Abstract:
:Childhood emotional trauma contributes significantly to certain psychopathologies, such as post-traumatic stress disorder. In experimental animals, however, whether or not early-life stress results in behavioral abnormalities in adult animals still remains controversial. Here, we investigated both short-term and long-term changes of anxiety- and depression-like behaviors of Wistar rats after being exposed to chronic feral cat stress in juvenile ages. The 2-week predator stress decreased spontaneous activities immediately following stress but did not increase depression- or anxiety-like behaviors 4 weeks after the stimulation in adulthood. Instead, juvenile predator stress had some protective effects, though not very obvious, in adulthood. We also exposed genetic depression model rats, Wistar Kyoto (WKY) rats, to the same predator stress. In WKY rats, the same early-life predator stress did not enhance anxiety- or depression-like behaviors in both the short-term and long-term. However, the stressed WKY rats showed slightly reduced depression-like behaviors in adulthood. These results indicate that in both normal Wistar rats and WKY rats, early-life predator stress led to protective, rather than negative, effects in adulthood.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Chen LJ,Shen BQ,Liu DD,Li STdoi
10.1155/2014/163908subject
Has Abstractpub_date
2014-01-01 00:00:00pages
163908eissn
2090-5904issn
1687-5443journal_volume
2014pub_type
杂志文章abstract::Most citizen people are exposed daily to environmental noise at moderate levels with a short duration. The aim of the present study was to determine the effects of daily short-term exposure to moderate noise on sound level processing in the auditory midbrain. Sound processing properties of auditory midbrain neurons we...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/3026749
更新日期:2017-01-01 00:00:00
abstract::Success in locomotor rehabilitation programs can be improved with the use of brain-computer interfaces (BCIs). Although a wealth of research has demonstrated that locomotion is largely controlled by spinal mechanisms, the brain is of utmost importance in monitoring locomotor patterns and therefore contains information...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2012/375148
更新日期:2012-01-01 00:00:00
abstract::The role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learning capacity of the...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/853654
更新日期:2013-01-01 00:00:00
abstract::Hearing impairment is one of the most common sensory disease, of which more than 50% is attributed to a genetic etiology. The goal of this research is to explore the genetic cause of a Chinese deafness pedigree who was excluded of GJB2, SLC26A4, or MtDNA12SrRNA variants. Three variants, c.3971C>A (p.A1324D), c.4011ins...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/5898025
更新日期:2018-04-05 00:00:00
abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/4135708
更新日期:2018-10-10 00:00:00
abstract:Background:Feedback postural control depends upon information from somatosensation, vision, and the vestibular system that are weighted depending on their relative importance within the central nervous system. Following loss of any sensory component, the weighting changes, e.g., when suffering a vestibular loss, the mo...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/4826238
更新日期:2019-02-18 00:00:00
abstract::Isoforms of apolipoprotein E (ApoE) have been implicated as risk factors in Alzheimer's disease. We have, therefore, examined the possible role of ApoE in memory formation, using a one-trial passive avoidance task in day-old chicks. Birds were trained on the task and then at various times pre or post-training were inj...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.1998.29
更新日期:1998-07-01 00:00:00
abstract::Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke. However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in diabetes. We aim to investigate the effect and the potential mechanism of NLRP3 inflammasome in diabetic mice with cerebral ischemia-reperfusion i...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/9163521
更新日期:2018-04-24 00:00:00
abstract::The present study investigates whether a combined cognitive and physical training may induce changes in the cortical activity as measured via electroencephalogram (EEG) and whether this change may index a deceleration of pathological processes of brain aging. Seventy seniors meeting the clinical criteria of mild cogni...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/172192
更新日期:2015-01-01 00:00:00
abstract::Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons. It has also been shown to acutely induce epileptic seizure behavior in freely moving rats. However, whether CTZ indu...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/310146
更新日期:2014-01-01 00:00:00
abstract::The role of attentional mechanisms in peripheral vision loss remains an outstanding question. Our study was aimed at determining the effect of genetically determined peripheral retinal dystrophy caused by Retinitis Pigmentosa (RP) on visual cortical function and tested the recruitment of attentional mechanisms using f...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/8136354
更新日期:2019-06-25 00:00:00
abstract::Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurodegenerative disorders such as Parkinson's disease (PD). In sporadic PD, the most common age-related neurodegenerative movement disorder, nigrostriatal dopaminergic deficits are responsible for the onset of motor symptoms...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/5012129
更新日期:2017-01-01 00:00:00
abstract::The entorhinal cortex (EC) is a nodal and independent mnemonic element of the medial temporal lobe memory circuit as it forms a bidirectional interface between the neocortex and hippocampus. Within the EC, intra- and inter-lamellar associational connections occur via horizontal and columnar projections, respectively. ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/814815
