Sustained Activity of Metabotropic Glutamate Receptor: Homer, Arrestin, and Beyond.

Abstract:

:When activated, metabotropic glutamate receptors (mGlus) exert long-lasting changes within the glutamatergic synapses. One mechanism is a tonic effect of downstream signal transduction pathways via sustained activation of mGlu itself. Like many other G protein-coupled receptors (GPCRs), mGlu can exist in a constitutively active state, which persists agonist independently. In this paper, we review the current knowledge of the mechanisms underlying the constitutive activity of group I mGlus. The issues concerning Homer1a mechanism in the constitutive activity of group I mGlus and recent findings regarding the significant role of β-arrestin in sustained GPCR activity are also discussed. We propose that once in a state of sustained activation, the mGlu persistently activates downstream signaling pathways, including various adaptor proteins and kinases, such as β-arrestin and mitogen-activated protein kinases. In turn, these effector molecules bind to or phosphorylate the mGlu C-terminal binding domains and consequently regulate the activation state of the mGlu.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Chung G,Kim SJ

doi

10.1155/2017/5125624

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

5125624

eissn

2090-5904

issn

1687-5443

journal_volume

2017

pub_type

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