Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats.

abstract：:Adaptive responses to stress are critical to enhance physical and mental well-being, but excessive or prolonged stress may cause inadaptability and increase the risks of psychiatric disorders, such as depression. GABABR signaling is fundamental to brain function and has been identified in neuropsychiatric disorders. K...

journal_title：Pharmacological research

authors： Deng SL,Hu ZL,Mao L,Gao B,Yang Q,Wang F,Chen JG

更新日期：2021-01-01 00:00:00

abstract：:Beneficial therapeutic effects of dihydropyridine derivatives in cardiovascular and neurological disorders are often associated with selective L-type Ca(2+)channel blockade. Here the new dihydropyridine derivatives Bay E5759 (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl-1-methylethyl ...

journal_title：Pharmacological research

authors： Himmel HM,Stengel W,Ravens U

更新日期：2001-08-01 00:00:00

abstract：:Folic acid-conjugated albumin nanospheres (FA-AN) have been developed to provide an actively targetable drug delivery system for improved drug targeting of cancer cells with reduced side effects. The nanospheres were prepared by conjugating folic acid onto the surface of albumin nanospheres using 1-ethyl-3-(3-dimethyl...

journal_title：Pharmacological research

authors： Shen Z,Li Y,Kohama K,Oneill B,Bi J

更新日期：2011-01-01 00:00:00

abstract：:In this lipopolysaccharide (LPS)-induced endotoxemia model, the effects of 3-aminobenzamide (3-AB), a poly(ADP-ribose) synthetase (PARS) inhibitor, on ileal apoptosis were evaluated by light microscopy and M30 cell death staining. Moreover, the relationship between Bcl-2, iNOS expression, and serum nitrate (NO(3)(-)) ...

journal_title：Pharmacological research

authors： Cinel I,Buyukafsar K,Cinel L,Polat A,Atici S,Tamer L,Oral U

更新日期：2002-08-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) is being sold as a panacea that has the capability of reducing or eliminating cancer, preventing heart disease, improving immune function, and altering body composition to treat obesity or build lean body mass. Unfortunately, there has been very little published human research on CLA. Th...

journal_title：Pharmacological research

authors： Whigham LD,Cook ME,Atkinson RL

更新日期：2000-12-01 00:00:00

abstract：:Possible interaction between adenosine and L type Ca2+ channel in the locomotor activity of rats was investigated. R-PIA (0.05 mg kg-1), an adenosine analogue, and caffeine (20 mg kg-1), an adenosine receptor antagonist, significantly decreased and increased locomotor activity, respectively. Ca2+ channel blocker nifed...

journal_title：Pharmacological research

authors： Eroglu L,Tuna R,Caglayan B

更新日期：1996-02-01 00:00:00

abstract：:Plasma lipid and lipoprotein levels were evaluated in 27 adults with essential hypertension at four different periods during a 12-month treatment with doxazosin. Mean plasma total cholesterol (TC), low-density lipoprotein-cholesterol (LDLC), triglyceride (TG), very low density lipoprotein-cholesterol (VLDLC) and the L...

journal_title：Pharmacological research

authors： Ahaneku JE,Taylor GO,Agbedana EO,Walker O,Salako LA

更新日期：1994-10-01 00:00:00

abstract：:Because many Ca2+ channel blocking agents are known to cause adverse systemic effects, in this study we tested the haemodynamic side effects of nimodipine with and without a mild hypoxic-ischaemic (HI) insult in a newborn piglet model. Fifteen min after completing a brief period of asphyxia we gave i.v. nimodipine as ...

journal_title：Pharmacological research

authors： Raju TN,John E,Shankararao R,Fornell L,Vasa R,Abu-Harb M

更新日期：1996-01-01 00:00:00

abstract：:The present study was aimed at investigating the role of endogenous nitric oxide (NO) in regulating Na,K-ATPase activity in the kidney. The expression of alpha-1 and beta-1 subunits; and the enzymatic activity of Na,K-ATPase were determined in the kidney of rats treated with an NO synthase inhibitor, N(G)-nitro-L-argi...

journal_title：Pharmacological research

authors： Kang DG,Kim JW,Lee J

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:There is still a need to develop new effective medications for the treatment of ulcerative colitis, particularly for patients who are intolerant or resistant to first line therapies. This article compared the efficacy and safety of etrolizumab and infliximab in moderate to severe ulcerative colitis. METHODS...

