Abstract:
:Associative fear learning, in which stimulation of whiskers is paired with mild electric shock to the tail, modifies the barrel cortex, the functional representation of sensory receptors involved in the conditioning, by inducing formation of new inhibitory synapses on single-synapse spines of the cognate barrel hollows and thus producing double-synapse spines. In the barrel cortex of conditioned, pseudoconditioned, and untreated mice, we analyzed the number and morphological features of dendritic spines at various maturation and stability levels: sER-free spines, spines containing smooth endoplasmic reticulum (sER), and spines containing spine apparatus. Using stereological analysis of serial sections examined by transmission electron microscopy, we found that the density of double-synapse spines containing spine apparatus was significantly increased in the conditioned mice. Learning also induced enhancement of the postsynaptic density area of inhibitory synapses as well as increase in the number of polyribosomes in such spines. In single-synapse spines, the effects of conditioning were less pronounced and included increase in the number of polyribosomes in sER-free spines. The results suggest that fear learning differentially affects single- and double-synapse spines in the barrel cortex: it promotes maturation and stabilization of double-synapse spines, which might possibly contribute to permanent memory formation, and upregulates protein synthesis in single-synapse spines.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Jasinska M,Siucinska E,Jasek E,Litwin JA,Pyza E,Kossut Mdoi
10.1155/2016/9828517subject
Has Abstractpub_date
2016-01-01 00:00:00pages
9828517eissn
2090-5904issn
1687-5443journal_volume
2016pub_type
杂志文章abstract::Cerebral palsy (CP) has long been investigated to be associated with a range of motor and cognitive dysfunction. As the two most common CP subtypes, spastic cerebral palsy (SCP) and dyskinetic cerebral palsy (DCP) may share common and distinct elements in their pathophysiology. However, the common and distinct dysfunc...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/7058953
更新日期:2018-08-15 00:00:00
abstract::Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscill...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/1478684
更新日期:2016-01-01 00:00:00
abstract:Background:Bilateral arm training (BAT) has shown promise in expediting progress toward upper limb recovery in chronic stroke patients, but its neural correlates are poorly understood. Objective:To evaluate changes in upper limb function and EEG power after a robot-assisted BAT in chronic stroke patients. Methods:In ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/8105480
更新日期:2018-03-26 00:00:00
abstract::Functional and morphological studies in children affected by Attention Deficit Hyperactivity Disorder (ADHD) suggest a prefrontal cortex (PFc) dysfunction. This cortical region is regulated by subcortical systems including noradrenergic (NEergic), dopaminergic (DAergic), cholinergic, serotonergic, and histaminergic pa...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2004.133
更新日期:2004-01-01 00:00:00
abstract::The recent developments of a particular approach to analyzing motor synergies based on the principle of motor abundance has allowed a quantitative assessment of multi-effector coordination in motor tasks involving anticipatory adjustments to self-triggered postural perturbations and in voluntary postural sway. This ap...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2005.119
更新日期:2005-01-01 00:00:00
abstract::Elevated brain activation, or hyperexcitability, induces cognitive impairment and confers an increased risk of Alzheimer's disease (AD). Blocking the overexcitation of the neural network may be a promising new strategy to prevent, halt, and even reverse this condition. Physical exercise has been shown to be an effecti...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/9132720
更新日期:2020-03-18 00:00:00
abstract::Dichoptic movie viewing has been shown to significantly improve visual acuity in amblyopia in children. Moreover, short-term occlusion of the amblyopic eye can transiently increase its contribution to binocular fusion in adults. In this study, we first asked whether dichoptic movie viewing could improve the visual fun...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/6208414
更新日期:2019-08-28 00:00:00
abstract:Background:Parkinson's disease (PD) patients experience cognitive impairment which has been related to reduced quality of life and functional disability. These symptoms usually progress until dementia occurs. Some studies have been published assessing the efficacy of cognitive treatments on improving cognition, functio...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2018/2651918
更新日期:2018-05-06 00:00:00
abstract:Background:Feedback postural control depends upon information from somatosensation, vision, and the vestibular system that are weighted depending on their relative importance within the central nervous system. Following loss of any sensory component, the weighting changes, e.g., when suffering a vestibular loss, the mo...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/4826238
更新日期:2019-02-18 00:00:00
abstract::Using functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimicked in vivo conditi...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/108969
更新日期:2008-01-01 00:00:00
abstract::Isoforms of apolipoprotein E (ApoE) have been implicated as risk factors in Alzheimer's disease. We have, therefore, examined the possible role of ApoE in memory formation, using a one-trial passive avoidance task in day-old chicks. Birds were trained on the task and then at various times pre or post-training were inj...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/NP.1998.29
更新日期:1998-07-01 00:00:00
abstract:Background:Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. Th...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/9460364
