Abstract:
:Isoforms of apolipoprotein E (ApoE) have been implicated as risk factors in Alzheimer's disease. We have, therefore, examined the possible role of ApoE in memory formation, using a one-trial passive avoidance task in day-old chicks. Birds were trained on the task and then at various times pre or post-training were injected intracerebrally with anti-ApoE. Immunofluorescence staining demonstrated the presence of the antibody bound to the neuropil, close to the injection site and adjacent to the ventricle, with a residence time in the brain of up to 30 min. Chicks that were injected 30 min pre-training or just post-training with 5 micrograms/hemisphere of the antibody learned the task, but were amnesic when tested at 30 min or at subsequent times up to 24 hr post-training. When tested at 24 hr, birds injected 5.5 hr post-training showed unimpaired retention. Birds injected with 5 micrograms/hemisphere of anti-ApoA-I (which has a brain distribution similar to that of anti-ApoE) at 30 min pretraining showed no amnesia, indicating the specificity of the effect to the ApoE. Possible mechanisms for this effect are discussed.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Lancashire C,Mileusnic R,Rose SPdoi
10.1155/NP.1998.29subject
Has Abstractpub_date
1998-07-01 00:00:00pages
29-40issue
3eissn
2090-5904issn
1687-5443journal_volume
6pub_type
杂志文章abstract::The role of attentional mechanisms in peripheral vision loss remains an outstanding question. Our study was aimed at determining the effect of genetically determined peripheral retinal dystrophy caused by Retinitis Pigmentosa (RP) on visual cortical function and tested the recruitment of attentional mechanisms using f...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/8136354
更新日期:2019-06-25 00:00:00
abstract::Dishabituation is a return of a habituated response if context or contingency changes. In the mammalian olfactory system, metabotropic glutamate receptor mediated synaptic depression of cortical afferents underlies short-term habituation to odors. It was hypothesized that a known antagonistic interaction between these...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/754014
更新日期:2009-01-01 00:00:00
abstract::The concept of a topographical map of the corpus callosum (CC) has emerged from human lesion studies and from electrophysiological and anatomical tracing investigations in other mammals. Over the last few years a rising number of researchers have been reporting functional magnetic resonance imaging (fMRI) activation i...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2013/251308
更新日期:2013-01-01 00:00:00
abstract::The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is necessary for proper hair cell (HC) mechanotransduction and hearing. Cell junctions are indispensable for the establishment of compositionally distinct fluid compartments in the inner ear. Ototoxic drug cisplatin can damage SV ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8851525
更新日期:2020-09-22 00:00:00
abstract::The endocannabinoids N-arachidonoylethanolamide (or anandamide, AEA) and 2-arachidonoylglycerol (2-AG) belong to the larger groups of N-acylethanolamines (NAEs) and monoacylglycerol (MAG) lipid classes, respectively. They are biologically active lipid molecules that activate G-protein-coupled cannabinoid receptors fou...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/2426398
更新日期:2016-01-01 00:00:00
abstract::Noninvasive brain stimulation (NBS), such as repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS), has been used in stroke patients with motor impairment. NBS can help recovery from brain damage by modulating cortical excitability. However, the efficacy of NBS varies am...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/3826495
更新日期:2019-04-07 00:00:00
abstract::Autosomal dominant nonsyndromic hearing loss (ADNSHL) is extremely heterogeneous. So far the genetic etiological contribution of the gene POU4F3 associated with ADNSHL has been rarely reported. In our previous study, a c.603_604delGG mutation in the hair cell specific gene POU4F3 has been identified as the pathogenic ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/9890827
更新日期:2016-01-01 00:00:00
abstract::Adverse early life experiences can negatively affect behaviors later in life. Maternal separation (MS) has been extensively investigated in animal models in the adult phase of MS. The study aimed to explore the mechanism by which MS negatively affects C57BL/6N mice, especially the effects caused by MS in the early pha...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/627837
更新日期:2015-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/103949
更新日期:2013-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8231726
更新日期:2016-01-01 00:00:00
abstract:Objective:To determine whether and how longitudinal acupuncture modulates the impaired default mode network (DMN) in chronic migraine (CM) patients without aura. Methods:Resting-state functional magnetic resonance imaging (fMRI) data from 14 CM patients treated with longitudinal pre- and postacupuncture treatment (PPA...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/5047463
更新日期:2019-03-18 00:00:00
abstract::In this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies and whole genome sear...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/np.2004.217
