L-histidine/medroxyprogesterone acetate interaction modulates human breast cancer cell growth and progestin receptor expression in vitro.

abstract：:Effect of moclobemide, a selective monoamine oxidase-type A enzyme inhibitor, was investigated on the body temperature of male mice. Moclobemide (15-30 mg kg(-1), i.p.) produced significant reductions of body temperature in both normal and yeast-induced hyperthermic male mice. The hypothermic effect of moclobemide was...

journal_title：Pharmacological research

authors： Ginawi OT

更新日期：2003-09-01 00:00:00

abstract：:Poorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns regarding gestational metformin use remain, as its long-term effects...

journal_title：Pharmacological research

authors： Garbarino VR,Santos TA,Nelson AR,Zhang WQ,Smolik CM,Javors MA,Daws LC,Gould GG

更新日期：2019-02-01 00:00:00

abstract：:Cardamom seeds are widely used for flavouring purposes in food and as carminative. Little information has been reported on their pharmacological and toxicological properties or, for their volatile oil which constitutes about 5% of the seed's total weight. A comparative study of the anti-inflammatory activity of the oi...

journal_title：Pharmacological research

authors： al-Zuhair H,el-Sayeh B,Ameen HA,al-Shoora H

更新日期：1996-07-01 00:00:00

abstract：:The endocannabinoid signalling system includes: (1) at least two G-protein-coupled receptors, known as the cannabinoid CB(1) and CB(2) receptors and discovered following studies on the mechanism of action of Delta(9)-tetrahydrocannabinol, the major psychoactive principle of the hemp plant Cannabis sativa; (2) the endo...

journal_title：Pharmacological research

authors： Di Marzo V

更新日期：2009-08-01 00:00:00

abstract：:Biochemical evaluations of the effects of the sulfhydryl-containing angiotensin-converting enzyme inhibitor (captopril) on the nephrotoxicity induced by doxorubicin in normal rats were carried out. A single dose of doxorubicin (15 mg kg-1) which caused nephrotoxicity was manifested biochemically by the elevation of se...

journal_title：Pharmacological research

authors： Mansour MA,El-Kashef HA,Al-Shabanah OA

更新日期：1999-03-01 00:00:00

abstract：:The human gut is populated by an array of bacterial species, which develop important metabolic and immune functions, with a marked effect on the nutritional and health status of the host. Dietary component also play beneficial roles beyond basic nutrition, leading to the development of the functional food concept and ...

journal_title：Pharmacological research

authors： Laparra JM,Sanz Y

更新日期：2010-03-01 00:00:00

abstract：:Kidney injury is one of the main complications of obstructive jaundice (OJ) and its pathogenesis has not been clarified. As an independent risk factor for OJ associated with significant morbidity and mortality, it can be mainly divided into two types of morphological injury and functional injury. We called these dysfu...

journal_title：Pharmacological research

authors： Liu J,Qu J,Chen H,Ge P,Jiang Y,Xu C,Chen H,Shang D,Zhang G

更新日期：2021-01-01 00:00:00

abstract：:The molecular complexity of human breast cancer (BC) renders the clinical management of the disease challenging. Long non-coding RNAs (lncRNAs) are promising biomarkers for BC patient stratification, early detection, and disease monitoring. Here, we identified the involvement of the long intergenic non-coding RNA 0108...

journal_title：Pharmacological research

authors： De Palma FDE,Del Monaco V,Pol JG,Kremer M,D'Argenio V,Stoll G,Montanaro D,Uszczyńska-Ratajczak B,Klein CC,Vlasova A,Botti G,D'Aiuto M,Baldi A,Guigó R,Kroemer G,Maiuri MC,Salvatore F

更新日期：2020-11-01 00:00:00

abstract：:Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which is a hallmark of cancer. The altered energy metabolism not only provides cancer cell with ATP for cellular energy, but also generate essen...

journal_title：Pharmacological research

authors： Abdel-Wahab AF,Mahmoud W,Al-Harizy RM

更新日期：2019-12-01 00:00:00

abstract：:Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX may play a role in the treatment of dysplastic Barrett's oesophagus. An ALA thermosetting gel Pluronic F-127) was developed and evaluated in an in vivo mouse model for potential use in PDT of Barrett's mucosa. In vitro studies of th...