更新日期:2020-09-22 00:00:00
abstract::Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures. GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system. Accumulating evidence de...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2020/8858415
更新日期:2020-08-01 00:00:00
abstract::Neuropathic pain increases the risk of cardiovascular diseases including hypertension with the characteristic of sympathetic overactivity. The enhanced tonically active glutamatergic input to the rostral ventrolateral medulla (RVLM) contributes to sympathetic overactivity and blood pressure (BP) in cardiovascular dise...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/4174010
更新日期:2017-01-01 00:00:00
abstract::Ample evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood. Through multiple approaches, we demonstrate that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HPA axis and in brain...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8866187
更新日期:2020-08-28 00:00:00
abstract::Prenatal stress (PS) has long-term sequelae for the morphological and functional status of the central nervous system of the progeny. A PS-induced proinflammatory status of the organism may result in an impairment of both hippocampal synaptic plasticity and hippocampus-dependent memory formation in adults. We addresse...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/3152129
更新日期:2019-01-21 00:00:00
abstract::Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke. However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in diabetes. We aim to investigate the effect and the potential mechanism of NLRP3 inflammasome in diabetic mice with cerebral ischemia-reperfusion i...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/9163521
更新日期:2018-04-24 00:00:00
abstract::Increasing research has evidenced that our brain retains a capacity to change in response to experience until late adulthood. This implies that cognitive training can possibly ameliorate age-associated cognitive decline by inducing training-specific neural plastic changes at both neural and behavioral levels. This lon...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/535618
更新日期:2015-01-01 00:00:00
abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/4135708
更新日期:2018-10-10 00:00:00
abstract::A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and exp...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2011/649325
更新日期:2011-01-01 00:00:00
abstract::Ceramides induce important intracellular signaling pathways, modulating proliferation, migration, apoptosis, and inflammation. However, the relevance of the ceramide metabolism in the reconvalescence phase after stroke is unclear. Besides its well-known property as a selective serotonin reuptake inhibitor, fluoxetine ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/503079
更新日期:2015-01-01 00:00:00
abstract::Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic ne...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2011/921680
更新日期:2011-01-01 00:00:00
abstract::To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/5625768
更新日期:2020-07-01 00:00:00
abstract::The plasticity of brain function, especially reorganization after stroke or sensory loss, has been investigated extensively. Based upon its special characteristics, the olfactory system allows the investigation of functional networks in patients with smell loss, as it holds the unique ability to be activated by the se...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/140419
更新日期:2014-01-01 00:00:00
abstract::Embryonic neuroepithelia and adult subventricular zone (SVZ) stem and progenitor cells express nestin. We characterized a transgenic line that expresses enhanced green fluorescent protein (eGFP) specified to neural tissue by the second intronic enhancer of the nestin promoter that had several novel features. During em...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2010/894374
更新日期:2010-01-01 00:00:00
abstract::The present study investigates whether a combined cognitive and physical training may induce changes in the cortical activity as measured via electroencephalogram (EEG) and whether this change may index a deceleration of pathological processes of brain aging. Seventy seniors meeting the clinical criteria of mild cogni...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/172192
更新日期:2015-01-01 00:00:00
abstract::Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression (LTD) at the medial perforant path-granule cell synapse in early postnat...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2012/237913
更新日期:2012-01-01 00:00:00
abstract::Childhood emotional trauma contributes significantly to certain psychopathologies, such as post-traumatic stress disorder. In experimental animals, however, whether or not early-life stress results in behavioral abnormalities in adult animals still remains controversial. Here, we investigated both short-term and long-...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2014/163908
更新日期:2014-01-01 00:00:00
abstract::The habituation/cross-habituation test (HaXha) is a spontaneous odor discrimination task that has been used for many decades to evaluate olfactory function in animals. Animals are presented repeatedly with the same odorant after which a new odorant is introduced. The time the animal explores the odor object is measure...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/9131284
更新日期:2016-01-01 00:00:00
abstract::Freezing of gait (FoG) is among the most disabling symptoms of Parkinson's disease (PD) patients. Recent studies showed that action observation training (AOT) with repetitive practice of the observed actions represents a strategy to induce longer-lasting effects compared with standard physiotherapy. We investigated wh...
journal_title:Neural plasticity
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/4897276
更新日期:2018-05-27 00:00:00