更新日期:2008-01-01 00:00:00
abstract::Neuropathic pain increases the risk of cardiovascular diseases including hypertension with the characteristic of sympathetic overactivity. The enhanced tonically active glutamatergic input to the rostral ventrolateral medulla (RVLM) contributes to sympathetic overactivity and blood pressure (BP) in cardiovascular dise...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/4174010
更新日期:2017-01-01 00:00:00
abstract::Aging is a complex process strongly determined by genetics. Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs). CNVs represent a significant source of genetic variation in the human genome and have been implicated in several diso...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/2406170
更新日期:2018-06-28 00:00:00
abstract::The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8882207
更新日期:2020-10-06 00:00:00
abstract::Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2007/91236
更新日期:2007-01-01 00:00:00
abstract::Previous studies have shown that a particular site in the periaqueductal gray (PAG), the rostrolateral PAG, influences the motivation drive to forage or hunt. To have a deeper understanding on the putative paths involved in the decision-making process between foraging, hunting, and other behavioral responses, in the p...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/612698
更新日期:2009-01-01 00:00:00
abstract::In this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies and whole genome sear...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/np.2004.217
更新日期:2004-01-01 00:00:00
abstract::Previous studies have demonstrated that amnestic mild cognitive impairment (aMCI) has disrupted properties of large-scale cortical networks based on cortical thickness and gray matter volume. However, it is largely unknown whether the topological properties of cortical networks based on geometric measures (i.e., sulca...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/3462309
更新日期:2016-01-01 00:00:00
abstract::Increasing research has evidenced that our brain retains a capacity to change in response to experience until late adulthood. This implies that cognitive training can possibly ameliorate age-associated cognitive decline by inducing training-specific neural plastic changes at both neural and behavioral levels. This lon...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/535618
更新日期:2015-01-01 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of axons projecting in...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/9828725
更新日期:2018-08-06 00:00:00
abstract::Functional and morphological studies in children affected by Attention Deficit Hyperactivity Disorder (ADHD) suggest a prefrontal cortex (PFc) dysfunction. This cortical region is regulated by subcortical systems including noradrenergic (NEergic), dopaminergic (DAergic), cholinergic, serotonergic, and histaminergic pa...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2004.133
更新日期:2004-01-01 00:00:00
abstract::Adverse early life experiences can negatively affect behaviors later in life. Maternal separation (MS) has been extensively investigated in animal models in the adult phase of MS. The study aimed to explore the mechanism by which MS negatively affects C57BL/6N mice, especially the effects caused by MS in the early pha...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/627837
更新日期:2015-01-01 00:00:00
abstract::The recent developments of a particular approach to analyzing motor synergies based on the principle of motor abundance has allowed a quantitative assessment of multi-effector coordination in motor tasks involving anticipatory adjustments to self-triggered postural perturbations and in voluntary postural sway. This ap...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2005.119
更新日期:2005-01-01 00:00:00
abstract::Motoneurons develop extensive dendritic trees for receiving excitatory and inhibitory synaptic inputs to perform a variety of complex motor tasks. At birth, the somatodendritic domains of mouse hypoglossal and lumbar motoneurons have dense filopodia and spines. Consistent with Vaughn's synaptotropic hypothesis, we pro...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/3423267
更新日期:2016-01-01 00:00:00
abstract::Several research studies point to the fact that sensory and cognitive reductions like cataracts, deafness, macular degeneration, or even lack of activity after job retirement, precede the onset of Alzheimer's disease. To simulate Alzheimer's disease earlier stages, which manifest in sensory cortices, we used a computa...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8895369
更新日期:2020-10-14 00:00:00
abstract::Horizontal connections in superficial cortical layers integrate information across sensory maps by connecting related functional columns. It has been hypothesized that these connections mediate cortical reorganization via synaptic plasticity. However, it is not known if the horizontal connections from discontinuous co...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/294192
更新日期:2009-01-01 00:00:00
abstract::Elevated brain activation, or hyperexcitability, induces cognitive impairment and confers an increased risk of Alzheimer's disease (AD). Blocking the overexcitation of the neural network may be a promising new strategy to prevent, halt, and even reverse this condition. Physical exercise has been shown to be an effecti...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/9132720
更新日期:2020-03-18 00:00:00
abstract::We analyzed operant discrimination in detelencephalated pigeons and neuroanatomical substrates after long-term detelencephalation. In Experiment I, experimental pigeons with massive telencephalic ablation and control pigeons were conditioned to key peck for food. Successive discrimination was made under alternating re...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.2003.247
更新日期:2003-01-01 00:00:00