Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine.

Abstract:

:Ceramides induce important intracellular signaling pathways, modulating proliferation, migration, apoptosis, and inflammation. However, the relevance of the ceramide metabolism in the reconvalescence phase after stroke is unclear. Besides its well-known property as a selective serotonin reuptake inhibitor, fluoxetine has been reported to inhibit the acid sphingomyelinase (ASM), a key regulator of ceramide levels which derives ceramide from sphingomyelin. Furthermore, fluoxetine has shown therapeutic potential in a randomized controlled rehabilitation trial in stroke patients. Our aim was to investigate and modulate ceramide concentrations in the peri-infarct cortex, whose morphological and functional properties correlate with long-term functional outcome in stroke. We show that certain ceramide species are modulated after experimental stroke and that these changes do not result from alterations of ASM activity, but rather from nontranscriptional induction of the ceramide de novo pathway. Unexpectedly, although reducing lesion size, fluoxetine did not improve functional outcome in our model and had no significant influence on ASM activity or the concentration of ceramides. The ceramide metabolism could emerge as a potential therapeutic target in the reconvalescence phase after stroke, as its accumulation in the peri-infarct cortex potentially influences membrane functions as well as signaling events in the tissue essential for neurological recovery.

journal_name

Neural Plast

journal_title

Neural plasticity

authors

Brunkhorst R,Friedlaender F,Ferreirós N,Schwalm S,Koch A,Grammatikos G,Toennes S,Foerch C,Pfeilschifter J,Pfeilschifter W

doi

10.1155/2015/503079

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

503079

eissn

2090-5904

issn

1687-5443

journal_volume

2015

pub_type

杂志文章
  • Operant discriminative learning and evidence of subtelencephalic plastic changes after long-term detelencephalation in pigeons.

    abstract::We analyzed operant discrimination in detelencephalated pigeons and neuroanatomical substrates after long-term detelencephalation. In Experiment I, experimental pigeons with massive telencephalic ablation and control pigeons were conditioned to key peck for food. Successive discrimination was made under alternating re...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/NP.2003.247

    authors: Cerutti SM,Diaz-Cintra S,Cintra L,Ferrari EA

    更新日期:2003-01-01 00:00:00

  • Autism: a "critical period" disorder?

    abstract::Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic ne...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2011/921680

    authors: LeBlanc JJ,Fagiolini M

    更新日期:2011-01-01 00:00:00

  • The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer's Disease or Vascular Diseases through Regulating Neuroplasticity.

    abstract::Dementia affects millions of elderly worldwide causing remarkable costs to society, but effective treatment is still lacking. Acupuncture is one of the complementary therapies that has been applied to cognitive deficits such as Alzheimer's disease (AD) and vascular cognitive impairment (VCI), while the underlying mech...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2021/8868447

    authors: Ji S,Duan J,Hou X,Zhou L,Qin W,Niu H,Luo S,Zhang Y,Chan P,Jin X

    更新日期:2021-01-12 00:00:00

  • Magnetic Seizure Therapy for Unipolar and Bipolar Depression: A Systematic Review.

    abstract:UNLABELLED:Objective. Magnetic seizure therapy (MST) is a novel, experimental therapeutic intervention, which combines therapeutic aspects of electroconvulsive therapy (ECT) and transcranial magnetic stimulation, in order to achieve the efficacy of the former with the safety of the latter. MST might prove to be a valua...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2015/521398

    authors: Cretaz E,Brunoni AR,Lafer B

    更新日期:2015-01-01 00:00:00

  • Manipulation of Auditory Inputs as Rehabilitation Therapy for Maladaptive Auditory Cortical Reorganization.

    abstract::Neurophysiological and neuroimaging data suggest that the brains of not only children but also adults are reorganized based on sensory inputs and behaviors. Plastic changes in the brain are generally beneficial; however, maladaptive cortical reorganization in the auditory cortex may lead to hearing disorders such as t...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2018/2546250

    authors: Okamoto H

    更新日期:2018-05-20 00:00:00

  • Evolution of Apparent Diffusion Coefficient and Fractional Anisotropy in the Cerebrum of Asphyxiated Newborns Treated with Hypothermia over the First Month of Life.

