Bmi1 drives the formation and development of intrahepatic cholangiocarcinoma independent of Ink4A/Arf repression.

abstract：:Given the high and increasing prevalence of obesity, the safe and effective treatment of obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A (HSYA), an active compound from the dried florets of Carthamus tinctorius L., can reduce high-fat (HF) diet-induced obesity in C57BL/6 J mice. Our...

journal_title：Pharmacological research

authors： Liu J,Yue S,Yang Z,Feng W,Meng X,Wang A,Peng C,Wang C,Yan D

更新日期：2018-08-01 00:00:00

abstract：:The effect of different L-histidine concentrations on human mammary tumour cell (CG5) proliferation was studied to test the hypothesis of a role of histidine in modulating sex steroid-regulated cell proliferation. Cell growth was only possible in the 10(-5) M and 10(-2) M range, while its inhibition by medroxyprogeste...

journal_title：Pharmacological research

authors： Ghezzo F,Racca S,Conti G,Berta GN,D'Avolio A,Abbadessa G,Gambino G,Di Carlo F

更新日期：1997-02-01 00:00:00

abstract：:We have recently synthesized a new series of 4,5-dihydrobenzo-oxa-cycloheptapyrazole derivatives with the aim to discover novel CB1 antagonist agents characterized by anti-obesity activity comparable to that of SR141716A but with reduced adverse effects such as anxiety and depression. Within the novel class, the CB1 a...

journal_title：Pharmacological research

authors： Mastinu A,Pira M,Pinna GA,Pisu C,Casu MA,Reali R,Marcello S,Murineddu G,Lazzari P

更新日期：2013-08-01 00:00:00

abstract：:Metastatic cancers account for more than 90% of cancer mortality. The metastasis of all cancers is critically mediated by enzymes that degrade extracellular matrix. Aggressive tumors are characterized by an imbalance between enzymes that degrade ECM and endogenous inhibitors of the enzymes. Matrix metalloproteinases (...

journal_title：Pharmacological research

authors： Lokeshwar BL

更新日期：2011-02-01 00:00:00

abstract：:Excess fructose consumption causes high prevalence of metabolic syndrome and inflammatory liver diseases. The aim of the current study was to investigate the therapeutic effects and underlying molecular mechanisms of curcumin and allopurinol in high fructose-induced hepatic inflammation. Male Sprague-Dawley rats were ...

journal_title：Pharmacological research

authors： Ding XQ,Wu WY,Jiao RQ,Gu TT,Xu Q,Pan Y,Kong LD

更新日期：2018-11-01 00:00:00

abstract：:Iron is an essential element for virtually all organisms. It facilitates cell proliferation and growth but also contributes to major hallmarks of cancer such as tumor initiation, growth, and metastasis. Often, iron handling of tumor cells is disturbed, with altered iron acquisition, efflux, and storage. Targeting pert...

journal_title：Pharmacological research

authors： Jung M,Mertens C,Bauer R,Rehwald C,Brüne B

更新日期：2017-06-01 00:00:00

abstract：:Oxylipins (OXLs) are bioactive molecules generated by the oxidation of fatty acids that promote the resolution of acute inflammation and prevent chronic inflammatory processes through molecular mechanisms that are not well known. We have previously reported the anti-inflammatory activity of microalgae-derived OXLs and...

journal_title：Pharmacological research

authors： Ávila-Román J,Talero E,de Los Reyes C,García-Mauriño S,Motilva V

更新日期：2018-02-01 00:00:00

abstract：:As a function of the structural modification of the steroid nucleus, the inhibitory interaction of 11 progesterone derivatives with human Na/K-ATPase (Na+/K(+)-transporting ATPase, EC 3.6.1.37), through C3-O-rhamnosylation, is either much decreased or weakly up to strongly increased, so that the rhamnosyl residue cont...

journal_title：Pharmacological research

authors： Weiland J,Schönfeld W,Menke KH,Repke KR

更新日期：1991-01-01 00:00:00

abstract：:A favourable option to management symptoms during menopausal transition is menopausal hormone therapy (MHT) but relation among MHT and risk of melanoma is controversial. This study aims to identify, analyse and present the evidence surrounding post-menopausal exogenous hormone therapy and the risk for melanoma in wome...

journal_title：Pharmacological research

authors： Tang X,Zhang H,Cui Y,Wang L,Wang Z,Zhang Y,Huo J,Cai J,Rinaldi G,Bhagavathula AS,Xiaopeng Y

更新日期：2020-10-01 00:00:00

abstract：:The anti-inflammatory effect of glucocorticoids depends, at least in part, on the induction of two regulatory proteins, lipocortin and vasocortin, both preventing the release of inflammatory mediators. Lipocortin inhibits phospholipase A2 (PLA2) and therefore reduces arachidonic acid metabolites formation. Vasocortin ...

