Abstract：
:Oxidative stress is related to the progression of renal diseases and modulation of oxidative stress can lead to a reduction in vascular events in patients with chronic renal insufficiency (CRI). Indoxyl sulfate (IS) and xanthine oxidase (XO) are related to impaired neovasculogenesis in CRI. Hydralazine is suggested for blood pressure control in CRI. This study aimed to investigate whether hydralazine could improve ischemia-induced neovasculogenesis in CRI animals by reducing reactive oxygen species (ROS) levels. Mice underwent subtotal nephrectomy or sham surgery. Nitrendipine, probenecid, and allopurinol were used to reduce blood pressure, uric acid (UA), and XO activity levels, respectively, for comparison. Blood pressure, XO activity and UA levels that were increased after subtotal nephrectomy were reduced by hydralazine treatment. Allopurinol decreased blood XO activity and UA levels. Only hydralazine and allopurinol increased the number of circulating endothelial progenitor cells (EPCs) and improved neovasculogenesis in CRI mice. IS activated XO mRNA and ROS and inhibited the functions of EPCs and endothelial cells, which could be reversed by hydralazine. However, no additional beneficial effects were observed when XO was inhibited with both hydralazine and siRNA. In conclusion, hydralazine, as a potential XO inhibitor, not only reduced blood pressure and UA levels but also increased the number of circulating EPCs and improved neovasculogenesis in CRI animals. Hydralazine directly inhibited IS-induced ROS and XO activation in EPCs and endothelial cells, and restored their functions in vitro. Future studies should evaluate whether hydralazine could provide additional vascular protection in patients with CRI.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Chang TT,Chen JWdoi
10.1016/j.phrs.2019.104509subject
Has Abstractpub_date
2020-01-01 00:00:00pages
104509eissn
1043-6618issn
1096-1186pii
S1043-6618(19)31612-3journal_volume
151pub_type
杂志文章abstract：OBJECTIVE:Nuclear factor (NF)-kappaB is a ubiquitous transcription factor that can be activated by multiple signals. To elucidate the role of NF-KB and the effects of NF-kappaB inhibitor on ureteric damages in obstructive uropathy, we conducted this study. METHODS:The expressions of NF-kappaBp50, NF-kappaBp65, interle...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2009.05.004
更新日期：2009-10-01 00:00:00
abstract：:Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulate the receptor's signaling output. In this proof-of-concept study, we explored the pain-relief potential of a pepducin series derived from ...
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abstract：:Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder caused by an impaired receptor-mediated low-density lipoprotein (LDL) removal from the circulation, mainly due to disruptive autosomal co-dominant mutations in the LDL receptor (LDLr) gene, but also less frequently in the apolipoprotein B100 (...
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abstract：:Tissue subjected to a period of ischemia undergoes functional and morphological damage that increases during the reperfusion phase. In this study, the protective effect of aprotinin, which is a protease inhibitor, was assessed in a rabbit unilateral renal ischemia-reperfusion (I/R) model. New Zealand rabbits, weighing...
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doi：10.1006/phrs.2001.0902
更新日期：2001-12-01 00:00:00
abstract：:The role of autophagy, a process in which the cell self-digests its own components, was investigated in glioma cell death induced by the hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase-inhibiting drug simvastatin. Induction of autophagy and activation of autophagy-regulating signalling pathways were analyzed by i...
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doi：10.1016/j.phrs.2011.08.003
更新日期：2012-01-01 00:00:00
abstract：:There is considerable evidence to support the role of anandamide (AEA), an endogenous ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects mediated by other biological targets, of which the transient receptor potential vanilloid type 1 (TRPV1) has been the most investigated. Both,...
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abstract：:The polyphenol resveratrol is considered to exert many beneficial actions, such as antioxidant, anti-inflammatory, insulin-sensitizer and anticancer effects. Its benefits in patients with type 2 diabetes mellitus (T2DM) are controversial. Our aims were to determine whether resveratrol supplementation at two different ...
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更新日期：2016-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2004-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2006-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.phrs.2008.02.006
更新日期：2008-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/1043-6618(90)90731-r
更新日期：1990-05-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1996.0099
更新日期：1997-01-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2007.09.009
更新日期：2007-12-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1999.0572
更新日期：2000-02-01 00:00:00
abstract：AIM AND SCOPE:To determine the acute effects of increased intra-abdominal pressure (IAP) on the biochemistry, morphology, and contractility of the isolated terminal ileum of rats. BACKGROUND:Laparoscopic procedures are used clinically in diagnostic and treatment modalities and experimentally as a model of ischemia-rep...
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doi：10.1016/j.phrs.2005.09.010
更新日期：2006-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-09-01 00:00:00
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更新日期：2010-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/1043-6618(94)80041-3
更新日期：1994-02-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1999.0552
更新日期：2000-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/1043-6618(91)90041-u
更新日期：1991-12-01 00:00:00
abstract：:Because many Ca2+ channel blocking agents are known to cause adverse systemic effects, in this study we tested the haemodynamic side effects of nimodipine with and without a mild hypoxic-ischaemic (HI) insult in a newborn piglet model. Fifteen min after completing a brief period of asphyxia we gave i.v. nimodipine as ...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1996.0002
更新日期：1996-01-01 00:00:00
abstract：:The review emphasizes the role of NGF, the most representative member of the neurotrophins family, in cardiac physiopathology with a particular focus on healing and sprouting processes occurring after tissue damage. Cardiac and circulating NGF levels dramatically increase following myocardial injury (MI). A very early...
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pub_type： 杂志文章,评审
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更新日期：2011-04-01 00:00:00
abstract：:Respiratory fluoroquinolones are currently considered by several guidelines among the most effective antimicrobial agents for the treatment of acute bacterial rhinosinusitis. The aim of this study was to assess levofloxacin penetration into paranasal sinuses mucosa of 15 patients with chronic rhinosinusitis 1h (n = 4)...
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更新日期：2007-01-01 00:00:00
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更新日期：2019-10-01 00:00:00
abstract：:Isoxanthohumol (IXN), a prenylated flavonoid from hops, exhibits diverse biological activities, e.g. antitumor, antiinflammatory, antioxidant and antiangiogenic. In this study, the effect of IXN is evaluated on two melanoma cell lines with dissimilar molecular background, B16 and A375. The treatment of both cell lines...
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更新日期：2016-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-06-01 00:00:00
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pub_type： 杂志文章,meta分析
doi：10.1016/j.phrs.2020.105250
更新日期：2020-11-01 00:00:00
abstract：:Boldo (Peumus boldus Mol.), a Chilean tree traditionally employed in folk medicine and recognized as a herbal remedy in a number of pharmacopoeias, mainly for the treatment of liver ailments, has recently been the subject of increasing attention. Boldine, in particular, the major and most characteristic alkaloidal con...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/1043-6618(94)80093-6
更新日期：1994-01-01 00:00:00
