Anxiety in mice: a principal component analysis study.

Abstract:

:Two principal component analyses of anxiety were undertaken investigating two strains of mice (ABP/Le and C57BL/6ByJ) in two different experiments, both classical tests for assessing anxiety in rodents. The elevated plus-maze and staircase were used for the first experiment, and a free exploratory paradigm and light-dark discrimination were used for the second. The components in the analyses produced definitions of four fundamental behavior patterns: novelty-induced anxiety, general activity, exploratory behavior, and decision making. We also noted that the anxious phenotype was determined by both strain and experimental procedure. The relationship between behavior patterns and the use of specific tests plus links with the genetic background are discussed.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Clément Y,Joubert C,Kopp C,Lepicard EM,Venault P,Misslin R,Cadot M,Chapouthier G

doi

10.1155/2007/35457

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

35457

eissn

2090-5904

issn

1687-5443

journal_volume

2007

pub_type

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