Enhanced Visual Attentional Modulation in Patients with Inherited Peripheral Retinal Degeneration in the Absence of Cortical Degeneration.

Abstract:

:The role of attentional mechanisms in peripheral vision loss remains an outstanding question. Our study was aimed at determining the effect of genetically determined peripheral retinal dystrophy caused by Retinitis Pigmentosa (RP) on visual cortical function and tested the recruitment of attentional mechanisms using functional magnetic resonance imaging (fMRI). We included thirteen patients and twenty-two age- and gender-matched controls. We analyzed cortical responses under attentional demands and passive viewing conditions while presenting a visual stimulus covering the central and paracentral visual field. Brain activity was studied in visual areas V1, V2, and V3 as well as in cortical regions of interest corresponding to the preserved and the damaged visual field. The influence of visual field extent and age of disease onset were also investigated. Cortical thickness of visual areas was also measured. We found that cortical visual responses under attentional demands were increased in patients with larger degeneration of visual field, as demonstrated by significant interaction effects between group and task conditions. Moreover, activation during the task condition was increased for patients in two cortical regions of interest corresponding to the preserved and damaged visual field, specifically in patients with severe visual field loss. These findings were observed in the presence of preserved visual cortical structure. We conclude that RP patients have enhanced visual attention recruitment despite their retinal degeneration, while cortical structure and overall response levels remain intact. The unmasking of feedback signals from higher level visual regions involved in attentional processes may explain the increased cortical responses. These findings are relevant for the design of strategies for treating retinal diseases, based on attentional cuing.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Ferreira S,Pereira AC,Quendera B,Reis A,Silva ED,Castelo-Branco M

doi

10.1155/2019/8136354

subject

Has Abstract

pub_date

2019-06-25 00:00:00

pages

8136354

eissn

2090-5904

issn

1687-5443

journal_volume

2019

pub_type

杂志文章
  • Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks.

    abstract::Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscill...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/1478684

    authors: Vanvinckenroye A,Vandewalle G,Phillips C,Chellappa SL

    更新日期:2016-01-01 00:00:00

  • Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer's Disease: A Diffusion MRI Study with DTI and HARDI Models.

    abstract::Alzheimer's disease (AD) is the most common form of dementia in elderly people. It is an irreversible and progressive brain disease. In this paper, we utilized diffusion-weighted imaging (DWI) to detect abnormal topological organization of white matter (WM) structural networks. We compared the differences between WM c...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/2947136

    authors: Wang T,Shi F,Jin Y,Yap PT,Wee CY,Zhang J,Yang C,Li X,Xiao S,Shen D

    更新日期:2016-01-01 00:00:00

  • Topological Properties of Large-Scale Cortical Networks Based on Multiple Morphological Features in Amnestic Mild Cognitive Impairment.

    abstract::Previous studies have demonstrated that amnestic mild cognitive impairment (aMCI) has disrupted properties of large-scale cortical networks based on cortical thickness and gray matter volume. However, it is largely unknown whether the topological properties of cortical networks based on geometric measures (i.e., sulca...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/3462309

    authors: Li Q,Li X,Wang X,Li Y,Li K,Yu Y,Yin C,Li S,Han Y

    更新日期:2016-01-01 00:00:00

  • Altered Brain Activity and Functional Connectivity in Unilateral Sudden Sensorineural Hearing Loss.

    abstract:Background:Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. Th...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/9460364

    authors: Chen J,Hu B,Qin P,Gao W,Liu C,Zi D,Ding X,Yu Y,Cui G,Lu L

    更新日期:2020-09-22 00:00:00

  • Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores.

    abstract:Background:One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in resting-state functional MRI have been investigated to a limited extent. Fluctuations...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/2357107

    authors: Goodin P,Lamp G,Vidyasagar R,Connelly A,Rose S,Campbell BCV,Tse T,Ma H,Howells D,Hankey GJ,Davis S,Donnan G,Carey LM

    更新日期:2019-07-28 00:00:00

  • Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain.

    abstract::Magnetic resonance imaging (MRI) of the human brain has provided converging evidence that visual deprivation induces regional changes in white matter (WM) microstructure. It remains unclear how these changes modify network connections between brain regions. Here we used diffusion-weighted MRI to relate differences in ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/6029241

    authors: Reislev NL,Dyrby TB,Siebner HR,Kupers R,Ptito M

    更新日期:2016-01-01 00:00:00

  • Dopaminergic Modulation of Striatal Inhibitory Transmission and Long-Term Plasticity.

    abstract::Dopamine (DA) modulates glutamatergic synaptic transmission and its plasticity in the striatum; however it is not well known how DA modulates long-term plasticity of striatal GABAergic inhibitory synapses. This work focused on the analysis of both dopaminergic modulation of inhibitory synapses and the synaptic plastic...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/789502

    authors: Nieto Mendoza E,Hernández Echeagaray E

    更新日期:2015-01-01 00:00:00

  • New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity.