journal_title：Pharmacological research

authors： Bourre L,Thibaut S,Briffaud A,Lajat Y,Patrice T

更新日期：2002-02-01 00:00:00

abstract：:Low-doses of fenofibrate and dipyridamole have pleiotropic renoprotective actions in diabetic rats. This study investigated their combined effect relative to their individual treatments and lisinopril in rats with diabetic nephropathy. Streptozotocin (55mg/kg, i.p., once)-administered diabetic rats were allowed for 10...

journal_title：Pharmacological research

authors： Balakumar P,Varatharajan R,Nyo YH,Renushia R,Raaginey D,Oh AN,Akhtar SS,Rupeshkumar M,Sundram K,Dhanaraj SA

更新日期：2014-12-01 00:00:00

abstract：:Extensive studies have reported the significant roles of numerous cellular features and processes in properly maintaining neuronal morphology and function throughout the lifespan of an animal. Any alterations in their homeostasis appear to be strongly associated with neuronal aging and the pathogenesis of various neur...

journal_title：Pharmacological research

authors： Kwon MJ,Kim JH,Kim T,Lee SB

更新日期：2017-05-01 00:00:00

abstract：:Levosulpiride is the (-)-enantiomer of sulpiride. It has shown greater central antidopaminergic activity, antiemetic and antidyspeptic effects and lower acute toxicity than both the racemic and dextro forms. Several clinical studies indicate that levosulpiride has therapeutic efficacy in depressive and somatoform diso...

journal_title：Pharmacological research

authors： Mucci A,Nolfe G,Maj M

更新日期：1995-02-01 00:00:00

abstract：:Erectile function is a widely accepted indicator of systemic endothelial activity since from a clinical standpoint erectile dysfunction (ED) often precedes cardiovascular events. Recently it has been described a potential role for β3 adrenoceptor in cardiovascular diseases emphasizing a possible development of new dru...

journal_title：Pharmacological research

authors： Mitidieri E,Tramontano T,Gurgone D,Imbimbo C,Mirone V,Fusco F,Cirino G,d'Emmanuele di Villa Bianca R,Sorrentino R

更新日期：2017-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. Compared with HCC, for which several drugs have been approved, ICC is associated with shorter survival, and no drug has been approved for this type. Previously, we reported that Bmi1 drives HC...

journal_title：Pharmacological research

authors： Guo J,Deng N,Xu Y,Li L,Kuang D,Li M,Li X,Xu Z,Xiang M,Xu C

更新日期：2020-12-08 00:00:00

abstract：:Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subseque...

journal_title：Pharmacological research

authors： Ganjali S,Blesso CN,Banach M,Pirro M,Majeed M,Sahebkar A

更新日期：2017-05-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer in women, and the second most frequent cause of cancer-related deaths in women worldwide. It is a heterogeneous disease composed of multiple subtypes with distinct morphologies and clinical implications. Quantitative systems pharmacology (QSP) is an emerging discipline brid...

journal_title：Pharmacological research

authors： Fleisher B,Brown AN,Ait-Oudhia S

更新日期：2017-10-01 00:00:00

abstract：:Recent studies have shown that a higher consumption of green tea leads to a lower prevalence of depressive symptoms in elderly individuals. However, no studies have explored the antidepressant-like effect of green tea in preclinical models of depression. The aim of this study was to investigate the antidepressant-like...

journal_title：Pharmacological research

authors： Zhu WL,Shi HS,Wei YM,Wang SJ,Sun CY,Ding ZB,Lu L

更新日期：2012-01-01 00:00:00

abstract：:Felbamate (FBM) is a relatively novel anticonvulsant agent which has been reported to exert its antiepileptic effects by blockade of the glycine recognition site on the N-methyl-D-aspartate subtype of glutamate receptor and potentiation at the gamma-aminobutyric acid (GABA) type A receptor. An increasing number of ant...

journal_title：Pharmacological research

authors： Fraser CM,Sills GJ,Forrest G,Thompson GG,Brodie MJ

更新日期：1999-09-01 00:00:00

abstract：:The purpose of the present work was to study the change in morphine metabolic ratio in obese subjects before and after Roux-en-Y Gastric Bypass (RYGB) and to identify clinical and/or biological factors associated with this change. The pharmacokinetics (PK) of oral morphine (30mg), morphine-3-glucuronide (M3G) and morp...

journal_title：Pharmacological research

authors： Lloret-Linares C,Luo H,Rouquette A,Labat L,Poitou C,Tordjman J,Bouillot JL,Mouly S,Scherrmann JM,Bergmann JF,Declèves X

