processes, a...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/103949
更新日期:2013-01-01 00:00:00
abstract::Motoneurons develop extensive dendritic trees for receiving excitatory and inhibitory synaptic inputs to perform a variety of complex motor tasks. At birth, the somatodendritic domains of mouse hypoglossal and lumbar motoneurons have dense filopodia and spines. Consistent with Vaughn's synaptotropic hypothesis, we pro...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/3423267
更新日期:2016-01-01 00:00:00
abstract::Dishabituation is a return of a habituated response if context or contingency changes. In the mammalian olfactory system, metabotropic glutamate receptor mediated synaptic depression of cortical afferents underlies short-term habituation to odors. It was hypothesized that a known antagonistic interaction between these...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/754014
更新日期:2009-01-01 00:00:00
abstract::Proper functioning of the visual system depends on maturation of both excitatory and inhibitory synapses within the visual cortex. Considering that perisomatic inhibition is one of the key factors that control the critical period in visual cortex, it is pertinent to understand its regulation by visual experience. To d...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/415135
更新日期:2009-01-01 00:00:00
abstract::Stimulating regeneration in the brain has the potential to rescue neuronal networks and counteract progressive pathological changes in Alzheimer's disease (AD). This study investigated whether drugs with different mechanisms of action could enhance neurogenesis and improve cognition in mice receiving human neural stem...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/370432
更新日期:2015-01-01 00:00:00
abstract::Chronic stress can impair hippocampal neurogenesis, increase neuronal apoptosis, and cause depressive-like behaviors. Our previous studies found that Radix Scutellariae (RS) can rescue the stress-induced neuronal injury, but the mechanism is not clear. Here, we continued to investigate the underlying antidepressant me...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8886715
更新日期:2020-11-13 00:00:00
abstract::Although quantitative analysis of the sleep electroencephalogram (EEG) has uncovered important aspects of brain activity during sleep in adolescents and adults, similar findings from preschool-age children remain scarce. This study utilized our time-frequency method to examine sleep oscillations as characteristic feat...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/6160959
更新日期:2017-01-01 00:00:00
abstract::Following central motor lesions, two forms of adaptation can be observed which lead to improved mobility: (1) the development of spastic muscle tone, and (2) the activation of spinal locomotor centers induced by specific treadmill training. Tension development during spastic gait is different from that during normal g...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2001.83
更新日期:2001-01-01 00:00:00
abstract::Neuropathies are characterized by a complex response of the central nervous system to injuries. Glial cells are recruited to maintain neuronal homeostasis but dysregulated activation leads to pain signaling amplification and reduces the glial neuroprotective power. Recently, we highlighted the property of α7 nicotinic...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/396908
更新日期:2015-01-01 00:00:00
abstract::Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2007/91236
更新日期:2007-01-01 00:00:00
abstract::Previous studies have shown that a particular site in the periaqueductal gray (PAG), the rostrolateral PAG, influences the motivation drive to forage or hunt. To have a deeper understanding on the putative paths involved in the decision-making process between foraging, hunting, and other behavioral responses, in the p...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/612698
更新日期:2009-01-01 00:00:00
abstract::Objective. To explore cortical reorganization of patients recovered from Bell's palsy (BP) by task-state functional magnetic resonance imaging (fMRI) during finger and orofacial movements and provide more evidence for acupuncture clinical treatment of BP. Methods. We collected 17 BP patients with complete clinical rec...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8231726
更新日期:2016-01-01 00:00:00
abstract::Aging is a complex process strongly determined by genetics. Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs). CNVs represent a significant source of genetic variation in the human genome and have been implicated in several diso...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/2406170
更新日期:2018-06-28 00:00:00
abstract::Action observation (AO) allows access to a network that processes visuomotor and sensorimotor inputs and is believed to be involved in observational learning of motor skills. We conducted three consecutive experiments to examine the boosting effect of AO on the motor outcome of the untrained hand by either mirror visu...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/8369262
更新日期:2018-04-10 00:00:00
abstract::Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable att...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/9364091
更新日期:2016-01-01 00:00:00