    abstract::Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/4605971

    authors: Huang YJ,Lane HY,Lin CH

    更新日期:2017-01-01 00:00:00

  • Neurorehabilitation in Parkinson's Disease: A Critical Review of Cognitive Rehabilitation Effects on Cognition and Brain.

    abstract:Background:Parkinson's disease (PD) patients experience cognitive impairment which has been related to reduced quality of life and functional disability. These symptoms usually progress until dementia occurs. Some studies have been published assessing the efficacy of cognitive treatments on improving cognition, functio...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2018/2651918

    authors: Díez-Cirarda M,Ibarretxe-Bilbao N,Peña J,Ojeda N

    更新日期:2018-05-06 00:00:00

  • Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus.

    abstract::Accumulating evidence implicates a role for brain structures outside the ascending auditory pathway in tinnitus, the phantom perception of sound. In addition to other factors such as age-dependent hearing loss, high-level sound exposure is a prominent cause of tinnitus. Here, we examined how noise exposure altered the...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2021/8833087

    authors: Zhang L,Wu C,Martel DT,West M,Sutton MA,Shore SE

    更新日期:2021-01-14 00:00:00

  • Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex.

    abstract::Associative fear learning, in which stimulation of whiskers is paired with mild electric shock to the tail, modifies the barrel cortex, the functional representation of sensory receptors involved in the conditioning, by inducing formation of new inhibitory synapses on single-synapse spines of the cognate barrel hollow...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/9828517

    authors: Jasinska M,Siucinska E,Jasek E,Litwin JA,Pyza E,Kossut M

    更新日期:2016-01-01 00:00:00

  • The gain modulation by N-methyl-D-aspartate in the projection neurons of robust nucleus of the arcopallium in adult zebra finches.

    abstract::The song of zebra finch is stable in life after it was learned successfully. Vocal plasticity is thought to be a motor exploration that can support continuous learning and optimization of performance. The activity of RA, an important pre-motor nucleus in songbird's brain, influences the song directly. This variability...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2012/931780

    authors: Liao SQ,Hou GQ,Pan X,Liao CS,Li DF

    更新日期:2012-01-01 00:00:00

  • GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway.

    abstract::Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures. GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system. Accumulating evidence de...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/8858415

    authors: Hou X,Rong C,Wang F,Liu X,Sun Y,Zhang HT

    更新日期:2020-08-01 00:00:00

  • Cortical Reorganization in Patients Recovered from Bell's Palsy: An Orofacial and Finger Movements Task-State fMRI Study.

    abstract::Objective. To explore cortical reorganization of patients recovered from Bell's palsy (BP) by task-state functional magnetic resonance imaging (fMRI) during finger and orofacial movements and provide more evidence for acupuncture clinical treatment of BP. Methods. We collected 17 BP patients with complete clinical rec...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/8231726

    authors: Lee J,Yang J,Li C,Yuan A,Wu H,Wang A,Xue Q,Wang T,Wang L,Gao T

    更新日期:2016-01-01 00:00:00

  • GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior.

    abstract::Ample evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood. Through multiple approaches, we demonstrate that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HPA axis and in brain...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8866187

    authors: Zheng Y,Wu M,Gao T,Meng L,Ding X,Meng Y,Jiao Y,Luo P,He Z,Sun T,Zhang G,Shi X,Rong W

    更新日期:2020-08-28 00:00:00

  • High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population.

    abstract::To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/5625768

    authors: Wang H,Bing D,Li J,Xie L,Xiong F,Lan L,Wang D,Guan J,Wang Q

    更新日期:2020-07-01 00:00:00

  • Brain connectivity plasticity in the motor network after ischemic stroke.

    abstract::The motor function is controlled by the motor system that comprises a series of cortical and subcortical areas interacting via anatomical connections. The motor function will be disturbed when the stroke lesion impairs either any of these areas or their connections. More and more evidence indicates that the reorganiza...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2013/924192

    authors: Jiang L,Xu H,Yu C

    更新日期:2013-01-01 00:00:00

  • Neural Plastic Effects of Cognitive Training on Aging Brain.

    abstract::Increasing research has evidenced that our brain retains a capacity to change in response to experience until late adulthood. This implies that cognitive training can possibly ameliorate age-associated cognitive decline by inducing training-specific neural plastic changes at both neural and behavioral levels. This lon...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/535618

    authors: Leung NT,Tam HM,Chu LW,Kwok TC,Chan F,Lam LC,Woo J,Lee TM

    更新日期:2015-01-01 00:00:00

  • Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation Exposure.

    abstract::Ionizing radiation is omnipresent. We are continuously exposed to natural (e.g., radon and cosmic) and man-made radiation sources, including those from industry but especially from the medical sector. The increasing use of medical radiation modalities, in particular those employing low-dose radiation such as CT scans,...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/1243527

    authors: Verreet T,Verslegers M,Quintens R,Baatout S,Benotmane MA

    更新日期:2016-01-01 00:00:00

  • Mirror Visual Feedback to Improve Bradykinesia in Parkinson's Disease.