更新日期：2017-04-01 00:00:00

abstract：:The possible involvement of adenosine 5'-triphosphate (ATP) receptors in the function of the hippocampus is reviewed. The involvement of these receptors in the hippocampus is suggested by data that ATP is released from hippocampal slices [1] and that it also induces fast synaptic currents in cultured hippocampal neuro...

journal_title：Pharmacological research

authors： Inoue K

更新日期：1998-11-01 00:00:00

abstract：:Serotonin (5-HT) is present in high concentration in enterochromaffin cells throughout the gastrointestinal tract, where it plays a very important role, being involved, e.g., in peristaltic and secretory reflexes in response to chemical or mechanical stimuli of the gut. Intestinal 5-HT is inactivated by metabolic degr...

journal_title：Pharmacological research

authors： Martel F

更新日期：2006-08-01 00:00:00

abstract：:By the use of combined radioreceptor binding and autoradiographic techniques we attempted to analyse the biochemical characteristics and the anatomical localization of GABA-B receptors in sections of rat circle of Willis and pialarachnoid arteries. 3H-GABA in the presence of 40 microM isoguvacine and 2.5 mM CaCl2 was ...

journal_title：Pharmacological research

authors： Napoleone P,Ferrante F,Amenta F

更新日期：1990-05-01 00:00:00

abstract：:Contrasting results have been reported on the role of rs628031 and rs683369 polymorphisms of SLC22A1 and rs776746 of CYP3A5 on imatinib treatment response in patients with chronic myeloid leukemia (CML). In the present study, we conducted a systematic review and meta-analysis of published studies to estimate the impac...

journal_title：Pharmacological research

authors： Cargnin S,Ravegnini G,Soverini S,Angelini S,Terrazzino S

更新日期：2018-05-01 00:00:00

abstract：:The transparent bodies of see-through medaka fish has led to their use as models for in vivo cell and tissue imaging. However, these fish may also prove useful as models for pathological processes. Accumulating reports show that pathology in fish is similar to that in mammals, including humans. In this study, patholog...

journal_title：Pharmacological research

authors： Kawasaki T,Saito K,Deguchi T,Fujimori K,Tadokoro M,Yuba S,Ohgushi H,Kawarabayasi Y

更新日期：2008-11-01 00:00:00

abstract：:It is generally accepted that divalent cations are involved in the nociceptive pathway. The effect of systemic co-administration of magnesium sulfate and calcium channel blockers (nifedipine, verapamil) on the analgesic effect of opioid (mixed mu/kappa: butorphanol) and non-opioid drugs (paracetamol) was investigated....

journal_title：Pharmacological research

authors： Assi AA

更新日期：2001-06-01 00:00:00

abstract：:This paper examines the effect of biphenylacetic acid on the antagonistic action of norfloxacin and enoxacin on the GABA(A)-mediated responses of the isolated guinea-pig ileum. GABA produced transient contractions followed by relaxation. The contractile effect of exogenously applied GABA was concentration-dependent wi...

journal_title：Pharmacological research

authors： Koutsoviti-Papadopoulou M,Nikolaidis E,Kounenis G

更新日期：2001-09-01 00:00:00

abstract：CONTEXT:Ticagrelor was related to bradycardia in DISPERSE-II trial. This risk has been integrated into the European risk-management plan, and its use is warned in at-risk patients. Nevertheless, this risk was not systematically assessed nor measured. OBJECTIVES:To estimate the risk of bradyarrhythmia associated with t...

journal_title：Pharmacological research

authors： Pujade I,Perino J,Mathieu C,Arnaud M,Raschi E,Gatti M,Bezin J,Salvo F

更新日期：2020-10-01 00:00:00

abstract：:The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the premise that physical agitation, such as pressure oscillation applied to an airway, is able to induce bronchodilation by reducing contractility and softening the cytoskeleton of ASM. Although the underlying mechanism is not entirely cle...

journal_title：Pharmacological research

authors： Wang L,Chitano P,Seow CY

更新日期：2020-09-01 00:00:00

abstract：:The neurohormonal factor arginine vasopressin (AVP) produces potent systemic vasoconstriction as well as water retention in the kidneys via the V(1a) and V(2) receptors, respectively. Therefore, AVP may be considered as an aggravating factor of cardiac failure. In the present study, the effects of intravenous (i.v.) i...

journal_title：Pharmacological research

authors： Yatsu T,Kusayama T,Tomura Y,Arai Y,Aoki M,Tahara A,Wada K,Tsukada J

更新日期：2002-11-01 00:00:00