Green tea polyphenols produce antidepressant-like effects in adult mice.


:Recent studies have shown that a higher consumption of green tea leads to a lower prevalence of depressive symptoms in elderly individuals. However, no studies have explored the antidepressant-like effect of green tea in preclinical models of depression. The aim of this study was to investigate the antidepressant-like effects and the possible mechanism of action of green tea in widely used mouse models of depression. Mice were orally administered green tea polyphenols (GTP; 5, 10 and 20mg/kg) for 7days and assessed in the forced swimming test (FST) and tail suspension test (TST) 60min after the last GTP administration. Serum corticosterone and adrenocorticotrophic hormone (ACTH) levels were also determined immediately after the FST. Green tea polyphenols significantly reduced immobility in both the FST and TST but did not alter locomotor activity in the open field test, suggesting that GTP has antidepressant-like effects, and this action did not induce nonspecific motor changes in mice. Green tea polyphenols also reduced serum corticosterone and ACTH levels in mice exposed to the FST. The present study demonstrated that GTP exerts antidepressant-like effects in a mouse behavioral models of depression, and the mechanism may involve inhibition of the hypothalamic-pituitary-adrenal axis.


Pharmacol Res


Pharmacological research


Zhu WL,Shi HS,Wei YM,Wang SJ,Sun CY,Ding ZB,Lu L




Has Abstract


2012-01-01 00:00:00














  • Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon.

    abstract::Diarrhea is a common side effect experienced by cancer patients undergoing clinical chemotherapy, such as with 5-fluorouracil (5-FU). However, the precise mechanisms underlying 5-FU-induced diarrhea remain unclear. In the present study, we examined the role of neutrophil in 5-FU-induced diarrhea. Mice were given 5-FU ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Sakai H,Sagara A,Matsumoto K,Jo A,Hirosaki A,Takase K,Sugiyama R,Sato K,Ikegami D,Horie S,Matoba M,Narita M

    更新日期:2014-09-01 00:00:00

  • Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is a debilitating condition where excess collagen deposition occurs in the extracellular matrix. At first sight, it is expected that the level of different kinds of matrix metalloproteinases might be downregulated in IPF as it is a matrix degrading collagenase. However, the role of ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Mahalanobish S,Saha S,Dutta S,Sil PC

    更新日期:2020-02-01 00:00:00

  • Haemodynamic effects of nisoldipine by oral route.

    abstract::The aim of this study is to investigate the acute haemodynamic effect of orally administered nisoldipine. Eight patients with stable angina and normal overall ventricular function were submitted to cardiac catheterization and angiography before and one hour after administration of nisoldipine 20 mg per os. Cardiac out...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Razzolini R,Boffa GM,Calvanese A,Isabella G,Ramondo A,Chioin R

    更新日期:1991-10-01 00:00:00

  • Activity-based protein profiling of the human failing ischemic heart reveals alterations in hydrolase activities involving the endocannabinoid system.

    abstract:AIM:Acute myocardial infarction and subsequent post-infarction heart failure are among the leading causes of mortality worldwide. The endocannabinoid system has emerged as an important modulator of cardiovascular disease, however the role of endocannabinoid metabolic enzymes in heart failure is still elusive. Herein, w...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: van Esbroeck ACM,Varga ZV,Di X,van Rooden EJ,Tóth VE,Onódi Z,Kuśmierczyk M,Leszek P,Ferdinandy P,Hankemeier T,van der Stelt M,Pacher P

    更新日期:2020-01-01 00:00:00

  • Antibody modulation: Limiting the efficacy of therapeutic antibodies.

    abstract::Monoclonal antibodies (mAb) have revolutionised the way in which we treat disease. From cancer to autoimmunity, antibody therapy has been responsible for some of the most impressive clinical responses observed in the last 2 decades. A key component of this success has been their generally low levels of toxicity, and u...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Vaughan AT,Cragg MS,Beers SA

    更新日期:2015-09-01 00:00:00

  • The non-NMDA receptor antagonist NBQX does not affect rats performance in the object recognition task.

    abstract::Though the AMPA receptor has been implicated in several neurodegenerative processes (epilepsy, ischemia, spasticity), its role in cognition is yet to be clarified. The aim of this study was to assess in the rat the effects of the AMPA receptor antagonist NBQX (3.5, 7, 10, 20 and 30 mgkg(-1), i.p.) on learning and memo...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Pitsikas N,Rigamonti AE,Cella SG,Muller EE

