Apolipoprotein E antibodies affect the retention of passive avoidance memory in the chick.

Abstract:

:Isoforms of apolipoprotein E (ApoE) have been implicated as risk factors in Alzheimer's disease. We have, therefore, examined the possible role of ApoE in memory formation, using a one-trial passive avoidance task in day-old chicks. Birds were trained on the task and then at various times pre or post-training were injected intracerebrally with anti-ApoE. Immunofluorescence staining demonstrated the presence of the antibody bound to the neuropil, close to the injection site and adjacent to the ventricle, with a residence time in the brain of up to 30 min. Chicks that were injected 30 min pre-training or just post-training with 5 micrograms/hemisphere of the antibody learned the task, but were amnesic when tested at 30 min or at subsequent times up to 24 hr post-training. When tested at 24 hr, birds injected 5.5 hr post-training showed unimpaired retention. Birds injected with 5 micrograms/hemisphere of anti-ApoA-I (which has a brain distribution similar to that of anti-ApoE) at 30 min pretraining showed no amnesia, indicating the specificity of the effect to the ApoE. Possible mechanisms for this effect are discussed.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Lancashire C,Mileusnic R,Rose SP

doi

10.1155/NP.1998.29

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

29-40

issue

3

eissn

2090-5904

issn

1687-5443

journal_volume

6

pub_type

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