Abstract:
:Dishabituation is a return of a habituated response if context or contingency changes. In the mammalian olfactory system, metabotropic glutamate receptor mediated synaptic depression of cortical afferents underlies short-term habituation to odors. It was hypothesized that a known antagonistic interaction between these receptors and norepinephrine ss-receptors provides a mechanism for dishabituation. The results demonstrate that a 108 dB siren induces a two-fold increase in norepinephrine content in the piriform cortex. The same auditory stimulus induces dishabituation of odor-evoked heart rate orienting bradycardia responses in awake rats. Finally, blockade of piriform cortical norepinephrine ss-receptors with bilateral intracortical infusions of propranolol (100 microM) disrupts auditory-induced dishabituation of odor-evoked bradycardia responses. These results provide a cortical mechanism for a return of habituated sensory responses following a cross-modal alerting stimulus.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Smith JJ,Shionoya K,Sullivan RM,Wilson DAdoi
10.1155/2009/754014subject
Has Abstractpub_date
2009-01-01 00:00:00pages
754014eissn
2090-5904issn
1687-5443journal_volume
2009pub_type
杂志文章abstract::Traumatic brain injury (TBI) is a serious medical and social problem worldwide. Because of the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still lacking. The microglial cells are resident tissue macrophages located in the brain and have two major polarization states, M1 phenotype and M2 ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/5405104
更新日期:2017-01-01 00:00:00
abstract::The habituation/cross-habituation test (HaXha) is a spontaneous odor discrimination task that has been used for many decades to evaluate olfactory function in animals. Animals are presented repeatedly with the same odorant after which a new odorant is introduced. The time the animal explores the odor object is measure...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/9131284
更新日期:2016-01-01 00:00:00
abstract::Damage to the visual system can result in (a partial) loss of vision, in response to which the visual system may functionally reorganize. Yet the timing, extent, and conditions under which this occurs are not well understood. Hence, studies in individuals with diverse congenital and acquired conditions and using vario...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/6067871
更新日期:2019-09-03 00:00:00
abstract::Cerebral palsy (CP) has long been investigated to be associated with a range of motor and cognitive dysfunction. As the two most common CP subtypes, spastic cerebral palsy (SCP) and dyskinetic cerebral palsy (DCP) may share common and distinct elements in their pathophysiology. However, the common and distinct dysfunc...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/7058953
更新日期:2018-08-15 00:00:00
abstract::Mirror visual feedback (MVF) therapy has been applied to improve upper limb function in stroke. When combined with motor training, MVF improves the performance of the trained and untrained hand by enhancing the excitability of both primary motor cortices (M1s). Bradykinesia is a typical feature of Parkinson's disease ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8764238
更新日期:2016-01-01 00:00:00
abstract::Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent gen...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2005.289
更新日期:2005-01-01 00:00:00
abstract::Accumulating evidence implicates a role for brain structures outside the ascending auditory pathway in tinnitus, the phantom perception of sound. In addition to other factors such as age-dependent hearing loss, high-level sound exposure is a prominent cause of tinnitus. Here, we examined how noise exposure altered the...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2021/8833087
更新日期:2021-01-14 00:00:00
abstract::The concept of a topographical map of the corpus callosum (CC) has emerged from human lesion studies and from electrophysiological and anatomical tracing investigations in other mammals. Over the last few years a rising number of researchers have been reporting functional magnetic resonance imaging (fMRI) activation i...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2013/251308
更新日期:2013-01-01 00:00:00
abstract::Recently, transcranial alternating current stimulation (tACS) has emerged as a tool to enhance human cognitive processes. Here, we provide a brief summary of the rationale behind tACS-induced effects on task-relevant brain oscillations and associated cognitive functions and review previous studies in young subjects th...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/4274127
更新日期:2016-01-01 00:00:00
abstract::Background. Clinically, electroacupuncture (EA) is the most common therapy for aging-related cognitive impairment (CI). However, the underlying pathomechanism remains unidentified. The aims of this study were to observe the effect of EA on cognitive function and explore the potential mechanism by which EA acts on the ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8853720
更新日期:2020-11-04 00:00:00
abstract::Hearing impairment is one of the most common sensory disease, of which more than 50% is attributed to a genetic etiology. The goal of this research is to explore the genetic cause of a Chinese deafness pedigree who was excluded of GJB2, SLC26A4, or MtDNA12SrRNA variants. Three variants, c.3971C>A (p.A1324D), c.4011ins...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/5898025
更新日期:2018-04-05 00:00:00
abstract::Objective. To explore cortical reorganization of patients recovered from Bell's palsy (BP) by task-state functional magnetic resonance imaging (fMRI) during finger and orofacial movements and provide more evidence for acupuncture clinical treatment of BP. Methods. We collected 17 BP patients with complete clinical rec...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8231726
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/6724631.]. ...