    更新日期:2002-01-01 00:00:00

  • Control of salt intake by steroids and cerebral peptides.

    abstract::Steroids (aldosterone and testosterone) and peptides of cerebral origin (angiotensin II and the tachykinins) control the salt intake of the rat. They arouse or suppress the behaviour and produce life-long enhancements of NaCl intake. Need-induced salt intake (salt appetite or salt hunger), which is the consequence of ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Epstein AN

    更新日期:1992-02-01 00:00:00

  • Application of pharmacometrics and quantitative systems pharmacology to cancer therapy: The example of luminal a breast cancer.

    abstract::Breast cancer (BC) is the most common cancer in women, and the second most frequent cause of cancer-related deaths in women worldwide. It is a heterogeneous disease composed of multiple subtypes with distinct morphologies and clinical implications. Quantitative systems pharmacology (QSP) is an emerging discipline brid...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Fleisher B,Brown AN,Ait-Oudhia S

    更新日期:2017-10-01 00:00:00

  • Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy.

    abstract::Lupeol is a natural triterpenoid that widely exists in edible fruits and vegetables, and medicinal plants. In the last decade, a plethora of studies on the pharmacological activities of lupeol have been conducted and have demonstrated that lupeol possesses an extensive range of pharmacological activities such as antic...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Liu K,Zhang X,Xie L,Deng M,Chen H,Song J,Long J,Li X,Luo J

    更新日期:2020-12-11 00:00:00

  • Anti-arrhythmic drug therapy in implantable cardioverter-defibrillator recipients.

    abstract::Implantable cardioverter-defibrillators (ICDs) have revolutionized the primary and secondary prevention of patients with ventricular arrhythmias. However, the adverse effects of appropriate or inappropriate shocks may require the adjunctive use of anti-arrhythmic drugs (AADs). Beta blockers are the cornerstone of phar...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: AlTurki A,Proietti R,Russo V,Dhanjal T,Banerjee P,Essebag V

    更新日期:2019-05-01 00:00:00

  • Gene silencing of receptor-interacting protein 2 protects against cigarette smoke-induced acute lung injury.

    abstract:BACKGROUND AND PURPOSE:Chronic obstructive pulmonary disease (COPD) is characterized by progressive alveolar damage and generally irreversible airflow limitation. Nuclear factor-κB (NF-κB) plays a critical role in COPD pathogenesis. Receptor-interacting protein 2 (Rip2), a 60 kDa adaptor protein, is a positive regulato...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Dong J,Liao W,Tan LH,Yong A,Peh WY,Wong WSF

    更新日期:2019-01-01 00:00:00

  • Levosulpiride: a review of its clinical use in psychiatry.

    abstract::Levosulpiride is the (-)-enantiomer of sulpiride. It has shown greater central antidopaminergic activity, antiemetic and antidyspeptic effects and lower acute toxicity than both the racemic and dextro forms. Several clinical studies indicate that levosulpiride has therapeutic efficacy in depressive and somatoform diso...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Mucci A,Nolfe G,Maj M

    更新日期:1995-02-01 00:00:00

  • Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway.

    abstract::Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread worldwide through person-to-person contact, causing a public health emergency of international concern. At present, there is no specific antiviral treatment recommended for SARS-CoV-2 infection. Liu Shen capsule (LS), a traditional Chinese medicin...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ma Q,Pan W,Li R,Liu B,Li C,Xie Y,Wang Z,Zhao J,Jiang H,Huang J,Shi Y,Dai J,Zheng K,Li X,Yang Z

    更新日期:2020-08-01 00:00:00

  • Simvastatin improves the attenuated heart rate recovery of type 2 diabetics.

    abstract::Heart rate recovery at 1min (HRR1) is a strong predictor of all-cause mortality. The effects of statins on the autonomic nervous system may account for their beneficial effects in survival. Our aim was to determine if statin therapy improves heart rate recovery in hypercholesterolemic patients with type 2 diabetes mel...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Tekin G,Tekin A,Canatar T,Sipahi I,Unsal A,Katircibaşi T,Koçum T,Erol T,Yiğit F,Demircan S,Ermiş N,Sezgin AT,Müderrisoğlu H