    abstract::The objective of this study was to assess the evolution of diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI) over the first month of life in asphyxiated newborns treated with hypothermia and to compare it with that of healthy newborns. Asphyxiated newborns treated with hypothermia were enrolled prosp...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2015/653727

    authors: Kwan S,Boudes E,Benseler A,Gilbert G,Saint-Martin C,Shevell M,Wintermark P

    更新日期:2015-01-01 00:00:00

  • Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer's Disease: A Diffusion MRI Study with DTI and HARDI Models.

    abstract::Alzheimer's disease (AD) is the most common form of dementia in elderly people. It is an irreversible and progressive brain disease. In this paper, we utilized diffusion-weighted imaging (DWI) to detect abnormal topological organization of white matter (WM) structural networks. We compared the differences between WM c...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/2947136

    authors: Wang T,Shi F,Jin Y,Yap PT,Wee CY,Zhang J,Yang C,Li X,Xiao S,Shen D

    更新日期:2016-01-01 00:00:00

  • Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification.

    abstract::The endocannabinoids N-arachidonoylethanolamide (or anandamide, AEA) and 2-arachidonoylglycerol (2-AG) belong to the larger groups of N-acylethanolamines (NAEs) and monoacylglycerol (MAG) lipid classes, respectively. They are biologically active lipid molecules that activate G-protein-coupled cannabinoid receptors fou...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/2426398

    authors: Keereetaweep J,Chapman KD

    更新日期:2016-01-01 00:00:00

  • Acupuncture Reversible Effects on Altered Default Mode Network of Chronic Migraine Accompanied with Clinical Symptom Relief.

    abstract:Objective:To determine whether and how longitudinal acupuncture modulates the impaired default mode network (DMN) in chronic migraine (CM) patients without aura. Methods:Resting-state functional magnetic resonance imaging (fMRI) data from 14 CM patients treated with longitudinal pre- and postacupuncture treatment (PPA...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/5047463

    authors: Zou Y,Tang W,Li X,Xu M,Li J

    更新日期:2019-03-18 00:00:00

  • Differential induction of long-term potentiation in the horizontal versus columnar superficial connections to layer II cells of the entorhinal cortex.

    abstract::The entorhinal cortex (EC) is a nodal and independent mnemonic element of the medial temporal lobe memory circuit as it forms a bidirectional interface between the neocortex and hippocampus. Within the EC, intra- and inter-lamellar associational connections occur via horizontal and columnar projections, respectively. ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2008/814815

    authors: Ma L,Alonso A,Dickson CT

    更新日期:2008-01-01 00:00:00

  • Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients.

    abstract::Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective function...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/8583420

    authors: Fan X,Yan H,Shan Y,Shang K,Wang X,Wang P,Shan Y,Lu J,Zhao G

    更新日期:2016-01-01 00:00:00

  • Quantification of Upper Limb Motor Recovery and EEG Power Changes after Robot-Assisted Bilateral Arm Training in Chronic Stroke Patients: A Prospective Pilot Study.

    abstract:Background:Bilateral arm training (BAT) has shown promise in expediting progress toward upper limb recovery in chronic stroke patients, but its neural correlates are poorly understood. Objective:To evaluate changes in upper limb function and EEG power after a robot-assisted BAT in chronic stroke patients. Methods:In ...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/8105480

    authors: Gandolfi M,Formaggio E,Geroin C,Storti SF,Boscolo Galazzo I,Bortolami M,Saltuari L,Picelli A,Waldner A,Manganotti P,Smania N

    更新日期:2018-03-26 00:00:00

  • Cortical Reorganization in Patients Recovered from Bell's Palsy: An Orofacial and Finger Movements Task-State fMRI Study.

    abstract::Objective. To explore cortical reorganization of patients recovered from Bell's palsy (BP) by task-state functional magnetic resonance imaging (fMRI) during finger and orofacial movements and provide more evidence for acupuncture clinical treatment of BP. Methods. We collected 17 BP patients with complete clinical rec...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/8231726

    authors: Lee J,Yang J,Li C,Yuan A,Wu H,Wang A,Xue Q,Wang T,Wang L,Gao T

    更新日期:2016-01-01 00:00:00

  • Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome.