journal_title：Pharmacological research

authors： Sautebin L,Carnuccio R,Ialenti A,Di Rosa M

更新日期：1992-01-01 00:00:00

abstract：:Male weanling Wistar rats were fed a 4% cholestyramine diet and used as a model to demonstrate that a reduction in serum low density lipoproteins stimulates de novo cholesterogenesis leading to DNA synthesis and cell proliferation. Feeding this diet resulted in a decrease in serum very low density lipoproteins and low...

journal_title：Pharmacological research

authors： Kazanecki ME,Melhem MF,Spichty KJ,Kelly RH,Rao KN

更新日期：1989-09-01 00:00:00

abstract：:The sphingolipid field has made significant strides over the past 10 years: from identifying metabolites of the sphingomyelin pathway as second messengers to discerning the molecular biology and biophysics of these lipid-derived second messengers. Building upon this vast basic science literature, scientists from multi...

journal_title：Pharmacological research

authors： Kester M,Kolesnick R

更新日期：2003-05-01 00:00:00

abstract：:A novel alkynylthiophene series of cannabinoid CB1 receptor antagonists has been described to exhibit distinct intrinsic activities with minimal substructure modifications. The three representatives, BPR0432, BPR0568 and BPR0569, functioning as a neutral antagonist, an inverse agonist and a partial agonist, respective...

journal_title：Pharmacological research

authors： Lin Y,Shia KS,Hsiao WC,Hsieh WP,Yeh TK,Tseng SL,Hsu CY,Chao YS,Hung MS

更新日期：2010-10-01 00:00:00

abstract：:The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the premise that physical agitation, such as pressure oscillation applied to an airway, is able to induce bronchodilation by reducing contractility and softening the cytoskeleton of ASM. Although the underlying mechanism is not entirely cle...

journal_title：Pharmacological research

authors： Wang L,Chitano P,Seow CY

更新日期：2020-09-01 00:00:00

abstract：:In recent clinical observation, the growth of endothelial tumors, such as hemangiomas of infancy, was repressed by the non-selective beta-adrenergic antagonist propranolol possibly through targeting of the vascular endothelial compartment. As human brain microvascular endothelial cells (HBMEC) play an essential role a...

journal_title：Pharmacological research

authors： Annabi B,Lachambre MP,Plouffe K,Moumdjian R,Béliveau R

更新日期：2009-11-01 00:00:00

abstract：:Most cancer cells generate energy through aerobic glycolysis to enable their rapid growth and proliferation, which is a phenomenon known as Warburg effect. Inhibition of aerobic glycolysis reduces lactate and ATP generation in cancer cells, and ultimately kills tumor cells. Increasing evidence suggests that wogonin, a...

journal_title：Pharmacological research

authors： Zhao Y,Zhang L,Wu Y,Dai Q,Zhou Y,Li Z,Yang L,Guo Q,Lu N

更新日期：2018-09-01 00:00:00

abstract：:In this study, we have investigated the vasodilator response to acetylcholine under diabetic conditions in isolated renal arteries of Wistar rats. The effect of nitric oxide synthase (NOS) inhibition on acetylcholine-induced vasodilator response was investigated. We have also examined the effects of two endothelium-de...

journal_title：Pharmacological research

authors： Yousif MH

更新日期：2003-09-01 00:00:00

abstract：:The aqueous extract from aerial parts of Artemisia copa Phil. (Compositae), was evaluated for antinociceptive activity using writhing, formalin, and hot-plate tests in mice. A dose-related antinociceptive response was obtained in the writhing test at doses of 500 and 1000 mg/kg p.o. (percentage of inhibition 23.3 and ...

journal_title：Pharmacological research

authors： Miño J,Moscatelli V,Hnatyszyn O,Gorzalczany S,Acevedo C,Ferraro G

更新日期：2004-07-01 00:00:00

abstract：:In the isolated myometrium obtained from pregnant women, diphenylhydantoin inhibited both spontaneous and K(+)-evoked contractions within the same range of potency. Nicardipine was less effective in inhibiting spontaneous than K(+)-induced contractions, whereas trifluoperazine was only effective against spontaneous co...

journal_title：Pharmacological research

authors： Medeiros YS,Calixto JB

更新日期：1990-09-01 00:00:00

abstract：:The gastrointestinal effects of single and repeated administration of ferrous sulphate was evaluated measuring faecal flora modifications and histology of stomach and duodenum of the rat. The acute experiments showed reversible histopathological lesions of stomach and duodenum with iron deposition and increase in faec...

