Abstract：
:Diabetes is a chronic metabolic disease characterized by hyperglycemia and several associated biochemical abnormalities. Diabetes leads to multiorgan complications that collectively reduce life expectancy. Hematopoietic stem cells (HSCs) are nested within bone marrow (BM) niches whence they can be mobilized to the peripheral circulation. Clinically, this is done for HSC collection and autologous or allogenic transplantation. A great amount of data from basic and clinical studies support that diabetic patients are poor HSC mobilizers owing to BM remodeling. Dysfunction of the BM shares pathophysiological features and pathways with typical chronic diabetic complications that affect other issues (e.g. the retina and the kidney). From a clinical perspective, impaired HSC mobilization translates into the failure to collect a minimum number of CD34+ cells to achieve a safe engraftment after transplantation. Furthermore, blunted mobilization is associated with reduced steady-state levels of circulating HSCs, which have been consistently described in diabetic patients and associated with increased risk of adverse outcomes, including cardiovascular events and death. In this review, we discuss the most clinically relevant pharmacological options to overcome impaired HSC mobilization in diabetes. These therapeutic strategies may result in an improved outcome of diabetic patients undergoing HSC transplantation and restore circulating HSC levels, thereby protecting from adverse cardiovascular outcomes.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Albiero M,Fadini GPdoi
10.1016/j.phrs.2018.07.017subject
Has Abstractpub_date
2018-09-01 00:00:00pages
18-24eissn
1043-6618issn
1096-1186pii
S1043-6618(18)30642-Xjournal_volume
135pub_type
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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pub_type： 杂志文章,评审
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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journal_title：Pharmacological research
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doi：
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：1996-03-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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journal_title：Pharmacological research
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pub_type： 杂志文章,评审
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journal_title：Pharmacological research
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