Green tea polyphenols produce antidepressant-like effects in adult mice.

abstract：:In the present study, hyperglycaemia was induced by intraperitoneal injection of streptozotocin (65 mg/kg). Treatment with glibenclamide (GB) in a dose of 0.45 or 0.9 mg/kg significantly decreased plasma glucose level in a dose-related manner. Administration of nadolol (ND) in a dose of 5 or 10 mg/kg did not affect pl...

journal_title：Pharmacological research

authors： Abdel Aziz AH,Moustafa AM,Abd Ellah MF,el-Mazar MA

更新日期：1996-07-01 00:00:00

abstract：:Hypercalcemia and hypercalciuria observed both in humans and in animals who were on long-term theophylline therapy, prompted us to investigate whether oral theophylline treatment at optimal doses causes any adverse side effects on bone metabolism in mild asthmatics. Therefore, serum osteocalcin (BGP) and total alkalin...

journal_title：Pharmacological research

authors： Oner P,Gürdöl F,Oner-Iyidon Y,Kolanci C,Büyüköztürk S

更新日期：1999-08-01 00:00:00

abstract：:Nebivolol, a third generation selective beta(1)-adrenoceptor (beta(1)-AR) antagonist, has been reported to reduce intracellular oxidative stress and to induce the release of nitric oxide (NO) from the endothelium. Nebivolol is also subjected to a complex metabolic process where glucuronidation, aromatic and alicyclic ...

journal_title：Pharmacological research

authors： Evangelista S,Garbin U,Pasini AF,Stranieri C,Boccioletti V,Cominacini L

更新日期：2007-04-01 00:00:00

abstract：:It is well known that type 2 diabetes mellitus is frequently associated with vascular dysfunction and an elevated systemic blood pressure, yet the underlying mechanisms are not completely understood. We previously reported that in mesenteric arteries from established type 2 diabetic Otsuka Long-Evans Tokushima fatty (...

journal_title：Pharmacological research

authors： Matsumoto T,Ishida K,Nakayama N,Taguchi K,Kobayashi T,Kamata K

更新日期：2010-09-01 00:00:00

abstract：:Tyrosine kinase inhibitors (TKIs) have been widely used for the clinical treatment of patients with non-small cell lung cancer (NSCLC) harboring mutations in the EGFR. Unfortunately, due to the secondary mutation in EGFR, eventual drug-resistance is inevitable. Therefore, to overcome the resistance, new agent is urgen...

journal_title：Pharmacological research

authors： Xie YJ,Gao WN,Wu QB,Yao XJ,Jiang ZB,Wang YW,Wang WJ,Li W,Hussain S,Liu L,Leung EL,Fan XX

更新日期：2020-09-01 00:00:00

abstract：:Visceral obesity is the excess deposition of visceral fat within the abdominal cavity that surrounds vital organs. Visceral obesity is directly associated with metabolic syndrome, breast cancer and endometrial cancer. In visceral obese subjects, signal transducer and activator of the transcription 3 (STAT3) in adipocy...

journal_title：Pharmacological research

authors： Su T,Huang C,Yang C,Jiang T,Su J,Chen M,Fatima S,Gong R,Hu X,Bian Z,Liu Z,Kwan HY

更新日期：2020-02-01 00:00:00

abstract：:Monoamine oxidases (MAO) are mitochondrial enzymes that catalyze the oxidation of monoamines in multiple tissues, including the brain. Elevated MAO activity has long been implicated in the etiology of depression, anxiety, and neurodegenerative disease, fuelling the search for inhibitors in the prevention and treatment...

journal_title：Pharmacological research

authors： Dreiseitel A,Korte G,Schreier P,Oehme A,Locher S,Domani M,Hajak G,Sand PG

更新日期：2009-05-01 00:00:00

abstract：:Fecal microbiota transplant (FMT) has seen a historic emergence in last decade with its sojourn recently entering into a chequered path, due to a few reports of infection and subsequent mortality. Though FMT has been extensively reported, there is no comprehensive report on the delivery routes available for this non-p...

journal_title：Pharmacological research

authors： Gulati M,Singh SK,Corrie L,Kaur IP,Chandwani L

更新日期：2020-09-01 00:00:00

abstract：:The presence of M(1)-M(4) receptors in guinea-pig gallbladder smooth muscle cells has been reported recently. The majority of these receptors are said to be of M(2) subtype. However, there are controversial reports about the functional muscarinic receptors that mediate contraction in this tissue. Similar to gallbladde...

