ACE inhibition, ACE2 and angiotensin-(1-7) axis in kidney and cardiac inflammation and fibrosis.

abstract：:We have recently synthesized a new series of 4,5-dihydrobenzo-oxa-cycloheptapyrazole derivatives with the aim to discover novel CB1 antagonist agents characterized by anti-obesity activity comparable to that of SR141716A but with reduced adverse effects such as anxiety and depression. Within the novel class, the CB1 a...

journal_title：Pharmacological research

authors： Mastinu A,Pira M,Pinna GA,Pisu C,Casu MA,Reali R,Marcello S,Murineddu G,Lazzari P

更新日期：2013-08-01 00:00:00

abstract：:The growing size of trials on primary and secondary prevention of acute coronary syndromes characterised by very broad inclusion criteria may seem logical to 'trialists', who reason that the the broader the inclusion criteria, the easier it is to recruit large numbers of patients in a short period of time and the more...

journal_title：Pharmacological research

authors： Monaco C,Cianflone D,Summaria F,Maseri A,Crea F

更新日期：1998-06-01 00:00:00

abstract：:The smoothened (SMO) receptor, an essential signal transducer in the Hedgehog pathway, was targeted with antagonists to suppress the tumor. It is interesting that SMO D473H mutation confers resistance on inhibitor LDE-225 rather than LEQ-506. In this paper, the binding modes of them against the wild type and mutant SM...

journal_title：Pharmacological research

authors： Tu J,Li JJ,Song LT,Zhai HL,Wang J,Zhang XY

更新日期：2018-03-01 00:00:00

abstract：:The cytokine thymic stromal lymphopoietin (TSLP) is involved in the development and the progression of allergic diseases. It is mainly released by epithelial cells at barriers such as skin and gut in response to danger signals. Overexpression of TSLP in keratinocytes (KC) can provoke the development of a type 2 inflam...

journal_title：Pharmacological research

authors： Schaper K,Rossbach K,Köther B,Stark H,Kietzmann M,Werfel T,Gutzmer R

更新日期：2016-11-01 00:00:00

abstract：:In this study, we have investigated the vasodilator response to acetylcholine under diabetic conditions in isolated renal arteries of Wistar rats. The effect of nitric oxide synthase (NOS) inhibition on acetylcholine-induced vasodilator response was investigated. We have also examined the effects of two endothelium-de...

journal_title：Pharmacological research

authors： Yousif MH

更新日期：2003-09-01 00:00:00

abstract：:The effects of betel leaf extract (0.10, 0.40, 0.80 and 2.0 g kg-1 day-1 for 15 days) on the alterations in thyroid hormone concentrations. lipid peroxidation (LPO) and on the activities of superoxide dismutase (SOD) and catalase (CAT) were investigated in male Swiss mice. Administration of betel leaf extract exhibite...

journal_title：Pharmacological research

authors： Panda S,Kar A

更新日期：1998-12-01 00:00:00

abstract：:A pharmacokinetic study of the metabolic profile of resveratrol has been performed in healthy men after moderate red wine (RW) consumption. The bioavailability of resveratrol is highly influenced by several factors such as the food matrix and, therefore, this study has been compared with a pilot study in which men ing...

journal_title：Pharmacological research

authors： Rotches-Ribalta M,Andres-Lacueva C,Estruch R,Escribano E,Urpi-Sarda M

更新日期：2012-11-01 00:00:00

abstract：:The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clon...

journal_title：Pharmacological research

authors： Miranda HF,Pinardi G

更新日期：2004-09-01 00:00:00

abstract：:Breast cancer, the most prevalent cancer in women, remains the second in the list of cancer mortality, the majority of these fatalities resulted from estrogen receptor alpha (ERα) positive disease. ERα is well known for its function on breast cancer initiation and development and has become the most successful biomark...

journal_title：Pharmacological research

authors： Zhao Y,Zhao C,Lu J,Wu J,Li C,Hu Z,Tian W,Yang L,Xiang J,Zhou H,Deng Z,Huang J,Hong K

更新日期：2019-08-01 00:00:00

abstract：:Myocardial infarction (MI) is a major cause of morbidity and mortality in western countries and the formation of intracoronary thrombi is recognized as a critical determinant of this ischaemic event. Since streptokinase and urokinase cause in vitro lysis of clots, it was though that these drugs were also effective in ...

journal_title：Pharmacological research

authors： Di Minno G,Margaglione M,Cerbone AM,Papa R,Mattei A

更新日期：1989-03-01 00:00:00

abstract：AIM AND SCOPE:To determine the acute effects of increased intra-abdominal pressure (IAP) on the biochemistry, morphology, and contractility of the isolated terminal ileum of rats. BACKGROUND:Laparoscopic procedures are used clinically in diagnostic and treatment modalities and experimentally as a model of ischemia-rep...

