Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo.


:Segetoside I is a plant-derived bisdesmosidic saponin from Vaccaria segetalis (Neck) with reported anticancer activities. This development has raised an interest in the therapeutic potential of segetoside I. Here, we report the in vitro and in vivo antitumor activities of segetoside I against some selected cancer cell lines (HepG2, human hepatoma; H22, mouse hepatoma; MCF-7, breast cancer; U251, gliocoma; BGC, HGC & SGC, gastric cancinoma; Lovo-1,colon cancer). MTT bioassay analysis showed that HepG2 cells were the most sensitive to segetoside I compared with other cancer cell lines, with lower toxicity in healthy mouse embryonic fibroblast cells. Segetoside I pretreatment of HepG2 resulted in apoptotic induction, dose-dependent DNA fragmentation, inhibition of cell migration, up-regulation of Bax and down-regulation of Bcl-2, which indicated that an apoptotic signaling event could have been initiated. The segetoside I also suppressed hepato-tumour growth in mice with virtually no cytotoxicity and prolonged animal survival, making it a strong oncology drug agent. These findings showed that segetoside I exhibited its antitumor activity via apoptotic induction and significantly support the possible application of the antitumor agent as a potential chemotherapeutic candidate worthy of further investigations.


Pharmacol Res


Pharmacological research


Firempong CK,Zhang HY,Wang Y,Chen J,Cao X,Deng W,Zhou J,Wang Q,Tong SS,Yu J,Xu X




Has Abstract


2016-08-01 00:00:00












  • Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders.

    abstract::Central nervous system (CNS) drug development faces significant difficulties that translate into high rates of failure and lack of innovation. The pathophysiology of neurological and psychiatric disorders often results in the breakdown of blood-CNS barriers, disturbing the CNS microenvironment and worsening disease pr...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Bicker J,Alves G,Fonseca C,Falcão A,Fortuna A

    更新日期:2020-12-01 00:00:00

  • Effect of vitamins C and E on cognitive function in mouse.

    abstract::The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250mg/kg per day) or Vitamin C (300mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Arzi A,Hemmati AA,Razian A

    更新日期:2004-03-01 00:00:00

  • Vitamin K1 attenuates hypoxia-induced relaxation of rat carotid artery.

    abstract::Vascular responses to hypoxia are heterogeneous and involve the release of vasodilators substances such as nitric oxide (NO) and prostacyclin (PGI(2)). In vitro studies have shown that Vitamin K(1) modulates the release of arachidonic acid (AA) in vascular cells, and thus inhibits the capacity of blood vessels to synt...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Tirapelli CR,Mingatto FE,De Godoy MA,Ferreira R,De Oliviera AM

    更新日期:2002-12-01 00:00:00

  • The future (or lack of future) of personalized prescription in psychiatry.

    abstract::Rapid technological advances in genetics have created conceptual chaos regarding the genetics of drug response. Terms for differing concepts are used interchangeably: pharmacogenetics with pharmacogenomics, personalized medicine with personalized prescription. Biomarker has many definitions. The author prefers the con...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: de Leon J

    更新日期:2009-02-01 00:00:00

  • ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo.

    abstract::Inflammation plays a key role in tumor promotion and development. Indeed, cyclooxygenase-2 (COX-2) expression is strongly associated with different types of cancer. An emerging class of compounds with significant anti-inflammatory properties is the hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs (H2S-...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: De Cicco P,Panza E,Ercolano G,Armogida C,Sessa G,Pirozzi G,Cirino G,Wallace JL,Ianaro A

    更新日期:2016-12-01 00:00:00

  • Diet-induced reduction in serum lipoproteins stimulates cell proliferation in weanling rats.

    abstract::Male weanling Wistar rats were fed a 4% cholestyramine diet and used as a model to demonstrate that a reduction in serum low density lipoproteins stimulates de novo cholesterogenesis leading to DNA synthesis and cell proliferation. Feeding this diet resulted in a decrease in serum very low density lipoproteins and low...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Kazanecki ME,Melhem MF,Spichty KJ,Kelly RH,Rao KN

