Intercepting neoplastic progression in lung malignancies via the beta adrenergic (β-AR) pathway: implications for anti-cancer drug targets.


:The understanding of signaling cascades involved in the induction, promotion, and progression of cancer, although advanced in recent years, is still incomplete. Tracing the imbalance of the impaired, physiologically-essential cellular signaling that drives the neoplastic process is a complex issue. This review discusses the role of the regulator of the fight or flight response, the beta-adrenergic signaling cascade, as a mediator of cancer growth and progression in in vitro and in vivo cancer models. We review a series of experiments from our own laboratory and those of others examining the contribution of this signaling network to lung and other human malignancies and thereby identifying potential targets for chemotherapeutic interventions. The stimulation of the β-adrenergic receptor by lifestyle and environmental factors, as well as a preexisting risk for neoplasm, activates downstream effector molecules (adenylyl cyclase/cAMP/PKA/CREB) concomitant to the transactivation of related pathways (EGFR) that lead to pro-oncogenic signaling; this β-adrenergic pathway thereby encourages cancer growth by evasion of apoptosis, invasion, angiogenesis, and metastasis. GABAergic signaling acts as an antagonist to the β-adrenergic cascade by intercepting adenylyl cyclase activation, and thereby neutralizing the pro-oncogenic effects of β-adrenergic stimulation. The regulation of cancer cell growth by neurobiological signals expands the possibilities for pharmacological interventions in cancer therapy.


Pharmacol Res


Pharmacological research


Al-Wadei HA,Ullah MF,Al-Wadei MH




Has Abstract


2012-07-01 00:00:00














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    authors: Ray M,Roy R,Chowdhury PD,Srivastava S,Dubey MP

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 社论,评审


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    pub_type: 杂志文章,多中心研究


    authors: Conklin LS,Damsker JM,Hoffman EP,Jusko WJ,Mavroudis PD,Schwartz BD,Mengle-Gaw LJ,Smith EC,Mah JK,Guglieri M,Nevo Y,Kuntz N,McDonald CM,Tulinius M,Ryan MM,Webster R,Castro D,Finkel RS,Smith AL,Morgenroth LP,Arrieta

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Saraceno R,Schipani C,Mazzotta A,Esposito M,Di Renzo L,De Lorenzo A,Chimenti S

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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


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    更新日期:2015-09-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lin Y,Shia KS,Hsiao WC,Hsieh WP,Yeh TK,Tseng SL,Hsu CY,Chao YS,Hung MS

    更新日期:2010-10-01 00:00:00