journal_title：Pharmacological research

authors： Unsal MA,Imamoglu M,Kadioglu M,Aydin S,Ulku C,Kesim M,Alver A,Kalyoncu NI,Yaris E,Bozkaya H

更新日期：2006-02-01 00:00:00

abstract：:Diabetes mellitus is an important risk factor for the development of cardiovascular disease. The impact of diabetes on the heart in part resides in the changes in metabolic fuel availability evoked by lack of insulin or resistance to its action. This review addresses how the metabolic abnormalities associated with poo...

journal_title：Pharmacological research

authors： Holness MJ,Samsuddin S,Sugden MC

更新日期：2009-09-01 00:00:00

abstract：:Targeting on the IKKβ to discover anti-inflammatory drugs has been launched for ten years, due to its predominant role in canonical NF-κB signaling. In the current study, we identified a novel IKKβ inhibitor, ellipticine (ELL), an alkaloid isolated from Ochrosia elliptica and Rauvolfia sandwicensis. We found that ELL ...

journal_title：Pharmacological research

authors： Chen Q,Liu J,Zhuang Y,Bai LP,Yuan Q,Zheng S,Liao K,Khan MA,Wu Q,Luo C,Liu L,Wang H,Li T

更新日期：2019-11-01 00:00:00

abstract：:Pulmonary fibrosis is a chronic condition characterized by progressive scarring of lung parenchyma. The aim of this study was to examine the effects of an ultramicronized preparation of palmitoylethanolamide (PEA-um(®)), an endogenous fatty acid amide, in mice subjected to idiopathic pulmonary fibrosis. Idiopathic pul...

journal_title：Pharmacological research

authors： Di Paola R,Impellizzeri D,Fusco R,Cordaro M,Siracusa R,Crupi R,Esposito E,Cuzzocrea S

更新日期：2016-09-01 00:00:00

abstract：:The hepatoprotective effects of acetylbergenin were examined against D -galactosamine (GalN)-induced liver damage in rats, compared with that of bergenin reported previously. Acetylbergenin was synthesized from acetylation of bergenin, isolated from Mallotus japonicus, to increase lipophilic and physiological activiti...

journal_title：Pharmacological research

authors： Lim HK,Kim HS,Choi HS,Oh S,Jang CG,Choi J,Kim SH,Chang MJ

更新日期：2000-11-01 00:00:00

abstract：:Selective cyclooxygenase 2 (COX2) inhibitors (COXIBs) are effective anti-inflammatory and analgesic drugs with improved gastrointestinal (GI) safety compared to nonselective nonsteroidal anti-inflammatory drugs known as traditional (tNSAIDs). However, their use is associated with a cardiovascular (CV) hazard (i.e. inc...

journal_title：Pharmacological research

authors： Martelli A,Testai L,Anzini M,Cappelli A,Di Capua A,Biava M,Poce G,Consalvi S,Giordani A,Caselli G,Rovati L,Ghelardini C,Patrignani P,Sautebin L,Breschi MC,Calderone V

更新日期：2013-12-01 00:00:00

abstract：:Fecal microbiota transplant (FMT) has seen a historic emergence in last decade with its sojourn recently entering into a chequered path, due to a few reports of infection and subsequent mortality. Though FMT has been extensively reported, there is no comprehensive report on the delivery routes available for this non-p...

journal_title：Pharmacological research

authors： Gulati M,Singh SK,Corrie L,Kaur IP,Chandwani L

更新日期：2020-09-01 00:00:00

abstract：:Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX may play a role in the treatment of dysplastic Barrett's oesophagus. An ALA thermosetting gel Pluronic F-127) was developed and evaluated in an in vivo mouse model for potential use in PDT of Barrett's mucosa. In vitro studies of th...

journal_title：Pharmacological research

authors： Bourre L,Thibaut S,Briffaud A,Lajat Y,Patrice T

更新日期：2002-02-01 00:00:00

abstract：:We tested the efficacy of novel cyclooxygenase 2 (COX-2) inhibitors in counteracting glia-driven neuroinflammation induced by the amyloidogenic prion protein fragment PrP90-231 or lipopolysaccharide (LPS). In search for molecules with higher efficacy than celecoxib, we focused our study on its 2,3-diaryl-1,3-thiazolid...

journal_title：Pharmacological research

authors： Villa V,Thellung S,Bajetto A,Gatta E,Robello M,Novelli F,Tasso B,Tonelli M,Florio T

更新日期：2016-11-01 00:00:00

abstract：:Though the AMPA receptor has been implicated in several neurodegenerative processes (epilepsy, ischemia, spasticity), its role in cognition is yet to be clarified. The aim of this study was to assess in the rat the effects of the AMPA receptor antagonist NBQX (3.5, 7, 10, 20 and 30 mgkg(-1), i.p.) on learning and memo...