journal_title：Pharmacological research

authors： Akici A,Karaalp A,Skender E,El-Fakahany EE,Oktay S

更新日期：1999-11-01 00:00:00

abstract：:Effect of moclobemide, a selective monoamine oxidase-type A enzyme inhibitor, was investigated on the body temperature of male mice. Moclobemide (15-30 mg kg(-1), i.p.) produced significant reductions of body temperature in both normal and yeast-induced hyperthermic male mice. The hypothermic effect of moclobemide was...

journal_title：Pharmacological research

authors： Ginawi OT

更新日期：2003-09-01 00:00:00

abstract：:Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity a...

journal_title：Pharmacological research

authors： Chiarugi A

更新日期：2005-07-01 00:00:00

abstract：:The objective of this study was to investigate the effects of 3-aminobenzamide (3-AB) on tissue damage in lung after hind limb ischemia-reperfusion (I/R), by assessing blood biochemical assay and histopathological analysis. Thirty-five adult Wistar rats were divided into five groups. After application of anaesthesia b...

journal_title：Pharmacological research

authors： Koksel O,Yildirim C,Cinel L,Tamer L,Ozdulger A,Bastürk M,Degirmenci U,Kanik A,Cinel I

更新日期：2005-05-01 00:00:00

abstract：:Selective cyclooxygenase 2 (COX2) inhibitors (COXIBs) are effective anti-inflammatory and analgesic drugs with improved gastrointestinal (GI) safety compared to nonselective nonsteroidal anti-inflammatory drugs known as traditional (tNSAIDs). However, their use is associated with a cardiovascular (CV) hazard (i.e. inc...

journal_title：Pharmacological research

authors： Martelli A,Testai L,Anzini M,Cappelli A,Di Capua A,Biava M,Poce G,Consalvi S,Giordani A,Caselli G,Rovati L,Ghelardini C,Patrignani P,Sautebin L,Breschi MC,Calderone V

更新日期：2013-12-01 00:00:00

abstract：:The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart and kidney homeostasis, but also plays an important role in the pathophysiology of heart and kidney diseases. Recently, new components of the RAS have been discovered, including angiotensin converting enzyme 2 (ACE2), Angiotensin(Ang)-(1-...

journal_title：Pharmacological research

authors： Simões E Silva AC,Teixeira MM

更新日期：2016-05-01 00:00:00

abstract：:In recent years, natural products have reemerged as biotherapeutic options, with several dietary carotenoids, viz. astaxanthin, fucoxanthin, siphonaxanthin, β-cryptoxanthin, α-carotene, β-carotene, and lycopene, developing as potential candidates for chemoprevention and chemotherapeutics of breast, colorectal, lung, a...

journal_title：Pharmacological research

authors： Saini RK,Keum YS,Daglia M,Rengasamy KR

更新日期：2020-07-01 00:00:00

abstract：:Flibanserin has been reported to be an agonist at 5-HT1A-receptors and an antagonist at 5-HT2A receptors, with higher affinity for 5-HT1A receptors. Despite the fact that less receptor occupation is required by full agonists than by antagonists to exert their effects, flibanserin was shown to exert 5-HT2A antagonism a...

journal_title：Pharmacological research

authors： Scandroglio A,Monferini E,Borsini F

更新日期：2001-02-01 00:00:00

abstract：:The objective of the study was to investigate possible changes in vancomycin serum levels induced by cardio-pulmonary bypass (CPB). Ten cardiac patients (seven males, three females, aged between 56 and 81), who underwent cardiac surgery requiring CPB, took part in the study. Vancomycin (15 mg kg-1) was intravenously i...

journal_title：Pharmacological research

authors： Miglioli PA,Merlo F,Grabocka E,Padrini R

更新日期：1998-10-01 00:00:00

abstract：:Experiments were designed to evaluate the mechanisms of propofol and adenosine in rat atrial muscle. Atria were suspended in the isolated organ bath system for isometric tension recording and response to propofol and adenosine were tested in the absence and presence of glibenclamide, N(G)-nitro-arginine-methyl-ester (...

journal_title：Pharmacological research

authors： Cinel I,Gür S

更新日期：2000-08-01 00:00:00

abstract：:Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding TCAs) is no...

journal_title：Pharmacological research

authors： Furlanut M,Benetello P

更新日期：1990-01-01 00:00:00

abstract：:A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer p...

journal_title：Pharmacological research

authors： Kim DH,Khan H,Ullah H,Hassan STS,Šmejkal K,Efferth T,Mahomoodally MF,Xu S,Habtemariam S,Filosa R,Lagoa R,Rengasamy KR