    abstract::Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learn...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9353929

    authors: Yang T,Zhao H,Lu C,Li X,Xie Y,Fu H,Xu H

    更新日期:2016-01-01 00:00:00

  • Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats.

    abstract::Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of axons projecting in...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2018/9828725

    authors: Hodgetts SI,Yoon JH,Fogliani A,Akinpelu EA,Baron-Heeris D,Houwers IGJ,Wheeler LPG,Majda BT,Santhakumar S,Lovett SJ,Duce E,Pollett MA,Wiseman TM,Fehily B,Harvey AR

    更新日期:2018-08-06 00:00:00

  • The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy.

    abstract::Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurodegenerative disorders such as Parkinson's disease (PD). In sporadic PD, the most common age-related neurodegenerative movement disorder, nigrostriatal dopaminergic deficits are responsible for the onset of motor symptoms...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5012129

    authors: Longhena F,Faustini G,Missale C,Pizzi M,Spano P,Bellucci A

    更新日期:2017-01-01 00:00:00

  • Different Degree Centrality Changes in the Brain after Acupuncture on Contralateral or Ipsilateral Acupoint in Patients with Chronic Shoulder Pain: A Resting-State fMRI Study.

    abstract::Chronic shoulder pain (CSP) is the third most common musculoskeletal problem. For maximum treatment effectiveness, most acupuncturists usually choose acupoint in the nonpainful side, to alleviate pain or improve shoulder function. This method is named opposite needling, which means acupuncture points on the right side...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/5701042

    authors: Yan CQ,Huo JW,Wang X,Zhou P,Zhang YN,Li JL,Kim M,Shao JK,Hu SQ,Wang LQ,Liu CZ

    更新日期:2020-04-25 00:00:00

  • Complete and partial lesions of the pyramidal tract in the rat affect qualitative measures of skilled movements: impairment in fixations as a model for clumsy behavior.

    abstract::Little is known about prenatal and perinatal brain injury resulting in subsequent clumsy behavior in children. One candidate motor system is the pyramidal tract. The tract traverses the entire central nervous system and, through direct and indirect connections to the brainstem and spinal cord sensory and motor nuclei,...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/NP.2003.77

    authors: Whishaw IQ,Piecharka DM,Drever FR

    更新日期:2003-01-01 00:00:00

  • Different Visual Weighting due to Fast or Slow Vestibular Deafferentation: Before and after Schwannoma Surgery.

    abstract:Background:Feedback postural control depends upon information from somatosensation, vision, and the vestibular system that are weighted depending on their relative importance within the central nervous system. Following loss of any sensory component, the weighting changes, e.g., when suffering a vestibular loss, the mo...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/4826238

    authors: Tjernström F,Fransson PA,Kahlon B,Karlberg M,Lindberg S,Siesjö P,Magnusson M

    更新日期:2019-02-18 00:00:00

  • The Gαo Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons.

    abstract::Mastoparan-7 (Mas-7), an analogue of the peptide mastoparan, which is derived from wasp venom, is a direct activator of Pertussis toxin- (PTX-) sensitive G proteins. Mas-7 produces several biological effects in different cell types; however, little is known about how Mas-7 influences mature hippocampal neurons. We exa...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/4258171

    authors: Ramírez VT,Ramos-Fernández E,Inestrosa NC

    更新日期:2016-01-01 00:00:00

  • Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus.

    abstract::Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate thedevelopment and maintenance of dendritic spines is limited. We recently reported that cyclin-dependent kinase 5 (Cdk5) is required f...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/6790743

    authors: Jin X,Sasamoto K,Nagai J,Yamazaki Y,Saito K,Goshima Y,Inoue T,Ohshima T

    更新日期:2016-01-01 00:00:00

  • Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores.

    abstract:Background:One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in resting-state functional MRI have been investigated to a limited extent. Fluctuations...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/2357107

    authors: Goodin P,Lamp G,Vidyasagar R,Connelly A,Rose S,Campbell BCV,Tse T,Ma H,Howells D,Hankey GJ,Davis S,Donnan G,Carey LM