    更新日期:1989-09-01 00:00:00

  • Canrenone on cardiovascular mortality in congestive heart failure: CanrenOne eFFects on cardiovascular mortality in patiEnts with congEstIve hearT failure: The COFFEE-IT study.

    abstract:AIM:To evaluate canrenone effects compared to other therapies on cardiovascular mortality in patients with chronic heart failure (CHF) and preserved systolic function after 10 years of evaluation. METHODS:We enrolled 532 patients with CHF and preserved systolic function. Patients were followed with a mean follow-up of...

    journal_title:Pharmacological research

    pub_type: 杂志文章,多中心研究


    authors: Derosa G,Maffioli P,Scelsi L,Bestetti A,Vanasia M,Cicero AFG,Spinardi L,Bentivenga C,Esposti DD,Caprio M,Borghi C,Pitt B,Cosentino E

    更新日期:2019-03-01 00:00:00

  • Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain.

    abstract:BACKGROUND AND PURPOSE:The enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) hydrolyze endogenous cannabinoids (eCBs), N-arachidonoyl ethanolamine (AEA) and 2-arachidonoyl glycerol (2-AG), respectively. These enzymes also metabolize eCB analogs such as lipoamines and 2-acyl glycerols, most of...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Leishman E,Cornett B,Spork K,Straiker A,Mackie K,Bradshaw HB

    更新日期:2016-08-01 00:00:00

  • Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity.

    abstract::Visceral obesity is the excess deposition of visceral fat within the abdominal cavity that surrounds vital organs. Visceral obesity is directly associated with metabolic syndrome, breast cancer and endometrial cancer. In visceral obese subjects, signal transducer and activator of the transcription 3 (STAT3) in adipocy...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Su T,Huang C,Yang C,Jiang T,Su J,Chen M,Fatima S,Gong R,Hu X,Bian Z,Liu Z,Kwan HY

    更新日期:2020-02-01 00:00:00

  • Endothelin-1 (ET-1) and vein graft failure and the therapeutic potential of ET-1 receptor antagonists.

    abstract::Despite the exploration of a large number of disparate drugs in animal models and clinical trials, no pharmacological intervention, with the exception of aggressive lipid lowering therapy has reduced late vein graft failure in man. The importance of devising more effective strategies is exemplified by the enormous eco...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Jeremy JY,Shukla N,Angelini GD,Wan S

    更新日期:2011-06-01 00:00:00

  • Protective actions of L-carnitine and acetyl-L-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors.

    abstract::The mechanism for the pathological increase in cell death in various disease states e.g. HIV immunodefficiency or even ageing or Alzheimer's disease, occurs by complex and as yet undefined mechanism(s) related to immunological, virological or biochemical disturbances (i.e. energy depletion, oxidative stress, increased...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Virmani MA,Biselli R,Spadoni A,Rossi S,Corsico N,Calvani M,Fattorossi A,De Simone C,Arrigoni-Martelli E

    更新日期:1995-12-01 00:00:00

  • Inhibition of the NANC relaxation of the guinea-pig proximal colon longitudinal muscle by the purinoceptor antagonist PPADS, inhibition of nitric oxide synthase, but not by a PACAP/VIP antagonist.

    abstract::The effects of the P(2)-purinoceptor antagonist pyridoxal-phosphate-6-azophenyl- 2('),4(')- disulphonic acid (PPADS), the nitric oxide (NO) synthase inhibitor N(G)-nitro- l -arginine (l -NOARG), the K(+)-channel blocker apamin, the pituitary adenylate cyclase activating peptide (PACAP) antagonist PACAP(6-38) and the s...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Rózsai B,Lázár Z,Benkó R,Barthó L

    更新日期:2001-01-01 00:00:00

  • Ketamine protects acetylcholinesterase against inhibition by propoxur and phoxim.

    abstract::In the present study the effect of ketamine on the contractions caused by propoxur and phoxim on the isolated guinea pig ileum was investigated. Ketamine was found able to inhibit in a concentration-dependent manner the contractile responses of the ileum to propoxur and phoxim, while it did not significantly modify th...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Koutsoviti-Papadopoulou M,Kounenis G,Elezoglou V

