Abstract:
:The song of zebra finch is stable in life after it was learned successfully. Vocal plasticity is thought to be a motor exploration that can support continuous learning and optimization of performance. The activity of RA, an important pre-motor nucleus in songbird's brain, influences the song directly. This variability in adult birdsong is associated with the activity of NMDA receptors in LMAN-RA synapses, but the detailed mechanism is unclear. The control of gain refers to modulation of a neuron's responsiveness to input and is critically important for normal sensory, cognitive, and motor functions. Here, we observed the change of gain in RA projection neurons after exogenous NMDA was applied to activate NMDA receptors using the whole-cell current clamp recording. We found that NMDA substantially increased the slope (gain) of the firing rate-current relationship in RA projection neurons. The AMPA receptor-dependent excitability played a crucial role in the modulation of gain by NMDA. These results suggested that NMDA receptors may regulate the dynamics of RA projection neurons by input-output gain.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Liao SQ,Hou GQ,Pan X,Liao CS,Li DFdoi
10.1155/2012/931780subject
Has Abstractpub_date
2012-01-01 00:00:00pages
931780eissn
2090-5904issn
1687-5443journal_volume
2012pub_type
杂志文章abstract::Measurement of sleep microarchitecture and neural oscillations is an increasingly popular technique for quantifying EEG sleep activity. Many studies have examined sleep spindle oscillations in sleep-disordered adults; however reviews of this literature are scarce. As such, our overarching aim was to critically review ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Neural plasticity
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,评审
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