    更新日期:2006-12-01 00:00:00

  • Hypolipidaemic activity in rodents of boron analogs of phosphonoacetates and cyanoborane adducts of dialkyl aminomethylphosphonates.

    abstract::Boron analogues of phosphonoacetates proved to be potent hypolipidaemic agents in rodents, lowering both serum cholesterol and triglyceride levels. (C2H5O)3PBH2COOCH3 proved to be the most effective agent in mice, lowering serum cholesterol 46% and serum triglycerides 54% after 16 days. (C2H5O)3PBH2COOH and Na+H+(C2H5...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Hall IH,Wong OT,Sood A,Sood CK,Spielvogel BF,Shrewsbury RP,Morse KW

    更新日期:1992-04-01 00:00:00

  • Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.

    abstract::Diabetic nephropathy (DN) is a common and serious complication of diabetes and causes kidney failure. Ginsenoside Rg5 (Rg5) is an important monomer in the main protopanaxadiol component of black ginseng. Rg5 has exhibited some beneficial biological effects, such as anti-cancer, neuroprotection, and anti-depression, bu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhu Y,Zhu C,Yang H,Deng J,Fan D

    更新日期:2020-05-01 00:00:00

  • Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors.

    abstract::In the field of kinase inhibitors for applications in cancer research, tubulin is emerging as a targeted cellular protein that can significantly contribute to their activities. However, investigation of kinase inhibitors beyond the kinome is an area often neglected. Herein, we describe the results of pharmacological s...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Hoque M,Abbassi RH,Froio D,Man J,Johns TG,Stringer BW,Day BW,Pajic M,Kassiou M,Munoz L

    更新日期:2018-08-01 00:00:00

  • Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53.

    abstract::Most cancer cells generate energy through aerobic glycolysis to enable their rapid growth and proliferation, which is a phenomenon known as Warburg effect. Inhibition of aerobic glycolysis reduces lactate and ATP generation in cancer cells, and ultimately kills tumor cells. Increasing evidence suggests that wogonin, a...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhao Y,Zhang L,Wu Y,Dai Q,Zhou Y,Li Z,Yang L,Guo Q,Lu N

    更新日期:2018-09-01 00:00:00

  • Evaluation of 137Cs activity in plant drugs and in some phytoderivatives from Chernobyl accident up to present (1986-1994).

    abstract::The accident to the nuclear power plant of Chernobyl (in April 1986) caused a radioactive contamination in large areas of the majority of European countries. During the first transient time the fall-out phenomenon was the most important method of contamination, particularly from 131I whose relative isotopic abundance ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Curini M,Rosati O,Borio R,Saetta DM,Cicioni R,Forini N,Rongoni A,Dipilato AC

    更新日期:1995-07-01 00:00:00

  • Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133.

    abstract::The aminosteroid derivative RM-133 is an effective anticancer molecule for which proof of concept has been achieved in several mouse xenograph models (HL-60, MCF-7, PANC-1 and OVCAR-3). To promote this new family of molecules toward a clinical phase 1 trial, the mechanism of action governing the anticancer properties ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Perreault M,Maltais R,Kenmogne LC,Létourneau D,LeHoux JG,Gobeil S,Poirier D

    更新日期:2018-02-01 00:00:00

  • Lean body weight is the best scale for venous thromboprophylaxis algorithm in severely obese patients undergoing bariatric surgery.

    abstract::Severely obese patients undergoing bariatric surgery (BS) are at increased risk for venous thromboembolism (VTE). How standard low molecular weight heparin (LMWH) regimen should be adapted to provide both sufficient efficacy and safety in this setting is unclear. We aimed to compare the influence of four body size des...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Gaborit B,Moulin PA,Bege T,Boullu S,Vincentelli C,Emungania O,Morange PE,Berdah S,Salem JE,Dutour A,Frere C

    更新日期:2018-05-01 00:00:00

  • Natural products, extracts and formulations comprehensive therapy for the improvement of motor function in alcoholic liver disease.

    abstract::Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide that afflicts human health. With the in-depth study of the disease, its pathogenesis has gradually become clear. Although great breakthroughs have been made in the research of ALD, the research and development of drugs related to ALD has...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Hu S,Li SW,Yan Q,Hu XP,Li LY,Zhou H,Pan LX,Li J,Shen CP,Xu T

    更新日期:2019-12-01 00:00:00

  • Influence of mianserin on some central effects of ethanol.