    更新日期:1994-08-01 00:00:00

  • Microalgae-derived oxylipins decrease inflammatory mediators by regulating the subcellular location of NFκB and PPAR-γ.

    abstract::Oxylipins (OXLs) are bioactive molecules generated by the oxidation of fatty acids that promote the resolution of acute inflammation and prevent chronic inflammatory processes through molecular mechanisms that are not well known. We have previously reported the anti-inflammatory activity of microalgae-derived OXLs and...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ávila-Román J,Talero E,de Los Reyes C,García-Mauriño S,Motilva V

    更新日期:2018-02-01 00:00:00

  • Interactions of gut microbiota with functional food components and nutraceuticals.

    abstract::The human gut is populated by an array of bacterial species, which develop important metabolic and immune functions, with a marked effect on the nutritional and health status of the host. Dietary component also play beneficial roles beyond basic nutrition, leading to the development of the functional food concept and ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Laparra JM,Sanz Y

    更新日期:2010-03-01 00:00:00

  • Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo.

    abstract::Evodiae fructus is a widely used herbal drug in traditional Chinese medicine. Evodia extract was found to inhibit hERG channels. The aim of the current study was to identify hERG inhibitors in Evodia extract and to investigate their potential proarrhythmic effects. Dehydroevodiamine (DHE) and hortiamine were identifie...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Baburin I,Varkevisser R,Schramm A,Saxena P,Beyl S,Szkokan P,Linder T,Stary-Weinzinger A,van der Heyden MAG,Houtman M,Takanari H,Jonsson M,Beekman JHD,Hamburger M,Vos MA,Hering S

    更新日期:2018-05-01 00:00:00

  • Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies.

    abstract::Dementia with Lewy bodies (DLB) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective treatments. This comparative ligand autoradiographical study has quantified histamine H3 recepto...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lethbridge NL,Chazot PL

    更新日期:2016-11-01 00:00:00

  • TRPM8 channel activation triggers relaxation of pudendal artery with increased sensitivity in the hypertensive rats.

    abstract:INTRODUCTION:Erectile dysfunction (ED) is frequently encountered in patients with arterial hypertension and there is a recent functional correlation between the expression of thermoreceptor channels TRPM8 (melastatin 8) and alterations in blood pressure in hypertension. The aim of this study was to investigate the func...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Silva DF,Wenceslau CF,Mccarthy CG,Szasz T,Ogbi S,Webb RC

    更新日期:2019-09-01 00:00:00

  • The acute alterations in biochemistry, morphology, and contractility of rat-isolated terminal ileum via increased intra-abdominal pressure.

    abstract:AIM AND SCOPE:To determine the acute effects of increased intra-abdominal pressure (IAP) on the biochemistry, morphology, and contractility of the isolated terminal ileum of rats. BACKGROUND:Laparoscopic procedures are used clinically in diagnostic and treatment modalities and experimentally as a model of ischemia-rep...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Unsal MA,Imamoglu M,Kadioglu M,Aydin S,Ulku C,Kesim M,Alver A,Kalyoncu NI,Yaris E,Bozkaya H

    更新日期:2006-02-01 00:00:00

  • Isobolographic analysis of the antinociceptive interactions of clonidine with nonsteroidal anti-inflammatory drugs.

    abstract::The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clon...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Miranda HF,Pinardi G

    更新日期:2004-09-01 00:00:00

  • Gastric motor effects of triptans: open questions and future perspectives.

    abstract::Sumatriptan is a 5-HT1B/D receptor agonist of documented efficacy in relieving migraine and associated symptoms such as nausea and vomiting. In the past decade, several studies reported an important delay of gastric emptying induced by sumatriptan in healthy humans. The impact of this gastric motor effect of sumatript...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Cipolla G,Sacco S,Crema F,Moro E,De Ponti F,Frigo G

    更新日期:2001-03-01 00:00:00

  • The effect of manganese chloride on gentamicin-induced nephrotoxicity in rats.

    abstract::The aim of this study was to investigate the effects of manganese chloride on gentamicin-induced nephrotoxicity in rats. Thirty-six adult Wistar Albino rats were divided into six equal groups. They were injected with gentamicin sulfate (100 mg kg(-1) per day i.p.) and manganese chloride (2 or 20 mg kg(-1) per day i.p....

