Abstract:
:Plasma lipid and lipoprotein levels were evaluated in 27 adults with essential hypertension at four different periods during a 12-month treatment with doxazosin. Mean plasma total cholesterol (TC), low-density lipoprotein-cholesterol (LDLC), triglyceride (TG), very low density lipoprotein-cholesterol (VLDLC) and the LDLC/HDLC ratio were significantly reduced following doxazosin therapy. The HDLC/C ratio was found to be increased, while mean high density lipoprotein cholesterol (HDLC) level remained unchanged at 3, 6, 9 and 12 months of measurement after doxazosin treatment. Our data showed that the duration of doxazosin treatment did not influence the observed favourable lipid changes; but TC and LDLC appear to be the lipid fractions most affected by doxazosin in all the patients. In order to determine the possible factors responsible for the lipid-altering actions of doxazosin treatment, we observed beneficial lipid and lipoprotein changes in both the male and female subpopulations of patients with a slightly higher magnitude in the females. The dosage of doxazosin was, however, found to have no influence on the lipid-altering actions; a further study was therefore recommended.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Ahaneku JE,Taylor GO,Agbedana EO,Walker O,Salako LAdoi
10.1016/1043-6618(94)80108-8subject
Has Abstractpub_date
1994-10-01 00:00:00pages
263-72issue
3eissn
1043-6618issn
1096-1186pii
1043-6618(94)80108-8journal_volume
30pub_type
临床试验,杂志文章abstract::Expression of abnormally long polyglutamine (polyQ) tracks is the source of a range of dominant neurodegenerative diseases, such as Huntington disease. Currently, there is no treatment for this devastating disease, although some chemicals, e.g., metformin, have been proposed as therapeutic solutions. In this work, we ...
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2006.03.006
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journal_title:Pharmacological research
pub_type: 杂志文章
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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doi:10.1016/j.phrs.2008.02.006
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journal_title:Pharmacological research
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doi:10.1016/j.phrs.2018.02.032
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2009.01.014
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2005.05.014
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更新日期:2018-11-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0572
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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更新日期:1996-01-01 00:00:00
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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journal_title:Pharmacological research
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更新日期:2019-12-01 00:00:00
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journal_title:Pharmacological research
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