    abstract::Mirror visual feedback (MVF) therapy has been applied to improve upper limb function in stroke. When combined with motor training, MVF improves the performance of the trained and untrained hand by enhancing the excitability of both primary motor cortices (M1s). Bradykinesia is a typical feature of Parkinson's disease ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/8764238

    authors: Bonassi G,Pelosin E,Ogliastro C,Cerulli C,Abbruzzese G,Avanzino L

    更新日期:2016-01-01 00:00:00

  • Postural synergies and their development.

    abstract::The recent developments of a particular approach to analyzing motor synergies based on the principle of motor abundance has allowed a quantitative assessment of multi-effector coordination in motor tasks involving anticipatory adjustments to self-triggered postural perturbations and in voluntary postural sway. This ap...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2005.119

    authors: Latash ML,Krishnamoorthy V,Scholz JP,Zatsiorsky VM

    更新日期:2005-01-01 00:00:00

  • Effects of Transcranial Alternating Current Stimulation on Cognitive Functions in Healthy Young and Older Adults.

    abstract::Recently, transcranial alternating current stimulation (tACS) has emerged as a tool to enhance human cognitive processes. Here, we provide a brief summary of the rationale behind tACS-induced effects on task-relevant brain oscillations and associated cognitive functions and review previous studies in young subjects th...

    journal_title:Neural plasticity

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/4274127

    authors: Antonenko D,Faxel M,Grittner U,Lavidor M,Flöel A

    更新日期:2016-01-01 00:00:00

  • Exposure to forced swim stress alters local circuit activity and plasticity in the dentate gyrus of the hippocampus.

    abstract::Studies have shown that, depending on its severity and context, stress can affect neural plasticity. Most related studies focused on synaptic plasticity and long-term potentiation (LTP) of principle cells. However, evidence suggests that following high-frequency stimulation, which induces LTP in principal cells, modif...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2008/194097

    authors: Yarom O,Maroun M,Richter-Levin G

    更新日期:2008-01-01 00:00:00

  • Baseline Motor Impairment Predicts Transcranial Direct Current Stimulation Combined with Physical Therapy-Induced Improvement in Individuals with Chronic Stroke.

    abstract::Transcranial direct current stimulation (tDCS) can enhance the effect of conventional therapies in post-stroke neurorehabilitation. The ability to predict an individual's potential for tDCS-induced recovery may permit rehabilitation providers to make rational decisions about who will be a good candidate for tDCS thera...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8859394

    authors: Baltar A,Piscitelli D,Marques D,Shirahige L,Monte-Silva K

    更新日期:2020-11-25 00:00:00

  • ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses.

    abstract::Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression (LTD) at the medial perforant path-granule cell synapse in early postnat...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2012/237913

    authors: Guli X,Tokay T,Rohde M,Bender RA,Köhling R,Kirschstein T

    更新日期:2012-01-01 00:00:00

  • Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic α7 Nicotinic Receptor Drugs.

    abstract::Stimulating regeneration in the brain has the potential to rescue neuronal networks and counteract progressive pathological changes in Alzheimer's disease (AD). This study investigated whether drugs with different mechanisms of action could enhance neurogenesis and improve cognition in mice receiving human neural stem...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/370432

    authors: Lilja AM,Malmsten L,Röjdner J,Voytenko L,Verkhratsky A,Ögren SO,Nordberg A,Marutle A

    更新日期:2015-01-01 00:00:00

  • Plasticity of horizontal connections at a functional border in adult rat somatosensory cortex.

    abstract::Horizontal connections in superficial cortical layers integrate information across sensory maps by connecting related functional columns. It has been hypothesized that these connections mediate cortical reorganization via synaptic plasticity. However, it is not known if the horizontal connections from discontinuous co...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2009/294192

    authors: Marik SA,Hickmott PW

    更新日期:2009-01-01 00:00:00

  • The role of NMDA receptor subtypes in short-term plasticity in the rat entorhinal cortex.

    abstract::We have previously shown that spontaneous release of glutamate in the entorhinal cortex (EC) is tonically facilitated via activation of presynaptic NMDA receptors (NMDAr) containing the NR2B subunit. Here we show that the same receptors mediate short-term plasticity manifested by frequency-dependent facilitation of ev...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2008/872456

    authors: Chamberlain SE,Yang J,Jones RS

    更新日期:2008-01-01 00:00:00

  • Spontaneous plasticity of multineuronal activity patterns in activated hippocampal networks.

    abstract::Using functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimicked in vivo conditi...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2008/108969

    authors: Usami A,Matsuki N,Ikegaya Y

    更新日期:2008-01-01 00:00:00

  • The Gαo Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons.

    abstract::Mastoparan-7 (Mas-7), an analogue of the peptide mastoparan, which is derived from wasp venom, is a direct activator of Pertussis toxin- (PTX-) sensitive G proteins. Mas-7 produces several biological effects in different cell types; however, little is known about how Mas-7 influences mature hippocampal neurons. We exa...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/4258171

    authors: Ramírez VT,Ramos-Fernández E,Inestrosa NC

    更新日期:2016-01-01 00:00:00