更新日期：2019-09-01 00:00:00

abstract：:In hypothermic rats with acute hypertension induced by intravenous injection of adrenalin, regional changes in blood-brain barrier permeability to macromolecules were investigated using Evans blue as indication. Evans blue albumin extravasation was determined as a macroscopic finding and a quantitative estimation with...

journal_title：Pharmacological research

authors： Oztaş B,Kaya M,Camurcu S

更新日期：1992-07-01 00:00:00

abstract：:Felbamate (FBM) is a relatively novel anticonvulsant agent which has been reported to exert its antiepileptic effects by blockade of the glycine recognition site on the N-methyl-D-aspartate subtype of glutamate receptor and potentiation at the gamma-aminobutyric acid (GABA) type A receptor. An increasing number of ant...

journal_title：Pharmacological research

authors： Fraser CM,Sills GJ,Forrest G,Thompson GG,Brodie MJ

更新日期：1999-09-01 00:00:00

abstract：:The modification in the composition of bile acids in hamster by the administration of high dose of ursodeoxycholic acid (UDCA) was investigated. Male Golden Syrian hamsters were divided into five groups: a control group, two groups that received 0.5 g of UDCA per 100 g of standard diet during 30 and 60 days and anothe...

journal_title：Pharmacological research

authors： Matejka M,Vescina C,Carducci CN,Alayón A,Dios A,Scarlatto E,Mamianetti A

更新日期：1990-05-01 00:00:00

abstract：:A major focus of contemporary drug screening strategies is the identification of novel anticancer compounds, which often results in underutilization of resources. Current drug evaluation involves in vivo tumor (xenograft) regression as proof-of-principle for cytotoxicity (POC). However, this end-point lacks any assess...

journal_title：Pharmacological research

authors： Naik RR,Luo T,Kohandel M,Bapat SA

更新日期：2016-09-01 00:00:00

abstract：:Cannabinoids have emerged as promising neuroprotective agents due to their capability to activate specific targets, which are involved in the control of neuronal homeostasis and survival. Specifically, those ligands that selectively target and activate the CB2 receptor may be useful for their anti-inflammatory and neu...

journal_title：Pharmacological research

authors： Gómez-Cañas M,Morales P,García-Toscano L,Navarrete C,Muñoz E,Jagerovic N,Fernández-Ruiz J,García-Arencibia M,Pazos MR

更新日期：2016-08-01 00:00:00

abstract：:Receptor concentrations for adrenaline, steroid hormones, PGF2alpha, LH and FSH were measured in the hypophysis and ovary of dairy cows with ovarian cysts and the results were compared with those of healthy animals. Significant modifications were found in all receptor concentrations, either between follicular and lute...

journal_title：Pharmacological research

authors： Odore R,Re G,Badino P,Donn A,Vigo D,Biolatti B,Girardi C

更新日期：1999-04-01 00:00:00

abstract：:The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the premise that physical agitation, such as pressure oscillation applied to an airway, is able to induce bronchodilation by reducing contractility and softening the cytoskeleton of ASM. Although the underlying mechanism is not entirely cle...

journal_title：Pharmacological research

authors： Wang L,Chitano P,Seow CY

更新日期：2020-09-01 00:00:00

abstract：:Cicletanine [(+/-)-C] is a racemic furopyridine derivative used as an antihypertensive agent. Pharmacokinetic and metabolic studies have shown that cicletanine is rapidly and almost fully metabolized into sulfo- and glucuro-conjugated metabolites. However, the stereoselective metabolism of cicletanine is not well-know...

journal_title：Pharmacological research

authors： Menard C,Lamiable D,Vistelle R,Morin E,Ratanasavanh D

更新日期：2000-07-01 00:00:00

abstract：:Monoclonal antibodies (mAb) have revolutionised the way in which we treat disease. From cancer to autoimmunity, antibody therapy has been responsible for some of the most impressive clinical responses observed in the last 2 decades. A key component of this success has been their generally low levels of toxicity, and u...

journal_title：Pharmacological research

authors： Vaughan AT,Cragg MS,Beers SA

更新日期：2015-09-01 00:00:00

abstract：:Sodium-glucose transporter 2 (SGLT2) inhibitors, also known as gliflozins, are a new class of orally active drugs used in the management of type 2 diabetes. By inhibiting the SGLT responsible for the reabsorption of glucose from the kidney, their use aims primarily to induce glycosuria and, as a consequence, lower gly...

journal_title：Pharmacological research

authors： Faillie JL

更新日期：2017-04-01 00:00:00