Plasticity of horizontal connections at a functional border in adult rat somatosensory cortex.

Abstract:

:Horizontal connections in superficial cortical layers integrate information across sensory maps by connecting related functional columns. It has been hypothesized that these connections mediate cortical reorganization via synaptic plasticity. However, it is not known if the horizontal connections from discontinuous cortical regions can undergo plasticity in the adult. Here we located the border between two discontinuous cortical representations in vivo and used either pairing or low-frequency stimulation to induce synaptic plasticity in the horizontal connections surrounding this border in vitro. Individual neurons revealed significant and diverse forms of synaptic plasticity for horizontal connections within a continuous representation and discontinuous representations. Interestingly, both enhancement and depression were observed following both plasticity paradigms. Furthermore, plasticity was not restricted by the border's presence. Depolarization in the absence of synaptic stimulation also produced synaptic plasticity, but with different characteristics. These experiments suggest that plasticity of horizontal connections may mediate functional reorganization.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Marik SA,Hickmott PW

doi

10.1155/2009/294192

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

294192

eissn

2090-5904

issn

1687-5443

journal_volume

2009

pub_type

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