Abstract:
:By the use of combined radioreceptor binding and autoradiographic techniques we attempted to analyse the biochemical characteristics and the anatomical localization of GABA-B receptors in sections of rat circle of Willis and pialarachnoid arteries. 3H-GABA in the presence of 40 microM isoguvacine and 2.5 mM CaCl2 was used to label GABA-B receptor sites. Sections of rat cerebellar cortex were also processed as a reference tissue. No specific 3H-GABA binding was detectable either in radioreceptor binding or autoradiographic experiments. In contrast, the ligand was bound to sections of cerebellar cortex in a manner consistent with the labelling of GABA-B receptor sites. These findings indicate that cerebrovascular physiological responses to GABA are not linked, in the rat cerebrovascular tree, to the activation of GABA-B receptors.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Napoleone P,Ferrante F,Amenta Fdoi
10.1016/1043-6618(90)90731-rsubject
Has Abstractpub_date
1990-05-01 00:00:00pages
337-42issue
3eissn
1043-6618issn
1096-1186pii
1043-6618(90)90731-Rjournal_volume
22pub_type
杂志文章abstract::The effect of gentamicin on both glutamate synthesis and glutamate deamination was studied in kidney-cortex mitochondria and tubules isolated from both control and gentamicin-treated animals. In kidney-cortex mitochondria which were permeabilized in order to make a free access of substrates and antibiotic to the gluta...
journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/s1043-6618(05)80106-9
更新日期:1991-01-01 00:00:00
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journal_title:Pharmacological research
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更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2016-05-01 00:00:00
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更新日期:2014-03-01 00:00:00
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journal_title:Pharmacological research
pub_type: 临床试验,杂志文章
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更新日期:1994-10-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1998.0302
更新日期:1998-05-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/s1043-6618(05)80018-0
更新日期:1995-11-01 00:00:00
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journal_title:Pharmacological research
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doi:10.1006/phrs.1998.0484
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journal_title:Pharmacological research
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abstract::Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide that afflicts human health. With the in-depth study of the disease, its pathogenesis has gradually become clear. Although great breakthroughs have been made in the research of ALD, the research and development of drugs related to ALD has...
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更新日期:2019-12-01 00:00:00
abstract::Disruption of the circadian clock is associated with a variety of human pathologies, including cancer. Rather than being a mere consequence of a global changes associated with the cancer cell transcriptome, the aberrant clock gene expression observed in many tumors may serve for cancer cell survival. This scenario sug...
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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更新日期:2021-01-13 00:00:00
abstract::The understanding of signaling cascades involved in the induction, promotion, and progression of cancer, although advanced in recent years, is still incomplete. Tracing the imbalance of the impaired, physiologically-essential cellular signaling that drives the neoplastic process is a complex issue. This review discuss...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
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更新日期:2012-07-01 00:00:00
abstract::A favourable option to management symptoms during menopausal transition is menopausal hormone therapy (MHT) but relation among MHT and risk of melanoma is controversial. This study aims to identify, analyse and present the evidence surrounding post-menopausal exogenous hormone therapy and the risk for melanoma in wome...
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更新日期:2020-10-01 00:00:00