journal_title：Pharmacological research

authors： Motaghi E,Ghasemi-Pirbaluti M,Zabihi M

更新日期：2019-01-01 00:00:00

abstract：:Oxidative stress is related to the progression of renal diseases and modulation of oxidative stress can lead to a reduction in vascular events in patients with chronic renal insufficiency (CRI). Indoxyl sulfate (IS) and xanthine oxidase (XO) are related to impaired neovasculogenesis in CRI. Hydralazine is suggested fo...

journal_title：Pharmacological research

authors： Chang TT,Chen JW

更新日期：2020-01-01 00:00:00

abstract：:Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate its beneficial role in management of diabetes and its complications. This review highlights recent...

journal_title：Pharmacological research

authors： Zhu R,Liu H,Liu C,Wang L,Ma R,Chen B,Li L,Niu J,Fu M,Zhang D,Gao S

更新日期：2017-08-01 00:00:00

abstract：:The modification in the composition of bile acids in hamster by the administration of high dose of ursodeoxycholic acid (UDCA) was investigated. Male Golden Syrian hamsters were divided into five groups: a control group, two groups that received 0.5 g of UDCA per 100 g of standard diet during 30 and 60 days and anothe...

journal_title：Pharmacological research

authors： Matejka M,Vescina C,Carducci CN,Alayón A,Dios A,Scarlatto E,Mamianetti A

更新日期：1990-05-01 00:00:00

abstract：:Endothelial dysfunction (ED), an established response to cardiovascular risk factors, is characterized by increased levels of soluble molecules secreted by endothelial cells (EC). Evidence suggest that ED is an independent predictor of cardiac events and that it is associated with a deficiency in production or bioavai...

journal_title：Pharmacological research

authors： Charles S,Raj V,Arokiaraj J,Mala K

更新日期：2017-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic and chronic autoimmune inflammatory disorder affecting multiple joints. Various cytokines, chemokines and growth factors synergistically modulate the joint physiology leading to bone erosion and cartilage degradation. Other than these conventional mediators that are well establi...

journal_title：Pharmacological research

authors： Dinesh P,Rasool M

更新日期：2018-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. Compared with HCC, for which several drugs have been approved, ICC is associated with shorter survival, and no drug has been approved for this type. Previously, we reported that Bmi1 drives HC...

journal_title：Pharmacological research

authors： Guo J,Deng N,Xu Y,Li L,Kuang D,Li M,Li X,Xu Z,Xiang M,Xu C

更新日期：2020-12-08 00:00:00

abstract：:Effect of moclobemide, a selective monoamine oxidase-type A enzyme inhibitor, was investigated on the body temperature of male mice. Moclobemide (15-30 mg kg(-1), i.p.) produced significant reductions of body temperature in both normal and yeast-induced hyperthermic male mice. The hypothermic effect of moclobemide was...

journal_title：Pharmacological research

authors： Ginawi OT

更新日期：2003-09-01 00:00:00

abstract：:Vaccinations have been used as an essential tool in the fight against infectious diseases, and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants--ASIA syndrome). It has been postulated ...

journal_title：Pharmacological research

authors： Soriano A,Nesher G,Shoenfeld Y

更新日期：2015-02-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is an extracellular lipid signaling molecule that acts as a selective, high-affinity ligand for a family of five G protein-coupled receptors. This signaling system was first identified twenty years ago, and has since been shown to regulate a diverse range of physiological processes and di...

journal_title：Pharmacological research

authors： Chew WS,Wang W,Herr DR

更新日期：2016-11-01 00:00:00

abstract：:Despite our insufficient understanding of the exact molecular mechanisms of general anesthetics and sedatives, every year millions of children are treated with these drugs in a seemingly safe manner. However, increasing evidence particularly from animal studies has suggested the possibility for deleterious effects in ...

journal_title：Pharmacological research

authors： Ward CG,Loepke AW

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF THE REVIEW:This review article discusses recent advances in the mechanism of dipeptidyl peptidase-4 (DPP-4) actions in renal diseases, especially diabetic kidney fibrosis, and summarizes anti-fibrotic functions of various DPP-4 inhibitors in diabetic nephropathy (DN). RECENT FINDINGS:DN is a common complica...