    abstract::The interaction of mianserin with ethanol in central nervous system (CNS) was investigated. Mianserin was administered at a single dose of 5 or 20 mgkg(-1) i.p. or as daily injections in a dose of 2.5 mgkg(-1) given for 14 days. The influence of mianserin on acute ethanol toxicity (LD(50)), on ED(50) of ethanol in rot...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Pietrzak B,Kubik-Bogucka E

    更新日期:2002-07-01 00:00:00

  • A TCM formula comprising Sophorae Flos and Lonicerae Japonicae Flos alters compositions of immune cells and molecules of the STAT3 pathway in melanoma microenvironment.

    abstract::A traditional Chinese medicine (TCM) formula (SL) comprising Sophorae Flos and Lonicerae Japonicae Flos was used for treating melanoma in ancient China. We have previously shown that an ethanolic extract of SL (SLE) possesses anti-melanoma effects and suppresses STAT3 signaling in vitro and in vivo. STAT3 has been lin...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Liu YX,Bai JX,Li T,Fu XQ,Guo H,Zhu PL,Chan YC,Chou JY,Yin CL,Li JK,Wang YP,Chen YJ,Yu ZL

    更新日期:2019-04-01 00:00:00

  • Long noncoding RNA AK039312 and AK079370 inhibits bone formation via miR-199b-5p.

    abstract::Osteoporosis caused by aging and menopause had become an emerging threat to human health. The reduction of osteoblast differentiation has been considered to be an essential cause of osteoporosis. Osteoblast differentiation could be regulated by LncRNAs, and increasing evidences have proved that LncRNAs may be adopted ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Yin C,Tian Y,Yu Y,Li D,Miao Z,Su P,Zhao Y,Wang X,Pei J,Zhang K,Qian A

    更新日期:2021-01-01 00:00:00

  • Notch in fibrosis and as a target of anti-fibrotic therapy.

    abstract::The Notch pathway represents a highly conserved signaling network with essential roles in regulation of key cellular processes and functions, many of which are critical for development. Accumulating evidence indicates that it is also essential for fibrosis and thus the pathogenesis of chronic fibroproliferative diseas...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Hu B,Phan SH

    更新日期:2016-06-01 00:00:00

  • Chaperones in autophagy.

    abstract::Cells continuously turn over proteins through cycles of synthesis and degradation in order to maintain a functional proteome and to exert a tight control in the levels of regulatory proteins. Selective degradation of proteins was initially thought to be an exclusive function of the ubiquitin-proteasome system, however...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Kaushik S,Cuervo AM

    更新日期:2012-12-01 00:00:00

  • Heart remodeling induced by adjuvant trastuzumab-containing chemotherapy for breast cancer overexpressing human epidermal growth factor receptor type 2: a prospective study.

    abstract::We aimed to investigate the cardiac changes in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer treated with trastuzumab in an adjuvant setting. Two hundred and fifty-three women with HER2-positive breast cancer were included. The assessment of cardiovascular system and echocardiogr...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Piotrowski G,Gawor R,Bourge RC,Stasiak A,Potemski P,Gawor Z,Nanda NC,Banach M

    更新日期:2013-12-01 00:00:00

  • Altered expression of connexin 43 and related molecular partners in a pig model of left ventricular dysfunction with and without dipyrydamole therapy.

    abstract::Gap junctions (GJ) mediate electrical coupling between cardiac myocytes, allowing the spreading of the electrical wave responsible for synchronized contraction. GJ function can be regulated by modulation of connexon densities on membranes, connexin (Cx) phosphorylation, trafficking and degradation. Recent studies have...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Del Ry S,Moscato S,Bianchi F,Morales MA,Dolfi A,Burchielli S,Cabiati M,Mattii L

    更新日期:2015-05-01 00:00:00

  • A possible cardioprotective effect of heat shock proteins during cardiac surgery in pediatric patients.

    abstract:BACKGROUND:Overexpression of heat shock proteins (Hsps) is associated to myocardial protection and it has been suggested that they could be a marker of cardiac preservation in conditions such as extracorporeal circulation. Aim of this study was to evaluate if cardioplegic arrest can modify the expression of Hsps in the...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Giannessi D,Caselli C,Vitale RL,Crucean A,Murzi B,Del Ry S,Vanini V,Biagini A

    更新日期:2003-11-01 00:00:00