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ateşşahin A,Karahan I,Yilmaz S,Ceribaşi AO,Princci I

    更新日期:2003-12-01 00:00:00

  • Immunological regulatory effect of flavonoid baicalin on innate immune toll-like receptors.

    abstract::As an essential component of the innate immune system, Toll-like receptors (TLRs) are a family of well-recognized ligand-binding receptors found in various organisms and initiate host immune responses. Activation of TLRs signaling pathways lead to the induction of numerous genes that function in host defense. Baicalin...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Jiang M,Li Z,Zhu G

    更新日期:2020-08-01 00:00:00

  • Reversible binding of celecoxib and valdecoxib with human serum albumin using fluorescence spectroscopic technique.

    abstract::Mechanism of interaction of non-steroidal anti-inflammatory drugs, celecoxib and valdecoxib with human serum albumin has been studied using fluorescence spectroscopic technique. There was only one high affinity site on serum albumin for both the drugs with association constants of the order of 10(4) in the case of cel...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Seedher N,Bhatia S

    更新日期:2006-08-01 00:00:00

  • Circadian clock: Time for novel anticancer strategies?

    abstract::Disruption of the circadian clock is associated with a variety of human pathologies, including cancer. Rather than being a mere consequence of a global changes associated with the cancer cell transcriptome, the aberrant clock gene expression observed in many tumors may serve for cancer cell survival. This scenario sug...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Ercolani L,Ferrari A,De Mei C,Parodi C,Wade M,Grimaldi B

    更新日期:2015-10-01 00:00:00

  • Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms.

    abstract::Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic accompany with metabolic and endocrine disorders worldwide. Most of DM patients are affected by type 2 diabetes mellitus (T2DM) with insulin resistance and insulin secretion defect. Generally, the strategies to treat T2DM are diet...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Xu L,Li Y,Dai Y,Peng J

    更新日期:2018-04-01 00:00:00

  • Improvement of glucocorticoid-impaired thymus function by dihydromyricetin via up-regulation of PPARγ-associated fatty acid metabolism.

    abstract::T lymphocytes produced by the thymus are essential mediators of immunity. Accelerated thymic atrophy appears in the patients with administration of glucocorticoids (GCs) which are commonly-used drugs to treat autoimmune and infectious diseases, leading to dysregulation of immunity with manifestation of progressive dim...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Li T,Yan F,Meng X,Wang J,Ting Kam RK,Zeng X,Liu Z,Zhou H,Yang F,Ren R,Liao K,Liu L

    更新日期:2018-11-01 00:00:00

  • Age, sex, and specific gene mutations affect the effects of immune checkpoint inhibitors in colorectal cancer.

    abstract::The effect of age and sex on the predictive value of colorectal cancer (CRC) patients treated with immune checkpoint inhibitors (ICIs) has been controversial, and the effect of specific gene mutations on the predictive value of CRC patients treated with ICIs remains to be explored. Our study analyzed the influence of ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lin A,Zhang H,Hu X,Chen X,Wu G,Luo P,Zhang J

    更新日期:2020-09-01 00:00:00

  • Disease modifying therapies in type 1 diabetes: Where have we been, and where are we going?

    abstract::With more than four decades of clinical research and 25 years of clinical trials, much is known about the natural history of T1D before and after clinical diagnosis. We know that autoimmunity occurs early in life, that islet autoimmunity inevitably leads to clinically overt disease, and that some immune therapies can ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Lord S,Greenbaum CJ

    更新日期:2015-08-01 00:00:00

  • Bmi1 drives the formation and development of intrahepatic cholangiocarcinoma independent of Ink4A/Arf repression.

    abstract::Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. Compared with HCC, for which several drugs have been approved, ICC is associated with shorter survival, and no drug has been approved for this type. Previously, we reported that Bmi1 drives HC...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Guo J,Deng N,Xu Y,Li L,Kuang D,Li M,Li X,Xu Z,Xiang M,Xu C

    更新日期:2020-12-08 00:00:00