journal_title：Pharmacological research

authors： Pitsikas N,Rigamonti AE,Cella SG,Muller EE

更新日期：2002-01-01 00:00:00

abstract：:We have studied the effect of acute trazodone (3--20 mg kg(-1)) and quipazine (1--3 mg kg(-1)) treatment on the apomorphine-induced (1 mg kg(-1), once daily over 2 weeks) aggressive behaviour in male Wistar rats. All doses of trazodone and quipazine tested attenuated the aggressiveness as evidenced by the abolished in...

journal_title：Pharmacological research

authors： Rudissaar R,Pruus K,Vaarmann A,Pannel P,Skrebuhhova-Malmros T,Allikmets L,Matto V

更新日期：2001-04-01 00:00:00

abstract：:Tachykinins are important in the development of pulmonary inflammation in mice but the tachykinin receptor subtype mediating this response has not been defined. To elucidate the role of tachykinin NK3-receptors on allergen-induced pulmonary inflammation, studies were performed on ovalbumin (OVA) sensitized and challen...

journal_title：Pharmacological research

authors： Kung TT,Crawley Y,Jones H,Luo B,Gilchrest H,Greenfeder S,Anthes JC,Lira S,Wiekowski M,Cook DN,Hey JA,Egan RW,Chapman RW

更新日期：2004-12-01 00:00:00

abstract：:The understanding of signaling cascades involved in the induction, promotion, and progression of cancer, although advanced in recent years, is still incomplete. Tracing the imbalance of the impaired, physiologically-essential cellular signaling that drives the neoplastic process is a complex issue. This review discuss...

journal_title：Pharmacological research

authors： Al-Wadei HA,Ullah MF,Al-Wadei MH

更新日期：2012-07-01 00:00:00

abstract：:Inflammatory reaction and cell apoptosis are two important processes in intestinal ischemia/reperfusion (II/R) injury, and exploration of effective lead compounds against II/R injury via regulating inflammation and apoptosis is critical important. In this paper, the results indicated that dioscin significantly increas...

journal_title：Pharmacological research

authors： Zheng L,Han X,Hu Y,Zhao X,Yin L,Xu L,Qi Y,Xu Y,Han X,Liu K,Peng J

更新日期：2019-01-01 00:00:00

abstract：:Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic actions in the heart (i.e., contractility, metabolism, hypertrophy, autophagy, senescence and cell ...

journal_title：Pharmacological research

authors： Westermeier F,Bustamante M,Pavez M,García L,Chiong M,Ocaranza MP,Lavandero S

更新日期：2015-11-01 00:00:00

abstract：:Possible interaction between adenosine and L type Ca2+ channel in the locomotor activity of rats was investigated. R-PIA (0.05 mg kg-1), an adenosine analogue, and caffeine (20 mg kg-1), an adenosine receptor antagonist, significantly decreased and increased locomotor activity, respectively. Ca2+ channel blocker nifed...

journal_title：Pharmacological research

authors： Eroglu L,Tuna R,Caglayan B

更新日期：1996-02-01 00:00:00

abstract：:Chrysin, a natural flavone compound found in plants, has anti-inflammatory activity that has been previously explained in part by the suppression of promoter activities of pro-inflammatory enzymes, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Here we present evidence that several chrysin deriva...

journal_title：Pharmacological research

authors： Cho H,Yun CW,Park WK,Kong JY,Kim KS,Park Y,Lee S,Kim BK

更新日期：2004-01-01 00:00:00

abstract：:The effect of chloroquine and other antimalarial drugs on glutamate dehydrogenase activity was studied in liver and renal mitochondria as well as in kidney-cortex tubules of rabbit. In permeabilized mitochondria, with free access of substrates and drugs to glutamate dehydrogenase, 100 microns chloroquine decreased bot...

journal_title：Pharmacological research

authors： Jarzyna R,Lenarcik E,Bryła J

更新日期：1997-01-01 00:00:00

abstract：:Cells continuously turn over proteins through cycles of synthesis and degradation in order to maintain a functional proteome and to exert a tight control in the levels of regulatory proteins. Selective degradation of proteins was initially thought to be an exclusive function of the ubiquitin-proteasome system, however...

journal_title：Pharmacological research

authors： Kaushik S,Cuervo AM

更新日期：2012-12-01 00:00:00

abstract：:The human gut is populated by an array of bacterial species, which develop important metabolic and immune functions, with a marked effect on the nutritional and health status of the host. Dietary component also play beneficial roles beyond basic nutrition, leading to the development of the functional food concept and ...

journal_title：Pharmacological research

authors： Laparra JM,Sanz Y

更新日期：2010-03-01 00:00:00