Abstract:
:Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective functional connectivity changes within the semantic cognition network between these two groups and those from normal controls. We found that gray matter atrophy of left mTLE patients was more severe than that of right mTLE patients in the whole brain and especially within the semantic cognition network in their contralateral hemisphere. It suggested that seizure attacks were rather targeted than random for patients with hippocampal sclerosis (HS) in the dominant hemisphere. Functional connectivity analysis during resting state fMRI revealed that subregions of the anterior temporal lobe (ATL) in the left HS patients were no longer effectively connected. Further, we found that, unlike in right HS patients, increased causal linking between ipsilateral regions in the left HS epilepsy patients cannot make up for their decreased contralateral interaction. It suggested that weakened contralateral connection and disrupted effective interaction between subregions of the unitary, transmodal hub of the ATL may be the primary cause of anomia in the left HS patients.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Fan X,Yan H,Shan Y,Shang K,Wang X,Wang P,Shan Y,Lu J,Zhao Gdoi
10.1155/2016/8583420subject
Has Abstractpub_date
2016-01-01 00:00:00pages
8583420eissn
2090-5904issn
1687-5443journal_volume
2016pub_type
杂志文章abstract::Emotionally arousing events are typically better remembered than mundane ones, in part because emotionally relevant aspects of our environment are prioritized in attention. Such biased attentional tuning is itself the result of associative processes through which we learn affective and motivational relevance of cues. ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/6817349
更新日期:2017-01-01 00:00:00
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journal_title:Neural plasticity
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/2306406
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
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journal_title:Neural plasticity
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更新日期:2017-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8886715
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/7453149
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/4843985
更新日期:2018-07-04 00:00:00
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journal_title:Neural plasticity
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doi:10.1155/2020/8866187
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pub_type: 杂志文章
doi:10.1155/2015/653727
更新日期:2015-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/9353929
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Neural plasticity
pub_type: 杂志文章
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/415135
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/814815
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journal_title:Neural plasticity
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Neural plasticity
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/9132720
更新日期:2020-03-18 00:00:00