journal_title：Pharmacological research

authors： Gupta S,Sen U

更新日期：2019-09-01 00:00:00

abstract：:TMEM16A plays critical roles in physiological process and may serve as drug targets for diverse diseases. Recently, TMEM16A has started to be regarded as potential primary lung adenocarcinoma targets. Here, we identified that arctigenin, a natural compound, is a novel TMEM16A inhibitor, and it can suppress lung adenoc...

journal_title：Pharmacological research

authors： Guo S,Chen Y,Shi S,Wang X,Zhang H,Zhan Y,An H

更新日期：2020-05-01 00:00:00

abstract：AIM AND SCOPE:To determine the acute effects of increased intra-abdominal pressure (IAP) on the biochemistry, morphology, and contractility of the isolated terminal ileum of rats. BACKGROUND:Laparoscopic procedures are used clinically in diagnostic and treatment modalities and experimentally as a model of ischemia-rep...

journal_title：Pharmacological research

authors： Unsal MA,Imamoglu M,Kadioglu M,Aydin S,Ulku C,Kesim M,Alver A,Kalyoncu NI,Yaris E,Bozkaya H

更新日期：2006-02-01 00:00:00

abstract：:It has demonstrated that carteolol can increase the endothelium-dependent vasodilation induced by alpha-2 adrenergic agonist. In order to evaluate the effect of carteolol, and to clarify the mechanism, we examined the effects of 10 microM carteolol on the vasodilation induced by increasing doses (10(-7)-10(-4) M) of c...

journal_title：Pharmacological research

authors： Ito M,Fukuda N,Izumi Y,Watanabe Y,Watanabe M,Soma M,Kanmatsuse K

更新日期：1995-05-01 00:00:00

abstract：:We previously demonstrated that the typical mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP) inhibited artery constriction, but CCCP was used only as a pharmacological tool. Niclosamide is an anthelmintic drug approved by FDA. Niclosamide ethanolamine (NEN) is a salt form of niclosamide and has ...

journal_title：Pharmacological research

authors： Li SL,Yan J,Zhang YQ,Zhen CL,Liu MY,Jin J,Gao JL,Xiao XL,Shen X,Tai Y,Hu N,Zhang XZ,Sun ZJ,Dong DL

更新日期：2017-01-01 00:00:00

abstract：:The understanding of signaling cascades involved in the induction, promotion, and progression of cancer, although advanced in recent years, is still incomplete. Tracing the imbalance of the impaired, physiologically-essential cellular signaling that drives the neoplastic process is a complex issue. This review discuss...

journal_title：Pharmacological research

authors： Al-Wadei HA,Ullah MF,Al-Wadei MH

更新日期：2012-07-01 00:00:00

abstract：:Gamma-vinyl GABA (vigabatrin; VGB), an irreversible inhibitor of GABA-transaminase, was evaluated for its effect on the contractile responses to PGE(2) or its precursor arachidonic acid (AA) in guinea pig ileum (GPI) and non-pregnant rat uterus. Rationale behind this study was the rise in gamma-aminobutyric acid (GABA...

journal_title：Pharmacological research

authors： Raza M,Al-Shabanah OA

更新日期：2003-06-01 00:00:00

abstract：:CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. The aim of the present study was to characterize the electrophysiological and metabolic profile of CHF5074 in the hippocampus. Electrophysiological recordings show that CHF5074 inhibits...

journal_title：Pharmacological research

authors： Mango D,Barbato G,Piccirilli S,Panico MB,Feligioni M,Schepisi C,Graziani M,Porrini V,Benarese M,Lanzillotta A,Pizzi M,Pieraccini S,Sironi M,Blandini F,Nicoletti F,Mercuri NB,Imbimbo BP,Nisticò R

更新日期：2014-03-01 00:00:00

abstract：:Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity a...

journal_title：Pharmacological research

authors： Chiarugi A

更新日期：2005-07-01 00:00:00

abstract：:Accumulation of amyloid-β peptides (Aβ) within brain is a major pathogenic hallmark of Alzheimer's disease (AD). Emerging evidence suggests that autophagy, an important intracellular catabolic process, is involved in Aβ clearance. Here, we investigated whether temsirolimus, a newly developed compound approved by Food ...

journal_title：Pharmacological research

authors： Jiang T,Yu JT,Zhu XC,Tan MS,Wang HF,Cao L,Zhang QQ,Shi JQ,Gao L,Qin H,Zhang YD,Tan L

更新日期：2014-03-01 00:00:00