journal_title:Neural plasticity
pub_type: 杂志文章,已发布勘误
doi:10.1155/2017/3634598
更新日期:2017-01-01 00:00:00
abstract::Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective function...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8583420
更新日期:2016-01-01 00:00:00
abstract::Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learn...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/9353929
更新日期:2016-01-01 00:00:00
abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/4135708
更新日期:2018-10-10 00:00:00
abstract::Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/4605971
更新日期:2017-01-01 00:00:00
abstract::Emotionally arousing events are typically better remembered than mundane ones, in part because emotionally relevant aspects of our environment are prioritized in attention. Such biased attentional tuning is itself the result of associative processes through which we learn affective and motivational relevance of cues. ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/6817349
更新日期:2017-01-01 00:00:00
abstract:Background and Purpose:Cancer-related fatigue (CRF) is widely recognized as one of the most common symptoms and side effects of cancer and/or its treatment. However, neuropathological mechanisms contributing to CRF are largely unknown, and the lack of knowledge makes CRF difficult to treat. Recent research has shown di...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/2490750
更新日期:2019-06-26 00:00:00
abstract::Postural problems play a central role in the motor dysfunction of children with cerebral palsy (CP). Therefore, they spend more time in sitting than in standing to perform vital tasks of daily life. The focus of this article is to describe the pathophysiology of postural control in sitting and outline some implication...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2005.221
更新日期:2005-01-01 00:00:00
abstract:Background:Bilateral arm training (BAT) has shown promise in expediting progress toward upper limb recovery in chronic stroke patients, but its neural correlates are poorly understood. Objective:To evaluate changes in upper limb function and EEG power after a robot-assisted BAT in chronic stroke patients. Methods:In ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/8105480
更新日期:2018-03-26 00:00:00
abstract::Focal hand dystonia (FHd) is a recalcitrant, disabling movement disorder, characterized by involuntary co-contractions of agonists and antagonists, that can develop in patients who overuse or misuse their hands. The aim of this study was to document clinical neuromusculoskeletal performance and somatosensory responses...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.2002.177
更新日期:2002-01-01 00:00:00
abstract:Objective:To determine whether and how longitudinal acupuncture modulates the impaired default mode network (DMN) in chronic migraine (CM) patients without aura. Methods:Resting-state functional magnetic resonance imaging (fMRI) data from 14 CM patients treated with longitudinal pre- and postacupuncture treatment (PPA...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/5047463
更新日期:2019-03-18 00:00:00
abstract::Aging is a complex process strongly determined by genetics. Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs). CNVs represent a significant source of genetic variation in the human genome and have been implicated in several diso...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/2406170
更新日期:2018-06-28 00:00:00
abstract::Homeostatic synaptic plasticity is a negative-feedback response employed to compensate for functional disturbances in the nervous system. Typically, synaptic activity is strengthened when neuronal firing is chronically suppressed or weakened when neuronal activity is chronically elevated. At both the whole cell and en...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2012/825364
更新日期:2012-01-01 00:00:00
abstract::Evidence from neuropathological, genetic, animal model, and biochemical studies has indicated that the accumulation of amyloid-beta (Aβ) is associated with, and probably induces, profound neuronal changes in brain regions critical for memory and cognition in the development of Alzheimer's disease (AD). There is consid...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/3204519
更新日期:2016-01-01 00:00:00
abstract::Dementia affects millions of elderly worldwide causing remarkable costs to society, but effective treatment is still lacking. Acupuncture is one of the complementary therapies that has been applied to cognitive deficits such as Alzheimer's disease (AD) and vascular cognitive impairment (VCI), while the underlying mech...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2021/8868447
更新日期:2021-01-12 00:00:00
abstract::Inbred mouse models are widely used to study age-related hearing loss (AHL). Many genes associated with AHL have been mapped in a variety of strains. However, little is known about gene variants that have the converse function-protective genes that confer strong resistance to hearing loss. Previously, we reported that...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8889264
更新日期:2020-06-08 00:00:00
abstract::The aim of this study was to investigate the effect of subdiaphragmatic vagotomy on insulin sensitivity, secretion, and degradation in metabolic programmed mice, induced by a low-protein diet early in life, followed by exposure to a high-fat diet in adulthood. Weaned 30-day-old C57Bl/6 mice were submitted to a low-pro...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/9652978
更新日期:2017-01-01 00:00:00
abstract::The recent developments of a particular approach to analyzing motor synergies based on the principle of motor abundance has allowed a quantitative assessment of multi-effector coordination in motor tasks involving anticipatory adjustments to self-triggered postural perturbations and in voluntary postural sway. This ap...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2005.119
更新日期:2005-01-01 00:00:00