journal_title：Pharmacological research

authors： Benoni G,Cuzzolin L,Zambreri D,Donini M,Del Soldato P,Caramazza I

更新日期：1993-01-01 00:00:00

abstract：:The aim of the present pilot study was to characterise the renal elimination of betalains after consumption of red beet juice (RBJ). Six healthy, non-smoking female volunteers were given a single oral dose of either 500 mL of a commercial RBJ containing 362.7 mg of betalains and 500 mL of tap water, respectively, in a...

journal_title：Pharmacological research

authors： Frank T,Stintzing FC,Carle R,Bitsch I,Quaas D,Strass G,Bitsch R,Netzel M

更新日期：2005-10-01 00:00:00

abstract：:Pulsatilla Decoction (Bai-Tou-Weng-Tang) has been used medically in China for thousands of years for the treatment of diseases caused by bacteria. In recent decades, Pulsatilla Decoction is becoming a well-known formula prescription used for the treatment of ulcerative colitis in traditional Chinese medicine. Pulsatil...

journal_title：Pharmacological research

authors： Li YH,Zou M,Han Q,Deng LR,Weinshilboum RM

更新日期：2020-10-01 00:00:00

abstract：:The role of autophagy, a process in which the cell self-digests its own components, was investigated in glioma cell death induced by the hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase-inhibiting drug simvastatin. Induction of autophagy and activation of autophagy-regulating signalling pathways were analyzed by i...

journal_title：Pharmacological research

authors： Misirkic M,Janjetovic K,Vucicevic L,Tovilovic G,Ristic B,Vilimanovich U,Harhaji-Trajkovic L,Sumarac-Dumanovic M,Micic D,Bumbasirevic V,Trajkovic V

更新日期：2012-01-01 00:00:00

abstract：:The effect of gentamicin on both glutamate synthesis and glutamate deamination was studied in kidney-cortex mitochondria and tubules isolated from both control and gentamicin-treated animals. In kidney-cortex mitochondria which were permeabilized in order to make a free access of substrates and antibiotic to the gluta...

journal_title：Pharmacological research

authors： Bryła J,Lietz T,Jarzyna R,Michalik M,Pietkiewicz J

更新日期：1992-12-01 00:00:00

abstract：:Atropine (5 mg/kg, s.c., twice daily) had no significant effect on 24-h water consumption on day 1 of treatment; on subsequent days the rats showed a significant increase. Procyclidine (5 mg/kg, s.c., twice daily) had a similar effect, except that the increase in daily water consumption began on the third day of treat...

journal_title：Pharmacological research

authors： Alharbi MM,Maickel RP

更新日期：1990-01-01 00:00:00

abstract：:As Traditional Chinese Medicine (TCM) transcends its cultural boundaries and becomes widely used in many countries around the world, one of the major risks to the growing use of TCM internationally is the damage caused to its reputation and to community safety when TCM practitioners are not adequately trained. Ensurin...

journal_title：Pharmacological research

authors： Li J,Graham D

更新日期：2020-11-01 00:00:00

abstract：:T lymphocytes produced by the thymus are essential mediators of immunity. Accelerated thymic atrophy appears in the patients with administration of glucocorticoids (GCs) which are commonly-used drugs to treat autoimmune and infectious diseases, leading to dysregulation of immunity with manifestation of progressive dim...

journal_title：Pharmacological research

authors： Li T,Yan F,Meng X,Wang J,Ting Kam RK,Zeng X,Liu Z,Zhou H,Yang F,Ren R,Liao K,Liu L

更新日期：2018-11-01 00:00:00

abstract：:Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of behavior. ASD is, however, often associated with medical comorbidities and gastrointestinal (GI) dysfunction is among the most common. Studies have demonstrated a corr...

journal_title：Pharmacological research

authors： Israelyan N,Margolis KG

更新日期：2018-06-01 00:00:00

abstract：:Metastatic melanoma has been described as a highly aggressive cancer with low sensibility to chemotherapeutic agents. New types of drug, such as metal-based drugs (ferrocifens) have emerged and could represent an alternative for melanoma treatment since they show interesting anticancer potential. Furthermore, molecula...

journal_title：Pharmacological research

authors： Resnier P,Galopin N,Sibiril Y,Clavreul A,Cayon J,Briganti A,Legras P,Vessières A,Montier T,Jaouen G,Benoit JP,Passirani C

更新日期：2017-12-01 00:00:00

abstract：:Potential risks of cyclohexanol (CH) and cyclohexanediol (CHD) isomers, which are the metabolites derived from cilexetil ester side-chain of several prodrugs such as antibiotics (e.g. cefotiam hexetil) and an antihypertensive agent (candesartan cilexetil), were examined in beagles that were made congestive heart failu...

journal_title：Pharmacological research

authors： Okunishi H,Shimoura K,Wang DQ,Kakizoe E

更新日期：2002-10-01 00:00:00