更新日期:2004-01-01 00:00:00
abstract::Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable att...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/9364091
更新日期:2016-01-01 00:00:00
abstract::Alzheimer's disease (AD) is one of the most serious public health concerns facing the world. Its characteristic feature is neuroinflammation due to microglial activation. Electroacupuncture is one of the therapies employed to improve the condition of patients with AD, although its mechanism of action is still to be de...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8867547
更新日期:2020-09-04 00:00:00
abstract::When activated, metabotropic glutamate receptors (mGlus) exert long-lasting changes within the glutamatergic synapses. One mechanism is a tonic effect of downstream signal transduction pathways via sustained activation of mGlu itself. Like many other G protein-coupled receptors (GPCRs), mGlu can exist in a constitutiv...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/5125624
更新日期:2017-01-01 00:00:00
abstract::The aim of the present study was to assess the role of action observation treatment (AOT) in the rehabilitation of upper limb motor functions in children with cerebral palsy. We carried out a two-group, parallel randomized controlled trial. Eighteen children (aged 5-11 yr) entered the study: 11 were treated children, ...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/4843985
更新日期:2018-07-04 00:00:00
abstract::The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8882207
更新日期:2020-10-06 00:00:00
abstract::Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/4605971
更新日期:2017-01-01 00:00:00
abstract::Ample evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood. Through multiple approaches, we demonstrate that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HPA axis and in brain...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8866187
更新日期:2020-08-28 00:00:00
abstract::Focal hand dystonia (FHd) is a recalcitrant, disabling movement disorder, characterized by involuntary co-contractions of agonists and antagonists, that can develop in patients who overuse or misuse their hands. The aim of this study was to document clinical neuromusculoskeletal performance and somatosensory responses...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.2002.177
更新日期:2002-01-01 00:00:00
abstract::Motoneurons develop extensive dendritic trees for receiving excitatory and inhibitory synaptic inputs to perform a variety of complex motor tasks. At birth, the somatodendritic domains of mouse hypoglossal and lumbar motoneurons have dense filopodia and spines. Consistent with Vaughn's synaptotropic hypothesis, we pro...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/3423267
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/8583420
更新日期:2016-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2001.83
更新日期:2001-01-01 00:00:00
abstract::Dopamine (DA) modulates glutamatergic synaptic transmission and its plasticity in the striatum; however it is not well known how DA modulates long-term plasticity of striatal GABAergic inhibitory synapses. This work focused on the analysis of both dopaminergic modulation of inhibitory synapses and the synaptic plastic...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/789502
更新日期:2015-01-01 00:00:00
abstract::Homeostatic synaptic plasticity is a negative-feedback response employed to compensate for functional disturbances in the nervous system. Typically, synaptic activity is strengthened when neuronal firing is chronically suppressed or weakened when neuronal activity is chronically elevated. At both the whole cell and en...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2012/825364
更新日期:2012-01-01 00:00:00
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journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2009/294192
更新日期:2009-01-01 00:00:00
abstract::To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/5625768
更新日期:2020-07-01 00:00:00
abstract::Cerebral palsy (CP) has long been investigated to be associated with a range of motor and cognitive dysfunction. As the two most common CP subtypes, spastic cerebral palsy (SCP) and dyskinetic cerebral palsy (DCP) may share common and distinct elements in their pathophysiology. However, the common and distinct dysfunc...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/7058953
更新日期:2018-08-15 00:00:00
abstract::Neurogenesis in the hippocampus is influenced by several factors including external stimuli. In addition to their involvement in learning and memory processes, newborn neurons of the dentate gyrus (DG) buffer against the effects of stress. Although the response of these cells to environmental stimuli has been shown, t...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/4960869
更新日期:2018-05-22 00:00:00
abstract:Background:Phosphene generation is an objective physical measure of potential transcranial alternating current stimulation (tACS) biological side effects. Interpretations from phosphene analysis can serve as a first step in understanding underlying mechanisms of tACS in healthy human subjects and assist validation of c...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/8525706
更新日期:2018-12-06 00:00:00