    更新日期:2019-07-28 00:00:00

  • Topological Properties of Large-Scale Cortical Networks Based on Multiple Morphological Features in Amnestic Mild Cognitive Impairment.

    abstract::Previous studies have demonstrated that amnestic mild cognitive impairment (aMCI) has disrupted properties of large-scale cortical networks based on cortical thickness and gray matter volume. However, it is largely unknown whether the topological properties of cortical networks based on geometric measures (i.e., sulca...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/3462309

    authors: Li Q,Li X,Wang X,Li Y,Li K,Yu Y,Yin C,Li S,Han Y

    更新日期:2016-01-01 00:00:00

  • Carbachol-Induced Reduction in the Activity of Adult Male Zebra Finch RA Projection Neurons.

    abstract::Cholinergic mechanism is involved in motor behavior. In songbirds, the robust nucleus of the arcopallium (RA) is a song premotor nucleus in the pallium and receives cholinergic inputs from the basal forebrain. The activity of projection neurons in RA determines song motor behavior. Although many evidences suggest that...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2016/7246827

    authors: Meng W,Wang SH,Li DF

    更新日期:2016-01-01 00:00:00

  • Baseline Motor Impairment Predicts Transcranial Direct Current Stimulation Combined with Physical Therapy-Induced Improvement in Individuals with Chronic Stroke.

    abstract::Transcranial direct current stimulation (tDCS) can enhance the effect of conventional therapies in post-stroke neurorehabilitation. The ability to predict an individual's potential for tDCS-induced recovery may permit rehabilitation providers to make rational decisions about who will be a good candidate for tDCS thera...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/8859394

    authors: Baltar A,Piscitelli D,Marques D,Shirahige L,Monte-Silva K

    更新日期:2020-11-25 00:00:00

  • Altered Brain Activity and Functional Connectivity in Unilateral Sudden Sensorineural Hearing Loss.

    abstract:Background:Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. Th...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2020/9460364

    authors: Chen J,Hu B,Qin P,Gao W,Liu C,Zi D,Ding X,Yu Y,Cui G,Lu L

    更新日期:2020-09-22 00:00:00

  • Functional Corticomuscular Signal Coupling Is Weakened during Voluntary Motor Action in Cancer-Related Fatigue.

    abstract:Background and Purpose:Cancer-related fatigue (CRF) is widely recognized as one of the most common symptoms and side effects of cancer and/or its treatment. However, neuropathological mechanisms contributing to CRF are largely unknown, and the lack of knowledge makes CRF difficult to treat. Recent research has shown di...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2019/2490750

    authors: Jiang C,Yang Q,Chen T,Siemionow V,Ranganathan VK,Yan AF,Yue GH

    更新日期:2019-06-26 00:00:00

  • Afferent connections to the rostrolateral part of the periaqueductal gray: a critical region influencing the motivation drive to hunt and forage.

    abstract::Previous studies have shown that a particular site in the periaqueductal gray (PAG), the rostrolateral PAG, influences the motivation drive to forage or hunt. To have a deeper understanding on the putative paths involved in the decision-making process between foraging, hunting, and other behavioral responses, in the p...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2009/612698

    authors: Mota-Ortiz SR,Sukikara MH,Felicio LF,Canteras NS

    更新日期:2009-01-01 00:00:00

  • Memory effects of benzodiazepines: memory stages and types versus binding-site subtypes.

    abstract::Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent gen...

    journal_title:Neural plasticity

    pub_type: 杂志文章,评审

    doi:10.1155/NP.2005.289

    authors: Savić MM,Obradović DI,Ugresić ND,Bokonjić DR

    更新日期:2005-01-01 00:00:00

  • Action Video Game Experience Related to Altered Large-Scale White Matter Networks.

    abstract::With action video games (AVGs) becoming increasingly popular worldwide, the cognitive benefits of AVG experience have attracted continuous research attention over the past two decades. Research has repeatedly shown that AVG experience can causally enhance cognitive ability and is related to neural plasticity in gray m...

    journal_title:Neural plasticity

    pub_type: 杂志文章

    doi:10.1155/2017/7543686

    authors: Gong D,Ma W,Gong J,He H,Dong L,Zhang D,Li J,Luo C,Yao D

    更新日期:2017-01-01 00:00:00