Abstract：
:Mitochondria are best known for their role in ATP generation. However, studies over the past two decades have shown that mitochondria do much more than that. Mitochondria regulate both necrotic and apoptotic cell death pathways, they store and therefore coordinate cellular Ca2+ signaling, they generate and metabolize important building blocks, by-products and signaling molecules, and they also generate and are targets of free radical species that modulate many aspects of cell physiology and pathology. Most estimates suggest that although the brain makes up only 2 percent of body weight, utilizes about 20 percent of the body's total ATP. Thus, mitochondrial dysfunction greatly impacts brain functions and is indeed associated with numerous neurodegenerative diseases. Furthermore, a number of abnormal disease-associated proteins have been shown to interact directly with mitochondria, leading to mitochondrial dysfunction and subsequent neuronal cell death. Here, we discuss the role of mitochondrial dynamics impairment in the pathological processes associated with neurodegeneration and suggest that a therapy targeting mitochondrialdysfunction holds a great promise.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Joshi AU,Mochly-Rosen Ddoi
10.1016/j.phrs.2018.08.010subject
Has Abstractpub_date
2018-12-01 00:00:00pages
2-15eissn
1043-6618issn
1096-1186pii
S1043-6618(18)30467-5journal_volume
138pub_type
杂志文章,评审abstract：:Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) are essential amino acids for humans and play an important role as the building blocks of proteins. Recent studies have disclosed that free BCAAs in the tissue amino acid pool function not only as substrates for protein synthesis, but also as regulato...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2018.05.014
更新日期：2018-07-01 00:00:00
abstract：INTRODUCTION:Erectile dysfunction (ED) is frequently encountered in patients with arterial hypertension and there is a recent functional correlation between the expression of thermoreceptor channels TRPM8 (melastatin 8) and alterations in blood pressure in hypertension. The aim of this study was to investigate the func...
journal_title：Pharmacological research
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journal_title：Pharmacological research
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doi：10.1006/phrs.2000.0790
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abstract：:In this lipopolysaccharide (LPS)-induced endotoxemia model, the effects of 3-aminobenzamide (3-AB), a poly(ADP-ribose) synthetase (PARS) inhibitor, on ileal apoptosis were evaluated by light microscopy and M30 cell death staining. Moreover, the relationship between Bcl-2, iNOS expression, and serum nitrate (NO(3)(-)) ...
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1006/phrs.1997.0254
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1996.0021
更新日期：1996-02-01 00:00:00
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journal_title：Pharmacological research
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doi：10.1016/j.phrs.2013.06.001
更新日期：2013-08-01 00:00:00
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doi：10.1016/s1043-6618(05)80084-2
更新日期：1991-04-01 00:00:00
abstract：:Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic accompany with metabolic and endocrine disorders worldwide. Most of DM patients are affected by type 2 diabetes mellitus (T2DM) with insulin resistance and insulin secretion defect. Generally, the strategies to treat T2DM are diet...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2018.01.015
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abstract：:Mechanism of interaction of non-steroidal anti-inflammatory drugs, celecoxib and valdecoxib with human serum albumin has been studied using fluorescence spectroscopic technique. There was only one high affinity site on serum albumin for both the drugs with association constants of the order of 10(4) in the case of cel...
journal_title：Pharmacological research
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doi：10.1016/j.phrs.2006.02.008
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2016-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2001-10-01 00:00:00
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journal_title：Pharmacological research
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doi：10.1006/phrs.2000.0778
更新日期：2001-03-01 00:00:00
abstract：:The mitochondrial citrate carrier (CIC) is a nuclear-encoded protein located in the inner mitochondrial membrane. By mediating efflux of citrate from the mitochondria to the cytosol, CIC links mitochondrial central carbon metabolism and cytosolic lipogenesis together. Abnormal activity or expression of CIC was found i...
journal_title：Pharmacological research
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更新日期：2020-11-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2021-01-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/s1043-6618(03)00217-2
更新日期：2003-11-01 00:00:00
abstract：:It has demonstrated that carteolol can increase the endothelium-dependent vasodilation induced by alpha-2 adrenergic agonist. In order to evaluate the effect of carteolol, and to clarify the mechanism, we examined the effects of 10 microM carteolol on the vasodilation induced by increasing doses (10(-7)-10(-4) M) of c...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/1043-6618(95)80038-7
更新日期：1995-05-01 00:00:00
abstract：:In this study, we evaluated anti-hyperglycemic effect and body weight reduction activity of Gymnema yunnanense extract in obese ob/ob and diabetic db/db mice. Animals received daily intraperitoneal injections of the extract 100 mg/kg for 12 days. On Day 5, the extract-treated ob/ob mice had significantly lower fasting...
journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2003-04-01 00:00:00
abstract：:The survey was carried out, between September 1995 and May 1996, in order to describe the prescriptive behaviour among Sicilian general practitioners (GPs) in choosing an empirical antibiotic regimen for LRTIs in adult patients and begin an educational process which involves the same GPs in decisions regarding their p...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1998.0484
更新日期：1999-07-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2012.05.004
更新日期：2012-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1999.0632
更新日期：2000-07-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2016.03.018
更新日期：2016-05-01 00:00:00
abstract：:Sodium-glucose transporter 2 (SGLT2) inhibitors, also known as gliflozins, are a new class of orally active drugs used in the management of type 2 diabetes. By inhibiting the SGLT responsible for the reabsorption of glucose from the kidney, their use aims primarily to induce glycosuria and, as a consequence, lower gly...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
abstract：AIM AND SCOPE:To determine the acute effects of increased intra-abdominal pressure (IAP) on the biochemistry, morphology, and contractility of the isolated terminal ileum of rats. BACKGROUND:Laparoscopic procedures are used clinically in diagnostic and treatment modalities and experimentally as a model of ischemia-rep...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2005.09.010
更新日期：2006-02-01 00:00:00
abstract：:The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clon...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2004.02.008
更新日期：2004-09-01 00:00:00
abstract：:Biochemical evaluations of the effects of the sulfhydryl-containing angiotensin-converting enzyme inhibitor (captopril) on the nephrotoxicity induced by doxorubicin in normal rats were carried out. A single dose of doxorubicin (15 mg kg-1) which caused nephrotoxicity was manifested biochemically by the elevation of se...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1998.0432
更新日期：1999-03-01 00:00:00
abstract：:In hypothermic rats with acute hypertension induced by intravenous injection of adrenalin, regional changes in blood-brain barrier permeability to macromolecules were investigated using Evans blue as indication. Evans blue albumin extravasation was determined as a macroscopic finding and a quantitative estimation with...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Green tea (Camellia sinensis, Theaceace) is the second most popular beverage in the world and has been extensively studied for its putative disease preventive effects. Green tea is characterized by the presence of a high concentrations of polyphenolic compounds known as catechins, with (-)-epigallocatechin-3-gallate (...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2010.12.013
更新日期：2011-08-01 00:00:00
abstract：:Cocoa contains flavonoids with antioxidant properties. The aim of this study was to ascertain the effect of cocoa intake on oxidative stress associated with a model of chronic inflammation such as adjuvant arthritis. Female Wistar rats were fed with a 5% or 10% cocoa-enriched diet or were given p.o. a quercetin suspen...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2012.05.009
更新日期：2012-09-01 00:00:00
